CN220703642U - Magnetic rack - Google Patents

Abstract

The utility model relates to the technical field of magnetic particle enrichment, and provides a magnetic frame, a support frame and a base, wherein at least two fixed positions are arranged on the support frame; the support frame is positioned on the base; the base is provided with a magnetic member; the magnetic force piece is provided with at least two magnetic conduction blocks, and the magnetic conduction blocks correspond to the fixing positions; each magnetic conduction block is positioned in the same direction of the corresponding fixed position. According to the magnetic rack, the magnetic conduction blocks act on magnetic particles of an external centrifuge tube, so that the purpose of enriching the magnetic particles is achieved; because the magnetic conduction blocks are all located in the same direction of the corresponding fixed positions, the magnetic particles on the fixed positions are enriched on the same side of the centrifuge tube where the magnetic particles are located, and when an operator sucks liquid in the outside centrifuge tube by adopting an outside pipettor, the operator can operate different centrifuge tubes on one side without frequently replacing positions due to different enrichment directions of the magnetic particles.

Description

Magnetic rack

Technical Field

The utility model relates to the technical field of magnetic particle enrichment, in particular to a magnetic frame.

Background

The magnetic particles are colloidal composite materials which are uniformly dispersed in liquid, and have the characteristics of superparamagnetism, higher specific surface area, modifiable functional groups and the like. Therefore, the method is commonly applied to biological sample extraction, purification and enrichment, and refers to enrichment and separation of target molecules from samples such as cells, blood, animal tissues, foods, pathogenic microorganisms and the like, and subsequent experiments are carried out.

The magnetic rack is an experimental tool commonly used for separating magnetic beads, and the magnetic rack in the prior art has the defects that the directions of the magnetic particles enriched in the centrifuge tube are different, and when different centrifuge tubes are operated, an operator needs to adjust the position of the magnetic rack.

Disclosure of Invention

The utility model provides a magnetic frame which is used for solving the defect that the enrichment directions of magnetic particles are different in the prior art, has long service life and can adjust magnetic force according to requirements.

The utility model provides a magnetic frame, comprising:

the support frame is provided with at least two fixed positions;

the support frame is positioned on the base; the base is provided with a magnetic member; the magnetic force piece is provided with at least two magnetic conduction blocks, and the magnetic conduction blocks correspond to the fixed positions; each magnetic conduction block is positioned in the same direction of the corresponding fixed position.

According to the magnetic frame provided by the utility model, the fixed positions are linearly arranged to form a plurality of rows of the fixed positions; two adjacent magnetic conductive blocks which are positioned in the same row and correspond to the fixed positions are mutually connected to form a magnetic conductive part.

According to the magnetic frame provided by the utility model, the fixing positions are the fixing grooves, and the magnetic conducting blocks are arranged on the outer walls of the corresponding fixing grooves.

According to the magnetic frame provided by the utility model, each fixing groove is correspondingly provided with at least two magnetic conducting blocks, and each magnetic conducting block is arranged on the side wall of the corresponding fixing groove along the depth direction of the fixing groove.

According to the magnetic frame provided by the utility model, each fixing groove is correspondingly provided with two magnetic conducting blocks, namely a first magnetic conducting block and a second magnetic conducting block, and the first magnetic conducting block and the second magnetic conducting block are arranged on the side wall of the corresponding fixing groove along the depth direction of the fixing groove; two adjacent first magnetic conductive blocks which are positioned in the same row and correspond to the two adjacent fixed grooves respectively are connected with each other to form a first magnetic conductive part; two second magnetic conductive blocks corresponding to two adjacent fixed grooves in the same row are connected with each other to form a second magnetic conductive part.

According to the magnetic frame provided by the utility model, the magnetic piece further comprises a magnetic part and a connecting part, wherein the connecting part is connected with the magnetic part and the magnetic conduction part, and the connecting part is made of magnetic conduction materials.

According to the magnetic frame provided by the utility model, the outer side of the magnetic part is wrapped with the magnetism isolating sleeve.

According to the magnetic frame provided by the utility model, the magnetic part is an electromagnet or a magnet.

The magnetic rack provided by the utility model further comprises a control piece and a radiator, wherein the magnetic piece is an electromagnet and is electrically connected with the control piece; the radiator is arranged on the base and is used for radiating the magnetic force piece.

According to the magnetic rack provided by the utility model, the bottom of the fixing groove is provided with the perforation, and the perforation is used for passing through an external centrifuge tube.

According to the magnetic frame provided by the utility model, the fixed position is a placing plane, and the magnetic conducting block is correspondingly arranged on the placing plane.

Additional aspects and advantages of the utility model will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the utility model.

The magnetic force frame comprises a support frame and a base, wherein at least two fixed positions are arranged on the support frame; the support frame is positioned on the base; the base is provided with a magnetic member; the magnetic force piece is provided with at least two magnetic conduction blocks, and the magnetic conduction blocks correspond to the fixing positions; each magnetic conduction block is positioned in the same direction of the corresponding fixed position.

Placing an external centrifuge tube on a fixed position, and enabling a magnetic conduction block to act on magnetic particles of the external centrifuge tube so as to achieve the aim of enriching the magnetic particles; because the magnetic conduction blocks are all located in the same direction of the corresponding fixed position, the magnetic particles on the fixed position are enriched on the same side of the centrifuge tube where the magnetic particles are located, and when an operator sucks liquid in the outside centrifuge tube by adopting an outside pipettor, the different centrifuge tubes can be operated on one side, the positions are not required to be frequently replaced due to different enrichment directions of the magnetic particles, and batch operation is convenient.

Drawings

In order to more clearly illustrate the utility model or the technical solutions of the prior art, the following description will briefly explain the drawings used in the embodiments or the description of the prior art, and it is obvious that the drawings in the following description are some embodiments of the utility model, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic structural view of a magnetic stand according to an embodiment of the present utility model;

fig. 2 is a schematic structural view of a support frame of a magnetic rack according to an embodiment of the present utility model;

FIG. 3 is another schematic structural view of a support frame of a magnetic rack according to an embodiment of the present utility model;

FIG. 4 is a schematic structural view of a magnetic member of a magnetic stand according to an embodiment of the present utility model;

FIG. 5 is another schematic structural view of a support frame of a magnetic rack according to an embodiment of the present utility model;

fig. 6 is another schematic structural diagram of a magnetic rack according to an embodiment of the present utility model.

Reference numerals:

100. a support frame; 110. fixing the position; 111. a fixing groove; 112. placing a plane;

200. a base;

300. a magnetic member; 310. a magnetic conduction part; 311. a magnetic conductive block; 320. a magnetic part; 330. a connection part; 331. a first connecting bar; 332. a second connecting bar;

400. centrifuging tube;

500. magnetic particles;

600. a control member;

700. a heat sink;

800. a power supply;

900. microplates.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the present utility model more apparent, the technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some embodiments of the present utility model, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

The present embodiment provides a magnetic rack, as shown in fig. 1 to 2, including a support 100 and a base 200, where at least two fixing positions 110 are disposed on the support 100; the support 100 is located on the base 200; the base 200 is provided with a magnetic member 300; the magnetic member 300 has at least two magnetic conductive blocks 311, and the magnetic conductive blocks 311 correspond to the fixing positions 110; each of the magnetic conductive blocks 311 is located in the same direction of the corresponding fixed position 110.

As shown in fig. 2 to 3, the outer centrifuge tube 400 is placed on the fixed position 110, and the magnetic conductive block 311 acts on the magnetic particles 500 of the outer centrifuge tube 400, so as to achieve the purpose of enriching the magnetic particles 500; because the magnetic conductive blocks 311 are all located in the same direction of the corresponding fixing position 110, the magnetic particles 500 on the fixing position 110 are enriched on the same side of the centrifuge tube 400 where the magnetic particles 500 are located, and when an operator sucks the liquid in the outside centrifuge tube 400 by adopting the outside pipettor, the operator can operate different centrifuge tubes 400 on one side without frequently replacing positions due to different enrichment directions of the magnetic particles 500.

To accommodate more centrifuge tubes 400 and to facilitate centralized handling, the securing locations 110 are arranged in a linear array to form a plurality of rows of securing locations 110 such that the plurality of securing locations 110 are arranged in a matrix; each row of fixed positions 110 are arranged in a linear sequence, two magnetic conducting blocks 311 corresponding to two adjacent fixed positions 110 in the same row are connected with each other to form a magnetic conducting part 310, namely the magnetic conducting parts 310 are arranged on the fixed positions 110 in a penetrating manner in the same row, so that the installation is convenient, and meanwhile, the magnetic conducting parts 310 are ensured to be positioned on the same side of the corresponding fixed positions 110, so that the magnetic particles 500 of the centrifuge tubes 400 are enriched towards the same direction, and the concentrated operation of operators is convenient; in the embodiment of the present utility model, as shown in fig. 3, the fixing bits 110 are provided in six rows, and each row of fixing bits 110 is provided with four fixing bits 110.

In this embodiment, the fixing location 110 is a fixing slot 111, so as to fix the external centrifuge tube 400 conveniently; specifically, the support 100 includes a frame and a plurality of support shells, each of which is connected to the frame in a matrix to form the support 100; a fixing groove 111 is formed in the support shell, the notch of the fixing groove 111 faces upwards, and the outer centrifuge tube 400 can be directly placed in the fixing groove 111 from the notch of the fixing groove 111; the direction of the outer centrifuge tube 400 extending into the fixing groove 111 is the depth direction of the fixing groove 111; in order to ensure stable placement of the centrifuge tube 400 positioned in the fixing groove 111, the magnetic conductive blocks 311 are all arranged on the outer wall of the corresponding fixing groove 111, namely, the magnetic conductive blocks 311 are arranged on the outer side of the supporting shell; in one embodiment, the magnetic conductive block 311 is a magnet block, and the magnetic conductive part 310 is a magnet bar connected to one side of a row of support shells, so that the magnetic particles 500 in the corresponding centrifuge tube 400 are enriched towards the magnet bar; because the magnetic force of the magnet weakens along with the increase of the distance, in order to avoid the centrifuge tube 400 from being interfered by the corresponding magnet strips of the adjacent centrifuge tube 400, the intervals between the support shells can be set according to the actual demands, and meanwhile, the magnet strips with different magnetic forces can be adopted according to the actual demands; for better magnetic conduction effect of the magnetic conduction block 311, the wall thickness of the supporting shell is generally one to two millimeters.

In one embodiment, as shown in fig. 4, the magnetic member 300 further includes a magnetic portion 320 and a connecting portion 330, where the connecting portion 330 connects the magnetic portion 320 and the magnetic conductive portion 310, and the connecting portion 330 and the magnetic conductive portion 310 are both made of magnetic conductive materials, and the connecting portion 330 and the magnetic conductive portion 310 are both iron cores, and the iron cores are made of soft magnetic materials, such as pure iron, silicon steel, and the like; the magnetic conductive parts 310 formed by mutually connecting the magnetic conductive parts 310 corresponding to the fixed positions 110 positioned in the same row are iron bars, namely the iron bars are sequentially connected with the supporting shells in the same row, and six iron bars are correspondingly arranged in the embodiment of the utility model; the magnetic force of the magnetic force part 320 is guided to the magnetic conduction part 310 through the connection part 330, and the magnetic force of the magnetic force part 320 is led to the magnetic conduction part 310, so that the magnetic force of the magnetic conduction blocks 311 are positioned in the same direction of the corresponding fixed positions 110, firstly, the magnetic force of the magnetic force part 320 can be uniformly distributed on each fixed position 110, secondly, the magnetic particles 500 of each fixed position 110 can be enriched towards the same direction, and the centrifuge tube 400 on different fixed positions 110 is convenient for operators to operate in the fixed positions 110, so that batch operation is convenient; generally, the magnetic force portion 320 is an electromagnet or a magnet, in this embodiment, the magnetic force portion 320 is an electromagnet, and specifically, the electromagnet includes a coil and a reinforcing iron core, and the reinforcing iron core is disposed inside the coil to strengthen the magnetic force; of course, the electromagnet can also be an integrated electromagnet; as shown in fig. 4, the connection portion 330 includes a first connection bar 331 and a second connection bar 332, the first connection bar 331 and the second connection bar 332 are connected and perpendicular to each other, the first connection bar 331 is used for connecting the magnetic conductive portion 310, and the second connection bar 332 is used for connecting the magnetic portion 320; in order to prevent the magnetic difference between the two magnetic conductive blocks 311 at the two ends of the magnetic conductive part 310 from being too large, two connecting parts 330 are provided, one end of the magnetic conductive part 310 is connected to one connecting part 330, and the other end is connected to the other connecting part 330; in order to increase the magnetic force of the magnetic member 300, the magnetic parts 320 are provided in plurality, corresponding to the two connection parts 330, the magnetic parts 320 are arranged in two rows, and each row of the magnetic parts 320 is connected to the corresponding connection part 330; of course, the outside of the magnetic part 320 is wrapped with a magnetism isolating sleeve, which can isolate the magnetism to a certain extent, preventing the magnetic part 320 from directly affecting the enrichment formation of the magnetic particles 500; generally, the magnetism isolating sleeve is made of glass or plastic.

In one embodiment, each fixing slot 111 is provided with at least two magnetic conductive blocks 311 correspondingly, and each magnetic conductive block 311 is arranged on the side wall of the corresponding fixing slot 111 along the depth direction of the fixing slot 111; the number of the magnetic conductive blocks 311 corresponding to each fixing groove 111 may be one or at least two, and the plurality of magnetic conductive blocks 311 are arranged on the side wall of the fixing groove 111 so as to disperse the magnetic force of the magnetic part 320 and improve the enrichment effect of the magnetic particles 500; specifically, the number of the magnetic conductive blocks 311 corresponding to each fixing slot 111 may be two, three, four or five, which is not limited in the embodiment of the present utility model; it can be appreciated that the number of the magnetic conductive blocks 311 can be set according to the length of the depth direction of the fixing groove 111, and when the number of the magnetic conductive blocks 311 increases, the magnetic force of the magnetic force portion 320 can be correspondingly increased to ensure the enrichment effect of the magnetic particles 500.

In one embodiment, as shown in fig. 5, two magnetic conductive blocks 311 are correspondingly disposed in each fixing slot 111, and the two magnetic conductive blocks 311 are a first magnetic conductive block 311 and a second magnetic conductive block 311, and the first magnetic conductive block 311 and the second magnetic conductive block 311 are arranged on the side wall of the corresponding fixing slot 111 along the depth direction of the fixing slot 111, so that the two magnetic conductive blocks 311 can disperse the magnetic force of the magnetic part 320, and the enrichment effect of the magnetic particles 500 is improved; two first magnetic conductive blocks 311 corresponding to two adjacent fixing grooves 111 in the same row are connected with each other to form a first magnetic conductive part 310, namely a first iron bar; two second magnetic conductive blocks 311 corresponding to two adjacent fixing grooves 111 in the same row are connected with each other to form a second magnetic conductive part 310, namely a second iron bar; it can be appreciated that the first iron bar and the second iron bar are sequentially connected with each supporting shell in the same row, and generally, the first iron bar and the second iron bar are arranged in parallel; in the case where the magnetic conductive block 311 is a magnet, the first magnetic conductive portion 310 and the second magnetic conductive portion 310 are both magnet bars.

In one embodiment, as shown in FIG. 5, the bottom of the holding tank 111 is provided with perforations for external centrifuge tubes 400 to pass through to accommodate centrifuge tubes 400 of different lengths; of course, the intervals and diameters of the different fixing grooves 111 are set, and the PCR plate can be adapted so that the hole grooves of the PCR plate are correspondingly arranged in the fixing grooves 111; a PCR plate is a carrier that is mainly used as a primer, buffer, etc. that participates in an amplification reaction in a polymerase chain reaction; PCR is abbreviated as english Polymerase Chain Reaction.

Centrifuge tube 400 is a tubular sample container, typically a prior art magnetic rack, that can only fit into centrifuge tube 400, while one embodiment of the present utility model can also fit into microplate 900 (microplate 900 is a flat plate with multiple "wells" serving as small test tubes, each well of microplate 900 typically containing tens of nanoliters to a few milliliters of liquid). As shown in fig. 6, when in use, the microplate 900 is directly placed on the support 100, and the hole slots on the microplate 900 correspond to the fixing positions 110 on the support 100; in order to adapt to the plane bottom of the microplate 900, the fixing location 110 is a placement plane 112, and the placement plane 112 is correspondingly provided with a magnetic conduction block 311; the magnetic conductive block 311 acts on the magnetic particles 500 in the external hole slots, so that the magnetic particles 500 are enriched at the bottoms of the hole slots of the micro-porous plate 900; in order to facilitate the operation of operators at the same position, the batch operation is facilitated; the magnetic conductive blocks 311 are biased to the same side of the corresponding fixed bits 110, as shown in fig. 6, and the magnetic conductive blocks 311 are biased to the left, so that the magnetic particles 500 in the hole slots of the micro-porous plate 900 are biased to the left of the hole slots.

According to the embodiment of the utility model, different support frames can be replaced to adapt to the existing micro-pore plate 900, PCR plate, 1.5ml, 2ml, 4ml, 15ml, 50ml and other centrifuge tubes, so that the operation of magnetic particles in containers with volumes of 0.1ml-50ml can be satisfied, and the universal performance is realized.

In one embodiment, as shown in fig. 1, the device further includes a control member 600, a heat sink 700, a power source 800, and a power switch, wherein the magnetic members 300 are electromagnets, the control member 600 is electrically connected to the power source 800 by the magnetic members 300, and the control member 600 is a circuit board for controlling the current of the electromagnets; when the power is on, the magnetic member 300 has magnetism, and when the power is off, the magnetic member 300 does not have magnetism; the power switch is electrically connected with the power supply to control the power on and power off; in this embodiment, the control member 600 can control the magnitude of the magnetic force of the magnetic member 300 by controlling the magnitude of the current; the radiator 700 is electrically connected with the control member 600, the radiator 700 is used for radiating heat of the magnetic member 300, and the power supply 800 is used for supplying power; in the present embodiment, the radiator 700 is composed of a radiation fan and a variable frequency switch so as to control the air volume.

The base 200 is provided with a mounting groove on which the magnetic part 320, the heat sink 700 and the power supply 800 are mounted; when the magnetic part 320 is an electromagnet, the base 200 is fixedly connected with the support 100, and the magnitude of the magnetic force of the magnetic member 300 is controlled by the control member 600; when the magnetic force part 320 is a magnet, the base 200 and the support 100 are detachably connected, and when the magnetic force is not needed, the support 100 is removed from the base 200; in this embodiment, the magnetic part 320 is an electromagnet, so that the existence of the magnetic force of the magnetic part 320 is conveniently controlled, so that operators can switch different working flows, and batch operation is convenient; in order to facilitate adapting to different support frames 100 according to different centrifuge tubes, the support frame 100 and the base 200 of the embodiment of the utility model are detachably connected, that is, when the support frame 100 is directly placed on the base 200, it should be noted that in the embodiment, the magnetic conductive portions 310 are connected to the fixed positions on the support frame 100, the connecting portions 330 are fixedly connected to the magnetic portions 320, and when the support frame 100 is placed on the base 200, the magnetic conductive portions 310 are abutted to the connecting portions 330 to achieve the magnetic conductive effect, and meanwhile, the support frame 100 is convenient to replace.

When the embodiment of the utility model is used, the support frame 100 is placed on the base, the power switch is turned on, the magnetic force piece 300 is electrified, and the external centrifugal tube 400 is respectively inserted into the fixing groove 111 on the embodiment of the utility model, so that the centrifugal tube 400 is fixed in the fixing groove 111; the control piece 600 controls the current of the electromagnet, at the moment, the electromagnet generates magnetic force, and the iron core has higher magnetic permeability than air, and is attracted by the magnetic conducting block 311, so that the magnetic particles 500 are enriched on one side of the centrifuge tube 400, and the magnetic particles 500 are concentrated in the same direction, thereby achieving the aim of enriching the magnetic particles 500; an operator can use the sample injector to operate different centrifuge tubes 400 at the same position, the operator sucks the supernatant contained in the centrifuge tubes 400, then adds eluent, turns off a power switch, controls the magnetic member 300 to be powered off by the control member 600, and adds washing liquid or other buffer solution to be resuspended for next operation; and turning on the power switch again to enrich the magnetic particles again. The experiment can be conveniently and rapidly completed by circulating the operation.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present utility model, and are not limiting; although the utility model has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present utility model.

Claims (11)

1. A magnetic stand, comprising:

the support frame (100), is provided with at least two fixed positions (110) on the support frame (100);

a base (200), the support (100) being located on the base (200); the base (200) is provided with a magnetic member (300); the magnetic member (300) is provided with at least two magnetic conduction blocks (311), and the magnetic conduction blocks (311) correspond to the fixed positions (110); each magnetic conduction block (311) is positioned in the same direction of the corresponding fixed position (110).

2. The magnetic rack according to claim 1, wherein the fixing locations (110) are arranged in a linear arrangement forming a number of rows of the fixing locations (110); two adjacent magnetic conductive blocks (311) which are positioned in the same row and correspond to the two fixed positions (110) are connected with each other to form a magnetic conductive part (310).

3. The magnetic stand according to claim 2, wherein the fixing locations (110) are fixing slots (111), and the magnetic conductive blocks (311) are all disposed on the outer walls of the corresponding fixing slots (111).

4. The magnetic stand according to claim 2, wherein at least two of the magnetic conductive blocks (311) are provided for each of the fixing grooves (111), and each of the magnetic conductive blocks (311) is disposed on a side wall of the corresponding fixing groove (111) in a direction of depth of the fixing groove (111).

5. A magnetic stand according to claim 3, characterized in that each fixing groove (111) is provided with two corresponding magnetic conducting blocks (311), namely a first magnetic conducting block (311) and a second magnetic conducting block (311), and the first magnetic conducting block (311) and the second magnetic conducting block (311) are arranged on the side wall of the corresponding fixing groove (111) along the depth direction of the fixing groove (111); two first magnetic conductive blocks (311) which are positioned in the same row and are respectively corresponding to two adjacent fixed grooves (111) are connected with each other to form a first magnetic conductive part (310); two second magnetic conductive blocks (311) which are positioned in the same row and are respectively corresponding to two adjacent fixed grooves (111) are connected with each other to form a second magnetic conductive part (310).

6. The magnetic stand according to claim 2, wherein the magnetic member (300) further comprises a magnetic portion (320) and a connection portion (330), the connection portion (330) connects the magnetic portion (320) and the magnetically permeable portion (310), and the connection portion (330) is a magnetically permeable material.

7. The magnetic rack according to claim 6, wherein the magnetic part (320) is surrounded by a magnetic shielding sleeve.

8. The magnetic stand according to claim 6, characterized in that the magnetic part (320) is an electromagnet or a magnet.

9. The magnetic rack according to any one of claims 1 to 8, further comprising a control member (600) and a heat sink (700), the magnetic member (300) being an electromagnet, the magnetic member (300) being electrically connected to the control member (600); the heat sink (700) is disposed on the base (200), and the heat sink (700) is used for heat dissipation of the magnetic member (300).

10. A magnetic rack according to claim 3, characterized in that the bottom of the fixing slot (111) is provided with perforations for the passage of an external centrifuge tube (400).

11. The magnetic rack according to any one of claims 1 to 8, wherein the fixing location (110) is a placement plane (112), and the placement plane (112) is correspondingly provided with the magnetic conductive block (311).