CN86102440A - The improvement of cleaning soln and preparation thereof - Google Patents

The improvement of cleaning soln and preparation thereof Download PDF

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Publication number
CN86102440A
CN86102440A CN86102440A CN86102440A CN86102440A CN 86102440 A CN86102440 A CN 86102440A CN 86102440 A CN86102440 A CN 86102440A CN 86102440 A CN86102440 A CN 86102440A CN 86102440 A CN86102440 A CN 86102440A
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CN
China
Prior art keywords
gram
solids composition
tap water
composition
biocide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN86102440A
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Chinese (zh)
Inventor
詹姆斯·弗雷德里克·皮卡德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Derventside Laboratories Ltd (gb) 9 Walker Terrace Gateshead United Kingdom
Original Assignee
Derventside Laboratories Ltd (gb) 9 Walker Terrace Gateshead United Kingdom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858506677A external-priority patent/GB8506677D0/en
Priority claimed from GB858528714A external-priority patent/GB8528714D0/en
Application filed by Derventside Laboratories Ltd (gb) 9 Walker Terrace Gateshead United Kingdom filed Critical Derventside Laboratories Ltd (gb) 9 Walker Terrace Gateshead United Kingdom
Publication of CN86102440A publication Critical patent/CN86102440A/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
    • A61L12/124—Hydrogen peroxide; Peroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/143—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/148—Mercury containing compounds, e.g. thimerosal
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/38—Cationic compounds
    • C11D1/62—Quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

Comprise biocide maybe precursor, a kind of superfluous calcium that appears in the typical tap water and superfluous mixture and a kind of dechlorinating agent that appears at the chlorine in the typical tap water usually of driving away of magnesium ion of closing of this kind biocide except that Tubulicid or its salt.This thing is recommended to make the sheet agent, during use, it is dissolved in the tap water and makes cleaning soln for object sterilization usefulness.These objects are apparatus or the surgical instrument for using such as rigid or soft contact lens, animal doctor then.

