CN220804580U - Liquid chromatographic column cleaning device - Google Patents
Liquid chromatographic column cleaning device Download PDFInfo
- Publication number
- CN220804580U CN220804580U CN202322106498.7U CN202322106498U CN220804580U CN 220804580 U CN220804580 U CN 220804580U CN 202322106498 U CN202322106498 U CN 202322106498U CN 220804580 U CN220804580 U CN 220804580U
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- fixedly connected
- box body
- liquid
- cleaning device
- pipe
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- 239000007788 liquid Substances 0.000 title claims abstract description 74
- 238000004140 cleaning Methods 0.000 title claims abstract description 43
- 238000010438 heat treatment Methods 0.000 claims abstract description 10
- 238000004811 liquid chromatography Methods 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000007789 sealing Methods 0.000 claims description 2
- 239000003344 environmental pollutant Substances 0.000 abstract description 5
- 231100000719 pollutant Toxicity 0.000 abstract description 5
- 238000004090 dissolution Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 238000011010 flushing procedure Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
Landscapes
- Cleaning By Liquid Or Steam (AREA)
Abstract
The utility model provides a liquid chromatographic column cleaning device, and belongs to the technical field of chromatographic column cleaning. The liquid chromatographic column cleaning device comprises a box body and a heating mechanism, wherein a placing plate is fixedly connected between the inner walls of the box body, a plurality of placing holes are formed in the placing plate, a baffle is arranged at the bottom of each of the plurality of placing holes, and the baffle is in sliding connection with the placing plate; the heating mechanism comprises a hot air blower, an air inlet pipe, an air outlet pipe and an exhaust hole, and the hot air blower is fixedly connected to one side of the box body; the air inlet pipe is fixedly connected with the air inlet end of the air heater; the air outlet pipe is fixedly connected to the air outlet end of the air heater; the exhaust hole is formed in one side of the box body, the air heater is started to generate hot air to enter the box body through the air outlet pipe, the inside of the box body is heated, the temperature of the inside of the box body is increased, the dissolution of pollutants and cleaning liquid in the liquid chromatographic column is accelerated, and the air is discharged through the exhaust hole, so that the cleaning effect is improved.
Description
Technical Field
The utility model relates to the technical field of chromatographic column cleaning, in particular to a liquid chromatographic column cleaning device.
Background
The liquid chromatography technology is a high-efficiency separation and purification technology and is widely applied in a plurality of fields, such as: chemical industry, biology, food, medicine, etc. The liquid chromatographic column is a liquid chromatographic analysis instrument, is a core part of liquid chromatography, is a main place for realizing substance separation, can directly influence the performance of separation and purification, is a core and a front edge in the technical research field of liquid chromatography all the time, has sample molecules remained in the column, a connector and a flow cell after being used, and needs to be cleaned in a correct mode in time at the moment, and can be flushed by acetonitrile, methanol or other organic solvents with different concentrations according to the components of an experimental sample during cleaning.
The existing liquid chromatographic column cleaning device uses cleaning liquid to clean in the cleaning process, the cleaning liquid is basically at normal temperature, so that pollutants in the liquid chromatographic column are not thoroughly dissolved in the cleaning process, the cleaning effect is reduced, and therefore, the liquid chromatographic column cleaning device is provided to solve the problems.
Disclosure of utility model
In order to overcome the above disadvantages, the present utility model provides a liquid chromatography column cleaning device that overcomes or at least partially solves the above technical problems.
The utility model provides a liquid chromatographic column cleaning device, which comprises
The box body is fixedly connected with a placing plate between the inner walls of the box body;
a heating mechanism, the heating mechanism comprising
The air heater is fixedly connected to the left side of the box body;
the air inlet pipe is fixedly connected with the air inlet end of the air heater;
The air outlet pipe is fixedly connected to the air outlet end of the air heater;
the exhaust hole is formed in the right side of the box body.
In a preferred scheme, a plurality of placing holes are formed in the placing plate, a baffle is arranged at the bottom of each placing hole, and the baffle is in sliding connection with the placing plate.
In a preferred scheme, the rear side fixedly connected with electric telescopic handle of box, electric telescopic handle's flexible end and baffle fixed connection.
In a preferred scheme, box sliding connection has the collecting box, the exhaust hole sets up between collecting box and baffle, the anterior fixedly connected with first handle of collecting box, the top surface of placing the board sets up to the inclined plane, place the board on and seted up down the mouth of a river.
In a preferred scheme, a box door is arranged on the box body, and a second handle is fixedly connected to the front part of the box door.
In a preferred scheme, the top fixedly connected with of placing the board is with placing the first fixed plate of hole the same quantity, the rear side fixedly connected with motor of box, the output fixedly connected with threaded rod of motor.
