CN2796842Y - Hand pressing type bio separation magnetic pen - Google Patents
Hand pressing type bio separation magnetic pen Download PDFInfo
- Publication number
- CN2796842Y CN2796842Y CN 200520042514 CN200520042514U CN2796842Y CN 2796842 Y CN2796842 Y CN 2796842Y CN 200520042514 CN200520042514 CN 200520042514 CN 200520042514 U CN200520042514 U CN 200520042514U CN 2796842 Y CN2796842 Y CN 2796842Y
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- outer tube
- pen core
- spring
- button
- depression bar
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Abstract
The utility model relates to a hand pressing type bio separation magnetic pen, which is applied to the field of a bio separation device. A pressing rod and a cartridge of the utility model are directly connected together, and the end head of the cartridge is connected with a magnetic head together. The pressing rod, the cartridge and the magnetic head are all arranged at the center part of the inner part of a pen holder which is composed of an outer tube, a lower tube and a casing tube. The pressing rod is connected with a pressing rod check ring. A pushing head is arranged at the outer side of the outer tube, and a sealing handle is arranged at the upmost end of the outer tube. A positioning structure which is composed of a button, a button seat, a check strip and a compression spring is positioned at the upper part of the outer tube. The button is arranged at the lateral face of the outer tube, and the casing tube is nested on the outer tube. A cartridge spring is arranged at the outer side of the cartridge. The cartridge, the cartridge spring and a pushing head spring are arranged in the outer tube. When the magnetic head is extended, a rubber tube is bunted to straight. The utility model has the advantages of compact and artful structure, convenient and flexible hold by hands and free portability. The utility model improves the structure that a magnetic field which adopts the way of magnetic separation is added into the device on the existing market, and the operating process of bio separation is simplified.
Description
Technical field
The utility model relates to a kind of magnetic pen of bio-separation, refers in particular to a kind of hand-held push type bio-separation magnetic pen.Be used for bio-separation device field.
Background technology
Along with development of molecular biology, adopt the magnetic bio isolation technics to carry out operations such as load, delivery and unloading as DNA, RNA, protein, cell etc., thereby realize lock out operation target biological molecules effectively to target biological molecules.The appearance of magnetic bio isolation technics makes biological worker avoid adopting means such as loaded down with trivial details column chromatography and high speed centrifugation to carry out bio-separation, has saved the input of equipment and the step and the time of lock out operation.The principle that magnetic bio separates is: the magnetic oxide microparticle surfaces to nanoscale exposed or the macromolecule embedding carries out chemical treatment, the aglucon that can combine with the target biological molecules specificity in the connection, these particulates are joined in the biological reagent that need separate, and the aglucon on magnetic particle surface just and the combination of target biological molecules generation specificity.Add the magnetic field of certain intensity in the outside of biological sample container, just can catch magnetic microsphere.Again the nontarget organism sample of not caught by magnetic field in the container is removed, just realized the separation of target biological molecules.Therefore, the mode that applies magnetic field just becomes the important component part of biomagnetism isolation technics.At present, having occurred the multiple device that is used for Magnetic Isolation on the market, serves as typical case's representative with the product of Norway Dynal company, German Miltenyi Bio company etc., and they all are the magnetic field producing methods that can not freely carry of desktop.
Find through literature search prior art, European patent EP 1308211, this patent is a desktop high-intensity magnetic field bio-separation device, what adopt is that structure is leant in the separation that has the soft magnetism microballoon to constitute the Biosample passage, although the efficient of separating is improved significantly, but still there is the shortcoming of can't be portable and can't handling small sample.
Summary of the invention
The purpose of this utility model is at the deficiencies in the prior art and defective, and the hand-held push type bio-separation magnetic pen that a kind of compact conformation is small and exquisite, hand-held convenient, flexible, can freely carry is provided.Make it improve the magnetic field adding apparatus of the Magnetic Isolation mode that adopts on the market at present greatly, can easily handle small sample, simplified the operating process of bio-separation.
The utility model is achieved through the following technical solutions, the utility model comprises: depression bar, outer tube, following pipe, sleeve pipe, the capping handle, cut somebody's hair, magnetic head, pen core, the pen core spring, the spring of cutting somebody's hair, the depression bar ring washer, sebific duct, button, push-button socket, blend stop, compression tower spring, its annexation is: depression bar and pen core directly link together, the termination and the magnetic head of pen core link together, depression bar, pen core, magnetic head all places by outer tube, the central authorities of the penholder inside that following pipe and sleeve pipe are formed, connect the depression bar ring washer on the depression bar, sleeve pipe is nested on the outer tube, cut somebody's hair and then be arranged on the outside of outer tube, the capping handle is arranged at the top of outer tube, by button, push-button socket, blend stop, the location structure that compression tower spring is formed is positioned at the top of outer tube, its button is arranged on the side of outer tube, pen core is outward the pen core spring, pen core and pen core spring and the spring of cutting somebody's hair are arranged in the outer tube, when magnetic head stretches out and to straight sebific duct.
Depression bar is one to have the cylinder of circular press cover, and its lower end connects a depression bar ring washer, when the pen core spring is upspring, the depression bar ring washer is resisted against on the lower surface of capping handle, the position of locking depression bar.Have two scrobicular rings on the depression bar cylinder,, when these two scrobicular rings move to the position of button, will be compressed the shelves bar locking that the tower spring supports in order to determine the stroke of depression bar.When button is pressed following time, a shelves bar is removed, the depression bar position until locking of being rebounded under the effect of pen core spring.
The penholder of being made up of outer tube, following pipe and sleeve pipe is the hollow penholder, the lower end of its middle external tube is for supporting the stress surface of the pen core spring and the spring of cutting somebody's hair, the centre is the aperture by pen core, following pipe is connected by hasp structure with cutting somebody's hair of side, can move up and down with cutting somebody's hair, finish the action of removal sebific duct from the sleeve pipe.Sleeve pipe is a tubular structure elongated, that slightly incline and bore in the top, and the upper end is connected with the endoporus of outer tube bottom, and the passage of pen core and magnetic head motion is provided.
Outer tube top is the cylindrical tube of a hollow, and the bottom is a short oblique cone, for ccontaining pen core and the pen core spring and the spring of cutting somebody's hair.Its top is connected with the capping handle, and the bottom then is provided with end face, and is connected with sleeve pipe, and its lateral opening is used for assembling and cuts somebody's hair.
Cutting somebody's hair is one to be positioned at the head of outer tube side, and its outer surface is designed to have the smooth relief fabric of comfortable hand-held sensation.The bottom of cutting somebody's hair overlaps with following pipe, cuts somebody's hair under downward external force effect, can move downward along chute freely, drive the motion of pipe down, thereby removal is enclosed within the sebific duct on the sleeve pipe.When the external force effect was removed, the effect of the spring of being cut somebody's hair was cut somebody's hair and is returned to usual position.
Pen core is the elongated tubular that a hollow non-magnet material constitutes, and upper end and depression bar link together, and lower end and magnetic head link together, and it moves up and down the control of compression rod.Pen core is outward the pen core spring, with the action as the control of the stress surface up and down pen core of pen core spring of the upper surface of the lower surface of depression bar ring washer and outer tube lower end.
Magnetic head is a solid thin cylinder permanent magnet, nests together with the lower end of pen core, can be with the moving up and down and move of pen core, for bio-separation provides required magnetic field.
It is one columniform pullover that the top of sebific duct is divided into, and mates just with the oblique cone of sleeve pipe, to guarantee that sebific duct can be enclosed within on the sheath easily.The bottom of sebific duct is a conical macromolecule sebific duct.When pen core moves down when magnetic head is stretched out, magnetic head supports straight sebific duct just slightly, so that sebific duct is tightened, is convenient to lock out operation.
In the location structure of being made up of button, push-button socket, blend stop, compression tower spring, button and push-button socket link together, and a grade bar is set in the push-button socket, and push-button socket is provided with a compression tower spring by opposite one side of button.Shelves bar compression tower spring is locked in the shelves bar in the scrobicular ring of depression bar.When the button pressing, the shelves bar is open, and depression bar is on moving certainly under the pen core spring action, lock onto the lower surface of capping until the depression bar ring washer, when depression bar was pressed down by external force to move to the fovea superior ring position, centring ring was subjected to the effect of side compression spring to be locked in this scrobicular ring the position of locking depression bar.
The utility model can guarantee that depression bar drives moving of pen core, and cutting somebody's hair with the side drives moving of pipe down, separate.The magnetic head that the pen core lower end connects constitutes by having ferromagnetic permanent-magnet material.The hypocone material of the macromolecule sebific duct of sleeve pipe has good elasticity.Press down when magnetic head is stretched out when depression bar, magnetic head is the top of stretching casing tube slightly.
Characteristics of the present utility model are that compact conformation is small and exquisite, and the permanent magnetism magnetic head material that produces magnetic field is constructed at the telescopic movable tip of the brushstyle of a writing or painting, have certain flexible macromolecular material in tip of the brushstyle of a writing or painting employing and separate Biosample and permanent-magnet material.Action by button on the outer tube and depression bar can realize moving up and down of magnetic head freely, by the side cut somebody's hair, the cooperation of sleeve pipe and sebific duct both can install additional and the removal sebific duct freely.When pen core drive magnetic head moved down in the sebific duct, the magnetic field that magnetic head provides can be caught the magnetic particle in the sample easily, and sebific duct is then isolated the magnetic particle and the magnetic head of catching; When moving away in the sebific duct on the pen core drive magnetic head, the magnetic particle of catching can elute from sebific duct easily owing to there is not the existence in magnetic field, gets back in the sample.In addition, the stroke and the location of depression bar have relied on location structure, can control moving up and down of pen core and stretching of magnetic head easily.The utility model is hand-held convenient, can freely carry, and has improved the magnetic field adding apparatus of the Magnetic Isolation mode that adopts on the market at present greatly, has simplified the operating process of bio-separation.
Description of drawings
Fig. 1 is a structural representation of the present invention
Fig. 2 is a structure cutaway view of the present invention
Fig. 3 is the cutaway view in cross section, location structure place
The specific embodiment
As Figure 1-3, the utility model comprises: depression bar 1, outer tube 2, under manage 3, sleeve pipe 4, capping handle 5, cut somebody's hair 6, magnetic head 7, pen core 8, pen core spring 9, the spring 10 of cutting somebody's hair, depression bar ring washer 11, sebific duct 12, button 13, push-button socket 14, blend stop 15, compression tower spring 16, its annexation is: depression bar 1 directly links together with pen core 8, the termination of pen core 8 and magnetic head 7 link together, depression bar 1, pen core 8, magnetic head 7 all places by outer tube 2, manage 3 and the central authorities of the penholder inside formed of sleeve pipe 4 down, connect depression bar ring washer 11 on the depression bar 1, sleeve pipe 4 is nested on the outer tube 2,6 outsides that are arranged on outer tube 2 of cutting somebody's hair, capping handle 5 is arranged at the top of outer tube 2, by button 13, push-button socket 14, blend stop 15, the location structure that compression tower spring 16 is formed is positioned at the top of outer tube 2, its button 13 is arranged on the side of outer tube 2, outside the pen core 8 is pen core spring 9, pen core 8 and pen core spring 9 and the spring 10 of cutting somebody's hair are arranged in the outer tube 2, when magnetic head 7 stretches out and to straight sebific duct 12.
Described depression bar 1 is one to have the cylinder of circular press cover, and its lower end connects a depression bar ring washer 11, has two scrobicular rings on depression bar 1 cylinder.
By outer tube 2, down manage 3 and the penholder formed of sleeve pipe 4 be the hollow penholder, the lower end of its middle external tube 2 is for supporting the stress surface of the pen core spring 9 and the spring 10 of cutting somebody's hair, middle for passing through the aperture of pen core 8, managing 3 down 6 is connected by hasp structure with cutting somebody's hair of side, sleeve pipe 4 is a tubular structure elongated, that slightly incline and bore in the top, and the upper end is connected with the endoporus of outer tube 2 bottoms.
Cutting somebody's hair 6 is a head, and its outer surface is designed to have the smooth relief fabric of comfortable hand-held sensation, and 6 the bottom of cutting somebody's hair overlaps with pipe 3 down.
It is one columniform pullover that the top of sebific duct 12 is divided into, and mates just with the oblique cone of sleeve pipe 4, and the bottom of sebific duct 12 is a conical macromolecule sebific duct.
As Fig. 3, cutaway view for cross section, location structure place, the stroke of locking depression bar 1 and the location structure that moves by button 13 control depression bars have been shown, button 13 links together with push-button socket 14, grade bar 15 is set in the push-button socket 14, and push-button socket 14 is provided with a compression tower spring 16 by opposite one side of button 13.When depression bar 1 made the scrobicular ring on top move to the cross section at button 13 places under external force, shelves bar 15 embedded in the scrobicular ring of depression bar under the effect of compression tower spring 16.Because the downside of scrobicular ring is a right-angle plane, shelves bar 15 has just locked depression bar 1 does not make its resilience.When pressing knob down 13, shelves bar 15 is removed, and depression bar 1 is rebounded under the effect of pen core spring 9.
Claims (9)
1, a kind of hand-held push type bio-separation magnetic pen, it is characterized in that, comprise: depression bar (1), outer tube (2), following pipe (3), sleeve pipe (4), capping handle (5), cut somebody's hair (6), magnetic head (7), pen core (8), pen core spring (9), the spring (10) of cutting somebody's hair, depression bar ring washer (11), sebific duct (12), button (13), push-button socket (14), blend stop (15), compression tower spring (16), its annexation is: depression bar (1) directly links together with pen core (8), the termination of pen core (8) and magnetic head (7) link together, depression bar (1), pen core (8), magnetic head (7) all places by outer tube (2), the central authorities of the penholder inside that following pipe (3) and sleeve pipe (4) are formed, depression bar (1) is gone up and is connected depression bar ring washer (11), sleeve pipe (4) is nested on the outer tube (2), capping handle (5) is arranged at the top of outer tube (2), cut somebody's hair (6) then be arranged on the outside of outer tube (2), by button (13), push-button socket (14), blend stop (15), the location structure that compression tower spring (16) is formed is positioned at the top of outer tube (2), its button (13) is arranged on the side of outer tube (2), pen core (8) is outer to be pen core spring (9), pen core (8) and pen core spring (9) and the spring of cutting somebody's hair (10) are arranged in the outer tube (2), and magnetic head (7) is when stretching out and to straight sebific duct (12).
2, hand-held push type bio-separation magnetic pen according to claim 1 is characterized in that, described depression bar (1) is one to have the cylinder of circular press cover, and its lower end connects a depression bar ring washer (11), has two scrobicular rings on depression bar (1) cylinder.
3, hand-held push type bio-separation magnetic pen according to claim 1, it is characterized in that, the penholder of being made up of outer tube (2), following pipe (3) and sleeve pipe (4) is the hollow penholder, the lower end of its middle external tube (2) is for supporting the stress surface of pen core spring (9) and the spring of cutting somebody's hair (10), middle for passing through the aperture of pen core (8), following pipe (3) is connected by hasp structure with cut somebody's hair (6) of side, sleeve pipe (4) is a tubular structure elongated, that the top band inclines and bores, and the upper end is connected with the endoporus of outer tube (2) bottom.
4, hand-held push type bio-separation magnetic pen according to claim 1, it is characterized in that, outer tube (2) top is the cylindrical tube of a hollow, the bottom is a short oblique cone, pen core (8) and pen core spring (9) and the spring of cutting somebody's hair (10) are set, and outer tube (2) top is connected with capping handle (5), and the bottom then is provided with end face, and be connected with sleeve pipe (4), its lateral opening is used for assembling cut somebody's hair (6).
5, hand-held push type bio-separation magnetic pen according to claim 1 is characterized in that cut somebody's hair (6) are a head, and its outer surface is smooth relief fabric, and the bottom of cut somebody's hair (6) overlaps with following pipe (3).
6, hand-held push type bio-separation magnetic pen according to claim 1 is characterized in that pen core (8) is an elongated tubular, material by non-magnetic conduction constitutes, its upper end links together with depression bar (1), and lower end and magnetic head (7) link together, and it moves up and down the control of compression rod (1).
7, hand-held push type bio-separation magnetic pen according to claim 1 is characterized in that, magnetic head (7) is a solid thin cylinder permanent magnet, nests together with the lower end of pen core (8).
8, hand-held push type bio-separation magnetic pen according to claim 1 is characterized in that, it is one columniform pullover that the top of sebific duct (12) is divided into, and mates just with the oblique cone of sleeve pipe (4), and the bottom of sebific duct (12) is a conical macromolecule sebific duct.
9, hand-held push type bio-separation magnetic pen according to claim 1, it is characterized in that, in the location structure of forming by button (13), push-button socket (14), blend stop (15), compression tower spring (16), button (13) links together with push-button socket (14), a grade bar (15) is set in the push-button socket (14), and push-button socket (14) is provided with a compression tower spring (16) by opposite one side of button (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520042514 CN2796842Y (en) | 2005-06-16 | 2005-06-16 | Hand pressing type bio separation magnetic pen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520042514 CN2796842Y (en) | 2005-06-16 | 2005-06-16 | Hand pressing type bio separation magnetic pen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2796842Y true CN2796842Y (en) | 2006-07-19 |
Family
ID=36868080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200520042514 Expired - Fee Related CN2796842Y (en) | 2005-06-16 | 2005-06-16 | Hand pressing type bio separation magnetic pen |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2796842Y (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102494921A (en) * | 2011-11-30 | 2012-06-13 | 北京交通大学 | Trace magnetic particle sampler |
| CN103738081A (en) * | 2013-12-25 | 2014-04-23 | 宁波江北瑞臣工艺品设计有限公司 | Pen which cannot be opened by child |
| CN103754011A (en) * | 2013-12-25 | 2014-04-30 | 宁波江北瑞臣工艺品设计有限公司 | Pen capable of preventing itself from being opened by children |
| CN103909010A (en) * | 2014-04-15 | 2014-07-09 | 洛阳惠尔纳米科技有限公司 | Mechanical type magnetic separation pen |
| CN104646176A (en) * | 2015-02-11 | 2015-05-27 | 英芮诚生化科技（上海）有限公司 | Manual magnetic solid extractor |
| CN113425347A (en) * | 2021-08-25 | 2021-09-24 | 深圳市资福医疗技术有限公司 | Conveying structure and ESD magnetic anchoring clamp applying same |
| CN113848320A (en) * | 2021-09-14 | 2021-12-28 | 中国农业大学 | Quick microorganism detection device and detection method |
-
2005
- 2005-06-16 CN CN 200520042514 patent/CN2796842Y/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102494921A (en) * | 2011-11-30 | 2012-06-13 | 北京交通大学 | Trace magnetic particle sampler |
| CN103738081A (en) * | 2013-12-25 | 2014-04-23 | 宁波江北瑞臣工艺品设计有限公司 | Pen which cannot be opened by child |
| CN103754011A (en) * | 2013-12-25 | 2014-04-30 | 宁波江北瑞臣工艺品设计有限公司 | Pen capable of preventing itself from being opened by children |
| CN103738081B (en) * | 2013-12-25 | 2015-10-14 | 宁波江北瑞臣工艺品设计有限公司 | The pen that children cannot open |
| CN103754011B (en) * | 2013-12-25 | 2016-07-06 | 宁波江北瑞臣工艺品设计有限公司 | The pen that a kind of child cannot open |
| CN103909010A (en) * | 2014-04-15 | 2014-07-09 | 洛阳惠尔纳米科技有限公司 | Mechanical type magnetic separation pen |
| CN104646176A (en) * | 2015-02-11 | 2015-05-27 | 英芮诚生化科技（上海）有限公司 | Manual magnetic solid extractor |
| CN113425347A (en) * | 2021-08-25 | 2021-09-24 | 深圳市资福医疗技术有限公司 | Conveying structure and ESD magnetic anchoring clamp applying same |
| CN113848320A (en) * | 2021-09-14 | 2021-12-28 | 中国农业大学 | Quick microorganism detection device and detection method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |