CS101391A2 - 3,5-disubstituted 2-isoxazolines and isoxazoles, method of their production, these compounds containing agents and their application - Google Patents

3,5-disubstituted 2-isoxazolines and isoxazoles, method of their production, these compounds containing agents and their application

Info

Publication number
CS101391A2
CS101391A2 CS911013A CS101391A CS101391A2 CS 101391 A2 CS101391 A2 CS 101391A2 CS 911013 A CS911013 A CS 911013A CS 101391 A CS101391 A CS 101391A CS 101391 A2 CS101391 A2 CS 101391A2
Authority
CS
Czechoslovakia
Prior art keywords
isoxazolines
isoxazoles
disubstituted
production
application
Prior art date
Application number
CS911013A
Other languages
English (en)
Inventor
Wilfried Dr Schwab
Hiristo Anagnostopulos
Elena Dr Porsche-Wiebking
John Dr Grome
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of CS101391A2 publication Critical patent/CS101391A2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CS911013A 1990-04-12 1991-04-10 3,5-disubstituted 2-isoxazolines and isoxazoles, method of their production, these compounds containing agents and their application CS101391A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4011880 1990-04-12

Publications (1)

Publication Number Publication Date
CS101391A2 true CS101391A2 (en) 1991-11-12

Family

ID=6404301

Family Applications (1)

Application Number Title Priority Date Filing Date
CS911013A CS101391A2 (en) 1990-04-12 1991-04-10 3,5-disubstituted 2-isoxazolines and isoxazoles, method of their production, these compounds containing agents and their application

Country Status (16)

Country Link
US (1) US5273989A (cs)
EP (1) EP0451790A1 (cs)
JP (1) JPH04234857A (cs)
KR (1) KR910018363A (cs)
CN (1) CN1055537A (cs)
AU (1) AU7428591A (cs)
BR (1) BR9101475A (cs)
CA (1) CA2040219A1 (cs)
CS (1) CS101391A2 (cs)
FI (1) FI911718A7 (cs)
HU (1) HU911183D0 (cs)
IE (1) IE911235A1 (cs)
IL (1) IL97821A0 (cs)
NO (1) NO911432L (cs)
PT (1) PT97329A (cs)
ZA (1) ZA912701B (cs)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994020475A1 (fr) * 1993-03-02 1994-09-15 Fujisawa Pharmaceutical Co., Ltd. Derive d'isoxazole
CZ283564B6 (cs) * 1993-11-26 1998-05-13 Pfizer Inc. 3-Aryl-2-isoxazolin-5-hydroxamové kyseliny a farmaceutické prostředky na jejich bázi
CA2177375A1 (en) * 1993-11-26 1995-06-01 Edward F. Kleinman 3-aryl-2-isoxazolines as antiinflammatory agents
US5767118A (en) * 1994-10-26 1998-06-16 Merck & Co., Inc. 4-Heterocyclic peperidines promote release of growth hormone
FR2752163B1 (fr) * 1996-08-12 1998-10-30 Pf Medicament Utilisation de l'efaroxan pour la fabricaton de medicament destine au traitement de la maladie de huntington
KR19990011062A (ko) * 1997-07-21 1999-02-18 손욱 이소옥사졸리딘 고리 함유 액정화합물 및 이를 포함하고 있는 액정 조성물
US6319937B1 (en) * 1998-11-18 2001-11-20 Dupont Pharmaceuticals Company Isoxazoline fibrinogen receptor antagonists
AU7353300A (en) 1999-09-08 2001-04-10 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
WO2002059080A2 (en) 2001-01-25 2002-08-01 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
AU2003221322A1 (en) * 2002-03-07 2003-09-16 Sds Biotech K.K. Substituted isoxazole alkylamine derivative and agri- and horticultural fungicide
AU2004267044B8 (en) * 2003-08-20 2009-12-17 Emisphere Technologies, Inc. Compounds, methods and formulations for the oral delivery of a glucagon like peptide (GLP)-1 compound or an melanocortin 4 receptor (MC4) agonist peptide
ES2278346T3 (es) 2003-08-20 2007-08-01 Eli Lilly And Company Compuestos, procedimientos y formulaciones para suministro oral de un compuesto peptido (glp)-1 del tipo de glucagon o un peptido agonista (glp)-4 del receptor 4 de melacortina (mc4).
CA2587224A1 (en) * 2004-11-19 2006-05-26 Plant Bioscience Limited Microcin b17 analogs and methods for their preparation and use
US8338635B2 (en) * 2007-05-31 2012-12-25 Satomi Niwayama Synthesis of half esters
US8765735B2 (en) * 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8927551B2 (en) * 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9149465B2 (en) * 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
CN114874131B (zh) * 2015-02-27 2025-03-25 海洋规划生物工厂株式会社 Kakeromycin及其衍生物的制造方法
PL3538525T3 (pl) * 2016-11-08 2022-09-12 Bristol-Myers Squibb Company 3-podstawione kwasy propionowe jako inhibitory integryny alfa v
CN111333590B (zh) * 2018-12-18 2022-05-17 沈阳中化农药化工研发有限公司 一种异恶唑烷盐酸盐的制备方法
CN113149926B (zh) * 2021-04-30 2023-05-26 华侨大学 一种3,5-二取代异恶唑衍生物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA826165A (en) * 1969-10-28 Gagneux Andre Process for the production of an isoxazole derivative
US3152139A (en) * 1961-10-17 1964-10-06 Geigy Chem Corp Certain aminoisoxazolone derivatives
CH450423A (de) * 1965-06-03 1968-01-31 Geigy Ag J R Verfahren zur Herstellung von 3-Hydroxy-5-aminomethyl-isoxazol
DK150615C (da) * 1982-10-26 1987-11-09 Cheminova As Fremgangsmaade til fremstilling af substituerede 3-isoxazololer
CA1261335A (en) * 1984-08-29 1989-09-26 Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee Ethylenediamine monoamide derivatives
DE3864124D1 (de) * 1987-05-20 1991-09-12 Zambon Spa Isoxazole mit nootropischer wirkung.
DE3736113A1 (de) * 1987-10-26 1989-05-03 Hoechst Ag Arzneimittel, darin enthaltene phosphorhaltige 2-isoxazoline und isoxazole, sowie herstellungsverfahren fuer diese heterocyclischen verbindungen
DE3914969A1 (de) * 1989-05-02 1990-11-08 Schering Ag 5-substituierte 3-arylisoxazol-derivate, deren herstellung und verwendung als schaedlingsbekaempfungsmittel
JP2786683B2 (ja) * 1989-08-15 1998-08-13 三共株式会社 グリコール誘導体およびその用途

Also Published As

Publication number Publication date
EP0451790A1 (de) 1991-10-16
CN1055537A (zh) 1991-10-23
HU911183D0 (en) 1991-10-28
IE911235A1 (en) 1991-10-23
JPH04234857A (ja) 1992-08-24
ZA912701B (en) 1991-12-24
PT97329A (pt) 1992-01-31
KR910018363A (ko) 1991-11-30
NO911432L (no) 1991-10-14
FI911718L (fi) 1991-10-13
US5273989A (en) 1993-12-28
IL97821A0 (en) 1992-06-21
NO911432D0 (no) 1991-04-11
CA2040219A1 (en) 1991-10-13
AU7428591A (en) 1991-10-17
BR9101475A (pt) 1991-11-26
FI911718A0 (fi) 1991-04-10
FI911718A7 (fi) 1991-10-13

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