In a preferred scheme, fixedly connected with gag lever post on the inner wall of box, threaded rod threaded connection has the slider, slider and gag lever post sliding connection, slider fixedly connected with connecting rod, connecting rod fixedly connected with mounting panel, one side fixedly connected with of mounting panel and first fixed plate equiquantity second fixed plate.
In a preferred scheme, the top fixedly connected with liquid reserve tank of box, be provided with the feed liquor pipe on the liquid reserve tank, be provided with sealed lid on the feed liquor pipe.
In a preferred scheme, the top fixedly connected with delivery pump of box, fixedly connected with connecting pipe between delivery pump's water inlet and the liquid reserve tank, delivery pump's delivery port fixedly connected with pivot pipe, pivot pipe fixedly connected with conveyer pipe, be provided with on the conveyer pipe with second fixed plate equiquantity drain pipe.
The liquid chromatographic column cleaning device provided by the utility model has the beneficial effects that:
1. Through starting the air heater, the air heater will produce hot-blast entering box inside through the tuber pipe of going out for inside temperature rises, accelerates the inside pollutant of liquid chromatography column and the dissolution of washing liquid, and gaseous discharge through the exhaust hole has improved the cleaning performance.
2. Through starting the delivery pump, the connecting pipe will extract the washing liquid in the liquid reserve tank, reaches the conveyer pipe through the pivot pipe, finally spouts by the drain pipe of a plurality of, washs a plurality of liquid chromatography columns, can wash a plurality of liquid chromatography columns simultaneously, has improved cleaning efficiency.
Drawings
For a clearer description of the technical solutions of the embodiments of the present utility model, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some examples of the present utility model and should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art;
FIG. 1 is a perspective view of an overall structure provided by an embodiment of the present utility model;
fig. 2 is a schematic view of an internal structure of a case according to an embodiment of the present utility model;
Fig. 3 is a perspective view of an internal top view structure of a case according to an embodiment of the present utility model;
FIG. 4 is a schematic diagram of a rear view structure according to an embodiment of the present utility model;
FIG. 5 is a schematic view of a partial cross-sectional structure provided in an embodiment of the present utility model;
In the figure: 1. a case; 2. a heating mechanism; 201. an air heater; 202. an air inlet pipe; 203. an air outlet pipe; 204. an exhaust hole; 3. placing a plate; 4. placing the hole; 5. an electric telescopic rod; 6. a baffle; 7. a collection box; 8. a first handle; 9. a door; 10. a second handle; 11. a water outlet; 12. a first fixing plate; 13. a motor; 14. a threaded rod; 15. a limit rod; 16. a slide block; 17. a connecting rod; 18. a mounting plate; 19. a second fixing plate; 20. a liquid storage tank; 21. a liquid inlet pipe; 22. sealing cover; 23. a transfer pump; 24. a connecting pipe; 25. a pivot tube; 26. a delivery tube; 27. and a liquid outlet pipe.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present utility model more apparent, the technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model, and it is apparent that the described embodiments are some embodiments of the present utility model, but not all embodiments. All other embodiments, based on the embodiments of the utility model, which are apparent to those of ordinary skill in the art without inventive faculty, are intended to be within the scope of the utility model.
Referring to fig. 1-5, the present utility model provides a technical solution: the liquid chromatographic column cleaning device comprises a box body 1 and a heating mechanism 2, wherein a placing plate 3 is fixedly connected between the inner walls of the box body 1; the heating mechanism 2 comprises a hot air blower 201, an air inlet pipe 202, an air outlet pipe 203 and an exhaust hole 204, wherein the hot air blower 201 is fixedly connected to the left side of the box body 1; the air inlet pipe 202 is fixedly connected with the air inlet end of the air heater 201; the air outlet pipe 203 is fixedly connected to the air outlet end of the air heater 201; the exhaust hole 204 is formed in the right side of the box body 1, hot air is generated by starting the hot air blower 201, the hot air blower 201 enters the box body 1 through the air outlet pipe 203, the interior of the box body 1 is heated, the temperature of the interior is increased, the dissolution of pollutants and cleaning liquid in the liquid chromatographic column is accelerated, and the gas is discharged through the exhaust hole 204, so that the cleaning effect is improved; the specific temperature in the box body 1 is specifically selected according to the proper temperature of different types of liquid chromatographic columns, and the general temperature range is maintained between 10 ℃ and 40 ℃; in specific implementation, the working temperature of the heating mechanism 2 can be controlled by a PLC system.
Offer a plurality of on placing the board 3 and placed hole 4, a plurality of place hole 4 bottom and be provided with baffle 6, baffle 6 and place board 3 sliding connection, the rear side fixedly connected with electric telescopic handle 5 of box 1, electric telescopic handle 5's flexible end and baffle 6 fixed connection place the liquid chromatography post in placing hole 4, under baffle 6's restriction for the liquid chromatography post can not the landing, after fixed, start electric telescopic handle 5, electric telescopic handle 5's flexible end drives baffle 6 and removes, so that discharge the washing liquid in the liquid chromatography post.
