CN211585289U - Continuous constant concentration crystallization device - Google Patents
Continuous constant concentration crystallization device Download PDFInfo
- Publication number
- CN211585289U CN211585289U CN201922268368.7U CN201922268368U CN211585289U CN 211585289 U CN211585289 U CN 211585289U CN 201922268368 U CN201922268368 U CN 201922268368U CN 211585289 U CN211585289 U CN 211585289U
- Authority
- CN
- China
- Prior art keywords
- pipeline
- crystallizer
- crystallization
- solenoid valve
- controller
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000002425 crystallisation Methods 0.000 title claims abstract description 56
- 230000008025 crystallization Effects 0.000 title claims abstract description 56
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 44
- 238000001514 detection method Methods 0.000 claims abstract description 15
- 238000003756 stirring Methods 0.000 claims abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 abstract description 8
- 239000012452 mother liquor Substances 0.000 description 11
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 description 8
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 description 8
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 description 8
- 239000013078 crystal Substances 0.000 description 3
- 238000005034 decoration Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010977 unit operation Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Abstract
The utility model provides a continuous constant concentration crystallization device, including crystallizer, No. 1 pipeline, No. 2 pipeline, controller, No. 1 solenoid valve, No. 2 solenoid valve and signal line, the crystallizer is inside to be set up the (mixing) shaft, sets up the stirring rake on this (mixing) shaft, the lower part sets up online alcohol concentration detection sensor in the crystallizer, be provided with No. 2 solenoid valve on the No. 1 pipeline, be provided with No. 1 solenoid valve on the No. 2 pipeline, this the one end of No. 1 pipeline and No. 2 pipeline gets into in the crystallizer from the crystallizer top, and the other end is used for putting through feed liquid and high concentration alcohol, the controller is connected with online alcohol concentration detection sensor, No. 1 solenoid valve and No. 2 solenoid valve through the signal line; the device simple structure, it is automatic strong, control accurate, guaranteed that the crystallization process is continuous, stable, crystallization product granularity homogeneous, purity height.
Description
Technical Field
The utility model belongs to the technical field of bio-separation engineering equipment and specifically relates to a continuous constant concentration crystallization device.
Background
Crystallization is one of the important chemical unit operations. Many biological products (e.g., cytidine) require crystallization operations to extract the desired product based on their solubility in alcohol (ethanol) and water. Research finds that the alcohol concentration in the crystallization mother liquor seriously influences the quality of the crystallized product in the crystallization process, including the crystal granularity, purity and the like of the product.
Most of the existing equipment is batch crystallization or continuous crystallization, the process is extensive, the automation degree of manual operation is low, the alcohol concentration in the crystallization mother liquor is suddenly high and suddenly low, and the quality of the crystallization product and the labor production efficiency are seriously influenced.
SUMMERY OF THE UTILITY MODEL
The utility model aims to solve the technical problem that a continuous constant concentration crystallization device is provided.
In order to solve the technical problem, the technical scheme of the utility model is that:
the utility model provides a continuous permanent concentration crystallization device, includes crystallizer, No. 1 pipeline, No. 2 pipelines, controller, No. 1 solenoid valve, No. 2 solenoid valve and signal line, the inside (mixing) shaft that sets up of crystallizer sets up the stirring rake on this (mixing) shaft, the lower part sets up online alcohol concentration detection sensor in the crystallizer, be provided with No. 2 solenoid valves on the No. 1 pipeline, be provided with No. 1 solenoid valve on the No. 2 pipeline, this the one end of No. 1 pipeline and No. 2 pipelines is followed in the crystallizer top gets into the crystallizer jar, and the other end is used for putting through feed liquid and high concentration alcohol, controller passing signal line is connected with online alcohol concentration detection sensor, No. 1 solenoid valve and No. 2 solenoid valve.
Preferably, in the continuous constant concentration crystallization device, a bottom discharge opening is arranged at the bottom of the crystallization tank.
In the continuous constant-concentration crystallization device, the low-speed stirring is performed when the stirring paddle in the crystallization tank works so as to strengthen the mass and heat transfer in the crystallization tank, the No. 1 electromagnetic valve and the No. 2 electromagnetic valve can control the opening and closing of a pipeline and the flow, and the controller can acquire signals of an online alcohol concentration detection sensor and serially control the electromagnetic valves to work; and the controller can set the alcohol concentration in the crystallizing tank according to the process requirements, set the response time and the response interval, and further control the flow of the pipeline by monitoring the crystallization of the crystallization mother liquor in the crystallizing tank in real time and controlling the electromagnetic valve, so that the alcohol concentration of the crystallization mother liquor is always kept relatively stable, and the continuous constant-concentration crystallization of a target product is realized.
Has the advantages that:
according to the continuous constant-concentration crystallization device, the controller collects the alcohol concentration of the crystallization mother liquor in real time through the online alcohol concentration detection sensor, the electromagnetic valve is controlled, the flow of the pipeline is further controlled, the alcohol concentration in the crystallization tank is maintained to be relatively stable, and the target product is crystallized in the crystallization tank at a continuous constant concentration; the device simple structure, it is automatic strong, control accurate, guaranteed that the crystallization process is continuous, stable, crystallization product granularity homogeneous, purity height.
Drawings
Fig. 1 is a schematic structural diagram of the continuous constant concentration crystallization device of the present invention.
In the figure: 1. the system comprises a crystallizing tank, a pipeline No. 2.1, a pipeline No. 3.2, an online alcohol concentration detection sensor No. 4, a controller No. 5, an electromagnetic valve No. 6.1, an electromagnetic valve No. 7.2 and a signal line 8.
Detailed Description
Example 1
As shown in fig. 1, continuous constant concentration crystallization device, including crystallizer 1, No. 1 pipeline 2, No. 2 pipeline 3, controller 5, No. 1 solenoid valve 6, No. 2 solenoid valve 7 and signal line 8, the inside (mixing) shaft that sets up of crystallizer sets up the stirring rake on this (mixing) shaft, the lower part sets up online alcohol concentration detection sensor 4 in the crystallizer, the crystallizer bottom sets up the bottom bin outlet, be provided with No. 2 solenoid valves on No. 1 pipeline, be provided with No. 1 solenoid valve on No. 2 pipeline, this the one end of No. 1 pipeline and No. 2 pipeline is followed in the crystallizer top gets into the crystallizer jar, the other end is used for putting through feed liquid and high concentration alcohol, controller passing signal line is connected with online alcohol concentration detection sensor, No. 1 solenoid valve and No. 2 solenoid valve.
In the continuous constant-concentration crystallization device, the low-speed stirring is performed when the stirring paddle in the crystallization tank works so as to strengthen the mass and heat transfer in the crystallization tank, the No. 1 electromagnetic valve and the No. 2 electromagnetic valve can control the opening and closing of a pipeline and the flow, and the controller can acquire signals of an online alcohol concentration detection sensor and serially control the electromagnetic valves to work; and the controller can set the alcohol concentration in the crystallizing tank according to the process requirements, set the response time and the response interval, and further control the flow of the pipeline by monitoring the crystallization of the crystallization mother liquor in the crystallizing tank in real time and controlling the electromagnetic valve, so that the alcohol concentration of the crystallization mother liquor is always kept relatively stable, and the continuous constant-concentration crystallization of a target product is realized.
Example 2
The above continuous constant concentration crystallization apparatus is further explained taking cytidine crystallization as an example:
cytidine extract (containing pigment and other water-soluble impurities, and not containing alcohol) is communicated with a No. 1 pipeline 2, 95% alcohol is communicated with a No. 2 pipeline 3, a crystallizing tank 1 is started to stir at a low speed, a little cytidine extract is put into the crystallizing tank 1, and the liquid level is over an online alcohol concentration detection sensor 4 and a stirring paddle.
Cytidine extract is continuously fed into the crystallization tank 1 at a low speed by a controller 5 through a No. 1 electromagnetic valve 6 controlled by a No. 1 pipeline 2, a crystallization mother liquor signal is continuously collected by an online alcohol concentration detection sensor 4 and is transmitted to the controller 5, the controller 5 (the alcohol concentration is set to be 60%, the response time is 3s, the corresponding interval is 3%, and the alcohol concentration is controlled to be 57-63%) detects that the alcohol concentration in the crystallization mother liquor is lower than a set value (57%), the controller 5 controls the No. 2 electromagnetic valve 7 to be opened at a small flow rate, 95% alcohol is continuously fed into the crystallization tank 1, the alcohol concentration is continuously increased, after 3s, the alcohol concentration in the crystallization mother liquor is still lower than the set value, the controller controls the No. 2 electromagnetic valve 7 to be opened at a large flow rate, the 95% alcohol is continuously fed into the crystallization tank 1 at a high speed, the flow rate; when the online alcohol concentration detection sensor 4 detects that the alcohol concentration in the crystallization tank 1 is higher than a set value (63%), the alcohol concentration is still higher than the set value after the first 3s, the flow of the controller 5 and the electromagnetic valve No. 2 7 is controlled to be reduced, the alcohol concentration in the crystallization tank 1 is always maintained at 57-63%, cytidine is stably crystallized and precipitated from mother liquor, the crystal granularity is uniform, and impurities are few. In the crystallization process, the cytidine extract and 95% alcohol are continuously fed to maintain the constant concentration of the alcohol, crystals are continuously separated out in the crystallization tank 1, the crystallized product is continuously discharged from a discharge outlet at the bottom of the crystallization tank 1, and the continuous constant concentration crystallization of the cytidine is realized in the whole process.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (2)
1. A continuous constant concentration crystallization apparatus, characterized in that: including crystallizer, No. 1 pipeline, No. 2 pipelines, controller, No. 1 solenoid valve, No. 2 solenoid valves and signal line, the inside (mixing) shaft that sets up of crystallizer sets up the stirring rake on this (mixing) shaft, the lower part sets up online alcohol concentration detection sensor in the crystallizer, be provided with No. 2 solenoid valves on No. 1 pipelines, be provided with No. 1 solenoid valve on No. 2 pipelines, this the one end of No. 1 pipeline and No. 2 pipelines is followed in the crystallizer top gets into the crystallizer, and the other end is used for putting through feed liquid and high concentration alcohol, controller passing signal line is connected with online alcohol concentration detection sensor, No. 1 solenoid valve and No. 2 solenoid valves.
