CO2024001950A2 - Un gel de emulsión de aceite en agua que comprende bromuro de tiotropio - Google Patents
Un gel de emulsión de aceite en agua que comprende bromuro de tiotropioInfo
- Publication number
- CO2024001950A2 CO2024001950A2 CONC2024/0001950A CO2024001950A CO2024001950A2 CO 2024001950 A2 CO2024001950 A2 CO 2024001950A2 CO 2024001950 A CO2024001950 A CO 2024001950A CO 2024001950 A2 CO2024001950 A2 CO 2024001950A2
- Authority
- CO
- Colombia
- Prior art keywords
- oil
- water emulsion
- emulsion gel
- tiotropium bromide
- dermis
- Prior art date
Links
- 239000007764 o/w emulsion Substances 0.000 title abstract 3
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 title abstract 2
- 229960000257 tiotropium bromide Drugs 0.000 title abstract 2
- 210000004207 dermis Anatomy 0.000 abstract 2
- 239000012466 permeate Substances 0.000 abstract 2
- 210000003491 skin Anatomy 0.000 abstract 2
- 208000008454 Hyperhidrosis Diseases 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 230000001166 anti-perspirative effect Effects 0.000 abstract 1
- 239000003213 antiperspirant Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 229940088679 drug related substance Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000002615 epidermis Anatomy 0.000 abstract 1
- 230000037315 hyperhidrosis Effects 0.000 abstract 1
- 239000002105 nanoparticle Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001839 systemic circulation Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Colloid Chemistry (AREA)
Abstract
La presente invención se refiere a un gel de emulsión de aceite en agua que comprende bromuro de tiotropio para uso tópico. Puede utilizarse en cosmética, como antitranspirante o en la prevención y/o tratamiento de la hiperhidrosis. Tras su aplicación en la piel, se forman nanopartículas y la sustancia farmacológica penetra en la piel donde ejerce su efecto. El gel de emulsión de aceite en agua está compuesto de tal manera que la sustancia farmacológica permea la epidermis y entra en la dermis, pero solo en menor medida permea a través de la dermis y en la circulación sistémica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP21382781.9A EP4140476A1 (en) | 2021-08-25 | 2021-08-25 | An oil-in-water emulsion gel comprising tiotropium bromide |
PCT/EP2022/073705 WO2023025900A1 (en) | 2021-08-25 | 2022-08-25 | An oil-in-water emulsion gel comprising tiotropium bromide |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2024001950A2 true CO2024001950A2 (es) | 2024-02-26 |
Family
ID=77520677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2024/0001950A CO2024001950A2 (es) | 2021-08-25 | 2024-02-22 | Un gel de emulsión de aceite en agua que comprende bromuro de tiotropio |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP4140476A1 (es) |
KR (1) | KR20240048011A (es) |
AR (1) | AR126875A1 (es) |
AU (1) | AU2022332631A1 (es) |
CA (1) | CA3229343A1 (es) |
CO (1) | CO2024001950A2 (es) |
IL (1) | IL310805A (es) |
TW (1) | TW202315630A (es) |
WO (1) | WO2023025900A1 (es) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2625966A1 (en) | 2012-02-13 | 2013-08-14 | Bionanoplus, S.L. | Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof |
CN107427582B (zh) * | 2015-04-30 | 2021-03-05 | 久光制药株式会社 | 多汗症治疗用外用剂 |
CN106137955B (zh) | 2016-08-17 | 2021-10-29 | 杭州百诚医药科技股份有限公司 | 一种外用噻托溴铵制剂的止汗用途 |
WO2021074314A1 (en) * | 2019-10-15 | 2021-04-22 | Notoxins IP B.V. | Aqueous formulations comprising buffered tiotropium bromide for topical treatment of hyperhidrosis |
-
2021
- 2021-08-25 EP EP21382781.9A patent/EP4140476A1/en not_active Withdrawn
-
2022
- 2022-08-08 TW TW111129744A patent/TW202315630A/zh unknown
- 2022-08-25 IL IL310805A patent/IL310805A/en unknown
- 2022-08-25 KR KR1020247008474A patent/KR20240048011A/ko unknown
- 2022-08-25 AR ARP220102292A patent/AR126875A1/es unknown
