CN220778480U - Tumor tissue homogenate nude mice subcutaneous inoculation model - Google Patents

Abstract

The utility model discloses a tumor tissue homogenate nude mouse subcutaneous inoculation model, which comprises a shell, wherein a limiting mechanism is arranged in the shell, a movable tube is movably connected in the shell, a sampling mechanism is arranged in the movable tube, the limiting mechanism comprises a positioning frame fixedly connected in the shell and a limiting plate rotatably connected in the shell, the upper surface of the inside of the limiting plate is provided with a first sliding groove and a limiting hole, a first sliding rod is connected in the first sliding groove in a sliding manner, the size of the first sliding rod is matched with that of the first sliding groove, one end of the first sliding rod is fixedly connected with a movable blade, the upper surface of the movable blade is fixedly connected with a second sliding rod, a plurality of positioning plates are fixedly connected in the positioning frame, and the second sliding grooves are arranged in the positioning plates.

Description

Tumor tissue homogenate nude mice subcutaneous inoculation model

Technical Field

The utility model relates to the technical field of medical experimental equipment, in particular to a tumor tissue homogenate nude mouse subcutaneous inoculation model.

Background

The tumor tissue homogenate nude mice subcutaneous inoculation model experiment is an important leap of gene function research from in vitro cell experiment to animal level in vivo experiment. Animal experiments, because it can simulate human physiology and pathology, in tumor research, the most common animal experiment is a nude mouse tumorigenesis experiment. Since most tumor studies use human cells, we need immunodeficient mice as carriers for the model of transplanted tumors due to the presence of xenogenic rejection, which are made neoplastic by injecting tumor cells and observing the growth of fluid to determine their biological changes.

Publication (bulletin) number: CN110680555a, patent title: the specification of the device discloses that the prior art has the following technical problems: the growth of tumors is affected by a number of factors, and the solid tumors formed are irregular in external shape, resulting in an inability to effectively measure the volume of the solid tumor. The solution in the related art is: preparing a large number of tumor models of the nude mice, then selecting the tumor-forming nude mice with relatively regular solid tumor shapes for measurement, and discarding the tumor-forming nude mice with irregular solid tumor shapes. However, this results in a great deal of waste of experimental resources and also in repeated labor for the experimenters;

the above-mentioned prior art is using, and although can restrict the shape of tumour and reach the experiment demand, but follow-up experimenter still need dismantle the device, just can excision processing to the tumour, because experimental sample is more, consequently causes experimenter's working strength increase easily under the circumstances of excision for a long time to lead to excision inefficiency's problem.

Disclosure of Invention

In order to overcome the technical problems, the utility model aims to provide a subcutaneous inoculation model of a tumor tissue homogenate nude mouse to solve the problems that the working strength of an experimenter is easily increased under the condition of long-time excision and the excision efficiency is reduced due to more experimental samples.

The aim of the utility model can be achieved by the following technical scheme:

the utility model provides a tumor tissue homogenate nude mouse inoculation model under skin, includes the shell, the inside of shell is provided with stop gear, the inside swing joint of shell has the movable tube, the inside of movable tube is provided with sampling mechanism, stop gear includes the locating rack of fixed connection inside the shell and rotates the limiting plate of connecting inside the shell, the inside upper surface of limiting plate is provided with first spout and spacing hole, the inside sliding connection of first spout has first slide bar, and the size of first slide bar and the size assorted of first spout, the one end fixedly connected with removal blade of first slide bar, the upper surface fixedly connected with second slide bar of removal blade, the inside fixedly connected with polylith locating plate of locating rack, the inside of locating plate all is provided with the second spout, the size of second spout and the inside sliding connection of second slide bar, and second slide bar.

The method is further characterized in that: one side fixedly connected with gag lever post of limiting plate, the one end fixedly connected with carousel of gag lever post, the inside bolted connection of carousel has the bolt, the periphery of locating rack and shell all is provided with spacing groove and fixed orifices, the size of bolt and the size phase-match of locating hole, the size phase-match of size of spacing groove and gag lever post.

The method is further characterized in that: the inside of shell is provided with the internal thread, the inside of removal pipe is provided with the external screw thread, external screw thread and internal screw thread assorted.

The method is further characterized in that: the shape of the first sliding groove is set to be isosceles hexagon, the size of the movable blade which is attached in a normal state is larger than the size of the limiting hole, a through hole is formed in the positioning frame, and the size of the through hole is matched with the size of the limiting hole.

The method is further characterized in that: the sampling mechanism comprises a first baffle and a second baffle which are rotationally connected inside a rotating pipe, two ends of the first baffle and two ends of the second baffle are respectively and fixedly connected with a gear and a rotating rod, the size of the rotating rod is matched with the axis size of the gear, a rotating disk is rotationally connected inside the rotating pipe, a gear ring is fixedly connected with the circumferential surface of the rotating disk, and the gear ring is matched with the gear.