2. The continuous constant concentration crystallization apparatus according to claim 1, wherein: the bottom of the crystallizing tank is provided with a bottom discharge outlet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922268368.7U CN211585289U (en) | 2019-12-17 | 2019-12-17 | Continuous constant concentration crystallization device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922268368.7U CN211585289U (en) | 2019-12-17 | 2019-12-17 | Continuous constant concentration crystallization device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211585289U true CN211585289U (en) | 2020-09-29 |
Family
ID=72593017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922268368.7U Expired - Fee Related CN211585289U (en) | 2019-12-17 | 2019-12-17 | Continuous constant concentration crystallization device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211585289U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114748888A (en) * | 2022-04-27 | 2022-07-15 | 安徽海华科技集团有限公司 | Thymol automatic continuous crystallization system and method |
-
2019
- 2019-12-17 CN CN201922268368.7U patent/CN211585289U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114748888A (en) * | 2022-04-27 | 2022-07-15 | 安徽海华科技集团有限公司 | Thymol automatic continuous crystallization system and method |
| CN114748888B (en) * | 2022-04-27 | 2024-06-07 | 安徽海华科技集团有限公司 | Automatic continuous crystallization system and method for thymol |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0185407B1 (en) | Method and device for the carrying out of a microbiological or enzymatic process | |
| CN109734582B (en) | Production process of sodium acetate | |
| CN106916726B (en) | A kind of fermentation process coupled with separation system for continuously fermenting on a large scale | |
| CN211585289U (en) | Continuous constant concentration crystallization device | |
| CN110451582A (en) | A kind of ferric trichloride quantity-produced method | |
| CN101693658B (en) | Method and device for continuously dynamic crystallization production of calcium lactate | |
| CN203577363U (en) | Automatic-control chilled water overflowing-prevention crystallization kettle | |
| CN102940975A (en) | Crystallization kettle | |
| CN211435164U (en) | Continuous crystallization process unit of sodium bisulfite menadione | |
| CN203763892U (en) | Continuous crystallization device for iminodiacetonitrile | |
| CN103266183A (en) | Cane juice transit container and method | |
| CN102830670A (en) | Online dilution system and dilution method for sugar boiling material | |
| CN207708564U (en) | Potassium permanganate DTB crystallizes production system | |
| CN100567312C (en) | Continuous crystallisation process in the glyphosate production | |
| CN107583482A (en) | Sugar refinery molasses serial dilution intelligence control system | |
| CN214050520U (en) | Ammonium chloride salt thick liquid cooling crystallization device | |
| CN111518119B (en) | Continuous amoxicillin crystallization process | |
| CN111235325A (en) | Automatic sugar boiling control system and method for sugar refinery | |
| CN202844629U (en) | Crystallizing kettle | |
| CN209173755U (en) | Strengthen the device of solid continuous-dissolution and lysate transfer | |
| CN209307256U (en) | The device of concentration of adipic acid in a kind of reduction cold mother liquor | |
| CN209405724U (en) | Continuous crystallisation device | |
| CN102826991B (en) | Process and device for continuous acidification of acidification section in production of sebacic acid | |
| CN212223017U (en) | Automatic control system for sugar boiling of sugar refinery | |
| CN219252229U (en) | Equipment for preparing high-purity disodium uridylate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200929 |