GB2355198A - An aldehyde-free sterilant and disinfectant based on a peroxide source in powder or kit form for mixing and/or diluting - Google Patents
An aldehyde-free sterilant and disinfectant based on a peroxide source in powder or kit form for mixing and/or diluting Download PDFInfo
- Publication number
- GB2355198A GB2355198A GB9910514A GB9910514A GB2355198A GB 2355198 A GB2355198 A GB 2355198A GB 9910514 A GB9910514 A GB 9910514A GB 9910514 A GB9910514 A GB 9910514A GB 2355198 A GB2355198 A GB 2355198A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formulation
- peroxide
- solution
- produce
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000843 powder Substances 0.000 title claims abstract description 7
- 150000002978 peroxides Chemical class 0.000 title claims abstract description 5
- 239000000645 desinfectant Substances 0.000 title description 3
- 238000007865 diluting Methods 0.000 title 1
- 238000009472 formulation Methods 0.000 claims abstract description 17
- 239000000203 mixture Substances 0.000 claims abstract description 17
- 239000007788 liquid Substances 0.000 claims abstract description 9
- 239000000872 buffer Substances 0.000 claims abstract description 4
- 239000004094 surface-active agent Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000007800 oxidant agent Substances 0.000 claims abstract 4
- 230000001590 oxidative effect Effects 0.000 claims abstract 4
- 239000003112 inhibitor Substances 0.000 claims abstract 3
- 230000007797 corrosion Effects 0.000 claims abstract 2
- 238000005260 corrosion Methods 0.000 claims abstract 2
- 229910052751 metal Inorganic materials 0.000 claims abstract 2
- 239000002184 metal Substances 0.000 claims abstract 2
- 239000002304 perfume Substances 0.000 claims abstract 2
- 239000000376 reactant Substances 0.000 claims abstract 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract description 12
- 239000000243 solution Substances 0.000 abstract description 11
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 abstract description 8
- 150000001450 anions Chemical class 0.000 abstract description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract description 6
- 230000003115 biocidal effect Effects 0.000 abstract description 5
- 239000003513 alkali Substances 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract description 3
- 229960001922 sodium perborate Drugs 0.000 abstract description 3
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 abstract description 3
- 239000007787 solid Substances 0.000 abstract description 3
- 239000003139 biocide Substances 0.000 abstract description 2
- 239000008366 buffered solution Substances 0.000 abstract description 2
- 239000012141 concentrate Substances 0.000 abstract description 2
- JZBWUTVDIDNCMW-UHFFFAOYSA-L dipotassium;oxido sulfate Chemical compound [K+].[K+].[O-]OS([O-])(=O)=O JZBWUTVDIDNCMW-UHFFFAOYSA-L 0.000 abstract description 2
- -1 peroxide anions Chemical class 0.000 abstract description 2
- 230000003389 potentiating effect Effects 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- FRPJTGXMTIIFIT-UHFFFAOYSA-N tetraacetylethylenediamine Chemical compound CC(=O)C(N)(C(C)=O)C(N)(C(C)=O)C(C)=O FRPJTGXMTIIFIT-UHFFFAOYSA-N 0.000 abstract 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
- 230000003330 sporicidal effect Effects 0.000 abstract 1
- BGRWYDHXPHLNKA-UHFFFAOYSA-N Tetraacetylethylenediamine Chemical compound CC(=O)N(C(C)=O)CCN(C(C)=O)C(C)=O BGRWYDHXPHLNKA-UHFFFAOYSA-N 0.000 description 3
- 239000000126 substance Substances 0.000 description 2
- 239000012224 working solution Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 150000004985 diamines Chemical class 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 150000004965 peroxy acids Chemical class 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A formulation is provided as a concentrate for producing a biocidally active solution. The formulation comprises a water soluble oxidant generator-peroxide source (eg hydrogen peroxide, sodium perborate or potassium peroxy monosulphate) and is in the form of:<BR> either a single-pack powder that is diluted and dissolved to produce the biocidally active solution<BR> or a twin-pack liquid or liquid-and-solid formulation which (when the components are mixed or are diluted, mixed and dissolved) provide the biocidally active solution. The formulation may optionally comprise a buffer (eg citric acid), an oxidant stable surfactant, a metal sequesterant (eg ethylenediamine tetramethylphosphonate), a peroxide reactant/trigger, a corrosion inhibitor, a colour, a perfume or an indicator which improves effective hygiene performance. Tetraacetyl ethylene diamine (TAED) may be included as a potentiating ingredient which, under slightly alkali conditions of a buffered solution, is activated to produce a very effective low temperature biocide, by reacting with peroxide anions to produce peracetic anions. This combination of hydrogen peroxide, peracetic acid and peracetic anions is synergistic and produces a rapidly biocidal and sporicidal solution with a very broad spectrum of activity. It may be used as a sterilant/sanitiser in medical, veterinary and food establishments (eg sterilising medical and dental instruments).
