CS203225B1 - Spdsob stabilizácie 6-bróm-2-ftexanónn - Google Patents
Spdsob stabilizácie 6-bróm-2-ftexanónn Download PDFInfo
- Publication number
- CS203225B1 CS203225B1 CS469079A CS469079A CS203225B1 CS 203225 B1 CS203225 B1 CS 203225B1 CS 469079 A CS469079 A CS 469079A CS 469079 A CS469079 A CS 469079A CS 203225 B1 CS203225 B1 CS 203225B1
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- hexanone
- brom
- stabilization
- bromo
- formula
- Prior art date
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- CZGOECYPTLSLNI-UHFFFAOYSA-N 6-bromohexan-2-one Chemical compound CC(=O)CCCCBr CZGOECYPTLSLNI-UHFFFAOYSA-N 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 3
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 2
- 230000000087 stabilizing effect Effects 0.000 claims description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 4
- YMIISQFLRUQIIW-UHFFFAOYSA-N 1-bromohexan-2-one Chemical compound CCCCC(=O)CBr YMIISQFLRUQIIW-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 150000002118 epoxides Chemical class 0.000 description 3
- PVFOHMXILQEIHX-UHFFFAOYSA-N 8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9-[2-(2-bromophenyl)ethyl]purin-6-amine Chemical compound C=1C=2OCOC=2C=C(Br)C=1SC1=NC=2C(N)=NC=NC=2N1CCC1=CC=CC=C1Br PVFOHMXILQEIHX-UHFFFAOYSA-N 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 description 1
- FQYUMYWMJTYZTK-UHFFFAOYSA-N Phenyl glycidyl ether Chemical compound C1OC1COC1=CC=CC=C1 FQYUMYWMJTYZTK-UHFFFAOYSA-N 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 239000002027 dichloromethane extract Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229960001476 pentoxifylline Drugs 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
ČESKOSLOVENSKA SOCIALISTICKÁ REPUBLIKA (195 POPIS VYNALEZU K AUTORSKÉMU OSVEDtENIU 203225 (11) (Bl) (22) Přihlášené 04 07 79(21) (PV 4690-79) (51) Int. Cl.3 C 07 C 49/173 • ES? (40) Zverejnené W 05 88 OSAD PRO VYNÁLEZY A OBJEVY (45) Vydané 15 09 83 (75)
Autor vynálezu JENDRIGHOVSKÝ JÁN j.ns.. ΰ’ίΤΒΕΑΝϊί LADISLAV ing. CSc,
γυβΛ:; a^í glíz mg. esc, Bratislava, mintzinger Stefan rndi·,SENEC a FANCOVIC KAROL ing. CSc, BRATISLAVA (54) Spdsob stohilizáíúe O-Swmm-2-hexanónu 1
Predmetom vynálezu je spSsob stabilizá-cie 6-brórn-2-hexanónu, vzorca I, 1-fenoxy--2,3-epoxípropánom vzorca II
Br—CHzC INC H2CH2— CO- CHs 11
Brómderivát vzorce í je velmi labilnázlúčenína, rozkládá sa tepelným spracova-ním a svetlom, co zapříčiňuje při jej výro-bě technologické problémy. Rozkladom lát-ky I vzniká brómovodík, ktorý pósobí au-tokatalyticky na rozklad tejto zlúčeniny apri ďalšom spracovaní brómhexanonu zni-žuje v alkylačnej reakcii výtažky. Přidáním epoxidu vzorca II v množstve0,1 až 5 % k brómderivátu sa bromovodíkzachytává, čím sa látka stabilizuje. Velmi 2 výhodnou vlastnosťou epoxidu je to, že jeprchavý a stabilizuje brómhexanón aj v pa-rách pri destilácii, čo umožňuje získatdestiláciou prakticky čistý brómhexanónstabilizovaný stopami epoxidu. 6-bróm-2-hexanón je medziproduktom převýrobu vazodilatancia pentoxifylínu. V ďalšom je predmet vynálezu objasně-ný na příklade bez toho, aby bol ním ob-medzený. Příklad 1 K 200 ml dichlórmetánového extraktu ob-sahujúceho 20 g surového 6-bróm-2-hexa-nónu sa přidá 1 g l-řenoxy-2,3-epoxipropá-nu. Díchlormetán sa odpaří a zvyšok pre-destiluje vákuovo. Získá sa 17 g (84,3% vý-ťažok) 6-bró.m-2-hexanónu t. v. 96 až 98stupňů Celsia( 1,6 kPa v 99% čistotě) sta-novené titračne a plynovou chromatogra-fiou. 203225
Claims (1)
- 203225 PREDMET VYNALEZU Spósob stabilizácie 6-bróm-2-hexanónu, čenine sa přidá l-fenoxy-2,3-epoxipropán vvyznačujúci sa tým, že k predmetne] zlú- množstve 0,1 až 5 %. Saverografia, n. p., závod 7, Most
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS469079A CS203225B1 (cs) | 1979-07-04 | 1979-07-04 | Spdsob stabilizácie 6-bróm-2-ftexanónn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS469079A CS203225B1 (cs) | 1979-07-04 | 1979-07-04 | Spdsob stabilizácie 6-bróm-2-ftexanónn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS203225B1 true CS203225B1 (cs) | 1981-02-27 |
Family
ID=5390237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS469079A CS203225B1 (cs) | 1979-07-04 | 1979-07-04 | Spdsob stabilizácie 6-bróm-2-ftexanónn |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS203225B1 (cs) |
-
1979
- 1979-07-04 CS CS469079A patent/CS203225B1/cs unknown
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