CO6210734A2 - Conjugados de anticuerpo anti-rg-1 - Google Patents
Conjugados de anticuerpo anti-rg-1Info
- Publication number
- CO6210734A2 CO6210734A2 CO10064681A CO10064681A CO6210734A2 CO 6210734 A2 CO6210734 A2 CO 6210734A2 CO 10064681 A CO10064681 A CO 10064681A CO 10064681 A CO10064681 A CO 10064681A CO 6210734 A2 CO6210734 A2 CO 6210734A2
- Authority
- CO
- Colombia
- Prior art keywords
- seq
- chain variable
- variable region
- antibody
- heavy chain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99169007P | 2007-11-30 | 2007-11-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6210734A2 true CO6210734A2 (es) | 2010-10-20 |
Family
ID=40427118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10064681A CO6210734A2 (es) | 2007-11-30 | 2010-05-28 | Conjugados de anticuerpo anti-rg-1 |
Country Status (18)
Country | Link |
---|---|
US (1) | US20110020329A1 (ko) |
EP (1) | EP2211908A2 (ko) |
JP (1) | JP2011505371A (ko) |
KR (1) | KR20100101122A (ko) |
CN (1) | CN101951960A (ko) |
AR (1) | AR069746A1 (ko) |
AU (1) | AU2008331507A1 (ko) |
BR (1) | BRPI0819765A2 (ko) |
CA (1) | CA2707443A1 (ko) |
CL (1) | CL2008003525A1 (ko) |
CO (1) | CO6210734A2 (ko) |
EA (1) | EA201000921A1 (ko) |
IL (1) | IL206060A0 (ko) |
MX (1) | MX2010005683A (ko) |
NZ (1) | NZ586514A (ko) |
TW (1) | TW200930407A (ko) |
WO (1) | WO2009073524A2 (ko) |
ZA (1) | ZA201003729B (ko) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8518403B2 (en) * | 2004-07-16 | 2013-08-27 | Amgen Research (Munich) Gmbh | Expression-enhanced polypeptides |
NO2344478T3 (ko) | 2008-11-03 | 2018-02-24 | ||
DK3056203T3 (da) | 2010-04-21 | 2018-01-29 | Syntarga Bv | Konjugater af cc-1065-analoger og bifunktionelle linkere. |
CA2800769C (en) | 2010-05-27 | 2021-11-02 | Genmab A/S | Monoclonal antibodies against her2 epitope |
JP6320753B2 (ja) | 2010-05-27 | 2018-05-09 | ゲンマブ エー/エス | Her2に対するモノクローナル抗体 |
US8852599B2 (en) * | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
US10266606B2 (en) | 2014-01-10 | 2019-04-23 | Synthon Biopharmaceuticals B.V. | Method for purifying Cys-linked antibody-drug conjugates |
CA2937561A1 (en) * | 2014-01-29 | 2015-08-06 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Ligand-cytotoxic drug conjugate, preparation method thereof, and uses thereof |
MX2020001270A (es) | 2017-07-31 | 2020-09-22 | Trishula Therapeutics Inc | Anticuerpos anti-cd39, composiciones que comprenden anticuerpos anti-cd39, y metodos de uso de anticuerpos anti-cd39. |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4978757A (en) * | 1984-02-21 | 1990-12-18 | The Upjohn Company | 1,2,8,8a-tetrahydrocyclopropa (C) pyrrolo [3,2-e)]-indol-4(5H)-ones and related compounds |
US4912227A (en) * | 1984-02-21 | 1990-03-27 | The Upjohn Company | 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds |
US5332837A (en) * | 1986-12-19 | 1994-07-26 | The Upjohn Company | CC-1065 analogs |
US5084468A (en) * | 1988-08-11 | 1992-01-28 | Kyowa Hakko Kogyo Co., Ltd. | Dc-88a derivatives |
JP2598116B2 (ja) * | 1988-12-28 | 1997-04-09 | 協和醗酵工業株式会社 | 新規物質dc113 |
US5187186A (en) * | 1989-07-03 | 1993-02-16 | Kyowa Hakko Kogyo Co., Ltd. | Pyrroloindole derivatives |
JP2510335B2 (ja) * | 1989-07-03 | 1996-06-26 | 協和醗酵工業株式会社 | Dc―88a誘導体 |
EP0527189A1 (en) * | 1990-04-25 | 1993-02-17 | PHARMACIA & UPJOHN COMPANY | Novel cc-1065 analogs |
US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
