CO2023014888A2 - Anticuerpos - Google Patents

Anticuerpos

Info

Publication number
CO2023014888A2
CO2023014888A2 CONC2023/0014888A CO2023014888A CO2023014888A2 CO 2023014888 A2 CO2023014888 A2 CO 2023014888A2 CO 2023014888 A CO2023014888 A CO 2023014888A CO 2023014888 A2 CO2023014888 A2 CO 2023014888A2
Authority
CO
Colombia
Prior art keywords
antibodies
trem1
bind
inhibit
interaction
Prior art date
Application number
CONC2023/0014888A
Other languages
English (en)
Inventor
Anastasios Spiliotopoulos
Peter Charles Elliott
Daniel John Lightwood
Irena Kadiu
Pallavi Bhatta
James Martin Keaney
Silvia L Delker
Jan Abendroth
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of CO2023014888A2 publication Critical patent/CO2023014888A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a anticuerpos que se unen a TREM1 e inhiben su interacción con uno o más de sus ligandos naturales. Se proporcionan ejemplos específicos de tales anticuerpos. También se proporcionan los usos terapéuticos de los anticuerpos y los métodos para generarlos.
CONC2023/0014888A 2021-05-03 2023-10-31 Anticuerpos CO2023014888A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163183280P 2021-05-03 2021-05-03
PCT/EP2022/061661 WO2022233764A1 (en) 2021-05-03 2022-05-02 Antibodies

Publications (1)

Publication Number Publication Date
CO2023014888A2 true CO2023014888A2 (es) 2024-04-29

Family

ID=81878071

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0014888A CO2023014888A2 (es) 2021-05-03 2023-10-31 Anticuerpos

Country Status (15)

Country Link
US (1) US20240254224A1 (es)
EP (1) EP4334355A1 (es)
JP (1) JP2024516305A (es)
KR (1) KR20240004694A (es)
CN (1) CN117642428A (es)
AR (1) AR125732A1 (es)
AU (1) AU2022268545A1 (es)
BR (1) BR112023022844A2 (es)
CA (1) CA3218933A1 (es)
CL (1) CL2023003241A1 (es)
CO (1) CO2023014888A2 (es)
IL (1) IL308100A (es)
MX (1) MX2023012984A (es)
TW (1) TW202309089A (es)
WO (1) WO2022233764A1 (es)

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Also Published As

Publication number Publication date
AU2022268545A9 (en) 2023-11-16
EP4334355A1 (en) 2024-03-13
CN117642428A (zh) 2024-03-01
TW202309089A (zh) 2023-03-01
US20240254224A1 (en) 2024-08-01
JP2024516305A (ja) 2024-04-12
KR20240004694A (ko) 2024-01-11
WO2022233764A1 (en) 2022-11-10
IL308100A (en) 2023-12-01
BR112023022844A2 (pt) 2024-01-23
MX2023012984A (es) 2023-11-15
AU2022268545A1 (en) 2023-11-02
AR125732A1 (es) 2023-08-09
CA3218933A1 (en) 2022-11-10
CL2023003241A1 (es) 2024-06-21

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