CN2561433Y - 带有药物膜的血管内支架 - Google Patents
带有药物膜的血管内支架 Download PDFInfo
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- CN2561433Y CN2561433Y CN02274690U CN02274690U CN2561433Y CN 2561433 Y CN2561433 Y CN 2561433Y CN 02274690 U CN02274690 U CN 02274690U CN 02274690 U CN02274690 U CN 02274690U CN 2561433 Y CN2561433 Y CN 2561433Y
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- endovascular stent
- drug
- stent
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- 210000004204 blood vessel Anatomy 0.000 title abstract description 3
- 239000011248 coating agent Substances 0.000 title abstract 4
- 238000000576 coating method Methods 0.000 title abstract 4
- 239000003814 drug Substances 0.000 claims abstract description 30
- HJTAZXHBEBIQQX-UHFFFAOYSA-N 1,5-bis(chloromethyl)naphthalene Chemical compound C1=CC=C2C(CCl)=CC=CC2=C1CCl HJTAZXHBEBIQQX-UHFFFAOYSA-N 0.000 claims abstract description 7
- GOLCXWYRSKYTSP-UHFFFAOYSA-N arsenic trioxide Inorganic materials O1[As]2O[As]1O2 GOLCXWYRSKYTSP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 5
- 238000002560 therapeutic procedure Methods 0.000 claims description 5
- 239000000956 alloy Substances 0.000 claims description 3
- 229910045601 alloy Inorganic materials 0.000 claims description 3
- 229940079593 drug Drugs 0.000 abstract description 14
- 208000037803 restenosis Diseases 0.000 abstract description 10
- 230000006378 damage Effects 0.000 abstract description 6
- 208000027418 Wounds and injury Diseases 0.000 abstract description 3
- 208000014674 injury Diseases 0.000 abstract description 3
- 230000002792 vascular Effects 0.000 abstract description 3
- 238000002513 implantation Methods 0.000 abstract description 2
- 230000003449 preventive effect Effects 0.000 abstract description 2
- 230000001225 therapeutic effect Effects 0.000 abstract description 2
- 229960002594 arsenic trioxide Drugs 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 206010020718 hyperplasia Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 4
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 231100000004 severe toxicity Toxicity 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000004026 tunica intima Anatomy 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
带有药物膜的血管内支架，它涉及用介入法治疗心脑血管狭窄所用的血管内支架。它是在介入疗法治疗心脑血管狭窄所用的血管内支架(1)的外表面粘固有含有三氧化二砷的药物层(2)。药物层(2)的厚度为1.6～300μm。该支架在植入动脉血管损伤处后，其药物层(2)中的药物在血管局部损伤处缓慢释放，使局部组织药物浓度高，系统机体的药物浓度低，因此含有剧毒三氧化二砷的药物层(2)不会对系统机体产生影响，而对损伤的血管内膜的增生所产生的再狭窄起到了很好的防治作用，并彻底解决了全身系统用药在局部无效果的问题。用该带有药物膜的血管内支架可使介入治疗后再狭窄发生率下降到5％以下。
Description
技术领域：本实用新型涉及用介入法治疗心脑血管狭窄所用的血管内支架。
背景技术：在治疗心脑血管狭窄的过程中，介入治疗术后再狭窄发生率高达30～50％，介入治疗联合支架植入术再狭窄发生率达14～34％，防治再狭窄是提高疗效的关键。目前应用的全身系统的药物在局部损伤处获得的药物浓度过低，无明显的防治再狭窄的作用，因而临床应用无效果。用三氧化二砷作为制备防治血管再狭窄的药物，其抑制血管再狭窄的效果显著，但由于三氧化二砷有剧毒，因而不易进行全身系统的用药。
