CO6190619A2 - Derivados de 2- quinolinona y 2-quinoxalinona y su uso como agentes antibacterianos - Google Patents

Derivados de 2- quinolinona y 2-quinoxalinona y su uso como agentes antibacterianos

Info

Publication number
CO6190619A2
CO6190619A2 CO09068489A CO09068489A CO6190619A2 CO 6190619 A2 CO6190619 A2 CO 6190619A2 CO 09068489 A CO09068489 A CO 09068489A CO 09068489 A CO09068489 A CO 09068489A CO 6190619 A2 CO6190619 A2 CO 6190619A2
Authority
CO
Colombia
Prior art keywords
6alkyl
6alkenyl
6alkynyl
optionally substituted
halo
Prior art date
Application number
CO09068489A
Other languages
English (en)
Inventor
Janelle Comita-Prevoir
Marck Cronin
Bolin Geng
Andrew Aydon Godfrey
Folkert Reck
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39046831&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6190619(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO6190619A2 publication Critical patent/CO6190619A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1.- Un compuesto de la fórmula (I):o una sal farmaceuticamente aceptable del mismo, en donde el compuesto de la fórmula es sustancialmente libre de una mezcla cis (±) de sus enantiómeros, y en donde A se selecciona a partir de CH y N; D se selecciona a partir de C- R7 y N; en donde al menos uno entre A y D es carbono; E se selecciona a partir de O, NH, y S, en donde: i) E es NH si R8 y R9 juntos forman =O; y ii) E es O o S si R8 y R9 son cada uno H; G se selecciona a partir de O y S; J se selecciona a partir de C- R4 y N; R1 se selecciona a partir de H, halo, ciano, C1-6alquilo, C2-6alquenilo, y C2-6alquinilo R1a y - N(R1a), en donde dichos C1-6alquilo, C2-6alquenilo, y C2-6alquinilo son opcionalmente sustituidos con uno o más R10;R1a en cada ocurrencia se selecciona independientemente a partir de H y C1-6alquilo, en donde dicho C1-6alquilo es opcionalmente sustituido con uno o más R20;R2 se selecciona a partir de halo, ciano, C1-6alquilo, C2-6alquenilo, C2-6alquinilo, -OR2a, -N(R2a) en donde dichos C1-6alquilo, C2-6alquenilo, y C2-6alquinilo son opcionalmente sustituidos con uno o más R20;R2a en cada ocurrencia se selecciona independientemente a partir de H y C1-6alquilo, en donde dicho C1-6alquilo es opcionalmente sustituido con uno o más R20; R3 se selecciona a partir de H, halo, ciano, C1-6alquilo, C2-6alquenilo, y C2-6alquinilo, OR3a y -N(R3a) 2, en donde dichos C1-6alquilo, C2-6alquenilo, y C2-6alquinilo son opcionalmente sustituidos con uno o más R30;R3a en cada ocurrencia se selecciona independientemente a partir de H y C1-6alquilo, en donde dicho C1-6alquilo es opcionalmente sustituido con uno o más R30;R4 se selecciona a partir de H, halo, ciano, -CO2H, C1-6alquilo, C2-6alquenilo, y C2-6 alquinilo, en donde dicho C1- 6alquilo, C2-6alquenilo, y C2-6alquinilo son opcionalmente sustituidos con uno o más R40;R6 se selecciona a partir de fluoro, C1-6alquilo, C2-6alquenilo, C2-6alquinilo, -OR6a, en donde dichos C1-6alquilo, C2-6alquenilo, y C2-6alquinilo son opcionalmente sustituidos con uno o más R60; ...
CO09068489A 2006-12-15 2009-07-02 Derivados de 2- quinolinona y 2-quinoxalinona y su uso como agentes antibacterianos CO6190619A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87018106P 2006-12-15 2006-12-15
US96916307P 2007-08-30 2007-08-30

Publications (1)

Publication Number Publication Date
CO6190619A2 true CO6190619A2 (es) 2010-08-19

Family

ID=39046831

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09068489A CO6190619A2 (es) 2006-12-15 2009-07-02 Derivados de 2- quinolinona y 2-quinoxalinona y su uso como agentes antibacterianos

Country Status (17)

Country Link
EP (1) EP2121702A1 (es)
JP (1) JP2010513255A (es)
KR (1) KR20090090385A (es)
AR (1) AR064369A1 (es)
AU (1) AU2007331247B2 (es)
BR (1) BRPI0720236A2 (es)
CA (1) CA2671485A1 (es)
CL (1) CL2007003641A1 (es)
CO (1) CO6190619A2 (es)
EC (1) ECSP099506A (es)
MX (1) MX2009006325A (es)
NO (1) NO20092655L (es)
PE (1) PE20081511A1 (es)
RU (1) RU2009126731A (es)
TW (1) TW200831517A (es)
UY (1) UY30788A1 (es)
WO (1) WO2008071961A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
WO2006137485A1 (ja) 2005-06-24 2006-12-28 Toyama Chemical Co., Ltd. 新規な含窒素複素環化合物およびその塩
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
BRPI0920870A2 (pt) 2008-10-10 2018-06-26 Actelion Pharmaceuticals Ltd antibióticos de oxazolidinila.
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
KR20140033309A (ko) * 2010-10-04 2014-03-18 브리티쉬 콜롬비아 캔써 에이전시 브랜치 위장 암을 진단하기 위해 위장의 샘플에서의 푸소박테리움의 검출
EP3672960A2 (en) * 2017-08-21 2020-07-01 Acadia Pharmaceuticals Inc. Compounds, salts thereof and their use for the treatment of diseases
CN111132976B (zh) 2017-08-21 2023-08-22 阿卡蒂亚药品公司 化合物、其盐和用于治疗疾病的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19601265A1 (de) * 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
WO2006046552A1 (ja) * 2004-10-27 2006-05-04 Toyama Chemical Co., Ltd. 新規な含窒素複素環化合物およびその塩
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
WO2006137485A1 (ja) * 2005-06-24 2006-12-28 Toyama Chemical Co., Ltd. 新規な含窒素複素環化合物およびその塩
KR101409261B1 (ko) * 2006-05-26 2014-06-18 다이쇼 세이야꾸 가부시끼가이샤 신규의 복소환 화합물 또는 그 염 및 그 중간체
WO2008006648A1 (en) * 2006-06-09 2008-01-17 Glaxo Group Limited Substituted 1-methyl-1h-quinolin-2-ones and 1-methyl-1h-1,5-naphthyridin-2-ones as antibacterials
GB0613208D0 (en) * 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) * 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
JP5315239B2 (ja) * 2006-07-20 2013-10-16 グラクソ グループ リミテッド Ｎ−エチルキノロンおよびｎ−エチルアザキノロンの誘導体およびアナログ

Also Published As

Publication number Publication date
NO20092655L (no) 2009-09-02
UY30788A1 (es) 2008-07-31
TW200831517A (en) 2008-08-01
AU2007331247A1 (en) 2008-06-19
AR064369A1 (es) 2009-04-01
CA2671485A1 (en) 2008-06-19
EP2121702A1 (en) 2009-11-25
WO2008071961A1 (en) 2008-06-19
KR20090090385A (ko) 2009-08-25
MX2009006325A (es) 2009-07-24
BRPI0720236A2 (pt) 2013-12-24
WO2008071961A8 (en) 2009-10-22
PE20081511A1 (es) 2008-12-12
RU2009126731A (ru) 2011-01-20
JP2010513255A (ja) 2010-04-30
CL2007003641A1 (es) 2008-09-22
ECSP099506A (es) 2009-08-28
AU2007331247B2 (en) 2011-10-20

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