TH128171B - Composition of 15-valent conjugate vaccine, pneumococcal polysaccharide-protein - Google Patents
Composition of 15-valent conjugate vaccine, pneumococcal polysaccharide-proteinInfo
- Publication number
- TH128171B TH128171B TH1201003974A TH1201003974A TH128171B TH 128171 B TH128171 B TH 128171B TH 1201003974 A TH1201003974 A TH 1201003974A TH 1201003974 A TH1201003974 A TH 1201003974A TH 128171 B TH128171 B TH 128171B
- Authority
- TH
- Thailand
- Prior art keywords
- protein
- composition
- conjugate vaccine
- pneumococcal polysaccharide
- valent conjugate
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 2
- 229960005486 vaccines Drugs 0.000 title abstract 2
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims abstract 2
- 102000016607 Diphtheria Toxin Human genes 0.000 claims abstract 2
- 108010053187 Diphtheria Toxin Proteins 0.000 claims abstract 2
- 241000194017 Streptococcus Species 0.000 claims abstract 2
- 239000002775 capsule Substances 0.000 claims abstract 2
- 150000004676 glycans Polymers 0.000 claims abstract 2
- 230000002163 immunogen Effects 0.000 claims abstract 2
- 229920001282 polysaccharide Polymers 0.000 claims abstract 2
- 239000005017 polysaccharide Substances 0.000 claims abstract 2
- 150000004804 polysaccharides Polymers 0.000 claims abstract 2
- 239000000969 carrier Substances 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminum Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 2
- 208000009856 Lung Disease Diseases 0.000 abstract 1
- 210000004940 Nucleus Anatomy 0.000 abstract 1
- 206010035664 Pneumonia Diseases 0.000 abstract 1
- 230000000240 adjuvant Effects 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000007822 coupling agent Substances 0.000 abstract 1
- 230000001506 immunosuppresive Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้จัดเตรียมองค์ประกอบแบบมัลติวาเลนท์ซึ่งสร้างภูมิคุ้มกัน ที่มี 15 คอนจูเกตโพลีเชคคาไรด์-โปรตีนแบบแตกต่าง แต่ละคอนจูเกตประกอบด้วย ของโพลีแซคคาไรด์แบบแคปซูลที่ถูกเตรียมจากซีไรไทป์ที่แตกต่างของสเตรปโตคอคคัส นิวโมนิอี้ (1,3,4,5,6A,6B,7F,9V,14,18C,19A,19F,22F,23F,หรือ33F) ถูกคอนจูเกตกับโปรตีนตัวพา ที่ให้ผลคือ CRM197 องค์ประกอบซึ่งสร้างภูมิคุ้มกัน, ที่ให้ผลดีถูกเตรียมสูตรเป็นวัคซีนบนสารเชื่อม ที่มีพื้นฐานเป็นอะลูมินัม (aluminum-based adjuvant), จัดเตรียมการครอบคลุมช่วงกว้างต่อโรคปอด บวมจากเชื้อนิวโมเนีย, โดยเฉพาะอย่างยิ่งในทารกและเด็กวัยรุ่น The invention provides a multivalent, immunosuppressive constituent containing 15 different polysaccharide-protein conjugates. Each conjugate consists of Of capsule polysaccharides prepared from different serotype of streptococcus nuclei (1,3,4,5,6A, 6B, 7F The immunogenic component, CRM197, was formulated as a vaccine on the coupling agent. Aluminum-based (aluminum-based adjuvant), provides broad coverage against lung disease. Pneumonia, especially in infants and adolescents
Claims (3)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH128171A TH128171A (en) | 2013-10-15 |
| TH128171B true TH128171B (en) | 2013-10-15 |
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