发明内容：本实用新型提供一种带有药物膜的血管内支架，它解决了介入法治疗心脑血管狭窄疾病过程中出现再狭窄的问题，以及用全身系统用药在局部无效果的问题。本实用新型是在介入疗法治疗心脑血管狭窄所用的血管内支架1的外表面粘固有含有三氧化二砷的药物层2。药物层2的厚度为1.6～300μm。该支架在植入动脉血管损伤处后，其药物层2中的药物在血管局部损伤处缓慢释放(参阅图三)，使局部组织药物浓度高，系统机体的药物浓度低，因此含有剧毒三氧化二砷的药物层2不会对系统机体产生影响，而对损伤的血管内膜的增生所产生的再狭窄起到了很好的防治作用，并彻底解决了全身系统用药在局部无效果的问题。用该带有药物膜的血管内支架可使介入治疗后再狭窄发生率下降到5％以下。
附图说明：图1是本实用新型带有药物膜的血管内支架的结构示意图，图2是图1中的血管内支架1中单条合金丝的断面图，图3是带有药物膜的血管内支架在动物体内时间—组织药物浓度曲线图。
具体实施方式一：本实施方式的带有药物膜的血管内支架1的外表面粘固有含三氧化二砷的药物层2，药物层2包裹在血管内支架1的每根合金丝3的外面，药物层2的厚度为10～30μm。
具体实施方式二：本实施方式与具体实施方式一不同的是药物层2的厚度为30～100μm。
Claims (5)
1、带有药物膜的血管内支架，其特征在于它是在介入疗法治疗心脑血管狭窄所用的血管内支架(1)的外表面粘固有含有三氧化二砷的药物层(2)。
2、根据权利要求1所述的带有药物膜的血管内支架，其特征在于药物层(2)的厚度为1.6～300μm。
3、根据权利要求1所述的带有药物膜的血管内支架，其特征在于药物层2的厚度为16～30μm。
4、根据权利要求1所述的带有药物膜的血管内支架，其特征在于药物层2的厚度为30～100μm。
5、根据权利要求1所述的带有药物膜的血管内支架，其特征在于药物层(2)包裹在血管内支架(1)的每根合金丝(3)的外面。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02274690U CN2561433Y (zh) | 2002-08-07 | 2002-08-07 | 带有药物膜的血管内支架 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02274690U CN2561433Y (zh) | 2002-08-07 | 2002-08-07 | 带有药物膜的血管内支架 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2561433Y true CN2561433Y (zh) | 2003-07-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN02274690U Expired - Lifetime CN2561433Y (zh) | 2002-08-07 | 2002-08-07 | 带有药物膜的血管内支架 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2561433Y (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006058479A1 (en) * | 2004-12-03 | 2006-06-08 | Beijing Amsino Medical Co., Ltd | A stent with impenetrable grooves or blind holes and a method for manufacturing it |
| CN100435756C (zh) * | 2005-01-31 | 2008-11-26 | 上海市第一人民医院 | 一种三氧化二砷控释洗脱支架 |
| WO2009067862A1 (en) * | 2007-11-27 | 2009-06-04 | Beijing Amsimo Medical Co., Ltd | An arsenic trioxide medical elution scaffold |
-
2002
- 2002-08-07 CN CN02274690U patent/CN2561433Y/zh not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006058479A1 (en) * | 2004-12-03 | 2006-06-08 | Beijing Amsino Medical Co., Ltd | A stent with impenetrable grooves or blind holes and a method for manufacturing it |
| CN100435756C (zh) * | 2005-01-31 | 2008-11-26 | 上海市第一人民医院 | 一种三氧化二砷控释洗脱支架 |
| WO2009067862A1 (en) * | 2007-11-27 | 2009-06-04 | Beijing Amsimo Medical Co., Ltd | An arsenic trioxide medical elution scaffold |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: BEIJING US-CHINA MEDICAL EQUIPMENT CO., LTD. Free format text: FORMER OWNER: YANG WEI Effective date: 20060224 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20060224 Address after: 100004, SOHO, outside the city of Beijing Building 16, 15 Floor Patentee after: Beijing AmsinoMed Medical Device Co., Ltd. Address before: 150001 No. 23, postal street, Nangang District, Heilongjiang, Harbin Patentee before: Yang Wei |
|
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20120807 Granted publication date: 20030723 |