CO2018013827A2 - Procesos para preparar oligómeros de morfolino fosforodiamidato - Google Patents
Procesos para preparar oligómeros de morfolino fosforodiamidatoInfo
- Publication number
- CO2018013827A2 CO2018013827A2 CONC2018/0013827A CO2018013827A CO2018013827A2 CO 2018013827 A2 CO2018013827 A2 CO 2018013827A2 CO 2018013827 A CO2018013827 A CO 2018013827A CO 2018013827 A2 CO2018013827 A2 CO 2018013827A2
- Authority
- CO
- Colombia
- Prior art keywords
- processes
- oligomer
- preparing
- morpholino phosphorodiamidate
- preparing morpholino
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- WROTXLSEMHAZEA-UHFFFAOYSA-N 4-diaminophosphoryloxymorpholine Chemical compound NP(N)(=O)ON1CCOCC1 WROTXLSEMHAZEA-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/062—Organo-phosphoranes without P-C bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a procesos para preparar un oligómero (por ejemplo, un oligómero de morfolino). Los procesos sintéticos descritos en la presente pueden ser ventajosos para el escalar la síntesis de oligómeros mientras se mantiene el rendimiento general y pureza de un oligómero sintetizado.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662340953P | 2016-05-24 | 2016-05-24 | |
US201662357134P | 2016-06-30 | 2016-06-30 | |
PCT/US2017/034284 WO2017205513A1 (en) | 2016-05-24 | 2017-05-24 | Processes for preparing phosphorodiamidate morpholino oligomers |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2018013827A2 true CO2018013827A2 (es) | 2018-12-28 |
Family
ID=59078166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2018/0013827A CO2018013827A2 (es) | 2016-05-24 | 2018-12-19 | Procesos para preparar oligómeros de morfolino fosforodiamidato |
Country Status (19)
Country | Link |
---|---|
US (2) | US10961262B2 (es) |
EP (1) | EP3464306B1 (es) |
JP (1) | JP6987081B2 (es) |
KR (1) | KR102504759B1 (es) |
CN (1) | CN109311920B (es) |
AU (1) | AU2017271524B2 (es) |
BR (1) | BR112018074270B1 (es) |
CA (1) | CA3024182A1 (es) |
CO (1) | CO2018013827A2 (es) |
DK (1) | DK3464306T3 (es) |
FI (1) | FI3464306T3 (es) |
IL (1) | IL263033B2 (es) |
LT (1) | LT3464306T (es) |
MA (1) | MA45155A (es) |
MX (1) | MX2018014162A (es) |
SA (1) | SA518400462B1 (es) |
SG (1) | SG11201809499UA (es) |
TW (1) | TWI737736B (es) |
WO (1) | WO2017205513A1 (es) |
Families Citing this family (12)
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TWI541024B (zh) | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
CN109563114B (zh) * | 2016-05-24 | 2022-08-12 | 萨勒普塔医疗公司 | 用于制备寡聚物的方法 |
US11472824B2 (en) | 2016-05-24 | 2022-10-18 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers |
MA45362A (fr) * | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
DK3464306T3 (da) * | 2016-05-24 | 2024-05-21 | Sarepta Therapeutics Inc | Fremgangsmåder til fremstilling af phosphorodiamidat-morpholino-oligomerer |
KR102523527B1 (ko) * | 2016-06-30 | 2023-04-20 | 사렙타 쎄러퓨틱스 인코퍼레이티드 | 포스포로디아미데이트 모르폴리노 올리고머의 제조 방법 |
CA3024153A1 (en) * | 2016-06-30 | 2017-11-30 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers |
WO2019060862A1 (en) * | 2017-09-25 | 2019-03-28 | Sarepta Therapeutics, Inc. | METHODS FOR PREPARING MORPHOLINO PHOSPHORODIAMIDATE OLIGOMERS VIA FAST FLOW SYNTHESIS |
CN109704980B (zh) * | 2019-02-16 | 2022-05-13 | 安徽大学 | 一种(z)-3-氨基-2-(2-氟-3-甲氧基苯基)-2-丁烯酸乙酯的制备方法 |
WO2021187392A1 (ja) * | 2020-03-16 | 2021-09-23 | 国立大学法人東京医科歯科大学 | モルホリノ核酸を含むヘテロ核酸 |
US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
WO2023077120A1 (en) * | 2021-11-01 | 2023-05-04 | Dyne Therapeutics, Inc. | Muscle targeting complexes for treating dystrophinopathies |
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DK3464306T3 (da) | 2016-05-24 | 2024-05-21 | Sarepta Therapeutics Inc | Fremgangsmåder til fremstilling af phosphorodiamidat-morpholino-oligomerer |
MA45362A (fr) * | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
US11472824B2 (en) | 2016-05-24 | 2022-10-18 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers |
CN109563114B (zh) * | 2016-05-24 | 2022-08-12 | 萨勒普塔医疗公司 | 用于制备寡聚物的方法 |
IL263044B1 (en) | 2016-05-24 | 2024-02-01 | Sarepta Therapeutics Inc | Processes for the preparation of phosphorodiamidate morpholino oligomers |
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-
2017
- 2017-05-24 DK DK17731337.6T patent/DK3464306T3/da active
- 2017-05-24 BR BR112018074270-8A patent/BR112018074270B1/pt active IP Right Grant
- 2017-05-24 US US16/302,443 patent/US10961262B2/en active Active
- 2017-05-24 EP EP17731337.6A patent/EP3464306B1/en active Active
- 2017-05-24 FI FIEP17731337.6T patent/FI3464306T3/fi active
- 2017-05-24 MX MX2018014162A patent/MX2018014162A/es unknown
- 2017-05-24 MA MA045155A patent/MA45155A/fr unknown
- 2017-05-24 WO PCT/US2017/034284 patent/WO2017205513A1/en unknown
- 2017-05-24 CA CA3024182A patent/CA3024182A1/en active Pending
- 2017-05-24 SG SG11201809499UA patent/SG11201809499UA/en unknown
- 2017-05-24 LT LTEPPCT/US2017/034284T patent/LT3464306T/lt unknown
- 2017-05-24 AU AU2017271524A patent/AU2017271524B2/en active Active
- 2017-05-24 KR KR1020187036634A patent/KR102504759B1/ko active IP Right Grant
- 2017-05-24 JP JP2018560662A patent/JP6987081B2/ja active Active
- 2017-05-24 TW TW106117191A patent/TWI737736B/zh active
- 2017-05-24 CN CN201780030642.8A patent/CN109311920B/zh active Active
-
2018
- 2018-11-15 IL IL263033A patent/IL263033B2/en unknown
- 2018-11-19 SA SA518400462A patent/SA518400462B1/ar unknown
- 2018-12-19 CO CONC2018/0013827A patent/CO2018013827A2/es unknown
-
2021
- 2021-02-08 US US17/169,611 patent/US20220340605A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
FI3464306T3 (fi) | 2024-05-16 |
TW201825506A (zh) | 2018-07-16 |
WO2017205513A1 (en) | 2017-11-30 |
US20190276480A1 (en) | 2019-09-12 |
BR112018074270B1 (pt) | 2021-02-02 |
SG11201809499UA (en) | 2018-12-28 |
CA3024182A1 (en) | 2017-11-30 |
KR20190013844A (ko) | 2019-02-11 |
JP2019523754A (ja) | 2019-08-29 |
MA45155A (fr) | 2019-04-10 |
SA518400462B1 (ar) | 2022-06-12 |
LT3464306T (lt) | 2024-05-10 |
AU2017271524A1 (en) | 2018-11-15 |
EP3464306A1 (en) | 2019-04-10 |
BR112018074270A2 (pt) | 2019-03-12 |
JP6987081B2 (ja) | 2021-12-22 |
US20220340605A1 (en) | 2022-10-27 |
DK3464306T3 (da) | 2024-05-21 |
IL263033A (en) | 2018-12-31 |
TWI737736B (zh) | 2021-09-01 |
EP3464306B1 (en) | 2024-03-27 |
CN109311920B (zh) | 2021-11-09 |
CN109311920A (zh) | 2019-02-05 |
US10961262B2 (en) | 2021-03-30 |
MX2018014162A (es) | 2019-04-01 |
KR102504759B1 (ko) | 2023-02-28 |
AU2017271524B2 (en) | 2021-06-24 |
IL263033B2 (en) | 2023-02-01 |
IL263033B (en) | 2022-10-01 |
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