- 2022-08-25 AU AU2022332631A patent/AU2022332631A1/en active Pending
- 2022-08-25 CA CA3229343A patent/CA3229343A1/en active Pending
- 2022-08-25 WO PCT/EP2022/073705 patent/WO2023025900A1/en active Application Filing
-
2024
- 2024-02-22 CO CONC2024/0001950A patent/CO2024001950A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20240048011A (ko) | 2024-04-12 |
WO2023025900A1 (en) | 2023-03-02 |
AU2022332631A1 (en) | 2024-03-07 |
CA3229343A1 (en) | 2023-03-02 |
AR126875A1 (es) | 2023-11-22 |
IL310805A (en) | 2024-04-01 |
EP4140476A1 (en) | 2023-03-01 |
TW202315630A (zh) | 2023-04-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0918878A2 (pt) | composição cosmética ou dermatológica e processo de tratamento cosmético da pele, dos cabelos e/ou dos lábios | |
Bielfeldt et al. | Assessment of human stratum corneum thickness and its barrier properties by in‐vivo confocal Raman spectroscopy | |
Arora et al. | Automated microneedling device-a new tool in dermatologist's kit-a review. | |
BRPI0515888A (pt) | sistema de liberação, composição para aplicação tópica em pele ou pêlo de mamìfero, e, método para tratar pele de mamìfero | |
BR112016000335A8 (pt) | método de tratamento da rosácea papulopustular, de tratamento de lesões inflamatórias da rosácea papulopustular e uso de uma composição farmacêutica | |
BR112014029769A2 (pt) | composição contendo n-metil-n-acilglucamina | |
BR112019004971A2 (pt) | gel para cuidados pessoais e método | |
GB201700220D0 (en) | Gel compositions for transdermal delivery to maximise drug concentrations in the stratum corneum and serum and method of use thereof | |
BR112014019440A8 (pt) | Composição para aplicação tópica, método para tratamento cosmético e uso de uma composição cosmética | |
AR072476A1 (es) | Un metodo para reducir la transpiracion en la axila. composicion cosmetica. uso. | |
BR112015029815A2 (pt) | composição cosmética para clarear uma pele e/ou cabelo de um indivíduo, conjunto para clarear uma pele e/ou um cabelo de um individuo, método cosmético para clarear uma pele e/ou um cabelo de um individuo, composição cosmética ou farmacêutica para aplicação na pele, cabelo e/ou unha de um indivíduo, conjunto para aplicar uma composição cosmética ou farmacêutica na pele cabelo e/ou unha de um individuo e método de administração de peróxido de hidrogênio na pele, cabelo e/ou unha de indivíduo. | |
BR112015020066A8 (pt) | composição na forma de uma emulsão óleo-em-água, processo cosmético para tratar e/ou cuidar das matérias queratínicas humanas, processo cosmético para tratar a transpiração humana, dispositivo de distribuição e uso de uma composição | |
SG10201908690WA (en) | Novel method of use and compositions | |
CO2024001950A2 (es) | Un gel de emulsión de aceite en agua que comprende bromuro de tiotropio | |
PH12017501756A1 (en) | Natural-substance combination containing at least one glycyrrhetinic acid and at least one guggelsterone and use thereof for cosmetic applications | |
BR112019003224A2 (pt) | método de transporte não invasivo | |
BR112018012632A2 (pt) | composição anidra em forma de aerossol, uso em uma composição anidra, processo cosmético para tratamento da perspiração humana e dispositivo de aerossol | |
Purnak et al. | Liquid formulation of minoxidil versus its foam formulation | |
TWI791506B (zh) | 身體化妝料 | |
EA201300198A1 (ru) | Косметическое средство, предназначенное для ухода за кожей лица и тела | |
WO2019100902A1 (zh) | 一种透皮促渗皮肤美容方法 | |
CO2017006690A1 (es) | Solución líquida transparente para la afeitada | |
Lee et al. | Stabilized Liposomes transdermal patch for loaded antioxidants skin therapy | |
BR112017028266A2 (pt) | composição, processo cosmético e dispositivo de aerossol | |
CO2023007557A2 (es) | Composiciones que contienen compuestos lipófilos y uno o más (bio)-alcanodioles |