The method is further characterized in that: the shape of first baffle and second baffle sets up to the arc, the inside of first baffle and second baffle all is provided with the magnetic path, and adsorbs each other between the magnetic path, first baffle, second baffle and rotation pipe are transparent material and make.

The method is further characterized in that: the upper surfaces of the first baffle and the second baffle are fixedly connected with handles, and ventilation holes are formed in the first baffle and the second baffle.

The method is further characterized in that: the circumference of shell all rotates and is connected with the commentaries on classics piece, the one end rotation of commentaries on classics piece is connected with the bandage, and the elastic material of bandage makes, the upper surface of bandage is provided with the magic subsides.

The utility model has the beneficial effects that:

1. when the device is used, the user rotates the limiting rod to move in the limiting groove, the limiting hole is completely opened by the rotating plate, tumors can be limited through the rotating tube in the growth process, after the proper size is produced, the tumors can be cut off, the limiting rod can be driven to drive the limiting plate to rotate at a proper angle, the limiting plate rotates and adjusts the position of the first sliding groove, the first sliding rod is driven to move by extrusion when the position of the first sliding groove changes, the first sliding rod drives the movable blade to slide, the movable blade slides to drive the second sliding rod to slide in the second sliding groove, so that a plurality of movable blades can be driven to move to a proper position and mutually attach, the root of the tumors can be cut, after the regulation is finished, the limiting rod is driven to reset, the fixing hole at the proper position is rotated to fix the limiting rod, the movable blade is driven to move the tumors after the tumor growth is finished, the device is not required to be disassembled, the excision operation is performed, the collection efficiency of the tumors is improved, and the collection efficiency of the nude mice model with a relatively regular solid tumor shape is accelerated.

2. Through being provided with sampling mechanism, the tumour is in the growth process, its height changes thereupon, thereby rotate the tumour that the movable tube through the internal thread of external screw thread and shell inside cooperatees can adjust the movable tube this moment, thereby conveniently adjust the adaptation growth process, need not to dismantle and change the operation, when needs carry out the sample operation to the tumour, rotate first baffle and drive gear rotation, gear and ring gear meshing can open the upper surface of movable tube, the user can take a sample the operation, need not to dismantle the operation, conveniently take a sample, the efficiency of taking a sample has been improved.

Drawings

The utility model is further described below with reference to the accompanying drawings.

FIG. 1 is a schematic view of the overall structure of the present utility model;

FIG. 2 is a cross-sectional view of the overall structure of the present utility model;

FIG. 3 is an exploded view of the structure of the spacing mechanism of the present utility model;

FIG. 4 is a schematic diagram of a sampling mechanism according to the present utility model;

fig. 5 is an enlarged view of a portion of fig. 1 a of the present utility model.

In the figure: 1. a housing; 2. a limiting plate; 3. a first chute; 4. a limiting hole; 5. moving the blade; 6. a first slide bar; 7. a second slide bar; 8. a positioning frame; 9. a positioning plate; 10. a second chute; 11. a limit rod; 12. a turntable; 13. a bolt; 14. a limit groove; 15. a fixing hole; 16. a moving tube; 17. a first baffle; 18. a rotating rod; 19. a gear; 20. a rotating plate; 21. a gear ring; 22. a handle; 23. ventilation holes; 24. a second baffle; 25. a magnetic block; 26. a rotating block; 27. a strap; 28. a magic tape; 29. an internal thread; 30. and (5) external threads.

Detailed Description

The technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model, and it is apparent that the described embodiments are only some embodiments of the present utility model, but not all embodiments, and all other embodiments obtained by those skilled in the art without making creative efforts based on the embodiments of the present utility model are included in the protection scope of the present utility model.

In order that the utility model may be readily understood, a more complete description of the utility model will be rendered by reference to the appended drawings. Several embodiments of the utility model are presented in the figures. This utility model may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

It will be understood that when an element is referred to as being "mounted" on another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like are used herein for illustrative purposes only.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this utility model belongs. The terminology used herein in the description of the utility model is for the purpose of describing particular embodiments only and is not intended to be limiting of the utility model. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.

Referring to fig. 1-5, a tumor tissue homogenate nude mouse subcutaneous inoculation model comprises a housing 1, wherein a limiting mechanism is arranged in the housing 1, a movable tube 16 is movably connected in the housing 1, a sampling mechanism is arranged in the movable tube 16, the limiting mechanism comprises a positioning frame 8 fixedly connected in the housing 1 and a limiting plate 2 rotatably connected in the housing 1, a first sliding groove 3 and a limiting hole 4 are formed in the upper surface of the inner part of the limiting plate 2, a first sliding rod 6 is slidably connected in the first sliding groove 3, the size of the first sliding rod 6 is matched with the size of the first sliding groove 3, a movable blade 5 is fixedly connected at one end of the first sliding rod 6, a second sliding rod 7 is fixedly connected to the upper surface of the movable blade 5, a plurality of positioning plates 9 are fixedly connected in the positioning frame 8, a second sliding groove 10 is arranged in the positioning plate 9, the size of the second sliding groove 10 is matched with the size of the second sliding rod 7, and the second sliding rod 7 is slidably connected with the inner part of the second sliding groove 10.

