IT1256320B - HETEROCYCLIC DERIVATIVES - Google Patents

HETEROCYCLIC DERIVATIVES

Info

Publication number
IT1256320B
IT1256320B ITMI922661A ITMI922661A IT1256320B IT 1256320 B IT1256320 B IT 1256320B IT MI922661 A ITMI922661 A IT MI922661A IT MI922661 A ITMI922661 A IT MI922661A IT 1256320 B IT1256320 B IT 1256320B
Authority
IT
Italy
Prior art keywords
compounds
relates
heterocyclic derivatives
new compounds
treatment
Prior art date
Application number
ITMI922661A
Other languages
Italian (it)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ITMI922661A0 publication Critical patent/ITMI922661A0/en
Publication of ITMI922661A1 publication Critical patent/ITMI922661A1/en
Application granted granted Critical
Publication of IT1256320B publication Critical patent/IT1256320B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invenzione riguarda composti farmaceuticamente utili di formula I, in cui R1, R2, R3, R4 e A1 hanno i diversi significati qui definiti, e loro sali non tossici e composizioni farmaceutiche che li contengono. I nuovi composti sono importanti nel trattamento di condizioni come ipertensione ed insufficienza cardiaca congestiva. L'invenzione riguarda inoltre procedimenti per la fabbricazione dei nuovi composti e l'impiego dei composti nel trattamento medico.The invention relates to pharmaceutically useful compounds of formula I, wherein R1, R2, R3, R4 and A1 have the different meanings defined herein, and their non-toxic salts and pharmaceutical compositions containing them. The new compounds are important in the treatment of conditions such as hypertension and congestive heart failure. The invention also relates to processes for the manufacture of the new compounds and the use of the compounds in medical treatment.

ITMI922661A 1991-12-04 1992-11-20 HETEROCYCLIC DERIVATIVES IT1256320B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919125842A GB9125842D0 (en) 1991-12-04 1991-12-04 Heterocyclic derivatives

Publications (3)

Publication Number Publication Date
ITMI922661A0 ITMI922661A0 (en) 1992-11-20
ITMI922661A1 ITMI922661A1 (en) 1994-05-20
IT1256320B true IT1256320B (en) 1995-11-30

Family

ID=10705730

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI922661A IT1256320B (en) 1991-12-04 1992-11-20 HETEROCYCLIC DERIVATIVES

Country Status (10)

Country Link
JP (1) JPH05255327A (en)
BE (1) BE1005473A3 (en)
CA (1) CA2082668A1 (en)
DE (1) DE4239440A1 (en)
FR (1) FR2684672A1 (en)
GB (2) GB9125842D0 (en)
IE (1) IE922785A1 (en)
IT (1) IT1256320B (en)
NL (1) NL9202091A (en)
ZA (1) ZA928742B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439911A (en) * 1992-12-28 1995-08-08 Shionogi & Co., Ltd. Aminopyrimidine derivatives and their production and use
EP0618207B1 (en) * 1993-03-24 1999-01-07 American Home Products Corporation Substituted pyridopyrimidines as antihypertensives
KR100300566B1 (en) * 1994-09-17 2001-11-22 조생현 Pyrimidinone derivative and method for preparation thereof
US6440965B1 (en) * 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
US6583148B1 (en) 1999-04-08 2003-06-24 Krenitsky Pharmaceuticals, Inc. Neurotrophic substituted pyrimidines
WO2002008205A1 (en) 2000-07-24 2002-01-31 Krenitsky Pharmaceuticals, Inc. Substituted 5-alkynyl pyrimidines having neurotrophic activity
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
DE60303238T2 (en) * 2003-04-25 2006-09-14 Actimis Pharmaceuticals, Inc., La Jolla Pyrimidine-acetic acid derivatives suitable for the treatment of CRTH2-related diseases
PT1718649E (en) 2004-01-31 2009-08-06 Actimis Pharmaceuticals Inc Imidazo 1,2-c pyrimidinylacetic acid derivatives
WO2009042138A1 (en) 2007-09-25 2009-04-02 Actimis Pharmaceuticals, Inc. Alkylthio pyrimidines as crth2 antagonists
KR20100061746A (en) 2007-09-25 2010-06-08 액티미스 파마수티컬스 인코포레이티드 2-s-benzyl substituted pyrimidines as crth2 antagonists
KR102481705B1 (en) * 2020-08-04 2022-12-27 연세대학교 산학협력단 A Composition for Preventing or Treating Hepatic Fibrosis Comprising Triazole Derivatives as Active Ingredients
CA3213709A1 (en) * 2021-04-09 2022-10-13 Wei Zhu Ubiquitin-specific protease 1 (usp1) inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424317A3 (en) * 1989-10-19 1991-09-25 Ciba-Geigy Ag Pyrimidines
IL99246A0 (en) * 1990-09-10 1992-07-15 Abbott Lab Angiotensin ii receptor antagonists and pharmaceutical compositions containing them
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
NL9202091A (en) 1993-07-01
CA2082668A1 (en) 1993-06-05
GB9225283D0 (en) 1993-01-27
BE1005473A3 (en) 1993-08-03
DE4239440A1 (en) 1993-06-09
IE922785A1 (en) 1993-06-16
FR2684672A1 (en) 1993-06-11
GB2262096A (en) 1993-06-09
JPH05255327A (en) 1993-10-05
ITMI922661A1 (en) 1994-05-20
ITMI922661A0 (en) 1992-11-20
GB9125842D0 (en) 1992-02-05
ZA928742B (en) 1993-06-09

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Legal Events

Date Code Title Description
0001 Granted