CA2165819C (en) * | 1994-04-22 | 2005-12-27 | Nobuyoshi Amishiro | Dc-89 derivatives |
JPH07309761A (ja) * | 1994-05-20 | 1995-11-28 | Kyowa Hakko Kogyo Co Ltd | デュオカルマイシン誘導体の安定化法 |
US5871969A (en) * | 1996-02-12 | 1999-02-16 | Human Genome Sciences, Inc. | Nucleic acids encoding human neuronal attachment factor-1 |
US6682902B2 (en) * | 1999-12-16 | 2004-01-27 | Schering Aktiengesellschaft | DNA encoding a novel RG1 polypeptide |
EP2266986A1 (en) * | 2001-05-31 | 2010-12-29 | Medarex, Inc. | Cytotoxins, Prodrugs, Linkers and Stabilizers useful therefor |
WO2003022806A2 (en) * | 2001-09-07 | 2003-03-20 | The Scripps Research Institute | Cbi analogues of cc-1065 and the duocarmycins |
US7091186B2 (en) * | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
KR101215218B1 (ko) * | 2003-07-22 | 2012-12-26 | 바이엘 파마 악티엔게젤샤프트 | Rg1 항체 및 그의 용도 |
US7691962B2 (en) * | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
EP1747021B1 (en) * | 2004-05-19 | 2015-09-09 | E. R. Squibb & Sons, L.L.C. | Self-immolative linkers and drug conjugates |
US7714016B2 (en) * | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
EP1940470B1 (en) * | 2005-09-26 | 2013-04-17 | Medarex, Inc. | Antibody-drug conjugates and their use |
WO2007059404A2 (en) * | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
JP5189082B2 (ja) * | 2006-05-25 | 2013-04-24 | バイエル・ファルマ・アクチェンゲゼルシャフト | 二量体分子複合体 |
-
2008
- 2008-11-26 WO PCT/US2008/084899 patent/WO2009073524A2/en active Application Filing
- 2008-11-26 TW TW097145816A patent/TW200930407A/zh unknown
- 2008-11-26 EA EA201000921A patent/EA201000921A1/ru unknown
- 2008-11-26 CL CL2008003525A patent/CL2008003525A1/es unknown
- 2008-11-26 AU AU2008331507A patent/AU2008331507A1/en not_active Abandoned
- 2008-11-26 BR BRPI0819765 patent/BRPI0819765A2/pt not_active IP Right Cessation
- 2008-11-26 KR KR1020107014394A patent/KR20100101122A/ko not_active Application Discontinuation
- 2008-11-26 CA CA2707443A patent/CA2707443A1/en not_active Abandoned
- 2008-11-26 CN CN2008801259196A patent/CN101951960A/zh active Pending
- 2008-11-26 EP EP08858236A patent/EP2211908A2/en not_active Withdrawn
- 2008-11-26 MX MX2010005683A patent/MX2010005683A/es not_active Application Discontinuation
- 2008-11-26 US US12/745,337 patent/US20110020329A1/en not_active Abandoned
- 2008-11-26 NZ NZ586514A patent/NZ586514A/en not_active IP Right Cessation
- 2008-11-26 JP JP2010536173A patent/JP2011505371A/ja not_active Withdrawn
- 2008-11-26 AR ARP080105135A patent/AR069746A1/es not_active Application Discontinuation
-
2010
- 2010-05-25 ZA ZA2010/03729A patent/ZA201003729B/en unknown
- 2010-05-28 CO CO10064681A patent/CO6210734A2/es not_active Application Discontinuation
- 2010-05-30 IL IL206060A patent/IL206060A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2211908A2 (en) | 2010-08-04 |
EA201000921A1 (ru) | 2010-12-30 |
AR069746A1 (es) | 2010-02-17 |
TW200930407A (en) | 2009-07-16 |
MX2010005683A (es) | 2010-06-11 |
WO2009073524A3 (en) | 2009-12-10 |
US20110020329A1 (en) | 2011-01-27 |
CA2707443A1 (en) | 2009-06-11 |
ZA201003729B (en) | 2011-08-31 |
IL206060A0 (en) | 2010-11-30 |
AU2008331507A1 (en) | 2009-06-11 |
JP2011505371A (ja) | 2011-02-24 |
CL2008003525A1 (es) | 2010-01-22 |
NZ586514A (en) | 2012-05-25 |
KR20100101122A (ko) | 2010-09-16 |
WO2009073524A2 (en) | 2009-06-11 |
BRPI0819765A2 (pt) | 2015-05-05 |
CN101951960A (zh) | 2011-01-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |