CO6190508A2 - Composiciones farmaceuticas de inhibidores de la hdac y compuestos metalicos quelables y complejos quelados metalicos inhibidores de la hdac - Google Patents
Composiciones farmaceuticas de inhibidores de la hdac y compuestos metalicos quelables y complejos quelados metalicos inhibidores de la hdacInfo
- Publication number
- CO6190508A2 CO6190508A2 CO09041802A CO09041802A CO6190508A2 CO 6190508 A2 CO6190508 A2 CO 6190508A2 CO 09041802 A CO09041802 A CO 09041802A CO 09041802 A CO09041802 A CO 09041802A CO 6190508 A2 CO6190508 A2 CO 6190508A2
- Authority
- CO
- Colombia
- Prior art keywords
- pharmaceutical composition
- chelated
- saha
- hdac
- iron
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1.- Una composición farmacéutica que comprende una cantidad terapéuticamente efectiva de un inhibidor de la histona desacetilasa (HDAC) y un compuesto metálico quelable, y un vehículo farmacéuticamente aceptable.2.- La composición farmacéutica de la Reivindicación 1, en donde el compuesto metálico quelable comprende hierro.3.- La composición farmacéutica de la Reivindicación 1, en donde el compuesto metálico quelable comprende zinc.4.- La composición farmacéutica de cualquiera de las Reivindicaciones 1 a 3, en donde el inhibidor de la HDAC es el ácido hidroxámico suberoilanilida (SAHA) o una sal o hidrato o solvato farmacéuticamente aceptable del mismo.5.- Una composición farmacéutica que comprende una cantidad terapéuticamente efectiva del complejo quelado Hierro-SAHA o un hidrato o solvato del mismo y un vehículo farmacéuticamente aceptable.6.- La composición farmacéutica de la Reivindicación 5, que comprende una cantidad terapéuticamente efectiva del complejo quelado Hierro-SAHA, en donde la relación estequiométrica de hierro a SAHA es de 1:3.7.- La composición farmacéutica de la Reivindicación 6, en donde el complejo quelado férrico SAHA es cristalino, y se caracteriza por un patrón de polvo de difracción de rayos X con radiación Ka del cobre, incluyendo picos característicos a 8.8, 14.5 y 1.8 grados 2?. 8.- La composición farmacéutica de la Reivindicación 6, en donde el complejo quelado férrico es cristalino, y se caracteriza por un patrón de difracción de polvo de rayos X con radiación Ka del cobre, incluyendo picos característicos a 8.8, 13.3, 14.5, 20.3, 21.8 y 24.6 grados 2?. 9.- La composición farmacéutica de la Reivindicación 6, en donde el complejo quelado férrico es cristalino, y se caracteriza por un patrón de difracción de rayos X con radiación Ka del cobre, incluyendo picos característicos a 8.8, 13.3, 14.5, 18.5, 20.3, 21.8, 24.6, 25.8 y 33.3 grados 2?.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84830006P | 2006-09-28 | 2006-09-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6190508A2 true CO6190508A2 (es) | 2010-08-19 |
Family
ID=39230785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO09041802A CO6190508A2 (es) | 2006-09-28 | 2009-04-24 | Composiciones farmaceuticas de inhibidores de la hdac y compuestos metalicos quelables y complejos quelados metalicos inhibidores de la hdac |
Country Status (14)
Country | Link |
---|---|
US (2) | US20090239946A1 (es) |
EP (2) | EP2079462A4 (es) |
JP (1) | JP2010504968A (es) |
KR (1) | KR20090064400A (es) |
CN (1) | CN101528212A (es) |
AU (1) | AU2007300532A1 (es) |
BR (1) | BRPI0717554A2 (es) |
CA (1) | CA2663569A1 (es) |
CO (1) | CO6190508A2 (es) |
IL (1) | IL197718A0 (es) |
MX (1) | MX2009003405A (es) |
NO (1) | NO20091664L (es) |
RU (1) | RU2009115860A (es) |
WO (1) | WO2008039421A2 (es) |
Families Citing this family (29)
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CA2678124C (en) * | 2003-11-17 | 2014-10-07 | Merck Eprova Ag | Crystalline forms of (6r)-l-erythro-tetrahydrobiopterin dihydrochloride |
WO2005118586A1 (en) * | 2004-06-02 | 2005-12-15 | Sandoz Ag | Meropenem intermediate in crystalline form |
US8779175B2 (en) | 2004-10-25 | 2014-07-15 | Synthonics, Inc. | Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients |
US8188138B2 (en) * | 2005-09-21 | 2012-05-29 | 4Sc Ag | Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors |
BRPI0617947A2 (pt) * | 2005-10-31 | 2011-08-09 | Janssen Pharmaceutica Nv | processos para a preparação de derivados de piperazinil e diazapanil benzamida |
CA2656057C (en) * | 2006-06-16 | 2012-10-02 | H. Lundbeck A/S | Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain |
CN101568544B (zh) * | 2006-10-27 | 2016-10-26 | 西格诺药品有限公司 | 包含4‑[9‑(四氢‑呋喃‑3‑基)‑8‑(2,4,6‑三氟‑苯氨基)‑9h‑嘌呤‑2‑基氨基]‑环己烷‑1‑醇的固体形式,其组合物,及其用途 |
EP2085397A1 (en) * | 2008-01-21 | 2009-08-05 | Esteve Quimica, S.A. | Crystalline form of abacavir |
US7935817B2 (en) * | 2008-03-31 | 2011-05-03 | Apotex Pharmachem Inc. | Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof |
AR071318A1 (es) * | 2008-04-15 | 2010-06-09 | Basilea Pharmaceutica Ag | Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso |
US8097719B2 (en) * | 2008-07-15 | 2012-01-17 | Genesen Labs | Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem |
CN102264694B (zh) | 2008-10-15 | 2015-11-25 | 基因里克斯(英国)有限公司 | 用于制备伏立诺他的方法 |
WO2010062333A1 (en) * | 2008-10-27 | 2010-06-03 | Plus Chemicals Sa | Polymorphs of vorinostat and vorinostat potassium salt and process for preparation thereof |
WO2010061219A2 (en) * | 2008-11-26 | 2010-06-03 | Generics [Uk] Limited | Polymorphs |
PT2544679T (pt) | 2010-03-12 | 2019-07-11 | Omeros Corp | Inibidores de pde-10 e composições e métodos relacionados |
CN103189360A (zh) * | 2010-09-01 | 2013-07-03 | 艾尼纳制药公司 | 5-ht2c激动剂的非吸湿性盐 |
CN103930419B (zh) * | 2011-09-30 | 2016-06-01 | 广东东阳光药业有限公司 | 阿齐沙坦的晶型及其制备方法 |
US20150141470A1 (en) | 2012-05-08 | 2015-05-21 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
TWI483721B (zh) | 2013-09-05 | 2015-05-11 | Profeat Biotechnology Co Ltd | The use of a composition containing a ferrous amino acid chelate for the manufacture of anti-cancer medicaments |
CA2898771C (en) * | 2013-09-05 | 2017-01-03 | Profeat Biotechnology Co., Ltd. | Use of composition containing ferrous amino acid chelate in preparation of anti-cancer medicament |
NZ716494A (en) | 2014-04-28 | 2017-07-28 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
NZ716462A (en) | 2014-04-28 | 2017-11-24 | Omeros Corp | Optically active pde10 inhibitor |
US10413517B2 (en) * | 2014-06-12 | 2019-09-17 | University Of Notre Dame Du Lac | Composition and method for the treatment of neurological diseases and cerebral injury |
US9879002B2 (en) | 2015-04-24 | 2018-01-30 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
JP2018535969A (ja) | 2015-11-04 | 2018-12-06 | オメロス コーポレーション | Pde10阻害剤の固体状態形態 |
CN107362148B (zh) * | 2017-07-27 | 2020-04-21 | 东曜药业有限公司 | 一种治疗肿瘤的药物组合物及其制备方法和应用 |
JP2020533412A (ja) * | 2017-09-07 | 2020-11-19 | アセネックス エイチケイ イノベイティブ リミテッド | 2−(5−(4−(2−モルホリノエトキシ)フェニル)ピリジン−2−イル)−n−ベンジルアセトアミドの固体形態 |
CN114829375A (zh) * | 2019-10-07 | 2022-07-29 | 维拉克塔附属公司 | 具有降低的副作用的hdac治疗的剂量 |
CN111303230B (zh) * | 2020-03-09 | 2021-07-13 | 中国食品药品检定研究院 | 一种黄体酮共晶物及其制备方法和用途 |
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GB1574822A (en) * | 1976-03-23 | 1980-09-10 | Lafon Labor | Acetohydroxamic acid derivatives and pharmaceutical compositions thereof |
US4315942A (en) * | 1979-05-21 | 1982-02-16 | New England Medical Center, Inc. | Intravenously administrable iron supplement |
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US4613616A (en) * | 1984-07-20 | 1986-09-23 | Research Corporation | Polymeric iron chelators |
US5608108A (en) | 1988-11-14 | 1997-03-04 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
