CR20140078A - Compuestos de benzofurano para el tratamiento de infecciones por el virus de hepatitis c (hcv) - Google Patents
Compuestos de benzofurano para el tratamiento de infecciones por el virus de hepatitis c (hcv)Info
- Publication number
- CR20140078A CR20140078A CR20140078A CR20140078A CR20140078A CR 20140078 A CR20140078 A CR 20140078A CR 20140078 A CR20140078 A CR 20140078A CR 20140078 A CR20140078 A CR 20140078A CR 20140078 A CR20140078 A CR 20140078A
- Authority
- CR
- Costa Rica
- Prior art keywords
- hcv
- hepatitis
- infections
- virus
- treatment
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title 2
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical class C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161525440P | 2011-08-19 | 2011-08-19 | |
| US201261650681P | 2012-05-23 | 2012-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20140078A true CR20140078A (es) | 2014-03-20 |
Family
ID=47746761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20140078A CR20140078A (es) | 2011-08-19 | 2014-02-18 | Compuestos de benzofurano para el tratamiento de infecciones por el virus de hepatitis c (hcv) |
Country Status (38)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6121419B2 (ja) * | 2011-08-17 | 2017-04-26 | グラクソスミスクライン エルエルシー | 治療方法 |
| US8927593B2 (en) | 2011-08-19 | 2015-01-06 | Glaxo Group Limited | Benzofuran compounds for the treatment of hepatitis C virus infections |
| PE20171061A1 (es) * | 2014-11-10 | 2017-07-21 | Glaxosmithkline Intellectual Property (No 2) Ltd | Composiciones farmaceuticas de accion prolongada para hepatitis c |
| MX2017006140A (es) | 2014-11-10 | 2017-11-16 | Glaxosmithkline Intellectual Property (No 2) Ltd | Composiciones de accion prolongada de combinacion y métodos para hepatitis c. |
| KR20180006522A (ko) | 2016-07-07 | 2018-01-18 | 삼성디스플레이 주식회사 | 액정 조성물 및 이를 포함하는 액정 표시 장치 |
| US11738088B2 (en) | 2016-08-01 | 2023-08-29 | University of Pittsburgh—of the Commonwealth System of Higher Education | Boryl ethers, carbonates, and cyclic acetals as oxidatively-triggered drug delivery vehicles |
| US11078170B2 (en) * | 2017-03-02 | 2021-08-03 | Assembly Biosciences, Inc. | Cyclic sulfamide compounds and methods of using same |
| TWI795510B (zh) * | 2018-01-17 | 2023-03-11 | 英商葛蘭素史密斯克藍智慧財產發展有限公司 | PI4KIIIβ抑制劑 |
| TWI873211B (zh) * | 2019-10-25 | 2025-02-21 | 日商住友製藥股份有限公司 | 新穎取代縮環型化合物 |
| CN111026203B (zh) * | 2019-12-02 | 2021-01-26 | 宁波德晶元科技有限公司 | 一种适用于真空热水壶的加热控制方法与系统 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| WO2001002424A2 (en) | 1999-07-07 | 2001-01-11 | Du Pont Pharmaceuticals Company | Peptide boronic acid inhibitors of hepatitis c virus protease |
| US6699835B2 (en) | 2001-01-25 | 2004-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Formulation of boronic acid compounds |
| CN1731993A (zh) * | 2002-11-01 | 2006-02-08 | 维洛药品公司 | 苯并呋喃化合物、组合物以及治疗和预防丙型肝炎病毒感染及相关疾病的方法 |
| AU2006349612A1 (en) | 2005-12-01 | 2008-05-02 | Wyeth | Anthranilic acid derivatives useful in treating infection with Hepatitis C virus |
| SI1988779T1 (sl) | 2006-02-16 | 2015-08-31 | Anacor Pharmaceuticals, Inc. | Bor-vsebujoče majhne molekule kot protivnetna sredstva |
| US8106031B2 (en) * | 2006-05-02 | 2012-01-31 | Anacor Pharmaceuticals, Inc. | Hydrolytically-resistant boron-containing therapeutics and methods of use |
| US20070286822A1 (en) | 2006-06-12 | 2007-12-13 | Anacor Pharmaceuticals Inc. | Compounds for the Treatment of Periodontal Disease |
| EP2520561B1 (en) | 2007-06-08 | 2016-02-10 | MannKind Corporation | IRE-1A Inhibitors |
| GB0719366D0 (en) * | 2007-10-03 | 2007-11-14 | Smithkline Beecham Corp | Compounds |
| CN101910145A (zh) * | 2008-02-14 | 2010-12-08 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒的杂环化合物 |
| EP2187893A4 (en) | 2008-03-06 | 2012-02-22 | Anacor Pharmaceuticals Inc | SMALL BORON-CONTAINING MOLECULES AS ANTI-INFLAMMATORY AGENTS |
| WO2009137500A1 (en) | 2008-05-05 | 2009-11-12 | Wyeth | 6-substituted benzofuran compounds to treat infection with hepatitis c virus |
| WO2009137493A1 (en) | 2008-05-05 | 2009-11-12 | Wyeth | 2-substituted benzofuran compounds to treat infection with hepatitis c virus |
| US7737157B2 (en) | 2008-08-29 | 2010-06-15 | Hutchison Medipharma Enterprises Limited | Pyrimidine compounds |
