CN220990819U - Production device of Carlong anhydride and production system of Carlong anhydride - Google Patents

Abstract

The application provides a production device of caron anhydride and a production system of caron anhydride, and relates to the field of production of caron anhydride.

Description

Production device of Carlong anhydride and production system of Carlong anhydride

Technical Field

The application relates to the field of production of caronic anhydride, in particular to a production device of caronic anhydride and a production system of caronic anhydride.

Background

Carbonic anhydride, also known as 6, 6-dimethyl-3-oxabicyclo hexane-2, 4-dione, is a pharmaceutical intermediate, mainly used for the synthesis of oral hepatitis C protease inhibitors.

In the related art, a large amount of equipment including various reaction kettles is needed in the production process of the caronic anhydride, so that the production period of the caronic anhydride is prolonged, and the production efficiency of the caronic anhydride is affected.

Disclosure of utility model

In order to overcome the defects in the prior art, the application provides a production device of caronic anhydride and a production system of caronic anhydride.

In a first aspect, the present application provides a production apparatus for caronic anhydride, comprising: the reaction unit comprises a feeding end and a discharging end, the filtering unit is connected with the discharging end so that first feed liquid in the reaction unit is input into the filtering unit, the crystallization unit is connected with the filtering unit so that filtrate in the filtering unit is input into the crystallization unit, the washing unit comprises a first end and a second end, the first end is connected with the filtering unit so that filter residues in the filtering unit are input into the washing unit, the second end is connected with the filtering unit so that washing liquid in the washing unit is input into the filtering unit, and the centrifugal unit is connected with the crystallization unit so that second feed liquid in the crystallization unit is input into the centrifugal unit.

With reference to the first aspect, in a possible implementation manner, the reaction unit includes: the device comprises a first reaction piece and a first valve, wherein the first reaction piece is provided with a first accommodating cavity, the feeding end is arranged on the first reaction piece, the discharging end is arranged on the first reaction piece, the first valve is arranged between the discharging end and the filtering unit, and the first valve is connected with the discharging end and the filtering unit.

With reference to the first aspect, in one possible implementation manner, the first reaction member is provided with a sampling port, the first reaction member is provided with a first temperature measurement member, and when the concentration of the first feed liquid in the sampling port reaches a preset concentration and the temperature value measured by the first temperature measurement member reaches a first preset temperature, the first valve is in an open state so as to input the first feed liquid into the filtering unit.

With reference to the first aspect, in one possible implementation manner, the first reaction member is provided with a first stirring member, and the first reaction member is connected with a temperature control member.

With reference to the first aspect, in one possible implementation manner, the filtering unit includes: the filter comprises an input end and an output end, wherein the input end is connected with the discharge end and the second end, the output end is connected with the first end and the crystallization unit, the second valve is arranged between the input end and the first end, and the second valve is connected with the input end and the first end.

With reference to the first aspect, in a possible implementation manner, a conveying member is disposed between the second valve and the first end, and the conveying member connects the first end and the second valve, and is used for inputting the washing liquid into the second valve.

With reference to the first aspect, in one possible implementation manner, the crystallization unit includes: the second reaction piece and third valve, the second reaction piece has the second and holds the chamber, be provided with the second stirring piece in the second reaction piece, just be provided with the second temperature measurement piece in the second reaction piece, work as second temperature measurement piece measuring temperature value is to the second when predetermineeing the temperature, the second stirring piece is in the stirring state, the third valve set up in the second reaction piece with between the centrifugal unit, the third valve is connected the second reaction piece with the centrifugal unit.

With reference to the first aspect, in one possible implementation manner, the second reaction member is provided with a measuring member, and the measuring member is used for measuring the acid-base number of the second feed liquid.

With reference to the first aspect, in one possible implementation manner, the washing unit includes: the third reaction piece and the fourth valve, the third reaction piece has the third and holds the chamber, first tip is located on the third reaction piece, the second tip is located on the third reaction piece, be provided with the third stirring piece in the third reaction piece, the fourth valve set up in the second tip with between the filter unit, just the fourth valve is connected the second tip with the filter unit.

In a second aspect, the application provides a production system of the caronic anhydride, which comprises the production device of the caronic anhydride.