The box body 1 is connected with a collecting box 7 in a sliding way, an exhaust hole 204 is arranged between the collecting box 7 and the baffle 6, and the front part of the collecting box 7 is fixedly connected with a first handle 8; preferably, the top surface of the placing plate 3 is an inclined surface, and the placing plate 3 is provided with a water outlet 11, so that residues on the surface of the placing plate 3 can be cleaned and maintained conveniently; the box body 1 is provided with the box door 9, the front portion fixedly connected with second handle 10 of box door 9, the top of placing the board 3 is located one side fixedly connected with and places hole 4 the same quantity first fixed plate 12 with placing hole 4, the rear side fixedly connected with motor 13 of box body 1, the output fixedly connected with threaded rod 14 of motor 13, fixedly connected with gag lever post 15 on the inner wall of box body 1, threaded rod 14 and gag lever post 15 horizontal direction are parallel, threaded rod 14 threaded connection has slider 16, slider 16 and gag lever post 15 sliding connection, slider 16 fixedly connected with connecting rod 17, connecting rod 17 fixedly connected with mounting panel 18, one side fixedly connected with of mounting panel 18 is with and first fixed plate 12 equiquantity second fixed plate 19, second fixed plate 19 is opposite with first fixed plate 12 direction, through placing the liquid chromatography post in proper order and being close to first fixed plate 12 on placing hole 4, then start motor 13, the output of motor 13 drives threaded rod 14 and rotates under the restriction of gag lever post 15, make slider 16 backward movement, and then drive the second fixed plate 19 on mounting panel 18 and be close to first fixed plate 12, with liquid chromatography post.
The top fixedly connected with liquid reserve tank 20 of box 1 is provided with feed liquor pipe 21 on the liquid reserve tank 20, be provided with sealed lid 22 on the feed liquor pipe 21, the top fixedly connected with delivery pump 23 of box 1, fixedly connected with connecting pipe 24 between the import of delivery pump 23 and the liquid reserve tank 20, the export fixedly connected with pivot pipe 25 of delivery pump 23, pivot pipe 25 fixedly connected with conveyer pipe 26, be provided with on the conveyer pipe 26 with second fixed plate 19 equiquantity drain pipe 27, drain pipe 27 and the access connection of liquid chromatographic column, through starting delivery pump 23, connecting pipe 24 will extract the flushing fluid in the liquid reserve tank 20, reach conveyer pipe 26 through pivot pipe 25, finally flow into the liquid chromatographic column by the drain pipe 27 of a plurality of, wash a plurality of liquid chromatographic columns, can wash a plurality of liquid chromatographic columns simultaneously, improved cleaning efficiency, the washing liquid is discharged from the liquid outlet of liquid chromatographic column respectively, reach in the collecting box 7, it is to be noted: the electric telescopic rod 5, the delivery pump 23 and the motor 13 are electrically connected with an external power supply; control of the flow rate of the rinse liquid can be achieved by adjusting the flow rate of the transfer pump 23.
In actual use, according to the cleaning requirements before and after the use of different liquid chromatographic columns, a proper flushing liquid is placed into the liquid storage tank 20; when multiple flushing liquids are adopted for flushing in sequence, after the flushing process of one flushing liquid is completed, the next flushing liquid is placed into the liquid storage tank 20 to continue the flushing process; the specific working process or working principle of the liquid chromatographic column cleaning device is as follows: the door 9 is opened to operating personnel, make it be located the downside of placing hole 4 through electric telescopic handle 5 regulation baffle 6, place the position that is close to first fixed plate 12 on placing hole 4 in proper order with the liquid chromatography post, then start motor 13, the output of motor 13 drives threaded rod 14 and rotates, under the restriction of gag lever post 15, make slider 16 backward movement, and then drive the second fixed plate 19 on the mounting panel 18 and be close to the liquid chromatography post, it is fixed with the liquid chromatography post to cooperate first fixed plate 12, then start electric telescopic handle 5, electric telescopic handle 5's flexible end drives baffle 6 and removes, so that discharge the washing liquid in the liquid chromatography post.
