CO6180444A2 - Marcacion con fluor radioactivo - Google Patents
Marcacion con fluor radioactivoInfo
- Publication number
- CO6180444A2 CO6180444A2 CO09034043A CO09034043A CO6180444A2 CO 6180444 A2 CO6180444 A2 CO 6180444A2 CO 09034043 A CO09034043 A CO 09034043A CO 09034043 A CO09034043 A CO 09034043A CO 6180444 A2 CO6180444 A2 CO 6180444A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- heteroaryl
- aryl
- hydrogen
- aralkyl
- Prior art date
Links
- 230000002285 radioactive effect Effects 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- 125000005865 C2-C10alkynyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003682 fluorination reaction Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0834—Compounds having one or more O-Si linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0896—Compounds with a Si-H linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/12—Organo silicon halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Radiology & Medical Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nuclear Medicine (AREA)
- Peptides Or Proteins (AREA)
Abstract
1.- Un compuesto que tiene la Fórmula química general IX representa un grupo saliente adecuado para fluoración seleccionado entre el grupo que comprende hidrógeno y OR3, en donde R3 representa hidrógeno, C1-C10 alquilo, C2-C10 alquenilo, C2-C10 alquinilo, arilo, heteroarilo o aralquilo, R1 y R2 se seleccionan, en forma independiente, entre el grupo que comprende hidrógeno, C1-C10 lineal y ramificado, arilo, heteroarilo y aralquilo, -B1- se selecciona entre el grupo que comprende -(CH2]m-D-[CH2]n-A-, en donde n y m son, en forma independiente, cualquier número entero entre 0 y 5, -D- representa una unión, -S-, -O- o -NR4-, en donde R4 representa hidrógeno, C1-C10 alquilo, arilo, heteroarilo o aralquilo, A representa alquilo, arilo sustituido o no sustituido o heteroarilo,E-Z1-Y1- representa una porción seleccionada entre el grupo que comprende EO-C(=O)-, ENR5-C(=O)-, EC(=O)-O-, EC(=O)-NR5-, ENR5-SO2-, ESO2-NR5-, E-O-, E-(S)p-, E-NR5-, ENR6C (=O)-NR7-, ENR6-C(=O)NR7-, ENR6C(=S)-NR7-, ENR6-C (=S)NR7-EO-C(=O)O-, EOC(=O)-O-, EOC(=S)-O-, EO-C(=S)O-, en donde el enlace simple largo que se muestra explícitamente en las Fórmulas precedentes es el enlace entre Z1 y Y1, y en donde las flechas que figuran en las Fórmulas precedentes indican el enlace entre Z1 y Y1, ...
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06076823A EP1908472A1 (en) | 2006-10-02 | 2006-10-02 | Silicon derivatives for PET imaging |
| EP06076869A EP1911452A1 (en) | 2006-10-11 | 2006-10-11 | Silicon-derivates for PET-Imaging |
| EP07090043A EP1970064A1 (en) | 2007-03-12 | 2007-03-12 | Silicon-derivatives for pet-imaging |
| EP07090079A EP1985624A3 (en) | 2007-04-23 | 2007-04-23 | Single step method of radiofluorination of biologically active compounds or biomolecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6180444A2 true CO6180444A2 (es) | 2010-07-19 |
Family
ID=39030886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09034043A CO6180444A2 (es) | 2006-10-02 | 2009-04-02 | Marcacion con fluor radioactivo |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20090035215A1 (es) |
| EP (1) | EP2074135A2 (es) |
| JP (1) | JP2010505776A (es) |
| KR (1) | KR20090085599A (es) |
| AR (1) | AR062795A1 (es) |
| AU (1) | AU2007304508A1 (es) |
| BR (1) | BRPI0719956A2 (es) |
| CA (1) | CA2664700A1 (es) |
| CO (1) | CO6180444A2 (es) |
| CR (1) | CR10703A (es) |
| IL (1) | IL197817A0 (es) |
| MA (1) | MA30824B1 (es) |
| MX (1) | MX2009003617A (es) |
| NO (1) | NO20091735L (es) |
| PA (1) | PA8747601A1 (es) |
| PE (1) | PE20081173A1 (es) |
| SV (1) | SV2009003205A (es) |
| TN (1) | TN2009000100A1 (es) |
| TW (1) | TW200820988A (es) |
| UY (1) | UY30596A1 (es) |
| WO (1) | WO2008040441A2 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011089267A1 (en) * | 2010-01-25 | 2011-07-28 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Silylated biomolecules |
| JP5717138B2 (ja) * | 2011-05-23 | 2015-05-13 | 独立行政法人産業技術総合研究所 | タンパク質固定化表面修飾材料 |
| KR102344233B1 (ko) * | 2013-06-06 | 2021-12-27 | 닛산 가가쿠 가부시키가이샤 | 액정 배향제, 액정 배향막 및 액정 표시 소자 |
| CA2982269C (en) * | 2015-05-26 | 2023-12-05 | The Regents Of The University Of California | Heteroaromatic silicon-fluoride-acceptors useful for 18f labeling of molecules and biomolecules, and methods of preparing same |
| GB2581619A (en) | 2017-09-15 | 2020-08-26 | Univ California | Inhibition of aminoacylase 3 (AA3) in the treatment of cancer |
| US20230226228A1 (en) * | 2020-05-04 | 2023-07-20 | The Research Foundation For The State University Of New York | Positron imaging tomography imaging agent composition and method for detection of bacterial infection |
| US20230357100A1 (en) * | 2020-09-28 | 2023-11-09 | National Institutes for Quantum Science and Technology | Method for producing radioactive labeled substance, device for producing radioactive labeled substance, and method for evaporatively concentrating radioactive metal nuclide |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5084555A (en) * | 1989-08-21 | 1992-01-28 | The Administrators Of The Tulane Educational Fund | An octapeptide bombesin analog |
| US5732578A (en) * | 1995-02-24 | 1998-03-31 | Hyundai Metal Co., Ltd. | Device for maintaining the horizontality of a door lock lever |
| TW432073B (en) * | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
| US6639076B1 (en) * | 1998-08-18 | 2003-10-28 | Eli Lilly And Company | Growth hormone secretagogues |
| EP1192132B1 (en) * | 1999-06-14 | 2005-09-07 | Eli Lilly And Company | Serine protease inhibitors |
| WO2002044144A2 (en) * | 2000-11-30 | 2002-06-06 | Advanced Research And Technology Institute, Inc. | Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds |
| GB0206750D0 (en) * | 2002-03-22 | 2002-05-01 | Amersham Plc | Radiofluorination methods |
| CA2516685A1 (en) * | 2003-02-20 | 2004-09-02 | University Of South Florida | Peptidomimetic inhibitors of stat3 activity and their medical uses |
| GB0305704D0 (en) * | 2003-03-13 | 2003-04-16 | Amersham Plc | Radiofluorination methods |
| US8114381B2 (en) * | 2004-02-13 | 2012-02-14 | The University Of British Columbia | Radiolabeled compounds and compositions, their precursors and methods for their production |
| US20080029548A1 (en) * | 2006-05-05 | 2008-02-07 | Ann De Wree | Fabric treatment dispensing package |
-
2007
- 2007-09-07 AU AU2007304508A patent/AU2007304508A1/en not_active Abandoned
- 2007-09-07 MX MX2009003617A patent/MX2009003617A/es not_active Application Discontinuation
- 2007-09-07 US US11/851,936 patent/US20090035215A1/en not_active Abandoned
- 2007-09-07 KR KR1020097009044A patent/KR20090085599A/ko not_active Application Discontinuation
- 2007-09-07 BR BRPI0719956-2A2A patent/BRPI0719956A2/pt not_active IP Right Cessation
- 2007-09-07 CA CA002664700A patent/CA2664700A1/en not_active Abandoned
- 2007-09-07 EP EP07818173A patent/EP2074135A2/en not_active Withdrawn
- 2007-09-07 WO PCT/EP2007/008044 patent/WO2008040441A2/en active Application Filing
- 2007-09-07 JP JP2009530773A patent/JP2010505776A/ja active Pending
- 2007-09-10 TW TW096133834A patent/TW200820988A/zh unknown
- 2007-09-14 AR ARP070104086A patent/AR062795A1/es unknown
- 2007-09-14 PA PA20078747601A patent/PA8747601A1/es unknown
- 2007-09-14 UY UY30596A patent/UY30596A1/es not_active Application Discontinuation
- 2007-09-14 PE PE2007001246A patent/PE20081173A1/es not_active Application Discontinuation
-
2009
- 2009-03-25 TN TN2009000100A patent/TN2009000100A1/fr unknown
- 2009-03-26 IL IL197817A patent/IL197817A0/en unknown
- 2009-04-01 CR CR10703A patent/CR10703A/es not_active Application Discontinuation
- 2009-04-02 CO CO09034043A patent/CO6180444A2/es not_active Application Discontinuation
- 2009-04-02 SV SV2009003205A patent/SV2009003205A/es not_active Application Discontinuation
- 2009-04-30 MA MA31834A patent/MA30824B1/fr unknown
- 2009-04-30 NO NO20091735A patent/NO20091735L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MA30824B1 (fr) | 2009-10-01 |
| PE20081173A1 (es) | 2008-11-06 |
| WO2008040441A3 (en) | 2009-01-08 |
| WO2008040441A2 (en) | 2008-04-10 |
| US20090035215A1 (en) | 2009-02-05 |
| JP2010505776A (ja) | 2010-02-25 |
| BRPI0719956A2 (pt) | 2014-04-29 |
| AU2007304508A8 (en) | 2009-05-14 |
| MX2009003617A (es) | 2009-04-22 |
| PA8747601A1 (es) | 2009-08-26 |
| UY30596A1 (es) | 2008-05-02 |
| CA2664700A1 (en) | 2008-04-10 |
| EP2074135A2 (en) | 2009-07-01 |
| IL197817A0 (en) | 2009-12-24 |
| KR20090085599A (ko) | 2009-08-07 |
| CR10703A (es) | 2009-06-25 |
| AU2007304508A1 (en) | 2008-04-10 |
| TW200820988A (en) | 2008-05-16 |
| TN2009000100A1 (en) | 2010-08-19 |
| SV2009003205A (es) | 2009-10-19 |
| AR062795A1 (es) | 2008-12-03 |
| NO20091735L (no) | 2009-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |