CO4970729A1 - PROCEDURE FOR FORMING PHARMACEUTICAL COMPOSITIONS IN PILLS OR SUBSTANTIALLY SPHERICAL GRANULES OF CONTROLLED AND SUSTAINED ACTION, WHICH CONTAIN AS AN ACTIVE AGENT 7-BROMO-1.3-DIHIDRO-5- (2-PIRIDINIL) -2H-1,4-BENZODIACEPIN-2 ( -ONA; AND COMPOSICI - Google Patents
PROCEDURE FOR FORMING PHARMACEUTICAL COMPOSITIONS IN PILLS OR SUBSTANTIALLY SPHERICAL GRANULES OF CONTROLLED AND SUSTAINED ACTION, WHICH CONTAIN AS AN ACTIVE AGENT 7-BROMO-1.3-DIHIDRO-5- (2-PIRIDINIL) -2H-1,4-BENZODIACEPIN-2 ( -ONA; AND COMPOSICIInfo
- Publication number
- CO4970729A1 CO4970729A1 CO98050771A CO98050771A CO4970729A1 CO 4970729 A1 CO4970729 A1 CO 4970729A1 CO 98050771 A CO98050771 A CO 98050771A CO 98050771 A CO98050771 A CO 98050771A CO 4970729 A1 CO4970729 A1 CO 4970729A1
- Authority
- CO
- Colombia
- Prior art keywords
- release
- forming
- bromazepan
- nodules
- benzodiacepin
- Prior art date
Links
Abstract
Procedimiento para formar composiciones farmacéuticas enpíldoras o gránulos sustancialmente esféricos de acción controlada y sostenida, que contienen como agente activo 7 bromo-1,3-dihidro-5-(2-piridinil)-2h-1,4-benzodiacepin-2(1h)-ona); caracterizado porque comprende las siguientes etapas:a) revestir nódulos o núcleos formados por partículas de azúcar consolidadas con almidón, en una operación de mezclado de dichos nódulos con bromazepan micronizado y un polímero ligante en solución, para formar una envolvente biodegradable sobre dichos núcleos, que retiene el material micronizado, formando el conjunto de nódulos revestidos, una primera formulación, de liberación rápida del bromazepan; b) formar sobre al menos una fracción separada de los nódulos de liberación provenientes de la etapa A), una segunda envolvente, en una operación de mezclado de dicha fracción con un polímero peliculizante eutérico en solución formando dicha fracción provista de dicho revestimiento eutérico en solución formando dicha fracción provista de dicho revestimiento eutérico, una segunda formulación, de liberación retardada;c) combinar cantidades suficientes de las formulaciones de bromazepan de liberación rápida y de liberación retardada o sostenida formada en las etapas A) y B), para formar composiciones que contienen dosis predeterminadas y de liberación programada de bromazepan.Procedure to form pharmaceutical compositions in pills or granules substantially spherical of controlled and sustained action, containing as active agent 7 bromo-1,3-dihydro-5- (2-pyridinyl) -2h-1,4-benzodiacepin-2 (1h) -ona); characterized in that it comprises the following steps: a) coating nodules or nuclei formed by consolidated sugar particles with starch, in a mixing operation of said nodules with micronized bromazepan and a binding polymer in solution, to form a biodegradable envelope on said nuclei, which it retains the micronized material, forming the set of coated nodules, a first formulation, for quick release of the bromazepan; b) forming on at least a separate fraction of the release nodules from stage A), a second envelope, in an operation of mixing said fraction with a solution etheric film-forming polymer forming said fraction provided with said solution etheric coating said fraction provided with said euteric coating forming a second, delayed-release formulation; c) combining sufficient amounts of the quick-release and delayed-release or sustained-release formulations of bromazepan formed in steps A) and B), to form compositions which They contain predetermined and scheduled release doses of bromazepan.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP970104185 AR009766A1 (en) | 1997-09-12 | 1997-09-12 | PROCEDURE FOR FORMING PHARMACEUTICAL COMPOSITIONS IN SUBSTANTIALLY SPHERICAL PILLS OR GRANULES OF CONTROLLED AND SUSTAINED ACTION, WHICH CONTAIN AS AN ACTIVE AGENT 7-BROMO-1,3-DIHIDRO-5- (2-PIRIDINYL) -2H-1,4-BENZODIACEPIN-2 ) -ONA); AND PHARMACEUTICAL COMPOSITIONS OBTAINED BY SUCH PROCEDURE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4970729A1 true CO4970729A1 (en) | 2000-11-07 |
Family
ID=40935254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98050771A CO4970729A1 (en) | 1997-09-12 | 1998-09-04 | PROCEDURE FOR FORMING PHARMACEUTICAL COMPOSITIONS IN PILLS OR SUBSTANTIALLY SPHERICAL GRANULES OF CONTROLLED AND SUSTAINED ACTION, WHICH CONTAIN AS AN ACTIVE AGENT 7-BROMO-1.3-DIHIDRO-5- (2-PIRIDINIL) -2H-1,4-BENZODIACEPIN-2 ( -ONA; AND COMPOSICI |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR009766A1 (en) |
| CO (1) | CO4970729A1 (en) |
-
1997
- 1997-09-12 AR ARP970104185 patent/AR009766A1/en active IP Right Grant
-
1998
- 1998-09-04 CO CO98050771A patent/CO4970729A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR009766A1 (en) | 2000-05-03 |
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