Description
2355198 An Aldehyde-Free Sterilant and Disinfectant A powder or liquid
formulation produced as a concentrate which is diluted with water to produce an aldehyde-free solution to clean, disinfect and sterilise medical instruments.
Background of the Invention
Medical, dental and other instruments are often made of high quality stainless steel and can be cleaned and sterilised between uses by high temperature steam under pressure. In contrast to this many instruments are made of heat-sensitive plastics, rubber, glass and electronic components. For this reason, heat sensitive instruments can only be sterilised by cold chemical germicides. Chemical sterilants presently available have many ethical and toxicological difficulties. The disclosed formula does not.
Details of the Invention The formulation provides a method of providing hydrogen peroxide, peracetic acid and peracetic anions in solution. The formulation can be a single pack powder that is simply diluted with water at the designated concentration and dissolved to provide the activated working solution. Or is a twin pack liquid, or liquid and solid formulation which when the components are mixed or diluted and mixed and dissolved provide and activated working solution. The resultant solution is a very powerful disinfectant and sterilising liquid with a combination of actives which because of the hurdle principle reduce the risk of the formation of resistant bacteria.
The resultant antimicrobial activity of the resultant solution is affected by pH - the greatest activity is under slightly alkali conditions pH 7-8.5. This pH has shown to be ideal for the protonated solution to move across the cytoplasmic membrane of a cell and cause disruption and death.
2 The potentiating ingredient in the formulation is tetra acetic ethylane diamine (T.A.E.D.) which, under the slightly alkali conditions of the buffered solution, is activated to produce a very effective low temperature biocide. Under such conditions one mole of TAED reacts with two moles of peroxide anion to produce two moles of peracetic anion.
The components of the system are TAED, a peroxide source (hydrogen peroxide, sodium perborate, potassium peroxy monosulphate) and a buffer complex. A sequesterant stabiliser - ethyle diamine tetra methyl phosphonate.
Typical Formulation Preferred Possible TAED 27% 10-60% Sodium Perborate 46% 20-70% Citric Acid 25% 10-50% EDTMTA 0.5% 0.1-5% Surfactant 1.5% 0-10% A powder or liquid formulation which is a combination of peracids and a perborate generating peroxide which produces a synergistic interaction of constituents when in solution. The active ingredient is a stabilised solid or stabilised liquid form of hydrogen peroxide. The concentrated formula contains a buffered trigger that on dilution produces a combination of peracetic acid and peracetic: anions at an alkali pH.
This combination of hydrogen peroxide, peracetic acid and peracetic anions is far more biocidal than the individual ingredient in isolation. The synergistic formulation produces a rapidly biocidal. and sporical solution with a very broad spectrum of activity.
Ideal for use as a sterilant/sanitiser in medical, veterinary and food establishments.
3
Claims (7)
1. A fon-nulation which is a dry powder, a powder and liquid, or a liquid and liquid which when combined and or diluted produce a biocidally active solution which comprises of, but not limited to a water soluble oxidant generator- peroxide source.