Description

The improvement of cleaning soln and preparation thereof
The present invention relates to the preparation of cleaning soln, concrete but nisi, be about preparation, for the sterilize cleaning soln of usefulness of so-called rigid and so-called soft contact lens.
At present, use contact lens to correct the visual impairment of human eye widely.So-called contact lens, as its name suggests, when wearing this eyeglass, it directly contacts with eyeball tissue.Use this eyeglass, when particularly using soft lens, the throw out of proteinic, mucous and mineral has the tendency of stack shaping, thereby makes blurred vision and hormesis is arranged on this eyeglass.Because of after cleaning or store (for example spending the night) or other and handling formalities eyeglass is taken out from eye,, must carry out disinfection to them for avoiding to cause ocular infection when wearing again.Therefore need carry out regular cleaning and disinfection to this eyeglass.This kind cleans and sterilization normally this eyeglass is put into salt solution or similar solution heats, perhaps with this eyeglass in containing the cleaning soln of sterilizing agent, place for some time.
This cleaning soln normally is loaded in the bottle to be sold with ready-made available form.During use, solution is poured into from bottle in the suitable container, this eyeglass soaks one section reasonable time in this solution.Pouring out certain quantity solution by the above-mentioned practice from bottle is not very easily.Yet main is: when so handling the solution in the bottle, might cause the solution in the bottle to be polluted at every turn.The opposing party, this solution and the used material of this bottle of manufacturing also may produce reaction to each other in period of storage.For reducing the appearance of above-mentioned various possibilities as far as possible, the cleaning soln that this type of that sell on the market is bottled, limit its capacity can only use for several weeks till.
By the cleanser compositions of solid shape is provided, the problems referred to above can be resolved to a certain extent, because of just preparing required cleaning soln as long as this solid cleaning agent composition is dissolved in the water.In actual applications, need these compositions are dissolved in distilled water or soft water, these water are not always to be easy to the thing that obtains.
Purpose of the present invention is intended to overcome above-mentioned variety of problems, by the solid that can be dissolved in common tap water constituent is provided, and obtain can be for the cleaning soln of contact lens and other objects sterilization usefulness, and other objects of indication are for needing in addition disinfectant surgical instruments, dental instrument and veterinary instruments herein.
By this solids composition of the present invention, the dechlorinating agent that carries out disinfection the precursor of the biocide except that Tubulicid (chlorhexidine) or its salt of usefulness or this biocide, drives away the chlorine in the typical tap water for the sequestrant and the confession of calcium in the typical tap water of chelating and magnesium ion by the supply and demand sterilising member.Therefore be to be suitable for the carry out disinfection cleaning soln of usefulness of confession object when said composition is dissolved in the tap water.
The relative proportion of each composition in the said composition, its standard should be: when in the typical tap water that said composition is dissolved in specified amount, comprising enough biocide foots in the cleaning soln that is produced in the usefulness for effective sterilising member; Enough sequestrant confession chelatings appear at calcium and the magnesium ion in the tap water; And enough dechlorinating agents are for the chlorine of driving away in the tap water.Meet above-mentioned minimum requirements, be dissolved in the tap water and the solution of preparing by solids composition, wherein the concentration of biocide, sequestrant and dechlorinating agent is low more good more usually.It is especially true when this requirement is the apparatus that similarly needs to contact with human or animal's muscle or tissue such as contact lens or other for this object.
Except that Tubulicid or its salt, other any suitable biocide all can be employed, as long as it can play a part cleaning soln, reasonably effectively object is being sterilized in the time.
The object that carries out disinfection when needs is to be used for contacting with human or animal's muscle or tissue, specific embodiments of the present invention is comprising the application of combating microorganisms agent, and promptly its content must be that (when the wetting object of cleaning soln and human or animal's muscle or tissue contacts) is the amount that muscle or tissue can bear.Therefore, by this specific embodiments, when coming disinfection of contact lense with this cleaning soln, then this biocide must be that is a kind of for the eyes acceptable.Eyes receptible typical biocide following salt is arranged: two kinds or above mixture of benzalkonium chloride, Thiomersalate, methyl three ethanol ammonium chlorides and these salt.When the composition that will be formed with this class biocide adds 10 milliliters tap water, require the content of biocide to be about 0.0001 gram usually between 0.0025 gram.In second specific embodiments, then non-that was a kind of for muscle or tissue bear for this biocide, in the case,, was neutralized the biocide that adheres on the object is first effectively with before muscle or tissue contact in object that use is sterilized.Hydrogen peroxide i.e. biocide example for this reason.
Therefore when this biocide was the situation of hydrogen peroxide, it will be appears in the solids composition with the form of precursor.Typical precursor has anhydrous sodium perborate, sodium perborate trihydrate, SPC-D, Urea Peroxide and their two or more mixture.Enough hydrogen peroxide precursors must be arranged to make the H that contains significant quantity in the composition 2O 2Cleaning soln.When sterilizing eyeglass with this kind cleaning soln, the H of indication 2O 2Significant quantity be 0.5% to 3%, be best at 0.5% to 1.5%.In other cases, can be H 2O 2Amount bring up to 6% level.Preparation contains H 2O 2Amount is 0.5% cleaning soln can dissolve 0.23 gram in 10 milliliters tap water a sodium perborate trihydrate, 0.15 gram sodium perborate, and 0.16 gram SPC-D or 0.014 gram Urea Peroxide (urine content 0.09 gram) are made.Contain H 2O 2The higher cleaning soln of concentration can prepare by this amount that increases its precursor routinely.Desire prepares given H 2O 2During the cleaning soln of concentration, the amount of required solids composition can be by the minimizing of the amount of used tap water and corresponding minimizing.Yet two contact lenss need 7 milliliters cleaning soln usually at least in order to sterilize.
When used biocide is a hydrogen peroxide, and need again in use carry out under the neutral situation hydrogen peroxide, available for example Sodium.alpha.-ketopropionate or other reductive agents achieve the goal as neutralizing agent.This type of neutralizing agent can mix in the solids composition, or in addition opens buffered soln from being made into to wait, and handles object after sterilizing with its.
Sequestrant wherein can be the sequestrant arbitrarily of calcium and magnesium ion.The object that carries out disinfection when needs is when being used for directly contact with human or animal's muscle or tissue, and then the content of this sequestrant must be that (as the wetting object of cleaning soln and human or animal's muscle or organize when contacting) is the amount that muscle or tissue can bear.Exemplary in the sequestrant that is suitable for is: ethylenediamine tetraacetic acid (EDTA) and its esters, or in the polyphosphate such as trisodium phosphate, Sodium hexametaphosphate 99 and three sodium polyphosphates.
When this solids composition was added the situation of 10 ml tap waters, then the content of sequestrant was preferably 0.01 gram between 0.1 gram in the composition.
Used dechlorinating agent can be arbitrarily, as long as meet following conditions, promptly when the object that need carry out disinfection be when being used for directly contact with human or animal's muscle or tissue, then the content of this dechlorinating agent must be that (as the wetting object of cleaning soln and human or animal's muscle or organize when contacting) is the amount that muscle or tissue can bear.The exemplary of the dechlorinating agent that is suitable for is sodium metabisulfite, S-WAT and Sulfothiorine.With this solids composition and 10 ml tap water blended situations the time, then the content of dechlorinating agent is preferably 0.0001 gram between 0.1 gram in the composition.
Also can contain other compositions that often have in the sterilized solution in this composition.In the solution that for example particularly is used for contact lens is carried out disinfection, it can contain a kind of acid (being used to adjust the pH value) and/or a kind of degree adjusted agent (Tonicity adjusting agent).
Added acid, normally foot maintains 4.0 to 8.0 in the pH value that makes solution, preferably at 5.5 to 8.0, especially at 6.0 to 7.5.The acid that is suitable for comprises: fumaric acid, citric acid, toxilic acid, hexanodioic acid, preferably oxysuccinic acid.As take, said composition can contain buffer reagent so that the solution that generates reaches required pH value.
Said composition can be that the sort of its generation solution is isotonicity substantially, but its degree of opening such as grade can then be got final product with sodium-chlor or urea with a degree adjustment agent if need by the component supply of making other purposes in the solution.
Preferably said composition is comprising a kind of tensio-active agent.The nonionic surface active agent that is suitable for includes: the alkyl ester of Voranol EP 2001, polyoxyethylene alkyl phenyl ether, polyoxyethylene sorbitol or other glycosyls.Herein the tensio-active agent of Tui Jianing be macrogol list cetyl ether (for example: cetomacrogol), polyoxyethylene 20 sorbitol monooleates (for example Polysorbate 80), sucrose monostearate, nonyl phenol ethoxylate (for example: trade mark reach " Eem BELAND (EMPILAN) N92 " for " Anda is this (Antarox) CO-630 slightly ") and especially be polyoxyethylene stearyl acyl ether (for example: trade mark is " benzyl pool (Brij) 78 ").
For using this composition to remove to sterilize specified needs in addition during the disinfectant object, then only this composition dissolves is got final product to make cleaning soln in tap water.When this composition is packed with unitary dose, just that problem becomes is simpler.Because as long as the composition dissolves of this unitary dose just can have been made required cleaning soln in the tap water of prescribed volume.Based on such consideration, this solids composition is made the sheet agent in this special recommendation.Thereby in the dissolving said composition in tap water the time, make the work of treatment of user to said composition.In such cases, said composition also can comprise the tablet annexation that contains routine, such as lubricant, antiadhesives and wedding agent etc.; So that this tablet has better characteristic.The annexation that is suitable for is exemplified below: alcoxyl Mierocrystalline cellulose, Docusate Sodium, polyvinylpyrrolidone and polyoxyethylene glycol.
In this solid combination is to make the sheet agent, and the cleaning soln of its generation need carry out under the neutral situation, and this neutralizing agent can be included in the sheet agent.In the specific embodiment of the present invention, this tablet can be made double-deck shape: the first layer is biocide or its precursor, and the second layer then is a neutralizing agent.It is slow that the dissolution rate of the latter in tap water needs than the former.In the another kind of specific embodiment, this tablet is to make the lamination coating tablet: neutralizing agent is positioned at the sheet heart and biocide or its precursor are wrapping this neutralizing agent.When being dissolved in this sheet in the water, biocide partly can be prior to neutralizing agent part and dissolved.In the another kind of again specific embodiment, be that they are made isolating two tablets; Wherein first tablet comprising biocide or its precursor, also comprises sequestrant and dechlorinating agent.With this tablet dissolved in an amount of tap water, and needing the disinfectant object in wherein soaking for some time.After this, second that is comprising neutralizing agent is joined in the cleaning soln, treat in the biocide and after, just can take out sterilising member and use.
Contain calcium and magnesium ion in the tap water and be very typical example, normally occur with the form of its carbonate or vitriol, total concentration can be up to 650 mg/litre, and the content of chlorine, then can reach the level of 3ppm.According to the specific embodiments of a special recommendation, the invention provides a kind of solids composition with unit dosage form, when being dissolved in it in the tap water, can be made into a kind of sterilized solution.Said composition comprises:
A) biocide or its precursor, its content is: in the time of in said composition being dissolved in 10 milliliters tap water, the amount of biocide foot is in effectively two contact lenss being sterilized in the cleaning soln that is generated;
B) sequestrant of 5% to 25% calcium and magnesium ion by weight;
C) 0.01% to 2.5% the dechlorinating agent that is used for driving away the chlorine in the tap water by weight
Above-mentioned sequestrant and the dechlorinating agent content in above-mentioned unitary dose must satisfy following requirement: promptly when the solids composition of one or more above-mentioned unitary doses was dissolved in 10 ml waters, the content of above-mentioned sequestrant was that the content of dechlorinating agent between 50 grams per liter to 250 grams per liters then is between 0.1 grams per liter to 25 grams per liter in the cleaning soln of its generation.The weight of per unit dosage is preferably by between 200 milligrams to 800 milligrams.
Owing to just just solids composition and tap water addition being made cleaning soln when needed, the possibility that therefore occurs contamination phenomenon in cleaning soln just greatly reduces.Moreover, owing to can replace distilled water or soft water, just be more convenient for when therefore using with tap water.
Following example can illustrate the present invention.
Example 1
0.15 gram urea, 0.0005 gram benzalkonium chloride, 0.04 gram, three sodium polyphosphates, 0.001 gram Sulfothiorine, 0.001 gram polyoxyethylene stearyl acyl ether and 0.005 gram oxysuccinic acid are blended together.
The solids composition that generates is made tablet.With this tablet dissolved in 10 milliliters tap water to form cleaning soln, it can be sterilized two rigid contact lenss that are immersed in wherein after spending the night effectively.
Example 2
Get up and the solids composition made by 0.0005 gram benzalkonium chloride, 0.04 gram trisodium phosphate, 0.001 gram Sulfothiorine, 0.09 gram sodium-chlor, 0.001 gram octadecanoic acid ester of polyethylene glycol and 0.005 gram oxysuccinic acid fusion.After fusion, make tablet.
During application, with this tablet dissolved in 10 milliliters tap water to make cleaning soln.Be soaked in two contact lenss wherein, after spending the night, be sterilized effectively.
Example 3
The solids composition of making by alkyl three ethanol ammonium chlorides, 0.04 gram trisodium phosphate, 0.001 gram Sulfothiorine, 0.09 sodium-chlor, 0.001 gram octadecanoic acid ester of polyethylene glycol and the 0.005 gram oxysuccinic acid fusion of 0.00025 gram.After making tablet, be dissolved in 10 milliliters the tap water.The cleaning soln that is generated can have been sterilized two contact lenss that are immersed in wherein after spending the night effectively.
Example 4
Repeat the prescription of example 3, and additional polyoxyethylene glycol, its weight is 5% of solids composition.Can obtain more favourable tablet.
Example 5
The solids composition of making by 0.140 gram Urea Peroxide, 0.160 gram SPC-D, 0.040 gram, three sodium polyphosphates, 0.001 gram Sulfothiorine and 0.002 gram macrogol list cetyl ether fusion.After making tablet, be dissolved in 10 milliliters the tap water and contain 1% H to make 2O 2Cleaning soln.
Two hydrophilic soft contact lens are immersed in wherein, after spending the night, change being immersed in the sterilized solution that contains 0.05 gram Sodium.alpha.-ketopropionate and 0.010 gram oxysuccinic acid, with neutralization superoxide wherein.These two contact lens proofs have been sterilized effectively.
Example 6
The solids composition of making by 0.42 gram Urea Peroxide, 0.04 gram, three sodium polyphosphates, 0.001 gram Sulfothiorine and 0.003 gram macrogol list cetyl ether fusion.After making tablet, be dissolved in 10 milliliters the tap water and contain 1.5% H to make 2O 2Cleaning soln.
Two hydrophilic soft contact lens are immersed in wherein, after spending the night, the tablet of Sodium.alpha.-ketopropionate that contains 0.050 gram and 0.050 gram oxysuccinic acid are added in the cleaning soln with this solution that neutralizes.These two contact lens proofs have been sterilized effectively.
Example 7
Repeat the prescription of example 6, but replace macrogol list cetyl ether with 0.001 gram polyoxyethylene (20) stearyl ether.
Example 8
Repeat example 5, but its deal then changes the tablet of 0.460 gram SPC-D, 0.040 gram, three sodium polyphosphates, 0.001 gram Sulfothiorine and 0.002 gram macrogol list cetyl ether into.The cleaning soln that generates contains 1.5% H 2O 2
Example 9
The solids composition of making by 0.230 gram sodium perborate trihydrate, 0.040 gram Sodium hexametaphosphate 99,0.001 gram Sulfothiorine and 0.003 gram macrogol list cetyl ether fusion.After making tablet, be dissolved in 10 milliliters the tap water and contain 0.5% H to make 2O 2Cleaning soln.
Two wetting ability contact lenss are immersed in wherein, after spending the night, change being immersed in the sterilized solution that contains 0.050 gram Sodium.alpha.-ketopropionate, 0.005 oxysuccinic acid and 0.050 gram urea, with neutralization superoxide wherein.These two contact lens proofs have been sterilized effectively.

Claims (10)

1, a kind of solids composition that is used to make confession object sterilization usefulness cleaning soln, it is characterized in that, said composition includes a kind of biocide except that Tubulicid or its salt or a kind of precursor of this agent, a kind ofly appear at the calcium in the tap water and the sequestrant of magnesium ion usually for chelating, with the dechlorinating agent that appears at the chlorine in the tap water for expeling usually, this composition is suitable for being dissolved in the tap water, to make desired cleaning soln.
By a kind of solids composition of claim 1, it is characterized in that 2, wherein said biocide is that is a kind of for the eyes acceptable.
3, by a kind of solids composition of claim 2, it is characterized in that wherein said biocide is two kinds or an above mixture of benzalkonium chloride, Thiomersalate, methyl three ethanol ammonium chlorides or these salt.
By a kind of solids composition of claim 1, it is characterized in that 4, biocide wherein is that unacceptable that is a kind of for eyes.
5, by a kind of solids composition of claim 1, it is characterized in that wherein said precursor is the precursor of hydrogen peroxide.
6, by a kind of solids composition of claim 5, it is characterized in that wherein said precursor is sodium perborate, SPC-D or Urea Peroxide.
7, by a kind of solids composition of claim 1, this sequestrant is ethylenediamine tetraacetic acid (EDTA) or its a kind of salt, or polyphosphate.
8, by a kind of solids composition of claim 1, it is characterized in that this dechlorinating agent is Sulfothiorine, S-WAT or sodium metabisulphite.
9, by a kind of solids composition of claim 1, it is characterized in that, after adding 10 ml tap waters, wherein contain 0.0001 described dechlorinating agent of gram and 0.01 gram to the described sequestrant of 0.1 gram.
10, by a kind of solids composition of claim 1, it is characterized in that it makes the sheet agent.
CN86102440A 1985-03-14 1986-03-14 The improvement of cleaning soln and preparation thereof Pending CN86102440A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB858506677A GB8506677D0 (en) 1985-03-14 1985-03-14 Cleansing of contact lenses
GB8506677 1985-03-14
GB8507664 1985-03-25
GB858507664A GB8507664D0 (en) 1985-03-14 1985-03-25 Production of cleansing solutions
GB8528714 1985-11-21
GB858528714A GB8528714D0 (en) 1985-03-14 1985-11-21 Production of cleansing solutions

Publications (1)

Publication Number Publication Date
CN86102440A true CN86102440A (en) 1986-10-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN86102440A Pending CN86102440A (en) 1985-03-14 1986-03-14 The improvement of cleaning soln and preparation thereof

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CN (1) CN86102440A (en)
AU (1) AU5623086A (en)
ES (1) ES552999A1 (en)
GR (1) GR860706B (en)
PT (1) PT82205B (en)
WO (1) WO1986005401A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1332917C (en) * 1986-03-22 1994-11-08 David John Drain Disinfection of contact lenses using sulphur-dioxide and/or benzoic acid
FR2677013B1 (en) * 1991-06-03 1994-11-04 Henri Rouleau SYSTEM FOR TREATING TREATED WATER AS A SURGICAL IRRIGATION LIQUID.
GB2355198A (en) * 1999-05-06 2001-04-18 Medichem Internat Ltd An aldehyde-free sterilant and disinfectant based on a peroxide source in powder or kit form for mixing and/or diluting
GB2354442A (en) * 1999-09-23 2001-03-28 Allied Bio Corp Ltd Sterilising block comprising a compound which produces sulphur dioxide on reaction with moisture absorbed by the block, eg a metabisulphite
DE10331557B3 (en) * 2003-07-11 2005-02-17 Herdeis, Claus, Prof. Dr. Use of taurolidine and taurultam in preparations for the treatment, cleaning, storage and conditioning of contact lenses
US20090220618A1 (en) * 2008-02-29 2009-09-03 Erning Xia Pharmaceutical formulations comprising polyanionic materials and source of hydrogen peroxide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873696A (en) * 1972-01-31 1975-03-25 Allergan Pharma Cleaning and sterilizing soft contact lens
US3908680A (en) * 1973-10-12 1975-09-30 Flow Pharma Inc Methods for cleaning and bleaching plastic articles
IL46397A (en) * 1974-01-07 1977-11-30 Nat Patent Dev Corp Process for sterilizing contact lenses
NZ192499A (en) * 1979-01-15 1982-09-07 Allergan Pharma Treatment of contact lenses with polymetaphosphate gluconic acid or borogluconic acid
DE3007397C2 (en) * 1980-02-27 1982-08-19 Titmus Eurocon Kontaktlinsen Gmbh & Co Kg, 8750 Aschaffenburg Aqueous isotonic storage and rinsing solution for contact lenses
DE3329922A1 (en) * 1983-08-19 1985-02-28 Fa. Carl Zeiss, 7920 Heidenheim CLEANING AND DISINFECTING SYSTEM FOR HARD AND SOFT CONTACT LENSES

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Publication number Publication date
GR860706B (en) 1986-07-11
WO1986005401A1 (en) 1986-09-25
AU5623086A (en) 1986-10-13
PT82205B (en) 1987-08-17
PT82205A (en) 1986-04-01
ES552999A1 (en) 1987-11-16

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