CN2905051Y - A precharged preparation of antibacterial drug - Google Patents
A precharged preparation of antibacterial drug Download PDFInfo
- Publication number
- CN2905051Y CN2905051Y CN 200620028630 CN200620028630U CN2905051Y CN 2905051 Y CN2905051 Y CN 2905051Y CN 200620028630 CN200620028630 CN 200620028630 CN 200620028630 U CN200620028630 U CN 200620028630U CN 2905051 Y CN2905051 Y CN 2905051Y
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- CN
- China
- Prior art keywords
- preparation
- precharging
- sulfate
- overcoat
- needle
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The utility model is a precharged preparation of antibacterial drug which relates to a pharmaceutical preparations field. The precharged injector is adopted to be the inner package of the antibacterial drug hydro-acupuncture, and the structure of the precharged injector is that an open is installed at the back end of the outer sleeve1, and the a protoctingcap5 is sleeved on the conical head of the front end; a needle 4 is installed on the coaxial line of the protoctingcap5; piston 2 connects with the core rod3; the needle is sealed by a rubber plug9. The volume of the outer sleeve is 1ml, or 2ml, or2.5ml or 5ml; the needle diameter is from 0.2ml to 0.5ml. The antibacterial drug comprises some injections, such as an amantadine sulfate, an acyclovir, ribavirin, a ganciclovir, a trimethoprim, an amikacin sulfate, a netilmicin sulfate, an etimicin sulfate and an amphotericin, etc. The utility mode reduces the residue medication and the dose is correct, which avoids using the diluent to suck repeatedly, decreases the pollution risk, and increase the safety of the patients; the volume of the utility model is small to be packed easily and decrease the medical cost; the needle is sharp and thin, which is easy to be operated and decrease the pain.
Description
Technical field
This utility model relates to a kind of precharging preparation of medicaments injection, especially a kind of precharging preparation of antibiotic medicine.
Background technology
Precharging preparation is with the inner packing of precharging type syringe as product, and precharging type syringe is a kind of high-grade medicine packaging material.Form as the drug packages system, it is directly packed liquid medicine into and preserves in the syringe, and this product is divided into the band pin and is not with two kinds on pin, all 10,000 grades of cleaning shops productions.
Simple and convenient when precharging preparation uses, syringe itself has good sealing simultaneously, and medicine can long term storage.Its syringe needle is different from traditional syringe needle, is three inclined-planes, can alleviate the misery that patient infusion brings like this.At some medicaments injection packaging fields, it replaces traditional glass ampule and cillin bottle just fast, both made things convenient for the fill of medicine and the use of user, had very high safety again, avoided the trouble of medicinal liquid suction syringe and the medicinal liquid secondary pollution that may bring.
The prior art the most close with this utility model is that name is called the Chinese invention patent application of " the recombinant human interferon alpha 2 b injection of prefilled injector package ", publication number CN1748788A.Precharging preparation is applied to the packing of biological preparation mostly at home, and as fields such as interferon, vaccine, human growth hormones, but the application in the antibiotics preparation does not but also occur.
The antibiotics injection products all uses cillin bottle or ampoule bottle packing on the present domestic medical market, in use, need unpack usually, and then use syringe pump, is easy to cause secondary pollution like this; The joint of syringe and pin chamber are long easily causes medicinal liquid residual, and use amount is inaccurate, easily the medical care operator is brought toxicity; Common in addition syringe needle subcutaneous injection area is big, makes patient's pain increase etc.Equally, after the powder pin need add the liquid redissolution, in use also there is same problem to exist.
The utility model content
The technical problems to be solved in the utility model provides a kind of precharging preparation, and it is in use not enough to overcome in the past the antibiotic medicine preparation, is suitable for packing the injection with small volume of activity stabilized antibiotic medicine liquid drugs injection.
The precharging preparation of a kind of antibiotic medicine of the present utility model, adopt the inner packing of precharging type syringe as the antibiotic medicine liquid drugs injection, it is characterized in that said precharging type syringe structure is: the overcoat open rearward end of hollow circular cylinder is set with helmet on the conehead of front end; Coaxial line is installed syringe needle on the helmet; One piston is arranged in the overcoat, and piston is connected with core bar, and core bar has one section to be inserted in the overcoat; Syringe needle seals with plug; Integral body encapsulates with aluminium foil behind the antibiotic medicinal liquid that charges into;
Said syringe needle diameter is at 0.2～0.5m, and syringe needle uses three thin, the most sharp-pointed inclined-planes, and the patient has only slight sensation during injection.
Use the moulding material of polypropylene material, use polyethylene, reduced the absorption of medicinal liquid as piston, pin connector as overcoat and core bar.
The volumetrical specifications and models of said overcoat can have 1ml, 2ml, 2.5ml or 5ml, according to the medical treatment and the market demand, can also increase new specification.The use amount difference of various medicinal liquids, can be different with a kind of medicinal liquid to different patient's use amounts, therefore, the specification of the precharging preparation of antibiotic medicine of the present utility model can be diversified
In the making of precharging type syringe, through sterilization treatment, after the detection, can be directly used in the fill of carrying out antibiotic medicine, program is simple, and is easy to use.
The embedding of precharging preparation, quality testing, decals, stubborn bar, plastic packaging all adopt automatic assembly line.
This utility model provides a kind of precharging preparation of antibiotic medicine, comprises the precharging preparation of antibiolics composition injections such as PK-Merz (Merz), acyclovir, ribavirin, ganciclovir, trimethoprim, amikacin sulfate, netilmicin sulfate, Etimicin sulfate., lincomycin hydrochloride, Clindamycin Hydrochloride, Lyphocin (Fujisawa), norfloxacin glutamate, griseofulvin, amphotericin.
The advantage that precharging preparation is used for the antibiotics preparation mainly contains:
1. simplify clinical manipulation, easy to use.
2. avoid using diluent to aspirate repeatedly, reduce residual and secondary pollution.
3. do not have dead space volume, dosage is accurate, reduces the medicinal liquid loss.
4. unit volume is little, packaged convenience.
5. syringe needle is sharp keen, handled easily, and the patient is painless.
6. disposable use, direct injection uses, and reduces pollution risk, increases patient's the security.
Because above advantage, the precharging preparation of decision antibiotic medicine will have higher using value and prospect, so the precharging preparation of invention antibiotic medicine is necessary.
Description of drawings
Fig. 1 is the structural representation of a kind of precharging type syringe of the present utility model.
The specific embodiment
Further specify structure of the present utility model with embodiment below, but do not limit protection domain of the present utility model.
The structure of the precharging preparation of embodiment 1 accompanying drawings antibiotic medicine of the present utility model.
The precharging preparation of antibiotic medicine of the present utility model is by precharging type syringe and antibiolics composition injection, and injection charges in the overcoat of hollow circular cylinder of precharging type syringe.
The precharging type syringe structure is seen Fig. 1.Among Fig. 1,1 is overcoat, and 2 is piston, and 3 is core bar, and 4 is syringe needle, and 5 is helmet, and 6 is medicinal liquid, and 7 is label, and 8 is aluminium foil, and 9 is plug.Overcoat 1 is a hollow circular cylinder, is set with helmet 5 on the conehead of its front end, open rearward end; Be provided with the capping of a piston 2 as overcoat 1 herb liquid 7 in the hollow circular cylinder overcoat 1, can slide in overcoat 1 and seal, piston 2 is connected with core bar 3; Core bar 3 has part to be inserted in the overcoat 1; Syringe needle 4 is socketed in an end of overcoat 1,9 sealings of reuse plug; Whole with aluminium foil 8 encapsulation behind the medicinal liquid that charges into.
The preparation and the specifications and models of the precharging preparation of embodiment 2 antibiotic medicines of the present utility model
1, preparation: at first select 1ml PK-Merz (Merz) medicinal liquid for use, charge into the 1ml precharging type syringe, carry out sterilization treatment; Seal with aluminium foil 8 behind the medicinal liquid that charges into 9 sealings of piston 2 and plug; Through ethylene oxide sterilizing.Should adopt the mechanization operation to finish the fill program of medicinal liquid.The embedding of precharging type syringe, quality testing, decals, stubborn bar, plastic packaging all adopt automatic assembly line.
2, silicidation in the preparation and purifying and sterilizing are handled:
1) overcoat 1 can adopt the I class borosilicate glass tube that meets American Pharmacopeia/European Pharmacopoeia regulation; Syringe needle 4 can be with hypodermic AISI304 rustless steel entry needle; Overcoat 1 and syringe needle 4 should be in ten thousand grades of purifying areas, and purified water, water for injection clean, to guarantee its cleaning.
2) overcoat 1 inwall and syringe needle 4 all pass through DC360 silicone oil silicidation, inject puncture with pin in easy to use.
3) after the syringe needle 4 on the overcoat 1 adds helmet 5, should be through dress nest machine dress nest, the nest box and carry out sealing operation of packing in hundred grades of districts more finally also will pass through ethylene oxide sterilizing, thereby guarantee the product cleaning sterile.
4) plug 10 can adopt French STELMI company ultra-clean explained hereafter plug (through water for injection clean and by the ultra-clean program silication in advance of authentication fully), cobalt 60 radiation sterilizations are finally passed through in subpackage under hundred grades of laminar flows of ten thousand grades of purifying areas.
3, specifications and models can have 1ml, 2ml, 2.5ml, 5ml, according to the medical treatment and the market demand, can also increase new specification.
The medicinal liquid of embodiment 3 prefilled injector packages
With the PK-Merz (Merz) injection among antibiolics composition injections such as acyclovir, ribavirin, ganciclovir, trimethoprim, amikacin sulfate, netilmicin sulfate, Etimicin sulfate., lincomycin hydrochloride, Clindamycin Hydrochloride, Lyphocin (Fujisawa), norfloxacin glutamate, griseofulvin, the amphotericin replacement embodiment 2, can make the precharging preparation of corresponding antibiotic medicine.
The observation of the injection of antibiotic liquid stability of embodiment 4 prefilled injector packages
With injection of antibiotic liquid such as the PK-Merz (Merz) of precharging type syringe, ampoule bottle, cillin bottle packing, acyclovir, ribavirin, ganciclovir, trimethoprim, amikacin sulfate, netilmicin sulfate, Etimicin sulfate., lincomycin hydrochloride, Clindamycin Hydrochloride, Lyphocin (Fujisawa), norfloxacin glutamate, griseofulvin, amphotericins, after depositing 1 month, 3 months, 6 months, 1 year under cold preservation (2～8 ℃), room temperature (20～25 ℃), high temperature (37 ℃) equal conditions, be the contrast experiment.Compare with the injection of ampoule bottle and cillin bottle packing through detecting the interior injection of precharging type syringe, testing results such as outward appearance, clarity, pH value, content, abnormal conditions all do not appear, show through experimental verification, precharging type syringe is can substitute existing cillin bottle and ampoule bottle fully as the inner packing of Tri-Biocin composition injection.
Claims (2)
1, a kind of precharging preparation of antibiotic medicine, adopt the inner packing of precharging type syringe, it is characterized in that said precharging type syringe structure is as the antibiotics injection, the overcoat of hollow circular cylinder (1) open rearward end is set with helmet (5) on the conehead of front end; Helmet (5) is gone up coaxial line syringe needle (4) is installed; One piston (2) is arranged in the overcoat (1), and piston (2) is connected with core bar (3), and core bar (3) has one section to be inserted in the overcoat (1); Syringe needle (4) seals with plug (9); Whole with aluminium foil (8) encapsulation behind the antibiotic medicinal liquid that charges into; Said overcoat (1) volume is 1ml or 2ml or 2.5ml or 5ml; Said syringe needle (4) diameter is at 0.2～0.5mm.
2, according to the precharging preparation of the described antibiotic medicine of claim 1, it is characterized in that said antibiotic medicine is PK-Merz (Merz), acyclovir, ribavirin, ganciclovir, trimethoprim, amikacin sulfate, netilmicin sulfate, Etimicin sulfate., lincomycin hydrochloride, Clindamycin Hydrochloride, Lyphocin (Fujisawa), norfloxacin glutamate, griseofulvin or amphotericin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620028630 CN2905051Y (en) | 2006-04-19 | 2006-04-19 | A precharged preparation of antibacterial drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620028630 CN2905051Y (en) | 2006-04-19 | 2006-04-19 | A precharged preparation of antibacterial drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2905051Y true CN2905051Y (en) | 2007-05-30 |
Family
ID=38113677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200620028630 Expired - Lifetime CN2905051Y (en) | 2006-04-19 | 2006-04-19 | A precharged preparation of antibacterial drug |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2905051Y (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2521391C2 (en) * | 2008-09-18 | 2014-06-27 | Ману ЧАУДХАРИ | Novel single-unit formulations of carbapenem and aminoglycoside |
| CN106139323A (en) * | 2016-08-04 | 2016-11-23 | 山东威高集团医用高分子制品股份有限公司 | The Prefilled syringe of safety |
| CN107773813A (en) * | 2016-08-31 | 2018-03-09 | 上海凯茂生物医药有限公司 | A kind of precharging preparation of the erythropoietin class parenteral solution with safety guard |
-
2006
- 2006-04-19 CN CN 200620028630 patent/CN2905051Y/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2521391C2 (en) * | 2008-09-18 | 2014-06-27 | Ману ЧАУДХАРИ | Novel single-unit formulations of carbapenem and aminoglycoside |
| CN106139323A (en) * | 2016-08-04 | 2016-11-23 | 山东威高集团医用高分子制品股份有限公司 | The Prefilled syringe of safety |
| CN107773813A (en) * | 2016-08-31 | 2018-03-09 | 上海凯茂生物医药有限公司 | A kind of precharging preparation of the erythropoietin class parenteral solution with safety guard |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: JILIN YIXIN PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME OR ADDRESS: JILIN A-THINK PHARMACEUTICAL CO., LTD. |
|
| CP03 | Change of name, title or address |
Address after: No. 1, one heart road, Shuangyang Economic Development Zone, Jilin, Changchun Province: 130616 Patentee after: Jilin Yixin pharmaceutical Limited by Share Ltd Address before: No. 1, one heart road, Shuangyang Economic Development Zone, Jilin, Changchun Province: 130616 Patentee before: Jilin Yixin Pharmaceutical Co., Ltd. |
|
| C56 | Change in the name or address of the patentee |
Owner name: JILIN A-THINK PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: JILIN YIXIN PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 130616 Jilin province Changchun Shuangyang Economic Development Zone on the road No. 1 Patentee after: Sinopharm Yixin Pharmaceutical Co., Ltd. Address before: 130616 Jilin province Changchun Shuangyang Economic Development Zone on the road No. 1 Patentee before: Jilin Yixin pharmaceutical Limited by Share Ltd |
|
| CX01 | Expiry of patent term |
Granted publication date: 20070530 |
|
| EXPY | Termination of patent right or utility model |