2. A formulation as claimed in claim I and further comprising a buffer or buffers.
3. A formulation according to claim I or claim 2 and further comprising an oxidant stable surfactant or surfactants.
4. A formulation according to any preceding claim and further comprising a metal sequesterant or sequesterants.
5. A formulation according to any preceding claim and further comprising a peroxide reactant/trigger or triggers.
6. A formulation according to any preceding claim and further comprising a corrosion inhibitor or inhibitors.
7. A formulation according to any preceding claim and further comprising a colour, perfume or indicator which improves effective hygiene performance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9910514A GB2355198A (en) | 1999-05-06 | 1999-05-06 | An aldehyde-free sterilant and disinfectant based on a peroxide source in powder or kit form for mixing and/or diluting |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9910514A GB2355198A (en) | 1999-05-06 | 1999-05-06 | An aldehyde-free sterilant and disinfectant based on a peroxide source in powder or kit form for mixing and/or diluting |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB9910514D0 GB9910514D0 (en) | 1999-07-07 |
| GB2355198A true GB2355198A (en) | 2001-04-18 |
Family
ID=10852945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9910514A Withdrawn GB2355198A (en) | 1999-05-06 | 1999-05-06 | An aldehyde-free sterilant and disinfectant based on a peroxide source in powder or kit form for mixing and/or diluting |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2355198A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1269844A1 (en) * | 2001-06-20 | 2003-01-02 | CASTELLINI S.p.A. | A disinfectant composition and method for disinfecting and/or sterilising a dental unit |
| WO2005112647A2 (en) * | 2004-05-21 | 2005-12-01 | Fellows Adrian | An antimicrobial composition |
| US7033511B2 (en) | 2004-01-20 | 2006-04-25 | A-Dec, Inc. | Sustained water treatment in dental equipment |
| EP2403541A1 (en) * | 2009-03-05 | 2012-01-11 | E. I. du Pont de Nemours and Company | Multi-part kit system for the preparation of a disinfectant of the peracetic acid type |
| EP2832721A1 (en) * | 2013-08-02 | 2015-02-04 | Cair L.G.L. | Tetraacetylethylenediamine composition for generating peracetic acid |
| WO2015074144A1 (en) | 2013-11-22 | 2015-05-28 | Agri-Néo Inc. | A novel composition and method of use to control pathogens and prevent diseases in seeds |
| US9497964B2 (en) | 2010-10-22 | 2016-11-22 | Agri-Neo Inc. | Synergistic activity of peracetic acid and at least one SAR inducer for the control of pathogens in and onto growing plants |
| US10136642B2 (en) | 2015-02-19 | 2018-11-27 | Agri-Neo, Inc. | Composition of peracetic acid and at least one organic fungicide for the control and/or the treatment of diseases associated with the presence of pathogens, and method, use and kit involving said composition |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108064879B (en) * | 2017-11-27 | 2020-11-03 | 中国人民解放军陆军防化学院 | Application method of compound solid fumigation disinfectant |
| CN114847289B (en) * | 2022-06-16 | 2024-05-31 | 深圳市质量安全检验检测研究院 | Acid virus nucleic acid degradation disinfection method |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3671629A (en) * | 1967-02-21 | 1972-06-20 | Richardson Merrell Ltd | Sterilizing composition comprising potassium monopersulphate and sodium chloride coated with an edible oil and magnesium stearate |
| GB2078522A (en) * | 1980-06-26 | 1982-01-13 | Antec Ah International Ltd | Improvements in and relating to sanitizing compositions |
| US4459217A (en) * | 1981-07-22 | 1984-07-10 | Reckitt & Colman Products Limited | Denture cleansing compositions |
| WO1986005401A1 (en) * | 1985-03-14 | 1986-09-25 | Derwentside Laboratories Limited | Production of cleansing and disinfecting solutions |
| US5015408A (en) * | 1988-03-19 | 1991-05-14 | Reckitt Gmbh | Denture cleaning tablet containing a bleach activator and an organic phosphonic acid stabilizer |
| WO1994018297A1 (en) * | 1993-02-08 | 1994-08-18 | Warwick International Group Limited | Oxidising agents |
| RU2025131C1 (en) * | 1992-07-16 | 1994-12-30 | Научно-исследовательский институт профилактической токсикологии и дезинфекции | Solid disinfectant |
| WO1999057980A1 (en) * | 1998-05-13 | 1999-11-18 | Oxyster S.N.C. Di Skepetaris & C. | Stabilized disinfectant preparation containing peroxides |
-
1999
- 1999-05-06 GB GB9910514A patent/GB2355198A/en not_active Withdrawn
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3671629A (en) * | 1967-02-21 | 1972-06-20 | Richardson Merrell Ltd | Sterilizing composition comprising potassium monopersulphate and sodium chloride coated with an edible oil and magnesium stearate |
| GB2078522A (en) * | 1980-06-26 | 1982-01-13 | Antec Ah International Ltd | Improvements in and relating to sanitizing compositions |
| US4459217A (en) * | 1981-07-22 | 1984-07-10 | Reckitt & Colman Products Limited | Denture cleansing compositions |
| WO1986005401A1 (en) * | 1985-03-14 | 1986-09-25 | Derwentside Laboratories Limited | Production of cleansing and disinfecting solutions |
| US5015408A (en) * | 1988-03-19 | 1991-05-14 | Reckitt Gmbh | Denture cleaning tablet containing a bleach activator and an organic phosphonic acid stabilizer |
| RU2025131C1 (en) * | 1992-07-16 | 1994-12-30 | Научно-исследовательский институт профилактической токсикологии и дезинфекции | Solid disinfectant |
| WO1994018297A1 (en) * | 1993-02-08 | 1994-08-18 | Warwick International Group Limited | Oxidising agents |
| WO1999057980A1 (en) * | 1998-05-13 | 1999-11-18 | Oxyster S.N.C. Di Skepetaris & C. | Stabilized disinfectant preparation containing peroxides |
Non-Patent Citations (1)
| Title |
|---|
| WPI Abstract Accession No 1995-253098/50 & RU 2025131 C1 * |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1269844A1 (en) * | 2001-06-20 | 2003-01-02 | CASTELLINI S.p.A. | A disinfectant composition and method for disinfecting and/or sterilising a dental unit |
| US7033511B2 (en) | 2004-01-20 | 2006-04-25 | A-Dec, Inc. | Sustained water treatment in dental equipment |
| WO2005112647A2 (en) * | 2004-05-21 | 2005-12-01 | Fellows Adrian | An antimicrobial composition |
| WO2005112631A3 (en) * | 2004-05-21 | 2006-03-09 | Fellows Adrian | An antimicrobial construction |
| WO2005112647A3 (en) * | 2004-05-21 | 2006-04-27 | Fellows Adrian | An antimicrobial composition |
| EP2403541A1 (en) * | 2009-03-05 | 2012-01-11 | E. I. du Pont de Nemours and Company | Multi-part kit system for the preparation of a disinfectant of the peracetic acid type |
| US9497964B2 (en) | 2010-10-22 | 2016-11-22 | Agri-Neo Inc. | Synergistic activity of peracetic acid and at least one SAR inducer for the control of pathogens in and onto growing plants |
| EP2832721A1 (en) * | 2013-08-02 | 2015-02-04 | Cair L.G.L. | Tetraacetylethylenediamine composition for generating peracetic acid |
| FR3009197A1 (en) * | 2013-08-02 | 2015-02-06 | Cair L G L | TETRAACETYLETHYLENEDIAMINE COMPOSITION FOR THE GENERATION OF PERACETIC ACID |
| WO2015074144A1 (en) | 2013-11-22 | 2015-05-28 | Agri-Néo Inc. | A novel composition and method of use to control pathogens and prevent diseases in seeds |
| US10292402B2 (en) | 2013-11-22 | 2019-05-21 | Agri-Neo Inc. | Method of sanitizing edible seeds, particularly mucilage producing seeds |
| US10136642B2 (en) | 2015-02-19 | 2018-11-27 | Agri-Neo, Inc. | Composition of peracetic acid and at least one organic fungicide for the control and/or the treatment of diseases associated with the presence of pathogens, and method, use and kit involving said composition |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9910514D0 (en) | 1999-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |