CO4700434A1 - NEW RETINOIDS - Google Patents
NEW RETINOIDSInfo
- Publication number
- CO4700434A1 CO4700434A1 CO96008294A CO96008294A CO4700434A1 CO 4700434 A1 CO4700434 A1 CO 4700434A1 CO 96008294 A CO96008294 A CO 96008294A CO 96008294 A CO96008294 A CO 96008294A CO 4700434 A1 CO4700434 A1 CO 4700434A1
- Authority
- CO
- Colombia
- Prior art keywords
- compound
- bond
- dosage unit
- amount
- unit form
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Un compuesto de fórmula:en donde el enlace C7 -C8 es un doble enlace o triple enlace; R1 y R2 son independientemente entre sí halógeno o alquilo inferior cuando el enlace C7 -C8 es un enlace doble ó R1 y R2 son indendientemente entre si alquilo inferior cuando el enlace C7 -C8 es un enlace triple; ó R1 y R2 tomados conjuntamente son alquileno de 3 a 13 átomos de carbono en el cual un átomo de carbono puede estar substituido con un heteroátomo seleccionado del grupo consistente en azufre, oxígeno y nitrógeno; ó R1 y R2 tomados conjuntamente con los átomos de carbono a los cuales están unidos con un anillo aromático de 5-6 átomos de carbono o un anillo heteroaromático de 5-6 átomos en el cual un átomo de R1 ó R2 es un heteroátomo seleccionado del grupo consistente en oxígeno, nitrógeno y azufre, y los restantes átomos de R1 y R2 son carbono; y las sales, esteres y amidas farmacéuticamente aceptables.2Una composición en forma de unidad de dosificación para la administración oral, que comprende: un primer compuesto que es un retinoide con actividad RARa; un segundo compuesto, de fórmula I, dado en la reivindicación 1, ó unas sales, ésteres o amida del mismo, farmacéuticamente aceptables, en donde dicho primer compuesto esta presente en dicha forma de unidad de dosificación en una cantidad de 10 a 50 mg y dicho segundo compuesto está presente en dicha forma de unidad de dosificación en una cantidad de 1 a 10 veces la cantidad de dicho primer compuesto.A compound of the formula: wherein the C7-C8 bond is a double bond or triple bond; R1 and R2 are independently from each other halogen or lower alkyl when the C7-C8 bond is a double bond or R1 and R2 are independently from each other lower alkyl when the C7-C8 bond is a triple bond; or R1 and R2 taken together are alkylene of 3 to 13 carbon atoms in which a carbon atom can be substituted with a heteroatom selected from the group consisting of sulfur, oxygen and nitrogen; or R1 and R2 taken together with the carbon atoms to which they are attached with an aromatic ring of 5-6 carbon atoms or a heteroaromatic ring of 5-6 atoms in which an atom of R1 or R2 is a heteroatom selected from group consisting of oxygen, nitrogen and sulfur, and the remaining atoms of R1 and R2 are carbon; and the pharmaceutically acceptable salts, esters and amides.2 A composition in dosage unit form for oral administration, comprising: a first compound which is a retinoid with RARa activity; a second compound, of formula I, given in claim 1, or pharmaceutically acceptable salts, esters or amide thereof, wherein said first compound is present in said dosage unit form in an amount of 10 to 50 mg and said second compound is present in said dosage unit form in an amount of 1 to 10 times the amount of said first compound.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39398095A | 1995-02-24 | 1995-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4700434A1 true CO4700434A1 (en) | 1998-12-29 |
Family
ID=23557042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO96008294A CO4700434A1 (en) | 1995-02-24 | 1996-02-22 | NEW RETINOIDS |
Country Status (8)
| Country | Link |
|---|---|
| AR (1) | AR002033A1 (en) |
| BR (1) | BR9600805A (en) |
| CO (1) | CO4700434A1 (en) |
| PE (1) | PE28197A1 (en) |
| PL (1) | PL184625B1 (en) |
| TR (1) | TR199600141A2 (en) |
| UY (1) | UY24174A1 (en) |
| ZA (1) | ZA961250B (en) |
-
1996
- 1996-02-16 ZA ZA961250A patent/ZA961250B/en unknown
- 1996-02-19 TR TR96/00141A patent/TR199600141A2/en unknown
- 1996-02-21 PE PE00012296A patent/PE28197A1/en not_active Application Discontinuation
- 1996-02-22 CO CO96008294A patent/CO4700434A1/en unknown
- 1996-02-23 BR BR9600805A patent/BR9600805A/en not_active Application Discontinuation
- 1996-02-23 UY UY24174A patent/UY24174A1/en not_active IP Right Cessation
- 1996-02-23 PL PL96312913A patent/PL184625B1/en not_active IP Right Cessation
- 1996-02-23 AR ARP960101489A patent/AR002033A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ZA961250B (en) | 1996-08-26 |
| PL184625B1 (en) | 2002-11-29 |
| AR002033A1 (en) | 1998-01-07 |
| BR9600805A (en) | 1997-12-23 |
| UY24174A1 (en) | 2000-12-29 |
| PL312913A1 (en) | 1996-09-02 |
| TR199600141A2 (en) | 1996-10-21 |
| PE28197A1 (en) | 1997-08-20 |
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