CO2020001426A2 - Método para incubar líquidos e inactivar virus - Google Patents

Método para incubar líquidos e inactivar virus

Info

Publication number
CO2020001426A2
CO2020001426A2 CONC2020/0001426A CO2020001426A CO2020001426A2 CO 2020001426 A2 CO2020001426 A2 CO 2020001426A2 CO 2020001426 A CO2020001426 A CO 2020001426A CO 2020001426 A2 CO2020001426 A2 CO 2020001426A2
Authority
CO
Colombia
Prior art keywords
liquids
incubate
inactivate viruses
inactivate
preparing
Prior art date
Application number
CONC2020/0001426A
Other languages
English (en)
Inventor
Nikolaus Hammerschmidt
Jure Sencar
Alois Jungbauer
Duarte Lima Martins
Original Assignee
Baxalta Inc
Baxalta GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta Inc, Baxalta GmbH filed Critical Baxalta Inc
Publication of CO2020001426A2 publication Critical patent/CO2020001426A2/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/452—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
    • B01F25/4524—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through foam-like inserts or through a bed of loose bodies, e.g. balls
    • B01F25/45241—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through foam-like inserts or through a bed of loose bodies, e.g. balls through a bed of balls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/06—Inactivation or attenuation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/00061—Methods of inactivation or attenuation
    • C12N2760/00063—Methods of inactivation or attenuation by chemical treatment

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

La presente invención se refiere a un método para incubar líquidos, a un método para preparar un fármaco biofarmacéutico y a un dispositivo para la preparación de un fármaco biofarmacéutico.
CONC2020/0001426A 2017-07-10 2020-02-10 Método para incubar líquidos e inactivar virus CO2020001426A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17180477 2017-07-10
EP18154196 2018-01-30
PCT/EP2018/068628 WO2019011900A1 (en) 2017-07-10 2018-07-10 METHOD FOR LIQUID INCUBATION AND VIRUS INACTIVATION

Publications (1)

Publication Number Publication Date
CO2020001426A2 true CO2020001426A2 (es) 2020-02-28

Family

ID=63209374

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2020/0001426A CO2020001426A2 (es) 2017-07-10 2020-02-10 Método para incubar líquidos e inactivar virus

Country Status (11)

Country Link
US (1) US20190022654A1 (es)
EP (1) EP3651811A1 (es)
JP (1) JP7218344B2 (es)
KR (1) KR102623471B1 (es)
CN (1) CN111050809B (es)
AU (1) AU2018299920B2 (es)
CA (1) CA3069593A1 (es)
CO (1) CO2020001426A2 (es)
MX (1) MX2020000353A (es)
SG (1) SG11202000269PA (es)
WO (1) WO2019011900A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3072885B1 (fr) * 2017-10-27 2019-11-15 IFP Energies Nouvelles Nouveau systeme de distribution par panneaux meridiens pour un procede de separation en lit mobile simule utilisant n-colonnes en serie
DE102018009597A1 (de) * 2018-12-07 2020-06-10 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren zur mehrfachen Änderung der Zusammensetzung eines Fluids
WO2021222735A1 (en) * 2020-04-30 2021-11-04 Massachusetts Institute Of Technology Model-based control for column-based continuous viral inactivation of biopharmaceuticals
US20220146485A1 (en) * 2020-11-12 2022-05-12 Essen Instruments, Inc. D/B/A Essen Bioscience, Inc. Viral clearance evaluation for biological medical product preparation processes

Family Cites Families (18)

* Cited by examiner, † Cited by third party
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US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
AU2001227653A1 (en) * 2000-03-09 2001-09-17 Transgenomic, Inc. Method and system for rna analysis by matched ion polynucleotide chromatography
IL136552A (en) * 2000-06-05 2005-05-17 Omrix Biopharmaceuticals Ltd Method for the inactivation of viruses by a solvent - detergent combination and by nanofiltration
CN1725998A (zh) * 2002-12-12 2006-01-25 旭化成株式会社 病毒除去袋及使用该病毒除去袋除去病毒的方法
PT1615959E (pt) 2003-04-10 2013-08-29 Evonik Corp Um método para a produção de micropartículas à base de emulsão
ES2454566T3 (es) * 2004-06-07 2014-04-10 Therapure Biopharma Inc. Aislamiento de proteínas de plasma o suero
AU2005229674B2 (en) * 2004-11-18 2010-11-04 Kedrion Melville Inc. Low concentration solvent/detergent process of immuneglobulin with pre-treatment
CN103562145B (zh) * 2010-12-06 2016-09-21 颇尔公司 生物制品的连续加工方法
CN103370072B (zh) * 2010-12-15 2016-02-03 巴克斯特国际公司 使用改进的溶剂-清洁剂方法进行病毒灭活
US9028678B2 (en) * 2011-06-28 2015-05-12 Phillips 66 Company Scrubbing hydrogen sulfide from hydrotreated product
EP2578286A1 (en) * 2011-10-04 2013-04-10 Merck Patent GmbH Method and apparatus for chromatographic purification
JP6268167B2 (ja) 2012-05-31 2018-01-24 エイジェンシー フォー サイエンス，テクノロジー アンド リサーチ タンパク質製剤中の凝集物含量を低減するために混合型多官能表面を使用する方法
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
WO2015048330A2 (en) * 2013-09-25 2015-04-02 Biogen Idec Ma Inc. On-column viral inactivation methods
EP2918294A1 (de) * 2014-03-11 2015-09-16 Bayer Technology Services GmbH Vorrichtung und Verfahren zur kontinuierlichen Virusinaktivierung
CN111632167B (zh) * 2014-04-15 2021-12-28 勃林格殷格翰国际公司 在制造生物制品期间连续灭活病毒的方法、装置和系统
EP3088006A1 (de) 2015-04-28 2016-11-02 Bayer Technology Services GmbH Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor
EP3141611A3 (en) * 2016-10-21 2017-05-10 Bayer Healthcare LLC Validation of continuous viral clearance

Also Published As

Publication number Publication date
RU2020105866A3 (es) 2022-02-25
WO2019011900A1 (en) 2019-01-17
MX2020000353A (es) 2020-08-17
US20190022654A1 (en) 2019-01-24
KR20200026955A (ko) 2020-03-11
CN111050809B (zh) 2021-12-24
SG11202000269PA (en) 2020-02-27
JP7218344B2 (ja) 2023-02-06
AU2018299920B2 (en) 2024-04-11
JP2020526210A (ja) 2020-08-31
AU2018299920A1 (en) 2020-02-06
KR102623471B1 (ko) 2024-01-09
BR112020000524A2 (pt) 2020-07-21
CN111050809A (zh) 2020-04-21
EP3651811A1 (en) 2020-05-20
CA3069593A1 (en) 2019-01-17
RU2020105866A (ru) 2021-08-10

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