CS196336B2 - Method of producing novel 3-substituted 1-/o-benzoylphenyl/-5-/tertiary aminomethyl/-1h-1,2,4,-triazoles - Google Patents
Method of producing novel 3-substituted 1-/o-benzoylphenyl/-5-/tertiary aminomethyl/-1h-1,2,4,-triazoles Download PDFInfo
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- CS196336B2 CS196336B2 CS768097A CS809776A CS196336B2 CS 196336 B2 CS196336 B2 CS 196336B2 CS 768097 A CS768097 A CS 768097A CS 809776 A CS809776 A CS 809776A CS 196336 B2 CS196336 B2 CS 196336B2
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- Czechoslovakia
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- formula
- carboxylic acid
- acid
- compounds
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- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 4
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- -1 o-benzoylphenyl Chemical group 0.000 claims description 9
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- 239000011159 matrix material Substances 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007530 organic bases Chemical group 0.000 description 1
- 239000003791 organic solvent mixture Substances 0.000 description 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960005453 strychnine Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 150000003738 xylenes Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1614775A CH601267A5 (enrdf_load_stackoverflow) | 1975-12-12 | 1975-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS196336B2 true CS196336B2 (en) | 1980-03-31 |
Family
ID=4414812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS768097A CS196336B2 (en) | 1975-12-12 | 1976-12-10 | Method of producing novel 3-substituted 1-/o-benzoylphenyl/-5-/tertiary aminomethyl/-1h-1,2,4,-triazoles |
Country Status (21)
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3709898A (en) * | 1971-02-09 | 1973-01-09 | Upjohn Co | Process for the production of triazolobenzodiazepines and intermediates |
| FR2285125A1 (fr) * | 1974-09-17 | 1976-04-16 | Takeda Chemical Industries Ltd | Derives de 1,2,4-triazole |
-
1975
- 1975-12-12 CH CH1614775A patent/CH601267A5/xx not_active IP Right Cessation
-
1976
- 1976-06-13 IE IE2701/76A patent/IE44688B1/en unknown
- 1976-12-03 GB GB50527/76A patent/GB1563735A/en not_active Expired
- 1976-12-03 CY CY1177A patent/CY1177A/xx unknown
- 1976-12-08 DE DE19762655483 patent/DE2655483A1/de not_active Ceased
- 1976-12-09 FR FR7637092A patent/FR2361884A2/fr active Granted
- 1976-12-10 BE BE173136A patent/BE849266R/xx not_active IP Right Cessation
- 1976-12-10 AU AU20470/76A patent/AU510423B2/en not_active Expired
- 1976-12-10 ZA ZA767380A patent/ZA767380B/xx unknown
- 1976-12-10 SE SE7613918A patent/SE431332B/xx unknown
- 1976-12-10 DK DK557676A patent/DK557676A/da not_active Application Discontinuation
- 1976-12-10 HU HU76CI00001704A patent/HU171999B/hu unknown
- 1976-12-10 ES ES454151A patent/ES454151A2/es not_active Expired
- 1976-12-10 AT AT914076A patent/AT351022B/de not_active IP Right Cessation
- 1976-12-10 ES ES454152A patent/ES454152A2/es not_active Expired
- 1976-12-10 CS CS768097A patent/CS196336B2/cs unknown
- 1976-12-10 NL NL7613786A patent/NL7613786A/xx not_active Application Discontinuation
- 1976-12-10 ES ES454153A patent/ES454153A2/es not_active Expired
- 1976-12-10 ES ES454150A patent/ES454150A2/es not_active Expired
- 1976-12-10 CA CA267,603A patent/CA1081236A/en not_active Expired
- 1976-12-11 JP JP51149324A patent/JPS5273871A/ja active Granted
-
1983
- 1983-01-14 SG SG17/83A patent/SG1783G/en unknown
- 1983-04-14 HK HK131/83A patent/HK13183A/xx unknown
-
1984
- 1984-12-30 MY MY90/84A patent/MY8400090A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG1783G (en) | 1983-09-16 |
| IE44688B1 (en) | 1982-02-24 |
| IE44688L (en) | 1977-06-12 |
| SE431332B (sv) | 1984-01-30 |
| ES454152A2 (es) | 1978-03-16 |
| ATA914076A (de) | 1978-12-15 |
| AU510423B2 (en) | 1980-06-26 |
| CH601267A5 (enrdf_load_stackoverflow) | 1978-06-30 |
| FR2361884B2 (enrdf_load_stackoverflow) | 1979-10-05 |
| ES454151A2 (es) | 1978-04-01 |
| MY8400090A (en) | 1984-12-31 |
| AT351022B (de) | 1979-07-10 |
| FR2361884A2 (fr) | 1978-03-17 |
| GB1563735A (en) | 1980-03-26 |
| NL7613786A (nl) | 1977-06-14 |
| AU2047076A (en) | 1978-06-15 |
| CY1177A (en) | 1983-06-10 |
| ZA767380B (en) | 1977-11-30 |
| HU171999B (hu) | 1978-05-28 |
| DK557676A (da) | 1977-06-13 |
| BE849266R (fr) | 1977-06-10 |
| HK13183A (en) | 1983-04-22 |
| ES454153A2 (es) | 1978-04-01 |
| SE7613918L (sv) | 1977-06-13 |
| CA1081236A (en) | 1980-07-08 |
| JPS5273871A (en) | 1977-06-21 |
| DE2655483A1 (de) | 1977-06-16 |
| ES454150A2 (es) | 1977-12-16 |
| JPS616825B2 (enrdf_load_stackoverflow) | 1986-03-01 |
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