When the device is used, the shell 1 is fixed at the growth position of a tumor through the binding belt 27, the binding belt 27 is fixed through the magic tape 28, after the fixing is completed, a user rotates the limiting rod 11 to move in the limiting groove 14, so that the limiting hole 4 is completely opened by the rotating plate, the tumor can be limited through the rotating tube in the growth process, when the tumor is required to be cut off after the tumor is produced to a proper size, the limiting rod 11 can be driven to drive the limiting plate 2 to rotate a proper angle, the position of the first sliding groove 3 is regulated while the limiting plate 2 rotates, the first sliding rod 6 is extruded and driven to move when the position of the first sliding groove 3 is changed, the first sliding rod 6 drives the movable blade 5 to slide, and the movable blade 5 drives the second sliding rod 7 to slide in the second sliding groove 10 when sliding, so that a plurality of movable blades 5 can be driven to move to a proper position and mutually attach, the root of a tumor can be cut, after adjustment is finished, the limiting rod 11 is driven to reset, the bolt 13 is rotated to enter the fixing hole 15 at a proper position, the limiting rod 11 can be fixed, a user can drive the movable blade 5 to move to cut the tumor after the growth of the tumor is finished, the device is not required to be detached and then cut off, the tumor acquisition efficiency is improved, and the efficiency of obtaining a nude mouse model with a relatively regular solid tumor shape is accelerated;

in the process of growing the tumor, the height of the tumor changes along with the change, at the moment, the rotating moving tube 16 is matched with the internal thread 29 in the shell 1 through the external thread 30, so that the height of the rotating tube can be adjusted, the tumor in the process of adapting to the growth is conveniently adjusted, the replacement operation is not required to be detached, when the tumor is required to be subjected to the sampling operation, the gear 19 is driven to rotate by the rotating first baffle 17, the gear 19 and the gear ring 21 are meshed, the upper surface of the rotating tube can be opened, the user can perform the sampling operation, the disassembly operation is not required, the sampling is convenient, and the sampling efficiency is improved.

One side fixedly connected with gag lever post 11 of limiting plate 2, the one end fixedly connected with carousel 12 of gag lever post 11, the inside bolt 13 of carousel 12 is connected with bolt 13, the circumferencial surface of locating rack 8 and shell 1 all is provided with spacing groove 14 and fixed orifices 15, the size of bolt 13 and the size phase-match of locating hole, the size phase-match of spacing groove 14 and gag lever post 11, the convenience is fixed gag lever post 11 to fix the position of limiting plate 2 and avoid external factor to lead to limiting plate 2 to take place pivoted problem.

The inside of shell 1 is provided with internal thread 29, and the inside of moving tube 16 is provided with external screw thread 30, and external screw thread 30 and internal screw thread 29 assorted, thereby conveniently improve the distance of moving tube 16 and conveniently carry out spacing operation to the tumour different height.

The shape of the first sliding groove 3 is set to be isosceles hexagon, the size of the movable blade 5 attached in a plurality of normal states is larger than the size of the limiting hole 4, the through hole is formed in the positioning frame 8, the size of the through hole is matched with the size of the limiting hole 4, the movable blade 5 is conveniently driven to move, therefore, when the movable blade 5 resets, the tumor can be cut, manual cutting operation of a worker is not needed, and the working efficiency of taking down the tumor is effectively improved.

The sampling mechanism comprises a first baffle 17 and a second baffle 24 which are rotationally connected inside a rotating pipe, two ends of the first baffle 17 and the second baffle 24 are respectively and fixedly connected with a gear 19 and a rotating rod 18, the size of the rotating rod 18 is matched with the axis size of the gear 19, a rotating disk 12 is rotationally connected inside the rotating pipe, a gear ring 21 is fixedly connected with the circumferential surface of the rotating disk 12, the gear ring 21 is matched with the gear 19, a user can take out tumors conveniently, the sampling working intensity of staff is reduced, and the model building efficiency is improved.

The shape of first baffle 17 and second baffle 24 sets up to the arc, thereby the convenience rotates to open the swivelling joint pipe and conveniently discharges the tumour, and the inside of first baffle 17 and second baffle 24 all is provided with magnetic path 25, and adsorbs each other between the magnetic path 25, and the convenience is fixed first baffle 17 and second baffle 24, and first baffle 17, second baffle 24 and swivelling joint pipe are transparent material and make, and the person of facilitating the use observes inside tumour growth condition.

The upper surfaces of the first baffle 17 and the second baffle 24 are fixedly connected with handles 22, so that the first baffle 17 and the second baffle 24 are conveniently pushed to move, and ventilation holes 23 are formed in the first baffle 17 and the second baffle.

The periphery of shell 1 all rotates and is connected with the commentaries on classics piece 26, and the one end rotation of commentaries on classics piece 26 is connected with bandage 27, and the elastic material of bandage 27 makes, makes things convenient for bandage 27 to stretch to suitable length and uses, and the upper surface of bandage 27 is provided with the magic subsides 28, conveniently fixes bandage 27.

In the description of the present specification, the descriptions of the terms "one embodiment," "example," "specific example," and the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present utility model. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

The foregoing is merely illustrative and explanatory of the utility model, as various modifications and additions may be made to the particular embodiments described, or in a similar manner, by those skilled in the art, without departing from the scope of the utility model or exceeding the scope of the utility model as defined in the claims.

Claims (8)

1. Tumor tissue homogenate nude mice inoculation model under skin, a serial communication port, including shell (1), the inside of shell (1) is provided with stop gear, the inside swing joint of shell (1) has movable tube (16), the inside of movable tube (16) is provided with sampling mechanism, stop gear includes fixed connection locating rack (8) and rotation connection limiting plate (2) inside shell (1) in shell (1), the inside upper surface of limiting plate (2) is provided with first spout (3) and spacing hole (4), the inside sliding connection of first spout (3) has first slide bar (6), and the size phase-match of first slide bar (6) and first slide bar (3), the one end fixedly connected with movable blade (5) of first slide bar (6), the upper surface fixedly connected with second slide bar (7) of movable blade (5), the inside fixedly connected with polylith locating plate (9) of locating plate (9), the inside of second slide bar (10) and second slide bar (10) are connected with second slide bar (10) and second slide bar (10).

2. The tumor tissue homogenate nude mouse subcutaneous inoculation model according to claim 1, wherein one side of the limiting plate (2) is fixedly connected with a limiting rod (11), one end of the limiting rod (11) is fixedly connected with a rotary disc (12), an inner bolt (13) of the rotary disc (12) is connected with a bolt (13), limiting grooves (14) and fixing holes (15) are formed in the circumferential surfaces of the locating frame (8) and the shell (1), the size of the bolt (13) is matched with the size of the locating hole, and the size of the limiting groove (14) is matched with the size of the limiting rod (11).

3. The tumor tissue homogenate nude mouse subcutaneous inoculation model according to claim 1, wherein an internal thread (29) is arranged inside the housing (1), an external thread (30) is arranged inside the moving tube (16), and the external thread (30) is matched with the internal thread (29).

4. The subcutaneous inoculation model for tumor tissue homogenate nude mice according to claim 1, wherein the shape of the first chute (3) is an isosceles hexagon, the size of the plurality of moving blades (5) which are attached in a normal state is larger than the size of the limiting hole (4), a through hole is formed in the positioning frame (8), and the size of the through hole is matched with the size of the limiting hole (4).

5. The tumor tissue homogenate nude mouse subcutaneous inoculation model according to claim 1, wherein the sampling mechanism comprises a first baffle (17) and a second baffle (24) which are rotatably connected in a rotating tube, two ends of the first baffle (17) and the second baffle (24) are fixedly connected with a gear (19) and a rotating rod (18) respectively, the size of the rotating rod (18) is matched with the axis size of the gear (19), a rotary disc (12) is rotatably connected in the rotating tube, a gear ring (21) is fixedly connected on the circumference surface of the rotary disc (12), and the gear ring (21) is matched with the gear (19).

6. The subcutaneous inoculation model for tumor tissue homogenate nude mice according to claim 5, wherein the first baffle (17) and the second baffle (24) are arc-shaped, magnetic blocks (25) are arranged inside the first baffle (17) and the second baffle (24), the magnetic blocks (25) are mutually adsorbed, and the first baffle (17), the second baffle (24) and the rotating tube are made of transparent materials.

7. The subcutaneous inoculation model for tumor tissue homogenate nude mice according to claim 6, wherein the upper surfaces of the first baffle (17) and the second baffle (24) are fixedly connected with handles (22), and ventilation holes (23) are formed in the first baffle (17) and the inside of the baffles.

8. The tumor tissue homogenate nude mice subcutaneous inoculation model according to claim 1, wherein the circumference of the housing (1) is rotationally connected with a rotating block (26), one end of the rotating block (26) is rotationally connected with a binding band (27), the binding band (27) is made of elastic materials, and the upper surface of the binding band (27) is provided with a magic tape (28).