CN220968163U - Liquid chromatographic column - Google Patents
Liquid chromatographic column Download PDFInfo
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- CN220968163U CN220968163U CN202322550683.5U CN202322550683U CN220968163U CN 220968163 U CN220968163 U CN 220968163U CN 202322550683 U CN202322550683 U CN 202322550683U CN 220968163 U CN220968163 U CN 220968163U
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- pipe
- end cover
- annular
- inlet pipe
- outlet
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- 239000007788 liquid Substances 0.000 title abstract description 21
- 238000007789 sealing Methods 0.000 claims abstract description 80
- 238000001125 extrusion Methods 0.000 claims abstract description 29
- 239000007791 liquid phase Substances 0.000 claims description 20
- 238000004811 liquid chromatography Methods 0.000 claims description 10
- 239000012071 phase Substances 0.000 description 5
- 238000000926 separation method Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 2
- 238000013375 chromatographic separation Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 239000008358 core component Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model discloses a liquid chromatographic column, which comprises a cylindrical tube with an opening at the upper end and a closed lower end, wherein the upper end of the cylindrical tube is in threaded connection with an end cover, the liquid inlet of the end cover is in threaded connection with an inlet tube, the liquid outlet of the lower end of the cylindrical tube is in threaded connection with an outlet tube, annular bosses and sealing rings are arranged between the end cover and the cylindrical tube, between the inlet tube and the end cover and between the outlet tube and the cylindrical tube, the annular bosses are matched with annular grooves, the annular bosses are clamped into the annular grooves for primary sealing, the sealing rings are matched with extrusion inclined planes for extruding the sealing rings, the extrusion inclined planes are matched with each other to form a sealing ring accommodating cavity, and the sealing rings are extruded by the extrusion inclined planes to realize another sealing. According to the utility model, the sealing ring of the sealing ring accommodating cavity and the annular sealing boss/groove are used for realizing twice sealing, so that the sealing performance of the liquid chromatographic tube is greatly improved.
Description
Technical Field
The utility model relates to the technical field of chromatographic columns, in particular to a liquid chromatographic column sealing structure.
Background
The liquid chromatography technology is a rapid preparation column chromatography form, which is based on the fact that pressure is generated by a pump to accelerate the elution speed of a mobile phase passing through a prefilled chromatographic separation column, the core component of the liquid chromatography column is the liquid chromatography column, and the separation principle is as follows: the sample of the mixture is dissolved in a mobile phase and is made to pass through the fixed phase adsorbent packed inside the liquid chromatographic column at certain speed, and the mixture components flow through the fixed phase adsorbent at different speed to reach the aim of separation. The performance of the liquid chromatographic column as a place and a tool for chromatographic separation fundamentally determines the quality of the separation effect. The usual liquid chromatography columns are filled with fine-particle size packing to obtain high resolution, but the fluid resistance of the fine-particle size packing is often high, and a high-pressure pump must be used to forcibly transport the mobile phase through the column, so the column itself must have good pressure-tight sealing properties.
The sealing structures at the head end and the tail end of the liquid chromatographic column have a critical influence on the column loading performance and the sealing performance of the liquid chromatographic column. The existing liquid chromatographic column has poor sealing performance and mostly has liquid leakage phenomenon.
Disclosure of utility model
The utility model aims to provide a sealing structure of a liquid chromatographic column, which can greatly improve the sealing performance of the liquid chromatographic column.
In order to achieve the technical purpose, the technical scheme of the utility model is as follows:
The liquid chromatographic column comprises an upper end opening and a lower end closed cylindrical tube, wherein an end cover is arranged at the upper end of the cylindrical tube, the end cover is in threaded connection with the cylindrical tube, an end cover annular boss is arranged at the upper end of the cylindrical tube, an end cover annular groove for clamping the end cover annular boss in is formed in the end cover annular groove, an end cover sealing ring is arranged on the end cover annular boss, an end cover extrusion inclined surface for extruding the end cover sealing ring is arranged on the end cover, and the end cover extrusion inclined surface and the cylindrical tube and the end cover annular boss form an end cover sealing ring accommodating cavity.
When the sealing sleeve is used, the end cover sealing sleeve is sleeved on the annular boss of the end cover, the end cover is rotated, the end cover and the cylindrical pipe are connected through threads, the annular boss of the end cover is gradually clamped into the annular groove of the end cover in the threaded connection process of the end cover and the cylindrical pipe, and the inclined surface of the end cover is extruded to extrude the end cover sealing ring, so that a gap between the sealing end cover and the cylindrical pipe is realized.
The end cover is provided with the liquid phase import, the liquid phase import is provided with the intake pipe, intake pipe and end cover threaded connection, the intake pipe is provided with the annular protruding edge of intake pipe, between the annular protruding edge of intake pipe and end cover, the annular protruding edge of intake pipe is provided with the annular boss of intake pipe, the end cover is provided with the annular recess of intake pipe that supplies the annular boss card of intake pipe to go into, the annular boss card of intake pipe goes into the annular recess of intake pipe, be provided with the intake pipe sealing washer on the intake pipe, the end cover is provided with the intake pipe extrusion inclined plane of extrusion intake pipe sealing washer, intake pipe extrusion inclined plane and intake pipe and the annular protruding edge of intake pipe constitute intake pipe sealing washer holding chamber.
When the sealing sleeve is used, the inlet pipe sealing sleeve is sleeved on the inlet pipe, the inlet pipe is rotated to enable the inlet pipe to be in threaded connection with the end cover, the annular boss of the inlet pipe is gradually clamped into the annular groove of the inlet pipe in the threaded connection process of the inlet pipe and the end cover, and the inlet pipe extrusion inclined plane extrudes the inlet pipe sealing ring, so that a gap between the sealing inlet pipe and the end cover is realized.
The liquid phase extrusion device is characterized in that a liquid phase outlet is arranged at the lower end of the cylindrical pipe, an outlet pipe is arranged at the liquid phase outlet, the outlet pipe is in threaded connection with the cylindrical pipe, an annular protruding edge of the outlet pipe is arranged between the annular protruding edge of the outlet pipe and the cylindrical pipe, an annular protruding edge of the outlet pipe is provided with an annular boss of the outlet pipe, the cylindrical pipe is provided with an annular groove of the outlet pipe, which is clamped in by the annular boss of the outlet pipe, the annular boss of the outlet pipe is clamped in the annular groove of the outlet pipe, an outlet pipe sealing ring is arranged on the outlet pipe, an outlet pipe extrusion inclined surface for extruding the outlet pipe sealing ring is arranged on the cylindrical pipe, and the outlet pipe extrusion inclined surface and the annular protruding edge of the outlet pipe form an outlet pipe sealing ring accommodating cavity.
When the sealing sleeve is used, the sealing sleeve of the outlet pipe is sleeved on the outlet pipe, the outlet pipe is rotated, the outlet pipe is connected with the cylindrical pipe through threads, the annular boss of the outlet pipe is gradually clamped into the annular groove of the outlet pipe in the process of connecting the outlet pipe with the cylindrical pipe through threads, and the extrusion inclined plane of the outlet pipe extrudes the sealing ring of the outlet pipe, so that the gap between the sealing outlet pipe and the cylindrical pipe is realized.
The annular convex edge of the inlet pipe is arranged in the cylindrical pipe and positioned at the inner side of the end cover.
The lower end of the cylindrical pipe is provided with a screen plate fixing groove which is communicated with the liquid phase outlet, and a first screen plate is arranged in the screen plate fixing groove.
And a second sieve plate is also arranged in the cylindrical tube.
The joint between the pipe wall of the cylindrical pipe and the lower end of the cylindrical pipe is arc transition-shaped.
The end cover annular groove, the inlet pipe annular groove and the outlet pipe annular groove are all provided with annular sealing rings. The sealing is carried out by the auxiliary annular groove of the annular sealing ring and the annular convex block, so that the sealing performance of the liquid chromatographic tube is further improved.
According to the utility model, the sealing ring of the sealing ring accommodating cavity and the annular sealing boss/groove are used for realizing twice sealing, so that the sealing performance of the liquid chromatographic tube is greatly improved. Meanwhile, the sieve plate fixing groove can bear the sieve plate with smaller size, so that a larger gap between the periphery of the sieve plate and the liquid phase outlet is avoided, and the separation effect is finally improved. Since the shrinkage of the screen panels of the same material is constant, the smaller the diameter of the screen panels, the smaller the shrinkage of the screen panels during actual use, thereby reducing the shrinkage of the lower screen panels.
Drawings
The utility model will be described in further detail with reference to the drawings and the detailed description.
FIG. 1 is a schematic diagram of the structure of the present utility model.
FIG. 2 is a schematic view of the inlet pipe structure of the present utility model.
FIG. 3 is a schematic view of the outlet pipe structure of the present utility model.
Detailed Description
As shown in fig. 1-3, the liquid chromatographic column comprises a cylindrical tube 1 with an opening at the upper end and a closed lower end, an end cover 2 is arranged at the upper end of the cylindrical tube 1, the end cover 2 is connected to the outer wall of the cylindrical tube 1 through threads, an end cover annular boss 11 is arranged on the upper end of the cylindrical tube 1 between the end cover 2 and the cylindrical tube 1, an end cover annular groove 21 for clamping the end cover annular boss 11 is arranged on the side wall of the cylindrical tube 1, an annular sealing ring is arranged in the end cover annular groove 21, the end cover annular boss 11 is clamped in the end cover annular groove 21, an end cover sealing ring is sleeved on the end cover annular boss 11, an end cover extrusion inclined surface 91 for extruding the end cover sealing ring is arranged on the end cover 2, and the end cover extrusion inclined surface 91 and the cylindrical tube 1 and the end cover annular boss 11 form an end cover sealing ring accommodating cavity.
The end cover 2 is provided with a liquid phase inlet, the liquid phase inlet is provided with an inlet pipe 3, the inlet pipe 3 is connected with the liquid phase inlet of the end cover 2 through threads, the inlet pipe 3 is provided with an inlet pipe annular convex edge 31, and the inlet pipe annular convex edge 31 is positioned at the root of the inlet pipe 3 and positioned in the cylindrical pipe 1.
Between the annular protruding edge 31 of the inlet pipe and the end cover 2, the annular protruding edge 31 of the inlet pipe is provided with an annular boss 32 of the inlet pipe, the end cover 2 is provided with an annular groove 22 of the inlet pipe for clamping the annular boss 32 of the inlet pipe, an annular sealing ring is arranged in the annular groove 22 of the inlet pipe, the annular boss 32 of the inlet pipe is clamped in the annular groove 22 of the inlet pipe, the inlet pipe 3 is sleeved with the sealing ring of the inlet pipe, the end cover 2 is provided with an extrusion inclined plane 92 of the inlet pipe for extruding the sealing ring of the inlet pipe, and the extrusion inclined plane 92 of the inlet pipe, the inlet pipe 3 and the annular protruding edge 31 of the inlet pipe form an accommodating cavity of the sealing ring of the inlet pipe.
The liquid phase outlet is arranged at the lower end of the cylindrical tube 1 and is positioned on the end face of the cylindrical tube 1, which is sealed at the lower end, the liquid phase outlet is provided with an outlet tube 4, the outlet tube 4 is connected with the liquid phase outlet of the cylindrical tube 1 through threads, the outlet tube 4 is provided with an outlet tube annular convex edge 41, an outlet tube annular convex edge 41 and the cylindrical tube 1 are arranged between the outlet tube annular convex edge 41 and the cylindrical tube 1, the outlet tube annular convex edge 41 is provided with an outlet tube annular boss 42, the cylindrical tube 11 is provided with an outlet tube annular groove 12 for the outlet tube annular boss 42 to be clamped in, an annular sealing ring is arranged in the outlet tube annular groove 12, the outlet tube 4 is sleeved with an outlet tube sealing ring, and the cylindrical tube 1 is provided with an outlet tube extrusion inclined surface 93 for extruding the outlet tube sealing ring, and the outlet tube 4 and the outlet tube annular convex edge 41 form an outlet tube sealing ring accommodating cavity.
The lower end of the cylindrical pipe 1 is provided with a sieve plate fixing groove 5, the sieve plate fixing groove 5 is communicated with the outlet pipe 4 (liquid phase outlet), and a first sieve plate 51 is arranged in the sieve plate fixing groove 5.
A second screen plate 52 is also arranged in the cylindrical tube 1.
The joint between the pipe wall of the cylindrical pipe 1 and the lower end of the cylindrical pipe 1 is arc transition-shaped.
When the liquid chromatograph tube sealing device is used, the sealing ring is assisted by the annular groove (the end cover annular groove 21, the inlet tube annular groove 22 and the outlet tube annular groove 12) and the annular convex block for primary sealing, and the sealing ring is extruded by the extrusion inclined plane (the end cover extrusion inclined plane 91, the inlet tube extrusion inclined plane 92 and the outlet tube extrusion inclined plane 93), so that the sealing ring is filled in the sealing ring accommodating cavity for secondary sealing, and the sealing performance of the liquid chromatograph tube is greatly improved.
The above embodiments do not limit the present utility model in any way, and all technical solutions obtained by equivalent substitution or equivalent transformation fall within the protection scope of the present utility model.
Claims (6)
1. A liquid chromatography column, characterized in that: the sealing device comprises a cylindrical pipe with an opening at the upper end and a closed lower end, wherein the upper end of the cylindrical pipe is provided with an end cover, the end cover is in threaded connection with the cylindrical pipe, the upper end of the cylindrical pipe is provided with an end cover annular boss, the end cover is provided with an end cover annular groove for the end cover annular boss to be clamped in, the end cover annular boss is clamped in the end cover annular groove, the end cover annular boss is provided with an end cover sealing ring, the end cover is provided with an end cover extrusion inclined plane for extruding the end cover sealing ring, and the end cover extrusion inclined plane, the cylindrical pipe and the end cover annular boss form an end cover sealing ring accommodating cavity; the end cover is provided with a liquid-phase inlet, the liquid-phase inlet is provided with an inlet pipe, the inlet pipe is in threaded connection with the end cover, the inlet pipe is provided with an inlet pipe annular convex edge, an inlet pipe annular boss is arranged between the inlet pipe annular convex edge and the end cover, the end cover is provided with an inlet pipe annular groove for the inlet pipe annular boss to be clamped in, the inlet pipe annular boss is clamped in the inlet pipe annular groove, the inlet pipe is provided with an inlet pipe sealing ring, the end cover is provided with an inlet pipe extrusion inclined plane for extruding the inlet pipe sealing ring, and the inlet pipe extrusion inclined plane, the inlet pipe and the inlet pipe annular convex edge form an inlet pipe sealing ring accommodating cavity; the liquid phase extrusion device is characterized in that a liquid phase outlet is arranged at the lower end of the cylindrical pipe, an outlet pipe is arranged at the liquid phase outlet, the outlet pipe is in threaded connection with the cylindrical pipe, an annular protruding edge of the outlet pipe is arranged between the annular protruding edge of the outlet pipe and the cylindrical pipe, an annular protruding edge of the outlet pipe is provided with an annular boss of the outlet pipe, the cylindrical pipe is provided with an annular groove of the outlet pipe, which is clamped in by the annular boss of the outlet pipe, the annular boss of the outlet pipe is clamped in the annular groove of the outlet pipe, an outlet pipe sealing ring is arranged on the outlet pipe, an outlet pipe extrusion inclined surface for extruding the outlet pipe sealing ring is arranged on the cylindrical pipe, and the outlet pipe extrusion inclined surface and the annular protruding edge of the outlet pipe form an outlet pipe sealing ring accommodating cavity.
2. The liquid chromatography column of claim 1, wherein: the annular convex edge of the inlet pipe is arranged in the cylindrical pipe.
3. The liquid chromatography column of claim 1, wherein: the lower end of the cylindrical pipe is provided with a screen plate fixing groove which is communicated with the liquid phase outlet, and a first screen plate is arranged in the screen plate fixing groove.
4. A liquid chromatography column according to claim 3, wherein: and a second sieve plate is also arranged in the cylindrical tube.
5. The liquid chromatography column of claim 1, wherein: the joint between the pipe wall of the cylindrical pipe and the lower end of the cylindrical pipe is arc transition-shaped.
6. The liquid chromatography column of claim 1, wherein: the end cover annular groove, the inlet pipe annular groove and the outlet pipe annular groove are all provided with annular sealing rings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322550683.5U CN220968163U (en) | 2023-09-20 | 2023-09-20 | Liquid chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322550683.5U CN220968163U (en) | 2023-09-20 | 2023-09-20 | Liquid chromatographic column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220968163U true CN220968163U (en) | 2024-05-17 |
Family
ID=91063531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322550683.5U Active CN220968163U (en) | 2023-09-20 | 2023-09-20 | Liquid chromatographic column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220968163U (en) |
-
2023
- 2023-09-20 CN CN202322550683.5U patent/CN220968163U/en active Active
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