Compared with the prior art, the application has the beneficial effects that:

The application provides a production device of caronic anhydride, which comprises: the method comprises the steps of filtering a first feed liquid in a reaction unit through the filtering unit to obtain filtrate and filter residues, crystallizing the filtrate through the crystallizing unit, conveying the filtrate into the centrifugal unit for centrifugation to obtain caron anhydride, washing the filter residues through the washing unit, and sequentially obtaining the caron anhydride after the obtained washing liquid sequentially passes through the filtering unit, the crystallizing unit and the centrifugal unit, so that the filter residues can be recycled, the yield of the caron anhydride is improved, the utilization rate of reaction raw materials is improved, and the production efficiency of the caron anhydride can be effectively improved.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present utility model and therefore should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 shows an overall construction of a production apparatus of a caron anhydride;

FIG. 2 shows a block diagram of a reaction unit of a production apparatus of a caron anhydride;

FIG. 3 shows a block diagram of a reaction unit of a filter unit of the caron anhydride;

FIG. 4 shows a block diagram of the reaction unit of the crystallization unit of the caron anhydride;

FIG. 5 shows a block diagram of the reaction unit of the washing unit of the caron anhydride;

FIG. 6 shows a block diagram of the reaction unit of the centrifugal unit of the Carbonic anhydride.

Description of main reference numerals:

A 100-reaction unit; 110-a first reaction member; 111-a feeding end; 112-a discharge end; 113-sampling port; 120-a first valve; 130-a first stirring member; 200-a filtration unit; 210-a filter; 211-input terminal; 212-an output; 220-a second valve; 300-crystallization unit; 310-a second reaction member; 311-a feed inlet; 312-a discharge port; 320-a third valve; 330-a second stirring member; 400-a washing unit; 410-a third reaction member; 411-first end; 412-a second end; 420-fourth valve; 430-a third stirring member; 500-a centrifugal unit; 510-centrifuge; 520-fifth valve; 600-a first window; 700-conveying member; 800-a flow guide; 900-sixth valve.

Detailed Description

Embodiments of the present application are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the application.

In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present application and simplifying the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present application.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present application, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.

In the present application, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art according to the specific circumstances.

In the present application, unless expressly stated or limited otherwise, a first feature "up" or "down" a second feature may be the first and second features in direct contact, or the first and second features in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.

Example 1

Referring to fig. 1 and 2, an embodiment of the present application provides a production apparatus of caronic anhydride, where the production apparatus of caronic anhydride includes: a reaction unit 100, a filtration unit 200, a crystallization unit 300, a washing unit 400, and a centrifugation unit 500. The reaction unit 100 includes a feeding end 111 and a discharging end 112. The filter unit 200 is connected to the discharge end 112, so that the first feed liquid in the reaction unit 100 is fed into the filter unit 200. The crystallization unit 300 is connected to the filtration unit 200 such that filtrate in the filtration unit 200 is inputted into the crystallization unit 300. Referring to fig. 1 and 5, the washing unit 400 includes a first end 411 and a second end 412. The first end 411 is connected to the filter unit 200 such that the filter residue in the filter unit 200 is inputted into the washing unit 400. The second end 412 is connected to the filter unit 200 to input the washing liquid in the washing unit 400 into the filter unit 200. The centrifugal unit 500 is connected with the crystallization unit 300, so that the second feed liquid in the crystallization unit 300 is input into the centrifugal unit 500, the first feed liquid in the reaction unit 100 is filtered by the filtering unit 200 to obtain filtrate and filter residues, the filtrate is crystallized by the crystallization unit 300 and then conveyed into the centrifugal unit 500 to be centrifuged to obtain the caron anhydride, and the filter residues are washed by the washing unit 400, and the obtained washing liquid sequentially passes through the filtering unit 200, the crystallization unit 300 and the centrifugal unit 500 to obtain the caron anhydride, so that the filter residues can be recycled, the yield of the caron anhydride is improved, the utilization ratio of reaction raw materials is improved, and the production efficiency of the caron anhydride can be effectively improved.

Referring to fig. 2, in some embodiments, the reaction unit 100 includes: the first reaction member 110 and the first valve 120. The first reaction part 110 has a first receiving chamber for receiving reaction raw materials. The feeding end 111 is disposed on the first reaction member 110, and a feeding port is disposed on the feeding end 111. The inlet is the inlet of reaction raw materials, and the number of the inlet is four, so as to be used for respectively inputting water, sodium hydroxide, cyhalofugic acid and potassium permanganate. The discharge end 112 is disposed on the first reaction member 110, and the discharge end 112 is located at an end of the first reaction member 110 away from the feeding end 111. The first valve 120 is disposed between the discharge end 112 and the filter unit 200, and the first valve 120 is connected to the discharge end 112 and the filter unit 200.

