CN220940005U - Combined tangential flow filtration device - Google Patents
Combined tangential flow filtration device Download PDFInfo
- Publication number
- CN220940005U CN220940005U CN202322653826.5U CN202322653826U CN220940005U CN 220940005 U CN220940005 U CN 220940005U CN 202322653826 U CN202322653826 U CN 202322653826U CN 220940005 U CN220940005 U CN 220940005U
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- end plate
- membrane package
- tangential flow
- filter membrane
- flow filtration
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- 238000009295 crossflow filtration Methods 0.000 title claims abstract description 27
- 239000012528 membrane Substances 0.000 claims abstract description 113
- 239000007788 liquid Substances 0.000 claims abstract description 102
- 238000001914 filtration Methods 0.000 claims abstract description 92
- 238000007789 sealing Methods 0.000 claims abstract description 45
- 239000000463 material Substances 0.000 abstract description 17
- 241000700605 Viruses Species 0.000 abstract description 12
- 238000009434 installation Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 4
- 230000003014 reinforcing effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- 239000012065 filter cake Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005374 membrane filtration Methods 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Landscapes
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The utility model discloses a combined tangential flow filtration device which comprises a filtration membrane package, a guide plate in sealing fit with one end face of the filtration membrane package and a sealing end plate in sealing fit with the other end face of the filtration membrane package, wherein the filtration membrane package is provided with at least one liquid inlet, at least one liquid outlet and at least one air outlet, one side of the guide plate, which is close to the filtration membrane package, is provided with a liquid inlet, a liquid outlet and an air outlet, which are respectively corresponding to the liquid inlet, the liquid outlet and the air outlet, and the guide plate is provided with a liquid inlet port communicated with the liquid inlet, a liquid outlet port communicated with the liquid outlet and an air outlet port communicated with the air outlet. The utility model aims to provide a combined tangential flow filtration device which forms an autologous seal under the clamping action of an external clamping device, so that the external clamping device is prevented from being in direct contact with materials, and viruses are effectively prevented from remaining on the external clamping device.
Description
Technical Field
The utility model belongs to the technical field of filtering equipment, and particularly relates to a combined tangential flow filtration device.
Background
The membrane filtration is a high-efficiency and stable separation technology, has the advantages of high filtration efficiency, low energy consumption, small occupied area and the like, and is widely applied to the biopharmaceutical industry. Membrane filtration can be classified into tangential flow filtration and dead-end filtration according to the relationship between the flow direction of the material and the material filtration direction during filtration. In dead-end filtration, the material filtering direction is the same as the flowing direction, a filter cake layer and a gel layer are easy to form on the surface of the filtering membrane, and the filtering efficiency of the filtering membrane is reduced; in tangential flow filtration, the material filtering direction is perpendicular to the flowing direction, the material continuously washes the surface of the filtering membrane to prevent the formation of a filter cake layer, and the service life and the filtering efficiency of the filtering membrane are improved
The filter membrane package is used as a most common tangential flow filtration module, such as chinese patent publication No.: CN217092921U, discloses an integrated sealing film package. In the virus removal process, the material containing the virus flows along the pipeline, the external clamping device and the filter membrane package, and the virus removal is completed under the action of the filter membrane package. The external clamping device is in direct contact with the filtering membrane bag, so that a large amount of viruses can remain, potential safety hazards exist, and particularly when the filtering membrane bag is assembled and disassembled with the external clamping device, materials with the viruses remain easily to leak, so that the safety of the production process is greatly reduced.
Disclosure of utility model
The utility model provides a combined tangential flow filtration device, which forms self-sealing under the clamping action of an external clamping device, prevents the external clamping device from directly contacting materials, and effectively prevents viruses from remaining on the external clamping device.
In order to achieve the above purpose, the present utility model adopts the following technical scheme:
The utility model provides a combination formula tangential flow filtration device, includes filtration membrane package, with filtration membrane package one of them terminal surface sealing fit's guide plate and with filtration membrane package another terminal surface sealing fit's sealed end plate, filtration membrane package is equipped with at least one inlet, at least one liquid outlet and at least one gas vent, the guide plate be close to filtration membrane package one side be equipped with inlet, liquid outlet and gas vent that correspond respectively of inlet, liquid outlet and gas vent, the guide plate be equipped with the inlet port of inlet intercommunication, with the outlet port of outlet intercommunication and with the exhaust interface of exhaust hole intercommunication. The material enters into the filtration membrane package through the guide plate drainage, and the both ends of filtration membrane package carry out sealing fit with guide plate and sealed end plate respectively, and outside clamping device forms extrusion seal through centre gripping guide plate and sealed end plate to filtration membrane package, can thoroughly isolate the contact between filtration membrane package and the clamping device to solve outside clamping device's virus residual problem, effectively improve production safety.
