CN2601095Y - Blood cell dialyser - Google Patents
Blood cell dialyser Download PDFInfo
- Publication number
- CN2601095Y CN2601095Y CN 03204609 CN03204609U CN2601095Y CN 2601095 Y CN2601095 Y CN 2601095Y CN 03204609 CN03204609 CN 03204609 CN 03204609 U CN03204609 U CN 03204609U CN 2601095 Y CN2601095 Y CN 2601095Y
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- bag
- dialysis
- blood
- hemocyte
- washing machine
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Abstract
The utility model relates to a dialysis blood corpuscle cleaning appliance, which comprises a blood pump, a dialysis post, a conduit, a filter, an electronic valve and a blood bag, wherein the dialysis post is applied to remove the glycerin, the dissociating hemoglobin and the toxic substance; and flowing speed of the blood pump can be automatically controlled. The entire system is closed and the cleaning lotion inlet is provided with a filter used to prevent the bacteria from passing. Such dialysis blood corpuscle cleaning appliance can rapidly remove the protection liquid and the dissociating hemoglobin in the frozen preserved red blood cell and at the same time purify the blood. The device can be widely used to the autologous red cell saver for the rare blood type and the patient receiving the tumor chemo-radiation therapy and can clean the red cells for the immunity disease sufferer. Meanwhile, the device can be used to separation of the component blood as well as the permutation therapy and detoxicating therapy for the blood. Compares with the centrifugal cleaning appliance, the device has the advantages of small volume, low price, simplified operating steps and accelerated cleaning speed.
Description
Technical field
This utility model relates to Medical Instruments, particularly about a kind of dialysis formula hemocyte washing machine.
Background technology
At present in the treatment of blood transfusion,, carry out from body erythrocyte long preservation being subjected to people's attention gradually because viral infection and carrier increase day by day among the blood donor.Stored frozen blood is that erythrocyte is added glycerol protection liquid, preserves with-80 ℃ of degree, can preserve more than 10 years.When patient needed the infusion erythrocyte, thawed red blood cell was with high saline solution and the washing liquid cyclic washing erythrocyte that oozes, to remove harmful glycerol and free hemoglobin; For the patient that allergic symptom is arranged, also should infusion erythrocyte after the washing, avoid the immunoreation after antibody component in the blood produces blood transfusion.Erythrocyte after the washing can also be removed insalubrious compositions such as hyperlipidemia.
The clinical method of removing glycerol or Washed Red Blood Cells commonly used has two kinds at present: 1) super-magnum centrifuge washing method: the instrument heaviness, be semi-open form, and washing back erythrocyte 4 degree only can be deposited 24 hours; 2) centrifugal hemocyte washing machine method: washing machine needs import, and every price RMB is about 350,000, and washing a unit erythrocyte needs 1 hour.
Summary of the invention
Main purpose of the present utility model provides a kind of hemocyte dialysis washing machine, make and preserve the erythrocytic glycerol process of going in back, reduced the volume and weight of washing machine simultaneously, shortened the time of operation carrying out in the closed pipeline relatively, reduce the contaminated chance of cell, reduced cost.In order to achieve the above object, this utility model is taked following technical scheme: a kind of hemocyte dialysis washing machine, comprise blood bag, cabinet, support and the consumptive material of adorning hemocyte, it is characterized in that: described cabinet inside is equipped with blood pump and controller, described consumptive material comprises is located at hypertonic saline bag, washing liquid bag, waste fluid bag, filter and the dialysis cartridge that cabinet is outer and be connected with blood pump and controller pipeline, described is set up in outside the described cabinet, contains above to carry described blood bag and described consumptive material.
In the above-mentioned hemocyte dialysis washing machine, the drain pipe of described hypertonic saline bag and washing liquid bag is communicated with described blood pump feed tube by described filter; The blood pump drain pipe is communicated with described dialysis cartridge feed tube, and described dialysis cartridge drain pipe is communicated with described blood bag feed tube, and dialysis cartridge is established a sewer pipe in addition and is communicated with described waste fluid bag; Described blood bag drain pipe is communicated with the blood pump feed tube.
In the above-mentioned hemocyte dialysis washing machine, described blood bag turnover pipe passes in and out between the pipe with two demountable two logical linking to each other with described dialysis cartridge, with demountable two logical linking to each other, usefulness tree fork shape tube for transfusion is in parallel between described hypertonic saline bag and the washing liquid bag between described hypertonic saline bag and washing liquid bag and dialysis cartridge feed tube.
In the above-mentioned hemocyte dialysis washing machine, described blood pump is positioned at the front of dialysis cartridge, and the feed tube of dialysis cartridge and drain pipe connect the drain pipe and the feed tube of blood receiving bag, and described dialysis cartridge upper end is established another sewer pipe and connected waste fluid bag.
In the above-mentioned hemocyte dialysis washing machine, on the described hypertonic saline bag drain pipe, on the drain pipe of described washing liquid bag, on the described blood pump feed tube, on the described blood bag feed tube, on the blood bag drain pipe and on the dialysis cartridge sewer pipe electromagnetic valve is set respectively.
In the above-mentioned hemocyte dialysis washing machine, described dialysis cartridge inner membrance is fibrous adsorbing material, and the aperture is 5-400 μ m.
In the above-mentioned hemocyte dialysis washing machine, described support is established the drip stand of hook on being, described blood bag and described hypertonic saline bag, washing liquid bag hang on the described hook.
In the above-mentioned hemocyte dialysis washing machine, described dialysis cartridge is connected in the chimeric mode that can dismantle automatically with described casing.
In the above-mentioned hemocyte dialysis washing machine, described cabinet outside dimension is 40 * 35 * 30 centimetres.
In the above-mentioned hemocyte dialysis washing machine, described blood pump is that rotating speed is the pump of 25-300 milliliter/min.
Owing to adopted above technical scheme, make and the utlity model has that volume is little, price is low, the step that simplifies the operation, the advantage of washing speed accelerated.
Description of drawings
Fig. 1 is a structural representation of the present utility model;
Fig. 2 is a work process sketch map of the present utility model;
Fig. 3 is DC motor control circuit figure in this utility model.
The specific embodiment
Be described in detail structure of the present utility model and work process below in conjunction with accompanying drawing.
As shown in Figure 1, this utility model is made of blood bag 1, cabinet 10, support 11 and consumptive material three parts, coat controller 12 and blood pump 6 in the cabinet 10, the effect of blood pump 6 is that cleaning mixture is pumped into blood bag 1, fully be mixed into cell suspension with hemocyte, the rotating speed of blood pump 6 can be set by the operator, is arranged on 25-300 milliliter/min usually; Under this set, washing 200 milliliters of erythrocytic times is 30-50 minute.The apparent size of cabinet 10 is 40 * 35 * 30 centimetres, and materials such as available rigid plastics or metal are made.
Consumptive material partly comprises hypertonic saline bag 2, washing liquid bag 3, waste fluid bag 4, filter 5 and hemodialysis post 7.Link to each other with two demountable two logical 81,82 between the turnover pipe that goes out inlet pipe 17,18 and hemodialysis post 7 of blood bag 1, adopt tree fork shape tube for transfusion 51 in parallel between hypertonic saline bag 2 and the washing liquid bag 3, liquid outlet after hypertonic saline bag 2 and washing liquid bag 3 are in parallel is connected with the feed tube 71 of hemodialysis post 7 by one demountable two logical 83 through behind the filter 5 again.Filter 5 can prevent that antibacterial from entering, and reduces the contaminated chance of hemocyte.More than the core of Lian Jieing is a hemodialysis post 7, and its inner membrance is fibrous adsorbing material 74, as to select polypropylene for use be that material is made, and the aperture is 5-400 μ m.The feed tube 71 of hemodialysis post 7 links to each other with the drain pipe 18 of blood bag 1 with two logical 82 respectively by blood pump 6, link to each other with the tree fork shape tube for transfusion 51 of washing liquid bag 3 with hypertonic saline bag 2 with two logical 83, drain pipe 72 links to each other with the feed tube 17 of blood bag 1 with two logical 81, and its top is established sewer pipe 73 and linked to each other with waste fluid bag 4.So just can utilize the dynamic action of blood pump 6 will be the cell suspension of mixing pump into dialysis cartridge 7, through the doughnut 74 in the dialysis cartridge 7, because the aperture of doughnut allows the composition except that erythrocyte to appear, so the composition in the cell suspension except that erythrocyte enters waste fluid bag through the fiber Outer Tube, and erythrocyte flow to the blood bag through the fiber interior conduit, when the residual quantity that the content that above-mentioned circulation repeats to cell suspension free hemoglobin is lower than 1 grams per liter, glycerol is lower than 1 grams per liter, closes washing machine and stop washing.
Be flowing of control blood and washing liquid, on described hypertonic saline bag 2 drain pipes 21, the first electromagnetic valve 8a is set, on the drain pipe 31 of described washing liquid bag 3, electromagnetic valve 8b is set, on described blood pump 6 feed tubes 61, electromagnetic valve 8c is set, on described blood bag 1 feed tube 17, electromagnetic valve 8e is set, on blood bag 1 drain pipe 18, electromagnetic valve 8d is set, and on dialysis cartridge 7 sewer pipes 73, electromagnetic valve 8f is set, above-mentioned electromagnetic valve is connected with circuit with controller 12 respectively, the switch of and a plurality of electromagnetic valves single by controller 12 controls.
Can realize that the circuit of above-mentioned control mainly is made up of pump speed (motor speed) control circuit, valve sequence circuit and drive circuit.Because peristaltic pump adopts direct current generator, by regulating the voltage-regulation motor speed of supplying with motor, as shown in Figure 3, a kind of DC motor control circuit with controller 12 control electromagnetic valve switch is disclosed.
This circuit is used for the H electric bridge assembly LMD18200 of motor control as motor-drive circuit.Circuit is for the fixing application model of turn-offing, and when the electric current in the motor surpassed controlling value, adding a meansigma methods to motor was 0 voltage, makes electric current in the motor around the bid value swing.Fixedly the turn-off time is by the outer meeting resistance R of LM355 and the value decision of capacitor C.tOFF＝1.1*R*C。The DIR of LMD18200 end input direction signal among the figure.When DIR is high level, two high-end crystal conductings in the H bridge in the sheet, during for low level, two low side crystal conductings.Current sampling signal and the MAG signal exported by 8 feet of LMD18200 relatively carry out speed controlling.
In this utility model, support 11 is located at the outside of cabinet 10, and the form and the structure of support are not particularly limited, be to be used for containing carrying blood bag 1, hypertonic saline bag 2, washing liquid bag 3 and other necessary pipeline and other consumptive material; Waste fluid bag 4 also can be placed on support 11 relatively by under the position on.In easier embodiment, support 11 can be drip stand, and for example long for 20cm, the metal rack of diameter 1cm is provided with some hooks above, and blood bag 1, hypertonic saline bag 2, washing liquid bag 3 and waste fluid bag 4 all can be suspended on the different hook of height.
In this utility model, for more attractive in appearance and convenient and practical, the shell of casing 10 can be processed into peculiar shape (not shown), hemodialysis post 7 directly is entrenched in reserved location on casing 10 shells, the pipeline of above-mentioned medical disposable material also can be embedded in reserved location on casing 10 shells respectively, thereby make a supporting integral body, it is more convenient that this utility model is used, and can dismantle freely, more increases convenience of the present utility model, the step that simplifies the operation shortens the operating time.
To use this utility model Washed Red Blood Cells procedure declaration as follows below, comprise two kinds of washing process:
Process 1: referring to Fig. 2, the drain pipe 18 of stored frozen erythrocyte bag 1 is linked to each other with two logical 82 with the feed tube 71 of dialysis cartridge 7, the tree fork shape tube for transfusion 51 of hypertonic saline bag 2 and washing liquid bag 3 is led to 83 with two link to each other with the feed tube 71 of dialysis cartridge 7.At first, open electromagnetic valve 8a, 8c, 8e and blood pump 6, the rotating speed of blood pump 6 is 50 milliliters/min, and hypertonic saline is pumped in the blood bag 1, leaves standstill 2min; Then, close electromagnetic valve 8a, open electromagnetic valve 8b, the rotating speed of blood pump 6 still is 50 milliliters/min, and washing liquid 75ml is pumped in the blood bag 1, leave standstill 2min after, pump into washing liquid 150ml with same rotating speed again, leave standstill 2min; Then with all valve opens, pump speed is adjusted into 150 milliliters/min, make red cell suspension and washing liquid mix the back and in circulation, constantly enter blood bag 1 by dialysis cartridge 7, and waste liquid drains in the waste fluid bag 4 by sewer pipe 73, detect the outflow waste liquid with colorimetric card, until reaching when setting color range, the residual quantity that the content that the hemoglobin of dissociating in the cell suspension in the blood bag 1 be described is lower than 1 grams per liter, glycerol is lower than 1 grams per liter.At last, close electromagnetic valve 8d, 8f, open electromagnetic valve 8b, pump into a small amount of washing liquid to blood bag 1, flushing pipe and dialysis cartridge 7, resuspended erythrocyte, washing finishes.
Process 2: referring to Fig. 2, the drain pipe 18 of stored frozen erythrocyte bag 1 is linked to each other with two logical 82 with the feed tube 71 of dialysis cartridge 7, the tree fork shape tube for transfusion 51 of hypertonic saline bag 2 and washing liquid bag 3 is led to 83 with two link to each other with the feed tube 71 of dialysis cartridge 7.At first, open electromagnetic valve 8a, 8c, 8e and blood pump 6, the rotating speed of blood pump 6 is 50 milliliters/min, and hypertonic saline is pumped in the blood bag 1; Then, close electromagnetic valve 8a, open electromagnetic valve 8b, the rotating speed of blood pump 6 still is 50 milliliters/min, and washing liquid is pumped in the blood bag 1; Then close electromagnetic valve 8b, 8c, open electromagnetic valve 8d, 8f, the rotating speed of blood pump 6 is transferred to 150 milliliters/min, make red cell suspension constantly enter blood bag 1 by dialysis cartridge 7 in circulation, and waste liquid drains in the waste fluid bag 4 by sewer pipe 73.Close electromagnetic valve 8d, 8f, open electromagnetic valve 8b, once more washing liquid is pumped in the blood bag 1, mixing then, is closed electromagnetic valve 8b, 8c once more, opens electromagnetic valve 8d, 8f, to the Red Blood Cells Suspension washing of dialysing, repeats above process.Detect to flow out waste liquid with colorimetric card, until reaching when setting color range, the residual quantity that the content that the hemoglobin of dissociating in the cell suspension in the blood bag 1 be described is lower than 1 grams per liter, glycerol is lower than 1 grams per liter.At last, close electromagnetic valve 8d, 8f, open electromagnetic valve 8b, pump into a small amount of washing liquid to blood bag 1, flushing pipe and dialysis cartridge 7, resuspended erythrocyte, washing finishes.
This laboratory has been finished the wash studies of 5 bags of frozen red cellses according to the aforesaid operations step, the results are shown in Table 1.
Table 1: hemocyte dialysis machine Washed Red Blood Cells effect
| Grouping | n | HB Mg/L | The residual mOsm of glycerol in the supernatant | The erythrocyte response rate (%) | Deformable index (ID) |
| Normal value | 4 | ＜1000 | ＜420 | 83.33±7.77 | ＞0.3000 |
| After the washing | 4 | 118.5±73.1 | 342.5±25.1 | 0.5000±0.04 |
Claims (10)
1, a kind of hemocyte dialysis washing machine, comprise blood bag, cabinet, support and the consumptive material of adorning hemocyte, it is characterized in that: described cabinet inside is equipped with blood pump and controller, described consumptive material comprises is located at hypertonic saline bag, washing liquid bag, waste fluid bag, filter and the dialysis cartridge that cabinet is outer and be connected with blood pump and controller pipeline, described is set up in outside the described cabinet, contains above to carry described blood bag and described consumptive material.
2, hemocyte dialysis washing machine as claimed in claim 1, it is characterized in that: the drain pipe of described hypertonic saline bag and washing liquid bag is communicated with described blood pump feed tube by described filter; The blood pump drain pipe is communicated with described dialysis cartridge feed tube, and described dialysis cartridge drain pipe is communicated with described blood bag feed tube, and dialysis cartridge is established a sewer pipe in addition and is communicated with described waste fluid bag; Described blood bag drain pipe is communicated with the blood pump feed tube.
3, hemocyte dialysis washing machine as claimed in claim 1, it is characterized in that: described blood bag turnover pipe passes in and out between the pipe with two demountable two logical linking to each other with described dialysis cartridge, with demountable two logical linking to each other, usefulness tree fork shape tube for transfusion is in parallel between described hypertonic saline bag and the washing liquid bag between described hypertonic saline bag and washing liquid bag and dialysis cartridge feed tube.
4, hemocyte dialysis washing machine as claimed in claim 1, it is characterized in that: described blood pump is positioned at the front of dialysis cartridge, and the feed tube of dialysis cartridge and drain pipe connect the drain pipe and the feed tube of blood receiving bag, and described dialysis cartridge upper end is established another sewer pipe and is connected waste fluid bag.
5, as the arbitrary described hemocyte dialysis of claim 1 to 4 washing machine, it is characterized in that: on the described hypertonic saline bag drain pipe, on the drain pipe of described washing liquid bag, on the described blood pump feed tube, on the described blood bag feed tube, on the blood bag drain pipe and on the dialysis cartridge sewer pipe electromagnetic valve is set respectively.
6, as the arbitrary described hemocyte dialysis washing machine of claim 1 to 4, it is characterized in that: described dialysis cartridge inner membrance is fibrous adsorbing material, and the aperture is 5-400 μ m.
7, as the arbitrary described hemocyte dialysis of claim 1 to 4 washing machine, it is characterized in that: described support is established the drip stand of hook on being, described blood bag and described hypertonic saline bag, washing liquid bag hang on the described hook.
8, as the arbitrary described hemocyte dialysis washing machine of claim 1 to 4, it is characterized in that: described dialysis cartridge is connected in the chimeric mode that can dismantle automatically with described casing.
9, as the arbitrary described hemocyte dialysis washing machine of claim 1 to 4, it is characterized in that: described cabinet outside dimension is 40 * 35 * 30 centimetres.
10, as the arbitrary described hemocyte dialysis washing machine of claim 1 to 4, it is characterized in that: described blood pump is that rotating speed is the pump of 25-300 milliliter/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03204609 CN2601095Y (en) | 2003-02-25 | 2003-02-25 | Blood cell dialyser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03204609 CN2601095Y (en) | 2003-02-25 | 2003-02-25 | Blood cell dialyser |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2601095Y true CN2601095Y (en) | 2004-01-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03204609 Expired - Lifetime CN2601095Y (en) | 2003-02-25 | 2003-02-25 | Blood cell dialyser |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100434124C (en) * | 2005-12-07 | 2008-11-19 | 陈家颖 | Guiding treatment apparatus for detoxicating blood dynamically |
| CN102899247A (en) * | 2012-10-26 | 2013-01-30 | 中国科学技术大学 | Blood cell separation device |
| CN103861161A (en) * | 2012-12-18 | 2014-06-18 | 苏州排头兵药业科技有限公司 | Red blood cell washing device and preparation method for washing red blood cells |
| CN105408467A (en) * | 2013-07-23 | 2016-03-16 | 株式会社钟化 | Method for producing cell concentrate, and cell suspension treatment system |
| CN107106744A (en) * | 2014-12-19 | 2017-08-29 | 生物安全股份有限公司 | The sequential processes of biofluid |
-
2003
- 2003-02-25 CN CN 03204609 patent/CN2601095Y/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100434124C (en) * | 2005-12-07 | 2008-11-19 | 陈家颖 | Guiding treatment apparatus for detoxicating blood dynamically |
| CN102899247A (en) * | 2012-10-26 | 2013-01-30 | 中国科学技术大学 | Blood cell separation device |
| CN102899247B (en) * | 2012-10-26 | 2014-01-01 | 中国科学技术大学 | Blood cell separation device |
| CN103861161A (en) * | 2012-12-18 | 2014-06-18 | 苏州排头兵药业科技有限公司 | Red blood cell washing device and preparation method for washing red blood cells |
| CN103861161B (en) * | 2012-12-18 | 2016-06-08 | 苏州排头兵药业科技有限公司 | The preparation method of Washed Red Blood Cells device and Washed Red Blood Cells |
| CN105408467A (en) * | 2013-07-23 | 2016-03-16 | 株式会社钟化 | Method for producing cell concentrate, and cell suspension treatment system |
| CN107106744A (en) * | 2014-12-19 | 2017-08-29 | 生物安全股份有限公司 | The sequential processes of biofluid |
| US10874778B2 (en) | 2014-12-19 | 2020-12-29 | Biosafe S.A. | Sequential processing of biological fluids |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: BEIJING JINGJING MEDICAL EQUIPMENT CO., LTD Free format text: FORMER OWNER: FEILD FLOOD TRANSFUSION INST., ACADEMY OF MILITARY MEDICINE SCIENCES, PLA Effective date: 20040702 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20040702 Address after: 100176 No. 11 Wanyuan street, Beijing economic and Technological Development Zone Patentee after: Jingjing Medical Equipment Co., Ltd., Beijing Address before: 100850 No. 27 Taiping Road, Beijing, Haidian District Patentee before: Inst. of Field Blood Transfusion, Academy of Military Medical Sciences, PLA |
|
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20130225 Granted publication date: 20040128 |