CO4990983A1 - CYCLLOALKYL BENZAMIDES STIMULATING HIGH AND LOW GASTROINTESTINAL MOTRICITY - Google Patents

CYCLLOALKYL BENZAMIDES STIMULATING HIGH AND LOW GASTROINTESTINAL MOTRICITY

Info

Publication number
CO4990983A1
CO4990983A1 CO98042279A CO98042279A CO4990983A1 CO 4990983 A1 CO4990983 A1 CO 4990983A1 CO 98042279 A CO98042279 A CO 98042279A CO 98042279 A CO98042279 A CO 98042279A CO 4990983 A1 CO4990983 A1 CO 4990983A1
Authority
CO
Colombia
Prior art keywords
alkyl group
branched
linear
cyclloalkyl
motricity
Prior art date
Application number
CO98042279A
Other languages
Spanish (es)
Inventor
Christian Jeanpetit
Thierry Bouyssou
Helene Christinaki
Serge Biosa
Boucheix Olivier
Original Assignee
Logeais Labor Jacques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Logeais Labor Jacques filed Critical Logeais Labor Jacques
Publication of CO4990983A1 publication Critical patent/CO4990983A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de fórmula general 1:Caracterizado porque:- R1 es un grupo alquilo linear, ramificado o ciclizado en C1 a C6 o un grupo cicloalquilo en C3 a C6 , dicho grupo alquilo pudiendo, dado el caso, formar un ciclo de 4 a 5 átomos de carbono en el ciclo, en asociación con el carbono en posición 3 del ciclo aromático, y con el cual portan el átomo de oxígeno. - R2 es H, un grupo alquilo en C1 a C6 , lineal o ramificado, OH, o un grupo hidroxialquílico, en el cual el grupo alquilo está en C1 a C4 lineal o ramificado. - R3 es H, un grupo alquilo en C1 a C6 lineal o ramificado, OH o un grupo de hidroxialquilico en el cual el grupo alquilo está en C1 a C4 linear o ramificado, bajo reserva que R2 y R3 no puedan representar simultáneamente a OH. -m = 1 ó 2; -n = 1, 2 ó 3.Compounds of general formula 1: Characterized in that: - R1 is a linear, branched or cyclized alkyl group at C1 to C6 or a cycloalkyl group at C3 to C6, said alkyl group being able, if appropriate, to form a cycle of 4 to 5 atoms carbon in the cycle, in association with carbon in position 3 of the aromatic cycle, and with which they carry the oxygen atom. - R2 is H, a linear or branched C1 to C6 alkyl group, OH, or a hydroxyalkyl group, in which the alkyl group is linear or branched C1 to C4. - R3 is H, a linear or branched C1 to C6 alkyl group, OH or a hydroxyalkyl group in which the linear or branched C1 to C4 alkyl group, subject to the fact that R2 and R3 cannot simultaneously represent OH. -m = 1 or 2; -n = 1, 2 or 3.

CO98042279A 1997-07-25 1998-07-24 CYCLLOALKYL BENZAMIDES STIMULATING HIGH AND LOW GASTROINTESTINAL MOTRICITY CO4990983A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9709478A FR2766486B1 (en) 1997-07-25 1997-07-25 HIGH AND LOW GASTROINTESTINAL MOTOR STIMULATING BENZAMIDE CYCLOALKYLES

Publications (1)

Publication Number Publication Date
CO4990983A1 true CO4990983A1 (en) 2000-12-26

Family

ID=9509624

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98042279A CO4990983A1 (en) 1997-07-25 1998-07-24 CYCLLOALKYL BENZAMIDES STIMULATING HIGH AND LOW GASTROINTESTINAL MOTRICITY

Country Status (8)

Country Link
EP (1) EP0998469A1 (en)
AR (1) AR014901A1 (en)
AU (1) AU8867998A (en)
CO (1) CO4990983A1 (en)
FR (1) FR2766486B1 (en)
TN (1) TNSN98137A1 (en)
WO (1) WO1999005133A1 (en)
ZA (1) ZA986632B (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1015921A (en) * 1961-10-06 1966-01-05 Benger Lab Ltd Benzamides
AR216043A1 (en) * 1974-03-21 1979-11-30 Anphar Sa PROCEDURE FOR THE PREPARATION OF 1-BENZOYLAMINE-4-PIPERIDINE DERIVATIVES AND ITS PHYSIOLOGICALLY ACCEPTABLE SALTS
EP0222533A1 (en) * 1985-10-25 1987-05-20 The Upjohn Company Cis-N-[(2-aminocycloaliphatic)benzene acetamide and -benzamide anticonvulsants
FR2674849B1 (en) * 1991-04-02 1994-12-23 Logeais Labor Jacques NOVEL N-CYCLOHEXYL BENZAMIDES OR THIOBENZAMIDES DERIVATIVES, THEIR PREPARATIONS AND THEIR THERAPEUTIC APPLICATIONS.
WO1996005166A1 (en) * 1994-08-11 1996-02-22 Yamanouchi Pharmaceutical Co., Ltd. Substituted amine derivative and medicinal composition containing the same
FR2735693B1 (en) * 1995-06-23 1997-09-26 Logeais Labor Jacques NEW THERAPEUTIC APPLICATIONS OF N-CYCLOHEXYL BENZAMIDES

Also Published As

Publication number Publication date
FR2766486A1 (en) 1999-01-29
ZA986632B (en) 1999-02-04
EP0998469A1 (en) 2000-05-10
TNSN98137A1 (en) 2005-03-15
FR2766486B1 (en) 1999-09-17
AU8867998A (en) 1999-02-16
AR014901A1 (en) 2001-04-11
WO1999005133A1 (en) 1999-02-04

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