CO7461130A2 - Multivalent composition of pneumococcal protein-polysaccharide conjugates - Google Patents
Multivalent composition of pneumococcal protein-polysaccharide conjugatesInfo
- Publication number
- CO7461130A2 CO7461130A2 CO15154485A CO15154485A CO7461130A2 CO 7461130 A2 CO7461130 A2 CO 7461130A2 CO 15154485 A CO15154485 A CO 15154485A CO 15154485 A CO15154485 A CO 15154485A CO 7461130 A2 CO7461130 A2 CO 7461130A2
- Authority
- CO
- Colombia
- Prior art keywords
- polysaccharide conjugates
- multivalent composition
- pneumococcal protein
- conjugates
- protein
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Se proporciona una composición inmunogénica que comprende 13 conjugados diferentes de proteína-polisacárido. Cada uno de los conjugados comprende un polisacárido capsular preparado a 5 partir de un serotipo diferente de Streptococcus pneumoniae conjugado con una proteína portadora, es decir, 12 serotipos seleccionados del grupo constituido por 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F y 23F, y el serotipo 22F o 33F. La composición inmunogénica formulada en una vacuna que comprende 10 un adyuvante basado en aluminio incrementa la cobertura respecto a enfermedades neumocócicas en bebés y niños.An immunogenic composition comprising 13 different protein-polysaccharide conjugates is provided. Each of the conjugates comprises a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae conjugated to a carrier protein, that is, 12 serotypes selected from the group consisting of 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F, and serotype 22F or 33F. The immunogenic composition formulated in a vaccine comprising an aluminum-based adjuvant increases coverage for pneumococcal diseases in infants and children.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020120143318A KR20140075201A (en) | 2012-12-11 | 2012-12-11 | Multivalent pneumococcal polysaccharide-protein conjugate composition |
Publications (1)
Publication Number | Publication Date |
---|---|
CO7461130A2 true CO7461130A2 (en) | 2015-11-30 |
Family
ID=50934609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO15154485A CO7461130A2 (en) | 2012-12-11 | 2015-07-06 | Multivalent composition of pneumococcal protein-polysaccharide conjugates |
Country Status (16)
Country | Link |
---|---|
US (1) | US20150343076A1 (en) |
EP (1) | EP2932980B1 (en) |
JP (1) | JP2016503016A (en) |
KR (1) | KR20140075201A (en) |
CN (1) | CN104837504A (en) |
BR (1) | BR112015013513B1 (en) |
CA (1) | CA2894532C (en) |
CO (1) | CO7461130A2 (en) |
DK (1) | DK2932980T3 (en) |
ES (1) | ES2881541T3 (en) |
MX (1) | MX366762B (en) |
PH (1) | PH12015501270A1 (en) |
PL (1) | PL2932980T3 (en) |
PT (1) | PT2932980T (en) |
RU (1) | RU2613148C2 (en) |
WO (1) | WO2014092378A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2425855A1 (en) | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US11160855B2 (en) * | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
ES2883343T3 (en) * | 2014-01-21 | 2021-12-07 | Pfizer | Capsular polysaccharides from Streptococcus pneumoniae and conjugates thereof |
IL297740A (en) | 2015-05-04 | 2022-12-01 | Pfizer | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
PL3313436T3 (en) * | 2015-06-23 | 2021-06-14 | Biological E Limited | Multivalent pneumococcal conjugate vaccine |
PE20180657A1 (en) | 2015-07-21 | 2018-04-17 | Pfizer | IMMUNOGENIC COMPOSITIONS INCLUDING CONJUGATED CAPSULAR SACRED ANTIGENS, KITS THAT INCLUDE THEM AND THEIR USES |
MY187472A (en) | 2015-09-10 | 2021-09-23 | Inventprise Llc | Multivalent vlp conjugates |
CA3000201A1 (en) * | 2015-10-07 | 2017-04-13 | Boehringer Ingelheim Vetmedica, Inc. | Streptococcus suis polysacchari de-protein conjugate composition |
CA3037056A1 (en) * | 2016-09-30 | 2018-04-05 | Biological E Limited | Multivalent pneumococcal vaccine compositions comprising polysaccharide-protein conjugates |
US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
CN118662649A (en) | 2016-12-30 | 2024-09-20 | Vaxcyte公司 | Polypeptide-antigen conjugates with unnatural amino acids |
WO2018156491A1 (en) * | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
JP7218358B2 (en) | 2017-09-07 | 2023-02-06 | メルク・シャープ・アンド・ドーム・エルエルシー | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
CA3074703A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
TWI725359B (en) | 2017-12-06 | 2021-04-21 | 美商默沙東藥廠 | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