Preferably, one side of the guide plate, which is close to the filtering membrane bag, is provided with a groove body matched with the periphery of the filtering membrane bag, the inner wall of the groove body is provided with a bulge, and the periphery of the filtering membrane bag is provided with a positioning groove matched with the bulge. The positioning grooves and the protrusions of the guide plates are used for positioning, so that the filter membrane package is accurately installed and positioned on the guide plates.
Preferably, a sealing part is arranged on the periphery of the filtering membrane bag, and the positioning groove is arranged on the sealing part. The sealing part can have good sealing effect with the guide plate when being extruded, and the positioning effect of the filtering membrane bag is ensured through the cooperation of the positioning groove and the bulge.
Preferably, the filtering membrane package and the guide plate are integrally formed. Better sealing performance is provided between the filtering membrane package and the guide plate, the possibility of leakage between the filtering membrane package and the guide plate is reduced, and the pollution caused by materials containing viruses is avoided.
Preferably, the baffle, the filter membrane package and the sealing end plate are integrally formed. Like this, have better sealing performance between guide plate and the filtration membrane package and between filtration membrane package and the sealed end plate to when using, only need be connected each interface on the guide plate with outside pipeline and can accomplish the installation, effectively avoid leaking because of the installation problem leads to the material that contains the virus.
Preferably, the guide plate is provided with a liquid inlet runner communicated with the liquid inlet hole and the liquid inlet interface, a liquid outlet runner communicated with the liquid outlet hole and the liquid outlet interface, and an exhaust runner communicated with the exhaust hole and the exhaust interface.
Preferably, at least two filter membrane bags are arranged between the guide plate and the sealing end plate, a middle end plate is arranged between the adjacent filter membrane bags, and an end plate liquid inlet, an end plate liquid outlet and an end plate air outlet are arranged on the middle end plate so as to be communicated with the adjacent filter membrane bags. The filter membrane bags are arranged, so that the requirements of various treatment capacities can be met, the middle end plate is arranged between the adjacent filter membrane bags, the material is isolated from leakage under the condition that the material flows between the adjacent filter membrane bags, and the pollution of viruses to the environment is reduced.
Preferably, a middle end plate is arranged between the filtering membrane package and the guide plate, and the middle end plate is provided with an end plate liquid inlet, an end plate liquid outlet and an end plate air outlet so as to be communicated with the filtering membrane package and the guide plate. The middle end plate can enable the filtering membrane package to be stressed uniformly, and improves the sealing performance between the filtering membrane package and the guide plate.
Preferably, the periphery of the middle end plate is provided with a middle end plate groove. The middle end plate groove corresponds to the positioning groove of the filtering membrane bag in position, so that the middle end plate is convenient to install.
Preferably, a plurality of reinforcing ribs are arranged on one side of the guide plate, which is far away from the filtering membrane bag. The reinforcing ribs improve the overall strength of the guide plate, and the mechanical stability of the guide plate is ensured after clamping.
The beneficial effects of the utility model are as follows: (1) The external clamping device is prevented from contacting with the material containing viruses and the filtering membrane bag by matching the guide plate, the filtering membrane bag and the sealing end plate, so that the possibility of pollution is reduced; (2) The liquid inlet interface, the liquid outlet interface and the exhaust interface are all arranged on the guide plate, so that materials circulate only between one end of the filter membrane bag, which is close to the guide plate, and the inside of the filter membrane bag, the circulation area of the materials is reduced, and the pollution risk area is reduced; (3) The installation steps of the combined tangential flow filtration device are simplified through integral molding, the installation difficulty is reduced, and meanwhile, the leakage risk caused by the installation problem of the filtration membrane package is avoided; (4) The plurality of filter membrane bags are stacked and sealed by the sealing end plate, so that the filter membrane bag can be used for meeting the process requirements of various treatment capacity and adapting to the process environment of various treatment requirements.
Drawings
FIG. 1 is a schematic structural view of embodiment 1 of the present utility model;
FIG. 2 is a schematic diagram of the structure of a filtration membrane pack according to example 1 of the present utility model;
FIG. 3 is an exploded view of example 1 of the present utility model;
FIG. 4 is a cross-sectional view of the inlet flow path location of embodiment 1 of the present utility model;
FIG. 5 is a schematic structural view of embodiment 2 of the present utility model;
FIG. 6 is an exploded view of example 2 of the present utility model;
FIG. 7 is a schematic view showing the structure of embodiment 3 of the present utility model;
FIG. 8 is an exploded view of example 3 of the present utility model;
In the figure: sealing end plate 1, sealing end plate groove 1a, filtering membrane package 2, liquid inlet 21, positioning groove 22, liquid outlet 23, sealing portion 24, air outlet 25, baffle 3, liquid inlet 3a, liquid outlet 3b, air outlet 3c, liquid inlet 31, liquid outlet 32, liquid outlet channel 33, air outlet 34, protrusion 35, groove 36, reinforcing rib 37, liquid inlet channel 38, middle end plate 4, end plate liquid inlet 41, end plate liquid outlet 42, middle end plate groove 43, end plate air outlet 44.
Detailed Description
The utility model is further described below with reference to the drawings and detailed description.
Example 1
In the embodiment shown in figure 1 of the drawings,
The utility model provides a modular tangential flow filtration device, as shown in FIG. 1, includes filtration membrane package 2, guide plate 3 and sealed end plate 1, and wherein, filtration membrane package 2 has two terminal surfaces, is respectively with the relative first terminal surface that sets up of guide plate 3 and the relative second terminal surface that sets up with sealed end plate 1, guide plate 3 and the sealed cooperation of the first terminal surface of filtration membrane package 2, sealed end plate 1 and the sealed cooperation of the second terminal surface of filtration membrane package 2. As shown in fig. 2, the structure of the filtering membrane package 2 is composed of a liquid inlet unit, a permeation unit and a sealing part 24, wherein a plurality of groups of liquid inlet 21, liquid outlet 23 and air outlet 25 corresponding to each other are arranged on the liquid inlet unit and the permeation unit, and each group of liquid inlet 21, liquid outlet 23 and air outlet 25 forms a liquid inlet channel, a liquid outlet channel and an air outlet channel of the filtering membrane package 2. The sealing portion 24 is provided on the outer periphery of the filtration membrane pack 2, and seals the outer periphery of the liquid inlet unit and the permeation unit.
As shown in fig. 3, the baffle 3 is provided with a liquid inlet 31 corresponding to the liquid inlet 21, a liquid outlet 32 corresponding to the liquid outlet 23, and an air outlet 34 corresponding to the air outlet 25 on the side close to the filtering membrane pack 2. The baffle 3 is provided with a liquid inlet port 3a communicated with the liquid inlet hole 31, a liquid outlet port 3b communicated with the liquid outlet hole 32 and an exhaust port 3c communicated with the exhaust hole 34.
The baffle 3 is provided with a liquid inlet channel 38 which is communicated with the liquid inlet hole 31 and the liquid inlet port 3a, a liquid outlet channel 33 which is communicated with the liquid outlet hole 32 and the liquid outlet port 3b, and an exhaust channel which is communicated with the exhaust hole 34 and the exhaust port 3 c. In the present embodiment, the liquid inlet channel 38 and the air outlet channel are provided inside the baffle plate 3, as shown in fig. 4, taking the liquid inlet channel 38 as an example, the liquid inlet channel 38 is provided below the liquid inlet holes 31 and communicates with all the liquid inlet holes 31 in sequence. The liquid outlet channels 33 are arranged on the surface of the baffle 3, which is close to one side of the filtering membrane bag 2, and as shown in fig. 3, after the liquid outlet channels 33 communicated with the liquid outlet holes 32 converge towards the center, the liquid outlet channels are communicated with the liquid outlet port 3b through the inside of the baffle 3. In addition, as shown in fig. 4, a plurality of reinforcing ribs 37 are provided on one side of the baffle 3 away from the filtering membrane pack 2, thereby improving the overall strength of the baffle 3.
As shown in fig. 3 and 4, a middle end plate 4 is arranged between the filtering membrane package 2 and the guide plate 3, and the middle end plate 4 is provided with an end plate liquid inlet 41, an end plate liquid outlet 42 and an end plate air outlet 44 so as to be communicated with the filtering membrane package 2 and the guide plate 3. The middle end plate 4 can be made of elastic materials, so that the tightness of connection between the filtering membrane bag 2 and the guide plate 3 can be further improved.
