CO7230336A2 - Indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof - Google Patents

Indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof

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Publication number
CO7230336A2
CO7230336A2 CO14219345A CO14219345A CO7230336A2 CO 7230336 A2 CO7230336 A2 CO 7230336A2 CO 14219345 A CO14219345 A CO 14219345A CO 14219345 A CO14219345 A CO 14219345A CO 7230336 A2 CO7230336 A2 CO 7230336A2
Authority
CO
Colombia
Prior art keywords
wnt signaling
signaling pathway
wnt
indazole
therapeutic uses
Prior art date
Application number
CO14219345A
Other languages
Spanish (es)
Inventor
John Hood
David Mark Wallace
Sunil Kumar Kc
Original Assignee
Samumed Llc
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49292798&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO7230336(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of CO7230336A2 publication Critical patent/CO7230336A2/en

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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

Se divulgan compuestos de indazol para tratar diversas enfermedades y patologías. Más particularmente, la presente invención se refiere al uso de un compuesto de indazol o análogos del mismo en el tratamiento de trastornos caracterizados por la activación de la ruta de señalización de Wnt (por ejemplo,cáncer, proliferación celular anormal, angiogénesis, enfermedad de Alzheimer, enfermedad pulmonar y osteoartritis), la modulación de acontecimientos celulares mediados por la ruta de señalización de Wnt, así como enfermedades genéticas y afecciones/trastornos/enfermedades genéticas debidas a mutaciones o alteración de la regulación de la ruta de Wnt y/o uno o más de los componentes de señalización de Wnt. También se proporcionan métodos para tratar estados de enfermedad relacionados con Wnt. Una realización divulgada en el presente documento incluye un compuesto que tiene la estructura de Formula I:Indazole compounds are disclosed to treat various diseases and pathologies. More particularly, the present invention relates to the use of an indazole compound or analogs thereof in the treatment of disorders characterized by the activation of the Wnt signaling pathway (eg, cancer, abnormal cell proliferation, angiogenesis, Alzheimer's disease , pulmonary disease and osteoarthritis), the modulation of cellular events mediated by the Wnt signaling pathway, as well as genetic diseases and genetic conditions / disorders / diseases due to mutations or alteration of the regulation of the Wnt pathway and / or one or more of the Wnt signaling components. Methods for treating disease states related to Wnt are also provided. An embodiment disclosed herein includes a compound having the structure of Formula I:

CO14219345A 2012-04-04 2014-10-03 Indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof CO7230336A2 (en)

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US201261620107P 2012-04-04 2012-04-04

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US (9) US8673936B2 (en)
EP (3) EP3915988A1 (en)
JP (3) JP6167169B2 (en)
KR (1) KR102048107B1 (en)
CN (2) CN106892916A (en)
AU (2) AU2013243899B2 (en)
BR (1) BR112014023639B1 (en)
CA (1) CA2853703C (en)
CL (1) CL2014002511A1 (en)
CO (1) CO7230336A2 (en)
CY (1) CY1119485T1 (en)
DK (1) DK2760285T3 (en)
ES (1) ES2635386T3 (en)
HR (1) HRP20171322T1 (en)
HU (1) HUE033829T2 (en)
IL (2) IL234743A (en)
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SI (1) SI2760285T1 (en)
WO (1) WO2013151708A1 (en)
ZA (3) ZA201406273B (en)

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