CO2023015033A2 - Formulación de sotorasib - Google Patents

Formulación de sotorasib

Info

Publication number
CO2023015033A2
CO2023015033A2 CONC2023/0015033A CO2023015033A CO2023015033A2 CO 2023015033 A2 CO2023015033 A2 CO 2023015033A2 CO 2023015033 A CO2023015033 A CO 2023015033A CO 2023015033 A2 CO2023015033 A2 CO 2023015033A2
Authority
CO
Colombia
Prior art keywords
sotorasib
formulation
disintegrant
diluent
lubricant
Prior art date
Application number
CONC2023/0015033A
Other languages
English (en)
Inventor
Fernando Antonio Alvarez-Nunez
Jiemin Bao
Sai Prasanth Chamarthy
Dominick Paul Daurio
Naga Duggirala
Brett E Houk
Yuan-Hon Kiang
Angela Olsofsky
Namita Sawant
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CO2023015033A2 publication Critical patent/CO2023015033A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La divulgación proporciona formulaciones que comprenden sotorasib (1), un diluyente, un disgregante y un lubricante. (1)
CONC2023/0015033A 2021-05-06 2023-11-03 Formulación de sotorasib CO2023015033A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163184941P 2021-05-06 2021-05-06
US202163212316P 2021-06-18 2021-06-18
PCT/US2022/027830 WO2022235904A1 (en) 2021-05-06 2022-05-05 Sotorasib formulation

Publications (1)

Publication Number Publication Date
CO2023015033A2 true CO2023015033A2 (es) 2023-11-20

Family

ID=81748639

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0015033A CO2023015033A2 (es) 2021-05-06 2023-11-03 Formulación de sotorasib

Country Status (13)

Country Link
EP (1) EP4333813A1 (es)
JP (1) JP2024516441A (es)
KR (1) KR20240004589A (es)
AU (1) AU2022270124A1 (es)
BR (1) BR112023023128A2 (es)
CA (1) CA3218087A1 (es)
CL (1) CL2023003289A1 (es)
CO (1) CO2023015033A2 (es)
CR (1) CR20230526A (es)
IL (1) IL307849A (es)
TW (1) TW202308640A (es)
UY (1) UY39758A (es)
WO (1) WO2022235904A1 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3738593A1 (en) * 2019-05-14 2020-11-18 Amgen, Inc Dosing of kras inhibitor for treatment of cancers

Also Published As

Publication number Publication date
AU2022270124A1 (en) 2023-11-02
CA3218087A1 (en) 2022-11-10
UY39758A (es) 2022-11-30
EP4333813A1 (en) 2024-03-13
IL307849A (en) 2023-12-01
KR20240004589A (ko) 2024-01-11
TW202308640A (zh) 2023-03-01
CL2023003289A1 (es) 2024-04-12
BR112023023128A2 (pt) 2024-01-30
CR20230526A (es) 2024-01-08
JP2024516441A (ja) 2024-04-15
WO2022235904A1 (en) 2022-11-10

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