CN200945454Y - Portable magnetic separating pen - Google Patents
Portable magnetic separating pen Download PDFInfo
- Publication number
- CN200945454Y CN200945454Y CN 200620042909 CN200620042909U CN200945454Y CN 200945454 Y CN200945454 Y CN 200945454Y CN 200620042909 CN200620042909 CN 200620042909 CN 200620042909 U CN200620042909 U CN 200620042909U CN 200945454 Y CN200945454 Y CN 200945454Y
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- pen
- permanent magnet
- magnetic
- cap
- separating
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Abstract
The utility model relates to a portable magnetic separating pen. The pen shape magnetic separating tool is designed according to construction of round ball pen, which comprises a cylinder permanent magnet iron pen core, a pen sheath(such as polyvinyl chloride or some plastic pipe), a metal spring and a plastic pen cap shaped like a cone. Because a spring is fixed on the lower end of the permanent magnet, the movement of the permanent magnet from up to down is controlled by executing pressure on the top of the pen, therefore the permanent magnet extends out or bounces bank to the pen sheath. When the permanent magnet extends out of the pen sheath, a pen cap is arranged on the exterior, thereby constituting a set of complete magnetic separating pen. The separating pen can separate the magnetic micro-ball or particle from the liquid, cultivating liquid or solid powder, and has the advantages of easy production method, low cost, convenient use and portability, fast separation for magnetic micro-ball or particle and good application value for separating cell and protein, immobilized enzyme, catalyze, heavy metal separation and detection and other biomedicine, medical engineering and environment protection fields.
Description
Technical field
The utility model belongs to the chemical Instrument technology field, separate research fields such as purification, immobilised enzymes, immunoassay, catalysis with biomedicine, cell separation, protein and nucleic acid etc. closely related, is specifically related to a kind of portable magnetic of using in above-mentioned field and separates pen.
Background technology
In recent years, along with blending and the infiltration as chemistry, biology, material etc. of nanosecond science and technology and traditional subject, the research of nano material becomes one of research hot fields of nanosecond science and technology just gradually.As a kind of advanced function material, magnetic nano particle or magnetic microsphere have caused the concern of academia and industrial quarters day by day.Magnetic Nano not only has numerous advantages of nano particle, and is big etc. as specific area, also the special superparamagnetism of tool; Magnetic microsphere also has the characteristics that the surface is easy to functionalization in addition, promptly can give its multiple reactive functional group in surface by various chemical reactions, as :-OH ,-COOH ,-COH ,-NH
2Deng, therefore, magnetic microsphere can and object (antibody, albumen, nucleic acid etc.) specific effect takes place, and under externally-applied magnetic field, from its residing environment, separate, thereby realize the separation and the enrichment of object.At present, people utilize these characteristics of magnetic microsphere, are carrying out a large amount of fruitful research work such as fields such as clinical diagnosis, targeted drug, cell marking, cell separation and immobilised enzymes.Yet, because correlative study at present is in laboratory stage mostly, most researchers is just simply utilized common block permanent magnet to separate and is collected magnetic microsphere, still there are not special separator or separating tool to be developed, along with the magnetic microsphere correlative study deeply and widen, large-scale production and applied magnetic microballoon are the development trends of following correlative study, therefore, research and develop a kind of can the separating tool that magnetic microsphere is separated from its environment fast is significant, it can not only improve separating rate greatly, and make lock out operation easy, the at present domestic report of not seeing relevant separating tool.
Summary of the invention
The purpose of this utility model provides a kind of portable magnetic separation pen simple, that cost is low, easy to use, separating rate is fast, efficient is high of making.
A kind of portable magnetic that the utility model proposes separates pen, this Magnetic Isolation pen is made up of pen top, the pen cap, pen core, spring, cap for brush each several part, in the middle of the pen cap 1 is cylindrical magnet stylus core 2, the pen cap 1 upper end is pen top 3, the lower end is the cap for brush 4, and spring 5 is fixed on the nib 6 of pen core 2 lower ends.
In the utility model, pen core 2 nearly end portions have annular shelves 7.
In the utility model, nib 6 parts of pen core 2 are conical.
In the utility model, the pen cap 1 lower end is conical.
In the utility model, the conical diameter in the pen cap 1 lower end is 0.3cm-2.0cm.
In the utility model, pen core is that intensity is the permanent magnet of 100-6000Gs.
In the utility model, the pen cap 1 internal diameter is 0.4cm-2.5cm.
In the utility model, pen core 2 diameters are 0.2cm-2.0cm, and length is 3.0cm-20.0cm, and conical written diameter is 0.1cm-1.0cm.
The structure of this form of a stroke or a combination of strokes Magnetic Isolation instrument and using method and ball pen are similar, mainly are made up of plastic tube, metal spring and the subconical plastics caps for brush such as cylindrical magnet iron, polyvinyl chloride.Because the lower end of permanent magnet is fixed with a spring, can control permanent magnet moving up and down in the pen cap by exerting pressure at a top, thereby permanent magnet be stretched out or the pen cap that rebounds.
When using Magnetic Isolation, by making permanent magnet stretch out the pen cap at a top application plus-pressure, in its appearance the cap for brush is installed, then the cap for brush is partly immersed and contain magnetic microsphere (in the different application occasion, this magnetic microsphere may selective binding large biological molecule, or specific adsorption objects such as specific cells) nutrient solution or solution in, under the effect of pen core magnetic field, magnetic microsphere by strong adsorption on cap for brush surface, after treating that suction-operated finishes, with the permanent magnet shaft of a writing brush that rebounds, utilize external force such as ultrasonic wave the magnetic microsphere on cap for brush surface can be transferred in other vessel, by dissociation object is disintegrated down from the magnetic microsphere surface then, collect the recovery magnetic microsphere with separating pen once more, thereby realize the purpose of separation and purification of target thing, whole separation process is consuming time few, and is simple to operate, fast.
The preparation method of this separating tool is simple; with low cost; use easy to carry; can be used for separating fast magnetic microsphere or particle, separate with Separation of Proteins, immobilised enzymes, catalysis, heavy metal with fields such as biomedicine, pharmaceutical engineering and environmental protection such as detection at cell and have the using value of wanting.
Description of drawings
Fig. 1 is the utility model structural representation.
Fig. 2 is that the utility model presses the back nib to stretch out pen cap structural representation to a top application.
Number in the figure: the 1st, the pen cap, the 2nd, pen core, the 3rd, pen top, the 4th, the cap for brush, the 5th, spring, the 6th, nib, the 7th, shelves handle.
The specific embodiment
Embodiment 1:
Get long 9cm, a D1=1.5cm, the polyvinyl chloride shaft of a writing brush of d1=0.8cm, a L=6cm is installed in inside, D2=1.1cm, the cylindrical neodymium magnesium permanent magnet of d2=0.6cm, the lower end magnetic field intensity is 1000Gs, keep off handle in the annular that diameter of distance permanent magnet lower end 1.0cm processing is 1.2cm, be used for fixing metal spring, it is 1.1cm that a diameter is installed then, and natural length is the spring of 2.0cm.At the cap for brush of a diameter d 3=1.2cm of nib place cover, so just made a portable magnetic separation pen that magnetic field intensity is 1000Gs at last.
Embodiment 2:
Get long 10cm, a D1=2.0cm, the polyvinyl chloride shaft of a writing brush of d1=1.2cm, a L=7cm is installed in inside, D2=1.5cm, the cylindrical neodymium magnesium permanent magnet of d2=1.0cm, the lower end magnetic field intensity is 3000Gs, keep off handle in the annular that diameter of distance permanent magnet lower end 1.5cm processing is 1.7cm, be used for fixing metal spring, it is 1.5cm that a diameter is installed then, and natural length is the spring of 3.0cm.At the polytetrafluoroethylene (PTFE) cap for brush of a diameter d 3=1.9cm of nib place cover, so just made a portable magnetic separation pen that magnetic field intensity is 3000Gs at last.
Embodiment 3:
Get long 9cm, a D1=1.5cm, the polyvinyl chloride shaft of a writing brush of d1=0.8cm, a L=6cm is installed in inside, D2=1.1cm, the cylindrical neodymium magnesium permanent magnet of d2=0.6cm, the lower end magnetic field intensity is 2000Gs, keep off handle in the annular that diameter of distance permanent magnet lower end 1.0cm processing is 1.2cm, be used for fixing metal spring, it is 1.1cm that a diameter is installed then, and natural length is the spring of 2.0cm.At the cap for brush of a diameter d 3=1.2cm of nib place cover, so just made a portable magnetic separation pen that magnetic field intensity is 2000Gs at last.
Embodiment 4:
Get long 9cm, a D1=1.5cm, the polyvinyl chloride shaft of a writing brush of d1=0.8cm, a L=6cm is installed in inside, D2=1.1cm, the cylindrical neodymium magnesium permanent magnet of d2=0.6cm, the lower end magnetic field intensity is 5000Gs, keep off handle in the annular that diameter of distance permanent magnet lower end 1.0cm processing is 1.2cm, be used for fixing metal spring, it is 1.1cm that a diameter is installed then, and natural length is the spring of 2.0cm.At the cap for brush of a diameter d 3=1.2cm of nib place cover, so just made a portable magnetic separation pen that magnetic field intensity is 5000Gs at last.
Claims (8)
1, a kind of portable magnetic separates pen, this Magnetic Isolation pen is made up of pen top, the pen cap, pen core, spring, cap for brush each several part, it is characterized in that in the middle of the pen cap (1) be cylindrical magnet stylus core (2), the pen cap (1) upper end is pen top (3), the lower end is the cap for brush (4), and spring (5) is fixed on the nib (6) of pen core (2) lower end.
2, portable magnetic as claimed in claim 1 separates pen, and it is characterized in that has annular shelves (7) at the nearly end portion of pen core (2).
3, portable magnetic as claimed in claim 1 separates pen, it is characterized in that nib (6) part of pen core (2) is conical.
4, portable magnetic as claimed in claim 1 separates pen, it is characterized in that the pen cap (1) lower end is conical.
5, portable magnetic as claimed in claim 4 separates pen, it is characterized in that the conical diameter in the pen cap (1) lower end is 0.3cm-2.0cm.
6, portable magnetic as claimed in claim 1 separates pen, it is characterized in that pen core (2) is that intensity is the permanent magnet of 100-6000Gs.
7, portable magnetic as claimed in claim 1 separates pen, it is characterized in that the pen cap (1) internal diameter is 0.4cm-2.5cm.
8, portable magnetic as claimed in claim 1 separates pen, it is characterized in that pen core (2) diameter is 0.2cm-2.0cm, and length is 3.0cm-20.0cm, and conical written diameter is 0.1cm-1.0cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620042909 CN200945454Y (en) | 2006-06-16 | 2006-06-16 | Portable magnetic separating pen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620042909 CN200945454Y (en) | 2006-06-16 | 2006-06-16 | Portable magnetic separating pen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN200945454Y true CN200945454Y (en) | 2007-09-12 |
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ID=38732515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200620042909 Expired - Fee Related CN200945454Y (en) | 2006-06-16 | 2006-06-16 | Portable magnetic separating pen |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN200945454Y (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102494921A (en) * | 2011-11-30 | 2012-06-13 | 北京交通大学 | Trace magnetic particle sampler |
| CN101533012B (en) * | 2008-02-15 | 2013-12-25 | 维里德克斯有限责任公司 | Method and apparatus for imaging target components in biological sample by using permanent magnet |
| CN103909010A (en) * | 2014-04-15 | 2014-07-09 | 洛阳惠尔纳米科技有限公司 | Mechanical type magnetic separation pen |
| CN104208906A (en) * | 2014-09-03 | 2014-12-17 | 上海市刑事科学技术研究院 | Simple and easy collection and elution device for magnetic nano enriching material and application method of simple and easy collection and elution device |
| CN104646176A (en) * | 2015-02-11 | 2015-05-27 | 英芮诚生化科技（上海）有限公司 | Manual magnetic solid extractor |
| CN105420074A (en) * | 2016-01-19 | 2016-03-23 | 山西振东基赛生物科技有限公司 | Multifunctional biological substance separating device |
| CN105543090A (en) * | 2016-01-19 | 2016-05-04 | 山西振东基赛生物科技有限公司 | Dehydration device and method |
| CN109789427A (en) * | 2016-09-30 | 2019-05-21 | 哈美顿博纳图斯股份公司 | Magnetic Isolation equipment with non-physical coupling between magnet apparatus and its motion drive |
-
2006
- 2006-06-16 CN CN 200620042909 patent/CN200945454Y/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101533012B (en) * | 2008-02-15 | 2013-12-25 | 维里德克斯有限责任公司 | Method and apparatus for imaging target components in biological sample by using permanent magnet |
| CN102494921A (en) * | 2011-11-30 | 2012-06-13 | 北京交通大学 | Trace magnetic particle sampler |
| CN103909010A (en) * | 2014-04-15 | 2014-07-09 | 洛阳惠尔纳米科技有限公司 | Mechanical type magnetic separation pen |
| CN104208906A (en) * | 2014-09-03 | 2014-12-17 | 上海市刑事科学技术研究院 | Simple and easy collection and elution device for magnetic nano enriching material and application method of simple and easy collection and elution device |
| CN104646176A (en) * | 2015-02-11 | 2015-05-27 | 英芮诚生化科技（上海）有限公司 | Manual magnetic solid extractor |
| CN105420074A (en) * | 2016-01-19 | 2016-03-23 | 山西振东基赛生物科技有限公司 | Multifunctional biological substance separating device |
| CN105543090A (en) * | 2016-01-19 | 2016-05-04 | 山西振东基赛生物科技有限公司 | Dehydration device and method |
| CN105420074B (en) * | 2016-01-19 | 2018-06-29 | 山西振东基赛生物科技有限公司 | A kind of multifunctional bio material disconnecting gear |
| CN109789427A (en) * | 2016-09-30 | 2019-05-21 | 哈美顿博纳图斯股份公司 | Magnetic Isolation equipment with non-physical coupling between magnet apparatus and its motion drive |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070912 Termination date: 20100616 |