CO4700419A1 - Procedimiento para encapsulado de clorofeniramina - Google Patents

Procedimiento para encapsulado de clorofeniramina

Info

Publication number
CO4700419A1
CO4700419A1 CO96004106A CO96004106A CO4700419A1 CO 4700419 A1 CO4700419 A1 CO 4700419A1 CO 96004106 A CO96004106 A CO 96004106A CO 96004106 A CO96004106 A CO 96004106A CO 4700419 A1 CO4700419 A1 CO 4700419A1
Authority
CO
Colombia
Prior art keywords
chlorpheniramine maleate
chloropheniramine
encapsulation
procedure
heated
Prior art date
Application number
CO96004106A
Other languages
English (en)
Inventor
Marie Jean Bettman
Rao Ghanta Sambasiva
Original Assignee
Eurand America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand America Inc filed Critical Eurand America Inc
Publication of CO4700419A1 publication Critical patent/CO4700419A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

En un procedimiento para microencapsular una cantidadpredeterminada de maleato de clorofeniramina finamente dividida en un medio de coacervación calentado y luego enfriado que incluye ciclohexano, y un polímero de encapsulado y una fase de polímero inductor y separar el maleato de clorofeniramina que contenga las microcápsulas, la mejora que consiste en cargar un exceso de maleato de clorofeniramina al medio de coacervación suficiente para saturar ciclohexano en el medio de coacervación calentado con maleato de clorofeniramina".
CO96004106A 1995-02-03 1996-01-31 Procedimiento para encapsulado de clorofeniramina CO4700419A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/383,033 US5622723A (en) 1995-02-03 1995-02-03 Procedure for encapsulating chlorpheniramine

Publications (1)

Publication Number Publication Date
CO4700419A1 true CO4700419A1 (es) 1998-12-29

Family

ID=23511421

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96004106A CO4700419A1 (es) 1995-02-03 1996-01-31 Procedimiento para encapsulado de clorofeniramina

Country Status (6)

Country Link
US (1) US5622723A (es)
EP (1) EP0724880A1 (es)
AR (1) AR004473A1 (es)
BR (1) BR9600310A (es)
CA (1) CA2168330A1 (es)
CO (1) CO4700419A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ334914A (en) * 1996-10-01 2000-09-29 Stanford Res Inst Int Taste-masked microcapsule compositions and methods of manufacture using a phase seperation-coacervation technique
US20040253311A1 (en) * 2002-12-18 2004-12-16 Roger Berlin Multi-layer tablet comprising non-steroidal anti-inflammatory drugs, decongestants and non-sedating antihist amines
TWI313598B (en) * 2002-12-18 2009-08-21 Wyeth Corp Compositions of non-steroidal anti-inflammatory drugs, decongestants and anti-histamines
US7632521B2 (en) 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2211019C3 (de) * 1972-03-08 1980-08-28 Bayer Ag, 5090 Leverkusen Geschmacksverbessernde Formulierungen oraler Penicilline
BE791458A (fr) * 1972-07-31 1973-05-16 Merck & Co Inc Produit microencapsule
JPS5524118A (en) * 1978-08-08 1980-02-21 Tetsuo Kato Microcapsulated preparation for mitomycinc
JPS56152739A (en) * 1980-04-25 1981-11-26 Tanabe Seiyaku Co Ltd Production of microcapsule
ATE133087T1 (de) * 1989-05-04 1996-02-15 Southern Res Inst Einkapselungsverfahren
US5084278A (en) * 1989-06-02 1992-01-28 Nortec Development Associates, Inc. Taste-masked pharmaceutical compositions

Also Published As

Publication number Publication date
CA2168330A1 (en) 1996-08-04
BR9600310A (pt) 1997-12-23
US5622723A (en) 1997-04-22
EP0724880A1 (en) 1996-08-07
AR004473A1 (es) 1998-12-16

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