CO2019006860A2 - Composiciones de silicona rápidamente reticulables a temperaturas ambiente y métodos para fabricarlas y usarlas - Google Patents

Composiciones de silicona rápidamente reticulables a temperaturas ambiente y métodos para fabricarlas y usarlas

Info

Publication number
CO2019006860A2
CO2019006860A2 CONC2019/0006860A CO2019006860A CO2019006860A2 CO 2019006860 A2 CO2019006860 A2 CO 2019006860A2 CO 2019006860 A CO2019006860 A CO 2019006860A CO 2019006860 A2 CO2019006860 A2 CO 2019006860A2
Authority
CO
Colombia
Prior art keywords
crosslinkable silicone
methods
manufacture
silicone compositions
room temperatures
Prior art date
Application number
CONC2019/0006860A
Other languages
English (en)
Inventor
Duan Li Ou
Leo B Kriksunov
Lamar Kirchhevel
Clifford Dwyer
Original Assignee
Ethicon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethicon Inc filed Critical Ethicon Inc
Publication of CO2019006860A2 publication Critical patent/CO2019006860A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/20—Polysiloxanes containing silicon bound to unsaturated aliphatic groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3294—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles comprising means for injection of two or more media, e.g. by mixing
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/38—Polysiloxanes modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/04—Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/12—Mammary prostheses and implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3114—Filling or refilling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1007—Breast; mammary
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/12—Polysiloxanes containing silicon bound to hydrogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Cardiology (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Se proporcionan composiciones de silicona rápidamente reticulable, sistemas, kits, y métodos para rellenar in situ dispositivos médicos implantados; los dispositivos médicos implantados incluyen, por ejemplo, implantes corporales y expansores de tejido; las composiciones incluyen un complejo platino-divinil disiloxano; un polidimetilsiloxano terminado en vinilo de baja viscosidad; un polidimetilsiloxano terminado en hidruro de baja viscosidad; y un reticulante de silicona, donde la composición de silicona rápidamente reticulable tiene una viscosidad de ≤150 cPs durante ≥1 min después de la preparación y ≤300 cPs ≤5 min después de la preparación, a temperatura ambiente.
CONC2019/0006860A 2016-12-30 2019-06-26 Composiciones de silicona rápidamente reticulables a temperaturas ambiente y métodos para fabricarlas y usarlas CO2019006860A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/395,724 US10533074B2 (en) 2016-12-30 2016-12-30 Silicone compositions rapidly cross-linkable at ambient temperatures and methods of making and using same
PCT/US2017/063996 WO2018125506A1 (en) 2016-12-30 2017-11-30 Silicone compositions rapidly cross-linkable at ambient temperatures and methods of making and using same

Publications (1)

Publication Number Publication Date
CO2019006860A2 true CO2019006860A2 (es) 2019-07-10

Family

ID=60935947

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0006860A CO2019006860A2 (es) 2016-12-30 2019-06-26 Composiciones de silicona rápidamente reticulables a temperaturas ambiente y métodos para fabricarlas y usarlas

Country Status (7)

Country Link
US (3) US10533074B2 (es)
EP (1) EP3562888A1 (es)
CN (1) CN110114416B (es)
AU (1) AU2017386952B2 (es)
BR (1) BR112019013589A2 (es)
CO (1) CO2019006860A2 (es)
WO (1) WO2018125506A1 (es)

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* Cited by examiner, † Cited by third party
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US10533074B2 (en) 2016-12-30 2020-01-14 Ethicon, Inc. Silicone compositions rapidly cross-linkable at ambient temperatures and methods of making and using same
US10531949B2 (en) 2016-12-30 2020-01-14 Ethicon, Inc. Silicone foam compositions rapidly cross-linkable at ambient temperatures and methods of making and using same
EP3718577A1 (en) * 2019-04-04 2020-10-07 TripleMed B.V. Kit of parts for preparing a biocompatible polymer
CN110305486B (zh) * 2019-07-24 2021-08-10 杭州之江新材料有限公司 一种有机硅凝胶及其制备方法
CN110577746B (zh) * 2019-09-18 2021-08-24 中蓝晨光化工研究设计院有限公司 一种低粘度高强度加成型室温固化液体硅橡胶及其制备方法
US11471268B2 (en) * 2020-04-25 2022-10-18 Mentor Worldwide Llc Implants having gel zones with higher levels of cohesiveness for eschewing scalloping, dimpling, and wrinkling
US11718753B2 (en) * 2020-05-28 2023-08-08 Ethicon, Inc. Topical skin closure compositions and systems
US11452593B2 (en) * 2020-08-17 2022-09-27 Amoena Medizin-Orthopädie-Technik GmbH Method for the manufacture of a breast prosthesis
US20220117722A1 (en) * 2020-10-15 2022-04-21 Expa Medical Devices Permanent expandable prosthetic breast implant and delivery system
CN114395368B (zh) * 2022-01-14 2023-06-06 东风汽车集团股份有限公司 一种双组份改性热固硅胶及其制备方法
US20230250249A1 (en) * 2022-02-09 2023-08-10 Cilag Gmbh International Porous Silicone Rubber with Closed-Cell Porosity
US20240000455A1 (en) 2022-06-30 2024-01-04 Cilag Gmbh International Wound closure systems, devices and methods incorporating therapeutic devices

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US10531949B2 (en) 2016-12-30 2020-01-14 Ethicon, Inc. Silicone foam compositions rapidly cross-linkable at ambient temperatures and methods of making and using same

Also Published As

Publication number Publication date
CN110114416A (zh) 2019-08-09
US20220049057A1 (en) 2022-02-17
US20200148832A1 (en) 2020-05-14
WO2018125506A1 (en) 2018-07-05
AU2017386952B2 (en) 2022-07-07
BR112019013589A2 (pt) 2020-01-07
CN110114416B (zh) 2022-04-29
EP3562888A1 (en) 2019-11-06
US10533074B2 (en) 2020-01-14
US11161937B2 (en) 2021-11-02
US11667756B2 (en) 2023-06-06
AU2017386952A1 (en) 2019-07-04
US20180186938A1 (en) 2018-07-05

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