CO5200836A1 - Derivados de bencimidazol sustituidos con arilsulfonamida, procedimiento para su preparacion y su empleo como medicamentos - Google Patents
Derivados de bencimidazol sustituidos con arilsulfonamida, procedimiento para su preparacion y su empleo como medicamentosInfo
- Publication number
- CO5200836A1 CO5200836A1 CO00072225A CO00072225A CO5200836A1 CO 5200836 A1 CO5200836 A1 CO 5200836A1 CO 00072225 A CO00072225 A CO 00072225A CO 00072225 A CO00072225 A CO 00072225A CO 5200836 A1 CO5200836 A1 CO 5200836A1
- Authority
- CO
- Colombia
- Prior art keywords
- arilsulfonamide
- medications
- employment
- procedure
- preparation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de bencimidazol de la fórmula general (I)<EMI FILE="00072225_1" ID="1" IMF=JPEG >En dondeR1 puede significar un radical elegido del grupo alquilo C1-C6, alquenilo C2-C6 y alquilino C2-C6 que, eventualmente, puede estar sustituido, una, dos o tres veces, con uno o varios de los radicales hidroxi, alcoxi, C1-C4, CF3, fenoxi, COOH, halógeno, -CO(alcoxi C1-C4), -CONH2, -CO-NH(alquilo C1-C4), -CO-N(alquilo C1-C4)2, -NH2, -fenoxi, o un cicloalquilo C3-C8, eventualmente enlazado a través de un puente de alquileno C1-C4, que puede estar sustituido, eventualmente una, dos o tres veces, con uno o varios de los radicales hidroxi, alcoxi C1-C4, carboxi, halógeno, alcoxi C1-C4-carbonilo o CF3, o fenil-alquilo C1-C4 que puede estar sustituido, eventualmente una, dos o tres veces, con uno o varios de los radicales hidroxi, alcoxi C1-C4, carboxi, halógeno, alcoxi C1-C4-carbonilo o CF3, o un heterociclo de 5 ó 6 miembros, saturado o insaturado, enlazado directamente o a través de un puente de alquileno C1-C4, que puede contener uno o dos heteroátomos elegidos del grupo de oxígeno, nitrógeno o azufre y que puede estar eventualmente sustituido con alquilo C1-C4 o bencilo; R2 puede significar -C(=NH)NH2 o -CH2-NH2; R3 puede significar fenilo, bencilo, naftilo, furanilo, benzofuranilo, quinolilo, isoquinolilo, tienilo o benzotienilo; R4 puede significar hidrógeno, un radical alquilo C1-C6 que puede estar sustituido, una o dos veces, con uno o dos de los radicales -NH2, -NH(alquilo C1-C4), -N(alquilo C1-C4)2, -C(=NH)NH2 o -NH-C(=NH)NH2, o un heterociclo de 5, 6 ó 7 miembros, saturado o insaturado, enlazado directamente o través de un puente de alquileno C1 -C4 o a través de un puente de alquilen C1-C4-CO, que puede contener eventualmente uno, dos o tres heteroátomos elegidos del grupo de oxígeno, nitrógeno o azufre y que puede estar eventualmente sustituido con alquilo C1-C4, hidroxialquilo C1-C4, bencilo o piridilo, cicloalquilo C3-C8 que puede estar sustituido, una o dos veces, con uno o dos de los radicales -NH2, -NH(alquilo C1-C4), -N(alquilo C1-C4)2, -C(=NH)NH2 o -NH-C(=NH)NH2, o fenilo, bencilo o feniletilo que pueden estar sustituidos en el anillo de fenilo, en cada caso una o dos veces, con uno o dos de los radicales -NH2, -NH(alquilo C1 -C4), -N(alquilo C1-C4)2, -alquiloC1-C4-NH2, -C(=NH)NH2 o -NH-C(=NH)NH2, eventualmente en forma de sus tautómeros, sus racetamos, sus enantiómeros, sus diastereoisómeros y sus mezclas, así como, eventualmente, sus sales por adición de ácidos farmacológicamente inocuos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19945787A DE19945787A1 (de) | 1999-09-24 | 1999-09-24 | Arylsulfonamid-substituierte Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5200836A1 true CO5200836A1 (es) | 2002-09-27 |
Family
ID=7923158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00072225A CO5200836A1 (es) | 1999-09-24 | 2000-09-22 | Derivados de bencimidazol sustituidos con arilsulfonamida, procedimiento para su preparacion y su empleo como medicamentos |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1220844B1 (es) |
| JP (1) | JP2003510310A (es) |
| AT (1) | ATE236887T1 (es) |
| AU (1) | AU7288900A (es) |
| CA (1) | CA2379557C (es) |
| CO (1) | CO5200836A1 (es) |
| DE (1) | DE50001742D1 (es) |
| DK (1) | DK1220844T3 (es) |
| ES (1) | ES2192543T3 (es) |
| MX (1) | MXPA02002622A (es) |
| PE (1) | PE20010622A1 (es) |
| PT (1) | PT1220844E (es) |
| WO (1) | WO2001023360A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10105628A1 (de) * | 2001-02-08 | 2002-08-22 | Boehringer Ingelheim Pharma | Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US6656956B2 (en) | 2001-02-08 | 2003-12-02 | Boehringer Ingelheim Pharma Kg | Benzimidazole derivatives, processes for preparing them and their use as pharmaceutical compositions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4316922A1 (de) * | 1993-05-20 | 1994-11-24 | Boehringer Mannheim Gmbh | Neue 4-Amidinophenylsulfonamide - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| PE121699A1 (es) * | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
| EP1030844A1 (en) * | 1997-11-10 | 2000-08-30 | Array Biopharma Inc. | Compounds which inhibit tryptase activity |
| WO1999040072A1 (de) * | 1998-02-03 | 1999-08-12 | Boehringer Ingelheim Pharma Kg | 5-gliedrige benzokondensierte heterocyclen als antithrombotika |
| DE19834751A1 (de) * | 1998-08-01 | 2000-02-03 | Boehringer Ingelheim Pharma | Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
-
2000
- 2000-09-21 PT PT00960686T patent/PT1220844E/pt unknown
- 2000-09-21 ES ES00960686T patent/ES2192543T3/es not_active Expired - Lifetime
- 2000-09-21 AU AU72889/00A patent/AU7288900A/en not_active Abandoned
- 2000-09-21 MX MXPA02002622A patent/MXPA02002622A/es active IP Right Grant
- 2000-09-21 JP JP2001526514A patent/JP2003510310A/ja active Pending
- 2000-09-21 AT AT00960686T patent/ATE236887T1/de not_active IP Right Cessation
- 2000-09-21 WO PCT/EP2000/009237 patent/WO2001023360A1/de active IP Right Grant
- 2000-09-21 DK DK00960686T patent/DK1220844T3/da active
- 2000-09-21 CA CA002379557A patent/CA2379557C/en not_active Expired - Fee Related
- 2000-09-21 DE DE50001742T patent/DE50001742D1/de not_active Expired - Lifetime
- 2000-09-21 EP EP00960686A patent/EP1220844B1/de not_active Expired - Lifetime
- 2000-09-22 PE PE2000000995A patent/PE20010622A1/es not_active Application Discontinuation
- 2000-09-22 CO CO00072225A patent/CO5200836A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PT1220844E (pt) | 2003-08-29 |
| DE50001742D1 (de) | 2003-05-15 |
| DK1220844T3 (da) | 2003-07-28 |
| CA2379557A1 (en) | 2001-04-05 |
| ES2192543T3 (es) | 2003-10-16 |
| EP1220844B1 (de) | 2003-04-09 |
| EP1220844A1 (de) | 2002-07-10 |
| JP2003510310A (ja) | 2003-03-18 |
| WO2001023360A1 (de) | 2001-04-05 |
| AU7288900A (en) | 2001-04-30 |
| MXPA02002622A (es) | 2002-10-24 |
| CA2379557C (en) | 2008-09-16 |
| ATE236887T1 (de) | 2003-04-15 |
| PE20010622A1 (es) | 2001-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |