CN220634806U - Centrifugal device and sample processing equipment - Google Patents

Abstract

The present application relates to a centrifugation device and sample processing apparatus, the centrifugation device comprising: a base; the first driving part is arranged on the base and comprises a rotor, a stator and a rotating shaft connected with the rotor; the centrifugal component is connected with the rotating shaft, and the rotor drives the rotating shaft to drive the centrifugal component to rotate and centrifuge; the second driving part is arranged on the base and is connected with the stator; when the first driving part is braked, the second driving part drives the first driving part and the centrifugal part to rotate, so that the centrifugal part rotates to a preset position to take and place the centrifugal sample. The centrifugal device can be applied to the field of gene detection and is used for carrying out centrifugal treatment on nucleic acid samples in peripheral venous blood, tissues and other body fluids of a detected person. The centrifugal device can also be used for eliminating bubbles in liquid, layering the liquids with different densities, collecting the liquid on the side wall of the micro-pore plate, and the like, and can greatly improve the centrifugal treatment efficiency.

Description

Centrifugal device and sample processing equipment

Technical Field

The application relates to the technical field of centrifuges, in particular to a centrifugal device and sample processing equipment.

Background

Laboratory centrifuges are necessary equipment for scientific research and production in the industries of biology, medicine, agriculture, bioengineering, biopharmaceuticals and the like. The principle of the centrifugal machine is to separate substances with different sedimentation coefficients and buoyancy densities from a sample by utilizing the strong centrifugal force generated when the centrifugal machine rotates at a high speed.

For example, chinese patent publication No. CN216704707U discloses that the servo motor performs both functions of centrifugation and positioning, and continuous centrifugation in a short time can cause excessive temperature rise of the motor, resulting in reduced centrifugation efficiency of some temperature sensitive reagents or samples. The motor relies on the encoder to gather rotation angle signal, and during high-speed centrifugation, the signal is lost easily and is led to centrifuge rotor location not to live.

Most of the existing centrifuges rotate at high speed, and the rotor is in a free stop state, and the stop positions of the rotors are random, so that the centrifuges cannot be accurately stopped at the corresponding positions, and the centrifuges are only suitable for single-machine manual operation and cannot be applied to automatic equipment. In medium-high throughput sample detection automation systems, a robotic arm is typically relied upon to transfer samples or reagents, however, the centrifuge lacks an automatic positioning function, resulting in a misalignment of the robotic arm with the centrifuge.

Disclosure of Invention

The utility model provides an object provides a centrifugal device, second drive division is connected through band pulley and hold-in range transmission with first drive division to make first drive division when the centrifugal part of drive rotates the centrifugation, can not influence first drive division, also can not increase noise and vibration. When the centrifugal part is positioned and rotated, the rotating shaft is locked by the braking part in the first driving part, and the second driving part can drive the first driving part and the centrifugal part to rotate, so that the sample to be centrifuged can be conveniently taken and placed by an operator or a mechanical arm after rotating to a preset position.

Embodiments of the present application are implemented as follows:

in a first aspect, the present application provides a centrifuge device comprising: a base; the first driving part is arranged on the base and comprises a rotor, a stator and a rotating shaft connected with the rotor; the centrifugal component is connected with the rotating shaft, and the rotor drives the rotating shaft to drive the centrifugal component to rotate and centrifuge; the second driving part is arranged on the base and is connected with the stator; when the first driving part is braked, the second driving part drives the first driving part and the centrifugal part to rotate, so that the centrifugal part rotates to a preset position, and centrifugal sample taking and placing are performed.

In the above technical scheme, because the stator in the first driving part is fixedly arranged, when the rotor of the first driving part drives the rotating shaft to rotate, and then drives the centrifugal component to rotate and centrifuge, the second driving part is fixedly connected with the stator in the first driving part, and the second driving part is in an unactuated state, so that the rotation of the first driving part is not influenced, and noise and vibration are not increased. When the first driving part brakes, the rotor stops rotating and is fixed with the stator, at the moment, the second driving part can drive the stator and the rotor of the first driving part to rotate together and further drive the centrifugal part to rotate, after reaching a preset position, the second driving part stops working, at the moment, an operator can take down the centrifuged sample from the preset position, or take down the centrifuged sample from the centrifugal part through the mechanical arm.

The centrifugal device can be applied to the field of gene detection and is used for carrying out centrifugal treatment on nucleic acid samples in peripheral venous blood, tissues and other body fluids of a detected person. The centrifugal device can also be used for eliminating bubbles in liquid, layering the liquids with different densities, collecting the liquid on the side wall of the micro-pore plate, and the like, and can greatly improve the centrifugal treatment efficiency.

In one embodiment, the centrifugal component comprises: a rotating frame and at least one basket; the rotating frame is connected with the rotating shaft, and the hanging basket is arranged on the rotating frame.

In the above technical solution, when the first driving part drives the rotating frame to move, the basket rotates around the central axis of the rotating frame along with the rotation of the rotating frame, and simultaneously the basket is swung under the combined action of the centrifugal force and the gravity center of the basket, and the initial horizontal state is changed into the state of rotating 90 degrees around the rotation axis of the basket. Due to the strong centrifugal force, the small beads attached in the microplate accommodating tube will be thrown toward the bottom of each accommodating tube of the microplate, thereby reducing the loss of the micro-sample. The centrifugal separation operation of liquid in the micro-pore plate is realized by separating substances with different sedimentation coefficients and buoyancy densities in the accommodating tube by utilizing the principle that sedimentation speeds of components with different specific weights (solid phase or liquid phase) are different.

In an embodiment, the first driving part further includes: brake disc, solenoid and frame; the brake disc is fixed at the bottom of the rotating shaft, and the electromagnetic coil is fixedly connected with the base; the stator is fixedly connected with the machine base; in the energized state, the brake disc and the electromagnetic coil adsorb and brake the rotating shaft.

In the technical scheme, after the power is on, the electromagnetic coil generates magnetic force to be closely combined with the adsorption of the brake disc, so that the brake disc locks the rotating shaft, and the rotating shaft cannot rotate, thereby realizing the braking of the rotating shaft.

In one embodiment, the second driving part includes: the driving piece, the first driving wheel, the second driving wheel and the driving piece; the driving piece is connected with the first driving wheel, the second driving wheel is arranged on the stator, and the first driving wheel is in transmission connection with the second driving wheel through the driving piece.

In the above technical scheme, the second driving wheel may be connected with a stand for fixing the stator. The output shaft of the driving piece is connected with the first driving wheel, and when the driving piece drives the first driving wheel to rotate, the driving piece drives the second driving wheel to rotate, so that the first driving part and the centrifugal part are driven to rotate.

In one embodiment, the centrifugal device further comprises: the first shell is arranged outside the centrifugal component and is fixed on the base through the supporting part.

In the technical scheme, the supporting part is used for supporting the first shell, so that the driving influence in the centrifugal process is reduced. The first housing serves as a protection against contamination of the centrifugal components during centrifugation.

In an embodiment, a photoelectric switch is disposed on the first housing, and a light blocking piece matched with the photoelectric switch is disposed on the centrifugal component.

In the technical scheme, when the first driving part drives the centrifugal part to rotate, the light blocking sheet is driven to rotate, and when the light blocking sheet passes through the groove of the photoelectric switch, the photoelectric switch detects the light blocking sheet, and the position is marked as the zero position of the rotating frame.

In an embodiment, the first housing is provided with a pick-and-place opening.

In the technical scheme, the micro-pore plate is conveniently taken and placed by an operator or a mechanical arm through the taking and placing opening.

In one embodiment, the centrifugal device further comprises: the second shell is arranged outside the first driving part, the centrifugal part and the second driving part, is connected with the base and is connected with a cover body.

In the technical scheme, the first driving part, the centrifugal part and the second driving part are isolated from the outside by the arrangement of the second shell, so that the pollution of the sample to be centrifuged in the centrifuging process is reduced.

In one embodiment, the centrifugal device further comprises: a door control part arranged on the base; the door control section includes: a third driving part and a baffle plate; the third driving part is arranged on the base and connected with the baffle door plate, a window is formed in the wall surface of one side of the picking and placing opening of the second shell, the window is opposite to the picking and placing opening, and the third driving part drives the baffle door plate to lift so as to separate the window from the picking and placing opening.

In the above technical solution, the third driving portion drives the baffle door plate to rise or fall, and when the third driving portion 810 drives the baffle door plate to rise to the upper limit, that is, the baffle door plate completely cuts off the window from the pick-and-place opening, so that the centrifugal component is blocked from the outside, and the centrifugal component can perform centrifugal operation without being polluted by the outside environment. When the third driving part drives the baffle plate to descend to the lower limit, the window and the taking and placing opening are completely exposed, and at the moment, an operator or a mechanical arm can take out the micro-porous plate after centrifugation through the window and the taking and placing opening.

In one embodiment, the door control part further includes: the sliding rail is arranged on the wall surface of one side of the picking and placing opening of the second shell, the sliding block is arranged on the baffle door plate, and the baffle door plate moves along the sliding rail through the sliding block.

In the above technical scheme, when the third driving part drives the baffle door plate, the baffle door plate can move on the sliding rail through the sliding block, so that the moving precision of the baffle door plate is improved.

In one embodiment, the centrifugal device further comprises: and the control part is arranged on the base and is connected with the first driving part and the second driving part.

In the above technical solution, the control part corresponds to a control center of the whole centrifugal device, and can receive the instruction and send the instruction, for example, control the rotation angle of the first driving part and the starting and braking of the first driving part; and controlling the starting and braking of the second driving part.

In a second aspect, the present application provides a sample processing apparatus comprising a centrifugation device according to any one of the embodiments of the first aspect of the present application.

In the technical scheme, the centrifugal device can be integrated into one sample processing device for use, and after the centrifugal operation is finished, other experimental operations can be directly carried out in the sample processing device, so that the pollution risk in the sample transferring process is reduced, and the processing efficiency is improved.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered limiting the scope, and that other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic view of the overall structure of a centrifugal device according to an embodiment of the present disclosure;

FIG. 2 is a schematic view of the internal structure of a centrifugal device according to an embodiment of the present disclosure;

FIG. 3 is a cross-sectional view of a centrifuge device according to an embodiment of the present application;

FIG. 4 is a schematic view of a portion of a centrifugal device according to an embodiment of the present disclosure;

FIG. 5 is a side view of a centrifuge device according to an embodiment of the present application;

FIG. 6 is a cross-sectional view of a first drive section provided in an embodiment of the present application;

fig. 7 is a schematic structural diagram of a second driving portion according to an embodiment of the present disclosure;

FIG. 8 is a schematic structural view of a centrifugal component according to an embodiment of the present disclosure;

FIG. 9 is an enlarged schematic view of FIG. 3A;

fig. 10 is a schematic structural diagram of a door control unit according to an embodiment of the present disclosure.

Icon:

1-a centrifugal device; 100-base; 200-a first driving part; 210-a rotor; 220-stator; 230-a rotation axis; 240-brake disc; 250-electromagnetic coils; 260-stand; 300-centrifuging the component; 310-rotating rack; 320-hanging basket; 330-light blocking sheet; 400-a second driving part; 410-a driver; 420-a first driving wheel; 430-a second drive wheel; 440-driving member; 500-microwell plates; 510-accommodating a tube; 600-a first housing; 610-a support; 620-a pick-and-place port; 630-photoelectric switch; 700-a second housing; 710—a cover; 720-window; 800-door control part; 810-a third drive section; 820-baffle door panels; 830-slide rails; 840-a slider; 900-control part.

Detailed Description

The terms "first," "second," "third," and the like are used merely for distinguishing between descriptions and not for indicating a sequence number, nor are they to be construed as indicating or implying relative importance.

Furthermore, the terms "horizontal," "vertical," "overhang," and the like do not denote a requirement that the component be absolutely horizontal or overhang, but rather may be slightly inclined. As "horizontal" merely means that its direction is more horizontal than "vertical", and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.

In the description of the present application, it should be noted that, directions or positional relationships indicated by terms such as "inner", "outer", "left", "right", "upper", "lower", etc. are directions or positional relationships based on those shown in the drawings, or those that are conventionally put in use for the product of the application, are merely for convenience of description and simplification of the description, and are not indicative or implying that the apparatus or element to be referred to must have a specific direction, be configured and operated in a specific direction, and therefore should not be construed as limiting the present application.

In the description of the present application, unless explicitly stated and limited otherwise, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements.

The technical solutions of the present application will be described below with reference to the accompanying drawings.

Referring to fig. 1-5, the present application provides a centrifugal device 1, comprising: a base 100, a first driving unit 200, a centrifugal member 300, and a second driving unit 400; referring to fig. 6, the first driving unit 200 is disposed on the base 100, and the first driving unit 200 includes a rotor 210, a stator 220, and a rotating shaft 230 connected to the rotor 210; the centrifugal part 300 is used for placing a centrifugal sample, the centrifugal part 300 is connected with the rotating shaft 230, and the rotor 210 drives the rotating shaft 230 to drive the centrifugal part 300 to rotate and centrifuge; the second driving part 400 is arranged on the base 100, and the second driving part 400 is connected with the stator 220; when the first driving unit 200 is braked, the second driving unit 400 drives the first driving unit 200 and the centrifugal member 300 to rotate, so that the centrifugal member 300 is rotated to a predetermined position, and the centrifugal sample is taken and placed.

Alternatively, the first driving part 200 may be a brushless dc motor.

In this embodiment, since the stator 220 in the first driving portion 200 is fixedly disposed, when the rotor 210 of the first driving portion 200 drives the rotation shaft 230 to rotate and further drives the centrifugal component 300 to rotate and centrifuge, the second driving portion 400 is fixedly connected with the stator 220 in the first driving portion 200, and the second driving portion 400 is in an inactive state, which does not affect the rotation of the first driving portion 200 and does not increase noise and vibration. When the first driving portion 200 brakes, the rotor 210 stops rotating and keeps fixed with the stator 220, at this time, the second driving portion 400 may drive the stator 220 and the rotor 210 of the first driving portion 200 to rotate together, and further drive the centrifugal component 300 to rotate, and after reaching the preset position, the second driving portion 400 stops working, at this time, an operator may take off the centrifuged sample from the preset position, or take off the centrifuged sample from the centrifugal component 300 through a mechanical arm.

Further, referring to fig. 6, the first driving portion 200 further includes: a braking portion including: a brake disc 240, an electromagnetic coil 250, and a housing 260; wherein, the brake disc 240 is fixed at the bottom of the rotating shaft 230, and the electromagnetic coil 250 is fixedly connected with the stand 260; the stator 220 is fixedly connected with the stand 260; in the energized state, the brake disc 240 and the electromagnetic coil 250 attract and brake the rotation shaft 230.

In this embodiment, the stand 260 is fixed, the stator 220 is fixedly connected with the stand 260, and when the power is on, the electromagnetic coil 250 generates magnetic force to be closely combined with the brake disc 240, so that the brake disc 240 locks the rotating shaft 230, and the rotating shaft 230 cannot rotate, thereby realizing braking of the rotating shaft 230. At this time, both the rotor 210 and the stator 220 remain stationary.

Optionally, a return spring may be further disposed on the first driving portion 200, where the return spring is connected to the brake disc 240, and when the brake disc 240 is in a power failure state, the electromagnetic coil 250 loses magnetism, and the return spring pulls back the brake disc 240 by means of elastic restoring force, so that the brake disc 240 and the electromagnetic wire 250 are separated from adsorption.

Further, referring to fig. 7, the second driving part 400 includes: a driving member 410, a first driving wheel 420, a second driving wheel 430 and a driving member 440; the driving member 410 is connected with the first driving wheel 420, the second driving wheel 430 is arranged on the stator 220, and the first driving wheel 420 is in driving connection with the second driving wheel 430 through a driving member 440.

In this embodiment, optionally, the second driving portion 400 is driven by a pulley and a synchronous belt, a gear or a sprocket. The driving member 410 may be a stepping motor. The transmission member 440 may be a conveyor belt or a belt. The second driving wheel 430 may be coupled to the housing 260 to which the stator 220 is fixed. The output shaft of the driving member 410 is connected to the first driving wheel 420, and when the driving member 410 drives the first driving wheel 420 to rotate, the driving member 440 drives the second driving wheel 430 to rotate, so as to drive the first driving part 200 and the centrifugal component 300 to rotate.

Further, referring to fig. 8, the centrifugal component 300 includes: a swivel mount 310 and at least one basket 320; the rotating frame 310 is connected to the rotating shaft 230, and the basket 320 is provided on the rotating frame 310.

The basket 320 is used for placing the microplate 500 thereon, and the microplate 500 may be composed of a plurality of receiving tubes 510, each receiving tube 510 being used for placing a sample to be centrifuged therein.

Alternatively, the basket 320 may be pivotally connected to the rotating frame 310 by a hinge or pin. Illustratively, the basket 320 is hinged to the rotating frame 310 through a pin, and can swing freely, at least one locking component for fixing the microplate 500 is disposed on the basket 320, and the locking component may be a buckle for clamping the microplate 500 and is distributed on the edge of the basket 320.

Alternatively, referring to fig. 4, the rotating frame 310 is in an i shape, and the basket 320 is positioned at an end of the i-shaped rotating frame 310. The number of baskets 320 may be two or more and are symmetrically arranged along the central axis of the spin basket 310. In this embodiment, there are two baskets 320. In other alternative embodiments, the baskets 320 may be 3, 4, 5, etc. and may be distributed in a circular array.

The basket 320 is generally in two states, i.e., the basket 320 is in a horizontal state when stopped, and when the first driving part 200 drives the rotating frame 310 to move, the basket 320 rotates around the central axis of the rotating frame 310 along with the rotation of the rotating frame 310, and simultaneously the basket 320 is thrown up under the combined action of centrifugal force and the gravity center of the basket 320, and is changed from the initial horizontal state to a state of rotating 90 ° around the rotation axis of the basket 320. Due to the strong centrifugal force, the beads attached to the inside of the accommodating tubes 510 of the microplate 500 are thrown toward the bottom of each accommodating tube 510 of the microplate 500, thereby reducing the loss of the micro sample. The centrifugal separation of the liquid in the microplate 500 is achieved by separating substances of different sedimentation coefficients and buoyancy densities located in the accommodation tube 510 using the principle that sedimentation rates of different specific gravity components (solid or liquid) are different.

Further, referring to fig. 2 and 3, the centrifugal device 1 further includes: the first casing 600, the first casing 600 is provided outside the centrifugal member 300, and is fixed to the base 100 by the supporting portion 610. Alternatively, the four supporting portions 610 are respectively disposed at the bottom of the first housing 600 at intervals, and are used for supporting the first housing 600, so as to reduce the driving effect in the centrifugation process. The first housing 600 plays a protective role to prevent the centrifugal member 300 from being contaminated during the centrifugation.

Further, referring to fig. 3 and 5, the first housing 600 is provided with a pick-and-place opening 620. Through the access port 620, an operator or a mechanical arm can conveniently access the microplate 500.

Further, referring to fig. 9, a photoelectric switch 630 is disposed on the first housing 600, and a light blocking sheet 330 matched with the photoelectric switch 630 is disposed on the centrifugal component 300.

Optionally, the photoelectric switch 630 is a groove-shaped photoelectric switch with a groove, and is fixed at the bottom of the first housing 600, the light blocking piece 330 is fixed at the bottom of the i-shaped rotating frame 310, when the first driving part 200 drives the centrifugal component 300 to rotate, the light blocking piece 330 is driven to rotate, when the light blocking piece 330 passes through the groove of the photoelectric switch 630, the photoelectric switch 630 detects the light blocking piece 330, and the position is marked as a zero position of the rotating frame 310.

Further, referring to fig. 1, the centrifugal device 1 further includes: the second casing 700 is provided outside the first driving unit 200, the centrifugal member 300, and the second driving unit 400, and is connected to the base 100, and the cover 710 is connected to the second casing 700.

In this embodiment, the second housing 700 isolates the first driving part 200, the centrifugal component 300 and the second driving part 400 from the outside, so as to reduce the pollution of the sample to be centrifuged during the centrifugation process.

Further, referring to fig. 10, the centrifugal device 1 further includes: a door control part 800, the door control part 800 being provided on the base 100; the door control section 800 includes: a third driving part 810 and a barrier door plate 820; the third driving part 810 is disposed on the base 100 and connected to the baffle door plate 820, a window 720 is disposed on a wall surface of the second housing 700 at one side of the access opening 620, the window 720 is opposite to the access opening 620, and the third driving part 810 drives the baffle door plate 820 to lift so as to separate the window 720 from the access opening 620.