By starting the air heater 201, the air heater 201 will generate hot air to enter the box 1 through the air outlet pipe 203, heat the box 1, raise the internal temperature and maintain the internal temperature at a proper temperature, accelerate the dissolution of pollutants and cleaning liquid in the liquid chromatographic column, and discharge the gas through the exhaust hole 204; by starting the delivery pump 23, the cleaning liquid in the liquid storage tank 20 is pumped by the connecting pipe 24, reaches the delivery pipe 26 through the pivot pipe 25, finally flows into the liquid chromatographic columns through the liquid outlet pipes 27 to clean the liquid chromatographic columns, and can clean the liquid chromatographic columns at the same time, so that the cleaning efficiency is improved, and the cleaning liquid is respectively discharged from the liquid outlets of the liquid chromatographic columns and reaches the collecting box 7; after the cleaning is finished, if residues on the surfaces of the liquid storage tank 20 or the placing plate 3 need to be cleaned, clean water can be added into the liquid storage tank 20 after the liquid chromatographic column is removed, the conveying pump 23 is started, the surfaces of the liquid storage tank 20, the connecting pipe 24, the pivot pipe 25, the conveying pipe 26, the liquid outlet pipe 27 and the placing plate 3 are cleaned by clean water, and water flows into the collecting box 7 through the water outlet 11 to finish maintenance cleaning work.
Claims (9)
1. The liquid chromatographic column cleaning device is characterized by comprising a box body (1), wherein a placing plate (3) is fixedly connected between the inner walls of the box body (1);
A heating mechanism (2), the heating mechanism (2) comprises
The air heater (201), the said air heater (201) is fixedly connected to one side of the box (1);
the air inlet pipe (202), the air inlet pipe (202) is fixedly connected with the air inlet end of the air heater (201);
The air outlet pipe (203) is fixedly connected to the air outlet end of the air heater (201);
The exhaust hole (204), exhaust hole (204) are opened in one side of box (1).
2. The liquid chromatography column cleaning device according to claim 1, wherein a plurality of placing holes (4) are formed in the placing plate (3), a baffle plate (6) is arranged at the bottom of each of the plurality of placing holes (4), and the baffle plate (6) is in sliding connection with the placing plate (3).
3. The liquid chromatography column cleaning device according to claim 2, wherein one side of the box body (1) is fixedly connected with an electric telescopic rod (5), and a telescopic end of the electric telescopic rod (5) is fixedly connected with a baffle plate (6).
4. A liquid chromatography column cleaning device according to claim 3, wherein the box body (1) is slidably connected with a collecting box (7), a first handle (8) is fixedly connected with the front part of the collecting box (7), the top surface of the placing plate (3) is set to be an inclined surface, and a water outlet (11) is formed in the placing plate (3).
5. The liquid chromatography column cleaning device according to claim 4, wherein a box door (9) is arranged on the box body (1), and a second handle (10) is fixedly connected to the front part of the box door (9).
6. The liquid chromatography column cleaning device according to claim 5, wherein the top of the placement plate (3) is fixedly connected with first fixing plates (12) with the same number as the placement holes (4) on one side of the placement holes (4), one side of the box body (1) is fixedly connected with a motor (13), and the output end of the motor (13) is fixedly connected with a threaded rod (14).
7. The liquid chromatography column cleaning device according to claim 6, wherein a limit rod (15) is fixedly connected to the inner wall of the box body (1), the limit rod (15) is parallel to the horizontal direction of the threaded rod (14), a sliding block (16) is connected to the threaded rod (14) in a threaded manner, the sliding block (16) is slidably connected with the limit rod (15), a connecting rod (17) is fixedly connected to the sliding block (16), a mounting plate (18) is fixedly connected to the connecting rod (17), and a second fixing plate (19) with the same number as the first fixing plate (12) is fixedly connected to one side of the mounting plate (18).
8. The liquid chromatography column cleaning device according to claim 7, wherein the top of the box body (1) is fixedly connected with a liquid storage tank (20), a liquid inlet pipe (21) is arranged on the liquid storage tank (20), and a sealing cover (22) is arranged on the liquid inlet pipe (21).
9. The liquid chromatography column cleaning device according to claim 8, wherein the top of the box body (1) is fixedly connected with a delivery pump (23), a connecting pipe (24) is fixedly connected between a water inlet of the delivery pump (23) and the liquid storage tank (20), a water outlet of the delivery pump (23) is fixedly connected with a pivot pipe (25), the pivot pipe (25) is fixedly connected with a delivery pipe (26), and a liquid outlet pipe (27) which is equal in number with the second fixing plate (19) is arranged on the delivery pipe (26).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322106498.7U CN220804580U (en) | 2023-08-07 | 2023-08-07 | Liquid chromatographic column cleaning device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322106498.7U CN220804580U (en) | 2023-08-07 | 2023-08-07 | Liquid chromatographic column cleaning device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220804580U true CN220804580U (en) | 2024-04-19 |
Family
ID=90697848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322106498.7U Active CN220804580U (en) | 2023-08-07 | 2023-08-07 | Liquid chromatographic column cleaning device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220804580U (en) |
-
2023
- 2023-08-07 CN CN202322106498.7U patent/CN220804580U/en active Active
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