CN108159408A (en) * | 2017-12-29 | 2018-06-15 | 云南沃森生物技术股份有限公司 | A kind of multivalent pneumococcal polysaccharide-protein combination compositions and its preparation method and application |
IL304977A (en) | 2018-02-05 | 2023-10-01 | Sanofi Pasteur Inc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
KR20190121713A (en) * | 2018-04-18 | 2019-10-28 | 에스케이바이오사이언스(주) | Capsular saccharide of Streptococcus pneumoniae and the immunogenic conjugates thereof |
CA3120926A1 (en) | 2018-10-12 | 2020-04-16 | Biological E Limited | Multivalent pneumococcal polysaccharide-protein conjugate vaccine |
JOP20210148A1 (en) | 2018-12-19 | 2023-01-30 | Merck Sharp & Dohme | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
US12036276B2 (en) | 2021-09-09 | 2024-07-16 | Affinivax, Inc. | Multivalent pneumococcal vaccines |
Family Cites Families (27)
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US4902506A (en) | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
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HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
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US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
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GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
AP1695A (en) * | 2000-06-29 | 2006-12-17 | Glaxosmithkline Biologicals Sa | Multivalent vaccine composition. |
EP1355918B9 (en) | 2000-12-28 | 2012-01-25 | Wyeth LLC | Recombinant protective protein from $i(streptococcus pneumoniae) |
EP2258842A1 (en) | 2001-04-16 | 2010-12-08 | Wyeth Holdings Corporation | Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof |
KR20080078717A (en) | 2001-06-07 | 2008-08-27 | 와이어쓰 홀딩스 코포레이션 | Mutant forms of cholera holotoxin as an adjuvant |
EP1404368B1 (en) | 2001-06-07 | 2009-12-09 | Wyeth Holdings Corporation | Mutant forms of cholera holotoxin as an adjuvant |
EP1603950A2 (en) | 2003-03-17 | 2005-12-14 | Wyeth Holdings Corporation | Mutant cholera holotoxin as an adjuvant and an antigen carrier protein |
EP2425855A1 (en) * | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
LT3017827T (en) * | 2005-12-22 | 2019-01-10 | Glaxosmithkline Biologicals S.A. | Pneumococcal polysaccharide conjugate vaccine |
US8808707B1 (en) * | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
KR20100045445A (en) * | 2007-06-26 | 2010-05-03 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
BRPI1014494A2 (en) * | 2009-04-30 | 2016-08-02 | Coley Pharm Group Inc | pneumococcal vaccine and its uses |
TW201136603A (en) * | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
-
2012
- 2012-12-11 KR KR1020120143318A patent/KR20140075201A/en not_active IP Right Cessation
-
2013
- 2013-12-05 RU RU2015121771A patent/RU2613148C2/en active
- 2013-12-05 US US14/651,046 patent/US20150343076A1/en not_active Abandoned
- 2013-12-05 CN CN201380064973.5A patent/CN104837504A/en active Pending
- 2013-12-05 BR BR112015013513-7A patent/BR112015013513B1/en active IP Right Grant
- 2013-12-05 CA CA2894532A patent/CA2894532C/en active Active
- 2013-12-05 PL PL13862871T patent/PL2932980T3/en unknown
- 2013-12-05 MX MX2015007301A patent/MX366762B/en active IP Right Grant
- 2013-12-05 PT PT138628714T patent/PT2932980T/en unknown
- 2013-12-05 ES ES13862871T patent/ES2881541T3/en active Active
- 2013-12-05 DK DK13862871.4T patent/DK2932980T3/en active
- 2013-12-05 EP EP13862871.4A patent/EP2932980B1/en active Active
- 2013-12-05 JP JP2015547845A patent/JP2016503016A/en active Pending
- 2013-12-05 WO PCT/KR2013/011195 patent/WO2014092378A1/en active Application Filing
-
2015
- 2015-06-04 PH PH12015501270A patent/PH12015501270A1/en unknown
- 2015-07-06 CO CO15154485A patent/CO7461130A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20140075201A (en) | 2014-06-19 |
MX2015007301A (en) | 2016-01-20 |
ES2881541T3 (en) | 2021-11-29 |
AU2013360597A1 (en) | 2015-07-02 |
PH12015501270A1 (en) | 2015-08-24 |
PL2932980T3 (en) | 2021-11-08 |
BR112015013513A8 (en) | 2018-07-31 |
BR112015013513B1 (en) | 2023-02-07 |
MX366762B (en) | 2019-07-23 |
CN104837504A (en) | 2015-08-12 |
RU2613148C2 (en) | 2017-03-15 |
EP2932980B1 (en) | 2021-06-30 |
JP2016503016A (en) | 2016-02-01 |
DK2932980T3 (en) | 2021-07-19 |
EP2932980A1 (en) | 2015-10-21 |
CA2894532C (en) | 2020-07-07 |
US20150343076A1 (en) | 2015-12-03 |
RU2015121771A (en) | 2017-01-19 |
EP2932980A4 (en) | 2016-07-06 |
CA2894532A1 (en) | 2014-06-19 |
BR112015013513A2 (en) | 2017-07-11 |
WO2014092378A1 (en) | 2014-06-19 |
PT2932980T (en) | 2021-07-29 |
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