| WO2010027975A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2011050284A1 (en) * | 2009-10-23 | 2011-04-28 | Glaxosmithkline Llc | Pyrazolylpyridine antiviral agents |
| TW201138786A (en) * | 2010-02-19 | 2011-11-16 | Glaxo Group Ltd | Therapeutic compounds |
| WO2011106986A1 (en) | 2010-03-02 | 2011-09-09 | Merck Sharp & Dohme Corp. | Inhibitors of hepatitis c virus ns5b polymerase |
| AR080433A1 (es) | 2010-03-02 | 2012-04-11 | Merck Sharp & Dohme | Derivados de benzofurancarboxamidas utiles para tratar o prevenir infecciones por vhc y composiciones farmaceuticas que los contienen. |
| WO2011106929A1 (en) | 2010-03-02 | 2011-09-09 | Merck Sharp & Dohme Corp. | Inhibitors of hepatitis c virus ns5b polymerase |
| AU2011329486A1 (en) | 2010-11-18 | 2013-04-18 | Glaxo Group Limited | Compounds |
| WO2012067663A1 (en) | 2010-11-18 | 2012-05-24 | Glaxo Group Limited | Compounds |
| WO2013025975A1 (en) * | 2011-08-17 | 2013-02-21 | Glaxosmithkline Llc | Combination treatments for hepatitis c |
| JP6121419B2 (ja) * | 2011-08-17 | 2017-04-26 | グラクソスミスクライン エルエルシー | 治療方法 |
| US8927593B2 (en) | 2011-08-19 | 2015-01-06 | Glaxo Group Limited | Benzofuran compounds for the treatment of hepatitis C virus infections |
-
2012
- 2012-08-10 US US13/885,500 patent/US8927593B2/en not_active Expired - Fee Related
- 2012-08-10 KR KR1020147007196A patent/KR101913800B1/ko not_active Expired - Fee Related
- 2012-08-10 HR HRP20161743TT patent/HRP20161743T1/hr unknown
- 2012-08-10 JP JP2014526090A patent/JP6367712B2/ja not_active Expired - Fee Related
- 2012-08-10 SI SI201230826A patent/SI2744332T1/sl unknown
- 2012-08-10 PT PT128264983T patent/PT2744332T/pt unknown
- 2012-08-10 EP EP16195408.6A patent/EP3199531A1/en not_active Withdrawn
- 2012-08-10 WO PCT/US2012/050268 patent/WO2013028371A1/en active Application Filing
- 2012-08-10 IN IN572CHN2014 patent/IN2014CN00572A/en unknown
- 2012-08-10 SG SG10201606883QA patent/SG10201606883QA/en unknown
- 2012-08-10 PE PE2014000197A patent/PE20141201A1/es not_active Application Discontinuation
- 2012-08-10 MX MX2014001989A patent/MX354676B/es active IP Right Grant
- 2012-08-10 SM SM20170028T patent/SMT201700028T1/it unknown
- 2012-08-10 CA CA2844086A patent/CA2844086A1/en not_active Abandoned
- 2012-08-10 LT LTEP12826498.3T patent/LT2744332T/lt unknown
- 2012-08-10 EP EP12826498.3A patent/EP2744332B1/en active Active
- 2012-08-10 ES ES12826498.3T patent/ES2611731T3/es active Active
- 2012-08-10 RS RS20161131A patent/RS55462B1/sr unknown
- 2012-08-10 PH PH1/2014/500385A patent/PH12014500385A1/en unknown
- 2012-08-10 CN CN201280040219.3A patent/CN103732065B/zh not_active Expired - Fee Related
- 2012-08-10 EA EA201490213A patent/EA032841B1/ru not_active IP Right Cessation
- 2012-08-10 PL PL12826498T patent/PL2744332T3/pl unknown
- 2012-08-10 AU AU2012299295A patent/AU2012299295B2/en not_active Ceased
- 2012-08-10 ME MEP-2016-287A patent/ME02588B/me unknown
- 2012-08-10 DK DK12826498.3T patent/DK2744332T3/en active
- 2012-08-10 HU HUE12826498A patent/HUE030300T2/en unknown
- 2012-08-10 BR BR112014002845A patent/BR112014002845A2/pt not_active Application Discontinuation
- 2012-08-16 AR ARP120103008A patent/AR087563A1/es unknown
- 2012-08-16 JO JOP/2012/0233A patent/JO3281B1/ar active
- 2012-08-17 TW TW101130017A patent/TWI538915B/zh not_active IP Right Cessation
- 2012-08-17 UY UY0001034274A patent/UY34274A/es not_active Application Discontinuation
-
2014
- 2014-01-16 IL IL230487A patent/IL230487B/en not_active IP Right Cessation
- 2014-01-23 CO CO14013113A patent/CO6862153A2/es active IP Right Grant
- 2014-02-10 ZA ZA201401020A patent/ZA201401020B/en unknown
- 2014-02-17 CL CL2014000393A patent/CL2014000393A1/es unknown
- 2014-02-18 CR CR20140078A patent/CR20140078A/es unknown
- 2014-02-19 DO DO2014000034A patent/DOP2014000034A/es unknown
- 2014-03-13 MA MA36832A patent/MA35443B1/fr unknown
- 2014-11-20 US US14/548,524 patent/US9682999B2/en not_active Expired - Fee Related
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2016
- 2016-12-22 JP JP2016249387A patent/JP2017125010A/ja active Pending
- 2016-12-27 CY CY20161101345T patent/CY1118399T1/el unknown
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2017
- 2017-01-18 SM SM201700028T patent/SMT201700028B/it unknown
- 2017-02-03 CL CL2017000293A patent/CL2017000293A1/es unknown
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