US5700811A (en) | 1991-10-04 | 1997-12-23 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
WO1997011366A1 (en) | 1995-09-20 | 1997-03-27 | Merck & Co., Inc. | Histone deacetylase as target for antiprotozoal agents |
US6387673B1 (en) | 1997-05-01 | 2002-05-14 | The Salk Institute For Biological Studies | Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds |
AUPP505798A0 (en) | 1998-08-04 | 1998-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Novel compound fr225497 substance |
EP1212357B1 (en) * | 1999-09-08 | 2007-05-02 | Sloan-Kettering Institute For Cancer Research | Crystal structure of a deacetylase and inhibitors thereof |
KR20020059393A (ko) | 1999-09-08 | 2002-07-12 | 제임스 에스. 쿼크 | 새로운 부류의 세포분화제 및 히스톤 데아세틸라아제, 및이의 사용 방법 |
US7456219B2 (en) * | 2002-03-04 | 2008-11-25 | Merck Hdac Research, Llc | Polymorphs of suberoylanilide hydroxamic acid |
US7148257B2 (en) * | 2002-03-04 | 2006-12-12 | Merck Hdac Research, Llc | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
ES2532607T3 (es) * | 2002-03-04 | 2015-03-30 | Merck Hdac Research, Llc | Métodos de inducción de la diferenciación terminal |
CN100566711C (zh) * | 2002-04-15 | 2009-12-09 | 斯隆-凯特林癌症研究院 | 治疗癌症的化合物及其用途 |
WO2005110399A2 (en) * | 2004-04-29 | 2005-11-24 | The Regents Of The University Of California | Zinc-binding groups for metalloprotein inhibitors |
JP2008510821A (ja) * | 2004-08-25 | 2008-04-10 | メルク エンド カムパニー インコーポレーテッド | ヒストンデアセチラーゼ阻害剤 |
US20060141054A1 (en) * | 2004-10-25 | 2006-06-29 | Thomas Piccariello | Metal coordinated compositions |
US7799937B2 (en) * | 2004-10-25 | 2010-09-21 | Synthonics, Inc. | Metal coordinated compositions |
-
2007
- 2007-09-24 KR KR1020097006462A patent/KR20090064400A/ko not_active Application Discontinuation
- 2007-09-24 US US12/311,299 patent/US20090239946A1/en not_active Abandoned
- 2007-09-24 EP EP07861361A patent/EP2079462A4/en not_active Withdrawn
- 2007-09-24 CN CNA2007800361811A patent/CN101528212A/zh active Pending
- 2007-09-24 CA CA002663569A patent/CA2663569A1/en not_active Abandoned
- 2007-09-24 MX MX2009003405A patent/MX2009003405A/es not_active Application Discontinuation
- 2007-09-24 JP JP2009530388A patent/JP2010504968A/ja active Pending
- 2007-09-24 BR BRPI0717554-0A patent/BRPI0717554A2/pt not_active IP Right Cessation
- 2007-09-24 RU RU2009115860/15A patent/RU2009115860A/ru not_active Application Discontinuation
- 2007-09-24 EP EP11195407A patent/EP2436382A1/en not_active Withdrawn
- 2007-09-24 AU AU2007300532A patent/AU2007300532A1/en not_active Abandoned
- 2007-09-24 WO PCT/US2007/020609 patent/WO2008039421A2/en active Application Filing
-
2009
- 2009-03-19 IL IL197718A patent/IL197718A0/en unknown
- 2009-04-24 CO CO09041802A patent/CO6190508A2/es not_active Application Discontinuation
- 2009-04-27 NO NO20091664A patent/NO20091664L/no not_active Application Discontinuation
-
2011
- 2011-11-16 US US13/297,994 patent/US20120142770A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20120142770A1 (en) | 2012-06-07 |
KR20090064400A (ko) | 2009-06-18 |
NO20091664L (no) | 2009-04-27 |
IL197718A0 (en) | 2009-12-24 |
WO2008039421A3 (en) | 2008-07-24 |
BRPI0717554A2 (pt) | 2013-10-29 |
US20090239946A1 (en) | 2009-09-24 |
EP2079462A2 (en) | 2009-07-22 |
MX2009003405A (es) | 2009-04-09 |
CN101528212A (zh) | 2009-09-09 |
CA2663569A1 (en) | 2008-04-03 |
EP2436382A1 (en) | 2012-04-04 |
EP2079462A4 (en) | 2009-12-02 |
AU2007300532A1 (en) | 2008-04-03 |
WO2008039421A2 (en) | 2008-04-03 |
RU2009115860A (ru) | 2010-11-20 |
JP2010504968A (ja) | 2010-02-18 |
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Legal Events
Date | Code | Title | Description |
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FA | Application withdrawn |