In other embodiments, the number of the input ports may be five, six, seven, eight, etc., which are not explicitly described herein.

In some embodiments, the first reaction member 110 is a reaction vessel, and the volume of the first reaction member 110 is 3000L. The input mass ratio of the water, the sodium hydroxide, the cyhalofugic acid and the potassium permanganate in the input port is 17.3:1:3.5:4.5.

Referring to fig. 2, in some embodiments, a first stirring member 130 is disposed in the first reaction member 110. The first stirring member 130 is used for stirring the reaction raw materials in the first reaction member 110.

In some embodiments, the first reaction member 110 is provided with a first temperature measurement member. The first temperature measuring member is configured to detect and display a temperature value of the first reaction member 110 in real time.

Referring to fig. 2, in some embodiments, the first reaction member 110 is provided with a sampling port 113. The sampling port 113 is located at one end of the first reaction member 110 near the discharge end 112, and the sampling port 113 is connected with a sampling bottle. When the concentration of the first feed liquid in the sampling bottle reaches a preset concentration and the temperature value measured by the first temperature measuring member reaches a first preset temperature, the first valve 120 is in an open state, so as to input the first feed liquid into the filtering unit 200.

In some embodiments, the reaction in the first reaction member 110 is ended when the main peak purity detected by gas chromatography of the first feed liquid in the sample bottle reaches a preset purity, and/or when the concentration of the cyhalofop acid in the first feed liquid reaches the preset concentration.

In some embodiments, the first reaction member 110 is in fluid communication with a temperature control member. The temperature control member is used for controlling the temperature of the first reaction member 110 so as to adjust the reaction temperature of the reaction raw materials according to actual requirements.

In some embodiments, the first valve 120 is a pneumatic valve, and the first valve 120 connects the discharge end 112 and the filter unit 200 through a flow guide 800. The flow guide 800 is a flow guide pipe.

Referring to fig. 2, in some embodiments, a first window 600 is disposed between the first valve 120 and the filter unit 200. The first window 600 is disposed on the flow guiding member 800, so that a worker can observe the first material liquid in the flow guiding member 800.

Referring to fig. 3, in some embodiments, the filtering unit 200 includes: a filter element 210 and a second valve 220. The filter 210 includes an input 211 and an output 212. The input end 211 is located at an end of the filter element 210 near the first reaction element 110, and the input end 211 connects the first valve 120 and the second end 412 through the flow guiding element 800. The output end 212 is located at one end of the filter 210 near the crystallization unit 300, the output end 212 is connected to the crystallization unit 300 through the guide 800 to convey the filtrate into the crystallization unit 300 for crystallization, and the output end 212 is connected to the first end 411 through a conveyor belt to convey the filter residue into the washing unit 400. The second valve 220 is disposed between the input end 211 and the first end 411, and the second valve 220 connects the input end 211 and the first end 411 through the flow guide 800.

In some embodiments, the second valves 220 are ball valves, the number of the second valves 220 is two, and two second valves 220 are disposed on the flow guiding member 800 in parallel, and the second valves 220 are used for controlling the amounts of the first liquid and the washing liquid input into the filtering member 210.

In some embodiments, a delivery member 700 is disposed between the second valve 220 and the first end 411. The delivery member 700 connects the first end 411 to the second valve 220 via the baffle member 800. The delivery member 700 is configured to deliver the washing liquid and the first liquid to the second valve 220.

In some embodiments, the delivery member 700 is a delivery pump.

Referring to fig. 4, in some embodiments, the crystallization unit 300 includes: the second reaction member 310 and the third valve 320. The second reaction part 310 has a second receiving chamber for receiving the filtrate. The second stirring member 330 is disposed in the second reaction member 310, and the second temperature measuring member is disposed in the second reaction member 310. When the temperature value measured by the second temperature measuring member reaches a second preset temperature, the second stirring member 330 is in a stirring state. The third valve 320 is disposed between the second reaction member 310 and the centrifugal unit 500, and the third valve 320 connects the second reaction member 310 and the centrifugal unit 500 through the flow guide member 800.

In some embodiments, the third valve 320 is a pneumatic valve, the third valve 320 is used for controlling the amount of the second feed liquid input into the centrifugal unit 500, and a second window is disposed between the third valve 320 and the centrifugal unit 500. The second window is disposed on the flow guiding member 800, so that a worker can observe the second material liquid in the flow guiding member 800.

In some embodiments, the second reaction member 310 is a crystallization kettle, the volume of the second reaction member 310 is 5000L, the second reaction member 310 uses cold ethylene glycol to cool, and a feed inlet 311 and a discharge outlet 312 are disposed on the second reaction member 310. The feeding port 311 is located at one end of the second reaction member 310 away from the centrifugal unit 500, and the feeding port 311 is used for feeding concentrated sulfuric acid. The discharge port 312 is located at one end of the second reaction member 310 near the centrifugal unit 500. The third valve 320 is disposed between the discharge port 312 and the centrifugal unit 500, and the third valve 320 is connected to the discharge port 312 and the centrifugal unit 500 through the flow guide 800.

In some embodiments, a measurement member is disposed in the second reaction member 310. The measuring part is configured to measure the ph of the second feed liquid in real time, and when the ph measured by the measuring part reaches a preset ph, a large amount of solids are precipitated in the second reaction part 310.

Referring to fig. 5, in some embodiments, the washing unit 400 includes: the third reaction member 410 and the fourth valve 420. The third reaction part 410 has a third receiving chamber for receiving the filter residue. The first end 411 is located at an end of the third reaction member 410 away from the filter member 210, and a dispensing opening is provided on the first end 411. The throwing port is used for throwing filter residues and water. The second end 412 is located at an end of the third reaction member 410 near the filter member 210, and a drain is provided on the second end 412. The discharge port is used for discharging the washing liquid. The fourth valve 420 is disposed between the discharge port and the delivery member 700, and the fourth valve 420 connects the discharge port and the delivery member 700 through the flow guide member 800.

In some embodiments, the third reaction member 410 is a reaction kettle, the volume of the third reaction member 410 is 2000L, and the third stirring member 430 is disposed in the third reaction member 410. The third stirring member 430 stirs the mixed water and the filter residue to form the washing solution. After the third stirring member 430 is stirred for a preset time, the fourth valve 420 is in an opened state, so that the washing liquid is input into the filtering member 210 for filtering, the filter residues can be recycled as the production raw material of the caronic anhydride, the recycling rate of the filter residues is improved, the production amount of the caronic anhydride can be effectively improved, and the production efficiency of the caronic anhydride is improved.

In some embodiments, the fourth valve 420 is a pneumatic valve, the fourth valve 420 is used to control the amount of the washing liquid input into the transporting member 700, and a third window is provided between the fourth valve 420 and the transporting member 700. The third window is disposed on the flow guiding member 800, so that a worker can observe the washing liquid in the flow guiding member 800.

Referring to fig. 6, in some embodiments, the centrifugal unit 500 includes: centrifuge 510 and fifth valve 520. The centrifuge 510 is connected to the third valve 320 via the flow guide 800. The second window is disposed between the third valve 320 and the centrifuge 510. The fifth valve 520 is a ball valve, the fifth valve 520 is disposed between the second window and the centrifugal member 510, and the fifth valve 520 is connected to the second window and the centrifugal member 510 through the flow guiding member 800, and the fifth valve 520 is used for controlling the amount of the second feed liquid input into the centrifugal member 510.

In some embodiments, the centrifuge 510 is a fluorine lined centrifuge, a filter bag is disposed in the centrifuge 510, and the centrifuge 510 is centrifuged until no mother liquor flows out to obtain a filter cake on the filter bag, and the filter cake is caronic anhydride.

Referring to fig. 1, in some embodiments, a sixth valve 900 is disposed between the transport 700 and the third window. The sixth valve 900 connects the third window with the conveying member 700 through the flow guiding member 800, the sixth valve 900 is a ball valve, and the sixth valve 900 is used for controlling the amounts of the washing liquid and the first liquid in the conveying member 700.

The method comprises the steps that each reaction raw material is put into the first reaction piece 110 through the input port, the first stirring piece 130 can stir each reaction raw material so that each reaction raw material is uniformly mixed, the reaction speed of each reaction raw material can be accelerated, the temperature control piece can control the reaction temperature of each reaction raw material according to actual reaction requirements, the reaction speed can be further accelerated so as to improve the production efficiency of the caron anhydride, after the reaction of each reaction raw material in the first reaction piece 110 is finished, the conveying piece 700 pumps the first material into the filtering piece 210 for filtering, so that filtrate is input into the second reaction piece 310 along the guide piece 800 for reaction crystallization, so that the second material is obtained, the second material is input into the centrifugal piece 510 along the guide piece 800 for centrifugation, so that caron anhydride is obtained on the filter bag, the filter residue can be input into the third reaction piece 410 for stirring so as to form the washing liquid, the washing liquid is pumped into the filter piece 210 along the guide piece, the second reaction piece 310 is used for pulping the second reaction piece, so that the production efficiency of the caron anhydride can be further improved, the production efficiency of the filter piece is improved, compared with the traditional apparatus can be further used for producing the caron anhydride, the quantity can be improved, and the production efficiency of the caron anhydride can be further improved, and the production device can be used for producing the caron anhydride by using the filter piece 510, and the filter piece is further improved.

Example two

The embodiment of the present application provides a production system (not shown in the figure) of caronic anhydride, which includes the production system of caronic anhydride in any one of the above embodiments, so that all the beneficial effects of the production system of caronic anhydride in any one of the above embodiments are not described in detail herein.

In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present application. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.

While embodiments of the present application have been shown and described above, it will be understood that the above embodiments are illustrative and not to be construed as limiting the application, and that variations, modifications, alternatives and variations may be made to the above embodiments by one of ordinary skill in the art within the scope of the application.

Claims (10)

1. A production device of caron anhydride, characterized by comprising:

The reaction unit comprises a feeding end and a discharging end;

The filtering unit is connected with the discharge end so that the first feed liquid in the reaction unit is input into the filtering unit;

the crystallization unit is connected with the filtering unit so that filtrate in the filtering unit is input into the crystallization unit;

The washing unit comprises a first end part and a second end part, the first end part is connected with the filtering unit so that filter residues in the filtering unit are input into the washing unit, and the second end part is connected with the filtering unit so that washing liquid in the washing unit is input into the filtering unit;

and the centrifugal unit is connected with the crystallization unit so that the second feed liquid in the crystallization unit is input into the centrifugal unit.

2. The production apparatus of caron anhydride according to claim 1, wherein the reaction unit comprises:

The first reaction piece is provided with a first accommodating cavity, the feeding end is arranged on the first reaction piece, and the discharging end is arranged on the first reaction piece;

The first valve is arranged between the discharge end and the filtering unit and is connected with the discharge end and the filtering unit.

3. The apparatus for producing of caron anhydride according to claim 2, wherein a sampling port is provided on the first reaction member, a first temperature measuring member is provided on the first reaction member, and when the concentration of the first feed liquid in the sampling port reaches a preset concentration and the temperature value measured by the first temperature measuring member reaches a first preset temperature, the first valve is in an opened state to input the first feed liquid into the filtration unit.

4. The apparatus for producing of caron anhydride according to claim 2, wherein a first stirring member is provided in the first reaction member, and the first reaction member is connected to a temperature control member.

5. The production apparatus of caron anhydride according to claim 1, wherein the filtration unit comprises:

The filter piece comprises an input end and an output end, the input end is connected with the discharge end and the second end, and the output end is connected with the first end and the crystallization unit;

The second valve is arranged between the input end and the first end part and is connected with the input end and the first end part.

6. The apparatus for producing caron anhydride according to claim 5, wherein a conveying member is provided between the second valve and the first end, the conveying member connecting the first end and the second valve, the conveying member being for inputting the washing liquid into the second valve.

7. The production apparatus of caron anhydride according to claim 1, wherein the crystallization unit comprises:

The second reaction piece is provided with a second accommodating cavity, a second stirring piece is arranged in the second reaction piece, a second temperature measuring piece is arranged in the second reaction piece, and the second stirring piece is in a stirring state when the temperature value measured by the second temperature measuring piece reaches a second preset temperature;

And the third valve is arranged between the second reaction piece and the centrifugal unit and is connected with the second reaction piece and the centrifugal unit.

8. The apparatus for producing caron anhydride according to claim 7, wherein a measuring member for measuring the acid-base number of the second feed liquid is provided in the second reaction member.

9. The production plant of caron anhydride according to any one of claims 1 to 8, characterized in that the washing unit comprises:

The third reaction piece is provided with a third accommodating cavity, the first end part is positioned on the third reaction piece, the second end part is positioned on the third reaction piece, and a third stirring piece is arranged in the third reaction piece;

And the fourth valve is arranged between the second end part and the filtering unit and is connected with the second end part and the filtering unit.

10. A production system of caronic anhydride, characterized by comprising a production device of caronic anhydride according to any one of claims 1-9.