In order to facilitate positioning of the filtering membrane package 2, the baffle 3, the sealing end plate 1 and the middle end plate 4, as shown in fig. 3, a groove body 36 matched with the periphery of the filtering membrane package 2 is arranged on one side, close to the filtering membrane package 2, of the baffle 3, a protrusion 35 is arranged on the inner wall of the groove body 36, a positioning groove 22 matched with the protrusion 35 is arranged on the sealing part 24 on the periphery of the filtering membrane package 2, a middle end plate groove 43 is arranged on the periphery of the middle end plate 4, a sealing end plate groove 1a is arranged on the periphery of the sealing end plate 1, and the positioning groove 22, the middle end plate groove 43 and the sealing end plate groove 1a correspond to each other, so that the filtering membrane package 2, the sealing end plate 1 and the middle end plate 4 can be conveniently and rapidly aligned for installation.
In order to improve the installation convenience and avoid the problems of incomplete lamination or installation dislocation and the like, the sealing end plate 1, the filtering membrane bag 2, the middle end plate 4 and the guide plate 3 can be integrally formed, and the integral forming comprises one or more of adhesive forming, thermal welding forming, ultrasonic welding forming and vortex welding forming.
Example 2
Embodiment 2 differs from embodiment 1 in that, as shown in fig. 5 and 6, two filter membrane packages 2 are provided between the baffle 3 and the sealing end plate 1, a middle end plate 4 is provided between the two filter membrane packages 2, and the middle end plate 4 is provided with an end plate liquid inlet 41, an end plate liquid outlet 42 and an end plate air outlet 44 to communicate with adjacent filter membrane packages 2. In addition, filtration membrane package 2, middle end plate 4 and guide plate 3 are as an organic whole formed, and sealed end plate 1 sets up on keeping away from the outer terminal surface of filtration membrane package 2 of guide plate 3, and sealed end plate 1 acts on filtration membrane package 2 closely laminating through outside centre gripping to realize the whole seal of combination formula tangential flow filtration device.
Example 3
A combined tangential flow filtration device, as shown in figures 7 and 8, comprises a seal endplate 1, a filter membrane package 2, a middle endplate 4, and a baffle 3. The filtering membrane package 2 includes a liquid inlet 21, an air outlet 25 and two liquid outlets 23, and in this embodiment, only one of the liquid outlets 23 is used to improve the liquid outlet stability and the stability of the baffle 3. The filtering membrane package 2 has two terminal surfaces, is respectively with the relative first terminal surface that sets up of guide plate 3 and the relative second terminal surface that sets up of sealed end plate 1, guide plate 3 and the sealed cooperation of the first terminal surface of filtering membrane package 2, sealed end plate 1 and the sealed cooperation of the second terminal surface of filtering membrane package 2.
The baffle 3 is provided with a liquid inlet hole 31 corresponding to the liquid inlet 21, a liquid outlet hole 32 corresponding to the liquid outlet 23 and an exhaust hole 34 corresponding to the exhaust port 25 on one side close to the filtering membrane bag 2. The baffle 3 is provided with a liquid inlet port 3a communicated with the liquid inlet hole 31, a liquid outlet port 3b communicated with the liquid outlet hole 32 and an exhaust port 3c communicated with the exhaust hole 34. The guide plate 3 is internally provided with a liquid inlet flow passage communicated with the liquid inlet hole 31 and the liquid inlet port 3a, a liquid outlet flow passage communicated with the liquid outlet hole 32 and the liquid outlet port 3b and an exhaust flow passage communicated with the exhaust hole 34 and the exhaust port 3c.
In order to facilitate positioning of the filtering membrane package 2, the baffle 3, the sealing end plate 1 and the middle end plate 4, as shown in fig. 8, a groove body 36 matched with the periphery of the filtering membrane package 2 is arranged on one side, close to the filtering membrane package 2, of the baffle 3, a protrusion 35 is arranged on the inner wall of the groove body 36, a positioning groove 22 matched with the protrusion 35 is arranged on the sealing part 24 on the periphery of the filtering membrane package 2, a middle end plate groove 43 is arranged on the periphery of the middle end plate 4, a sealing end plate groove 1a is arranged on the periphery of the sealing end plate 1, and the positioning groove 22, the middle end plate groove 43 and the sealing end plate groove 1a correspond to each other, so that the filtering membrane package 2, the sealing end plate 1 and the middle end plate 4 can be aligned and installed conveniently and rapidly.
The sealing end plate 1, the filtering membrane package 2, the middle end plate 4 and the guide plate 3 are stacked, and are tightly attached through the external clamping effect, so that the combined tangential flow filtration device is obtained. In addition, in order to increase the throughput of the combined tangential flow filtration device, the stacking amount of the filtration membrane packages 2 may be increased, thereby obtaining a combined tangential flow filtration device having different throughput, and an additional middle endplate 4 is provided between the filtration membrane packages 2, thereby improving the sealability between the filtration membrane packages 2.
The foregoing has outlined rather broadly the more detailed description of embodiments of the utility model, wherein the principles and embodiments of the utility model are explained in detail using specific examples, the above examples being provided solely to facilitate the understanding of the method and core concepts of the utility model; meanwhile, as those skilled in the art will have variations in the specific embodiments and application scope in light of the ideas of the present utility model, the present description should not be construed as limiting the present utility model.
Claims (10)
1. The utility model provides a modular tangential flow filtration device, characterized by, including filtration membrane package (2), with filtration membrane package (2) one of them terminal surface sealing fit's guide plate (3) and with filtration membrane package (2) another terminal surface sealing fit's sealed end plate (1), filtration membrane package (2) are equipped with at least one inlet (21), at least one liquid outlet (23) and at least one gas vent (25), one side that guide plate (3) are close to filtration membrane package (2) is equipped with inlet (21), liquid outlet (23) and gas vent (25) respectively corresponding inlet (31), outlet (32) and exhaust hole (34), guide plate (3) are equipped with inlet (3 a) with inlet (31) intercommunication, outlet (3 b) with outlet (32) intercommunication and exhaust interface (3 c) with exhaust hole (34) intercommunication.
2. A combined tangential flow filtration device according to claim 1, characterized in that the side of the deflector (3) close to the filter membrane package (2) is provided with a groove body (36) matching the periphery of the filter membrane package (2), the inner wall of the groove body (36) is provided with a protrusion (35), and the periphery of the filter membrane package (2) is provided with a positioning groove (22) matching the protrusion (35).
3. A combined tangential flow filtration device according to claim 2, wherein the outer periphery of the filter membrane package (2) is provided with a sealing portion (24), and wherein the positioning groove (22) is provided on the sealing portion (24).
4. A combined tangential flow filtration device according to claim 1, wherein the filter membrane package (2) is integrally formed with the baffle (3).
5. A combined tangential flow filtration device according to claim 1, characterized in that the baffle (3), the filter membrane package (2) and the sealing end plate (1) are integrally formed.
6. A combined tangential flow filtration device according to claim 1, characterized in that the baffle (3) is provided with a liquid inlet channel (38) communicating with the liquid inlet opening (31) and the liquid inlet port (3 a), a liquid outlet channel (33) communicating with the liquid outlet opening (32) and the liquid outlet port (3 b), and an air outlet channel communicating with the air outlet opening (34) and the air outlet port (3 c).
7. A combined tangential flow filtration device according to claim 1, characterized in that at least two filter membrane packages (2) are arranged between the baffle (3) and the sealing end plate (1), an intermediate end plate (4) is arranged between adjacent filter membrane packages (2), and the intermediate end plate (4) is provided with an end plate liquid inlet (41), an end plate liquid outlet (42) and an end plate air outlet (44) for communicating with adjacent filter membrane packages (2).
8. A combined tangential flow filtration device according to claim 1, characterized in that an intermediate endplate (4) is arranged between the filter membrane package (2) and the baffle (3), said intermediate endplate (4) being provided with an endplate liquid inlet (41), an endplate liquid outlet (42) and an endplate gas outlet (44) for communicating the filter membrane package (2) with the baffle (3).
9. A combined tangential flow filtration device according to claim 7 or 8, characterized in that the intermediate endplate (4) is peripherally provided with intermediate endplate grooves (43).
10. A combined tangential flow filtration device according to claim 1, characterized in that the side of the baffle (3) remote from the filter membrane package (2) is provided with a number of stiffening ribs (37).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322653826.5U CN220940005U (en) | 2023-09-28 | 2023-09-28 | Combined tangential flow filtration device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322653826.5U CN220940005U (en) | 2023-09-28 | 2023-09-28 | Combined tangential flow filtration device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220940005U true CN220940005U (en) | 2024-05-14 |
Family
ID=91024486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322653826.5U Active CN220940005U (en) | 2023-09-28 | 2023-09-28 | Combined tangential flow filtration device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220940005U (en) |
-
2023
- 2023-09-28 CN CN202322653826.5U patent/CN220940005U/en active Active
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240527 Address after: Room 1522-4, Building 2, Lianke Business Center, No. 1558 Xisaishan Road, Huzhou City, Zhejiang Province, 313001 (self declared) Patentee after: Huzhou Xinkecheng Technology Co.,Ltd. Country or region after: China Address before: Room 101, 1 / F, building 6, Heke science and technology center, No.500 QiaoXin Road, Xiasha street, Qiantang New District, Hangzhou City, Zhejiang Province, 310018 Patentee before: Hangzhou Huawei Biotechnology Co.,Ltd. Country or region before: China |