Alternatively, the third driving part 810 may be a screw motor, a hydraulic cylinder, or a pneumatic cylinder. In this embodiment, the third driving portion 810 drives the baffle door plate 820 to rise or fall, and when the third driving portion 810 drives the baffle door plate 820 to rise to the upper limit, the baffle door plate 820 completely separates the window 720 from the access opening 620, so that the centrifugal component 300 is blocked from the outside, and the centrifugal component 300 can perform centrifugal operation without being polluted by the outside environment. When the third driving part 810 drives the baffle door plate 820 to descend to the lower limit so that the window 720 and the taking and placing port 620 are completely exposed to each other, an operator or a mechanical arm can take out the centrifuged microplate 500 through the window 720 and the taking and placing port 620.

The upper limit is a position where the shutter plate 820 is raised to completely seal the window 720 and the access opening 620 from each other, and the lower limit is a position where the shutter plate 820 is lowered to completely expose the window 720 and the access opening 620 from each other.

Further, the door control section 800 further includes: the sliding rail 830 is arranged on the wall surface of the second shell 700, which is positioned on one side of the taking and placing port 620, and the sliding block 840 is arranged on the baffle door plate 820, and the baffle door plate 820 moves along the sliding rail 830 through the sliding block 840.

In this embodiment, two sliding rails 830 are symmetrically disposed on the wall surface of the second housing 700 on one side of the access 620, and at least two corresponding sliding blocks 840 are provided, so that when the third driving portion 810 drives the baffle plate 820, the baffle plate 820 can move on the sliding rails 830 through the sliding blocks 840, so as to improve the moving accuracy of the baffle plate 820.

Further, referring to fig. 2, the centrifugal device 1 further includes: the control unit 900, the control unit 900 is provided on the base 100, and the control unit 900 is connected to the first driving unit 200 and the second driving unit 400. Optionally, the control part 900 is also connected to the door control part 800.

The control unit 900 corresponds to a control center of the whole centrifugal device 1, and may receive or send instructions, for example, control the rotation angle of the first driving unit 200 and the start and stop of the first driving unit 200; the activation and braking of the second driving part 400 are controlled. Illustratively, the control portion 900 includes: the device comprises a power supply unit, a man-machine interaction interface, a communication unit, a processor and a control unit. The power supply unit can be an external power supply or a storage battery. The man-machine interaction interface can be a computer input and output device such as a display screen, a keyboard, a touch screen, keys, a knob, a sound, an led lamp and the like, and is used for inputting instructions and reading information, so that man-machine interaction and information intercommunication are realized. The communication unit may be a transceiver and the control unit may be a microcontroller (Microcontroller Unit, abbreviated as MCU).

As described above, when the first driving portion 200 drives the centrifugal component 300 to rotate, the light blocking sheet 330 is driven to rotate, when the light blocking sheet 330 passes through the groove of the photoelectric switch 630, the photoelectric switch 630 detects the light blocking sheet 330, the position is marked as the zero position of the rotating frame 310, the photoelectric switch 630 can send a signal to the control portion 900, and the control portion 900 can pulse to control the rotor 210 of the first driving portion 200 to rotate, so as to drive the rotating shaft 230 to rotate to drive the rotating frame 310 on the centrifugal component 300 to rotate by a preset angle to stop. Each time the first driving part 200 stops, it stops at a position of a preset angle after passing through the zero position. Since the positions of the light blocking sheet 330 and the photo switch 630 are determined, the position where the basket 320 stops is also determined. The arrangement of the light blocking sheet 330 and the photoelectric switch 630 can be used to detect the position of the rotating frame 310 and to realize precise control of the rotating movement of the rotating frame 310, so that the basket 320 can be precisely stopped at a fixed position after the first driving part 200 stops operating.

Referring to fig. 1-8, the working procedure of the centrifugal device 1 of the present application is as follows:

a. in the initial state, the components of the centrifugal device 1 are in the zero position, the baffle door plate 820 is in the closed state, and the baskets 320 of the centrifugal components 300 are in the respective plate areas. Illustratively, one basket 320 is opposite to the baffle door plate 820, the taking and placing port 620 and the window 720, the plate area is a plate, and the other basket 320 opposite to the basket 320 in the plate a is located in the opposite direction away from the baffle door plate 820 and the taking and placing port 620 and the window 720, and the plate area is a plate B, as shown in fig. 4.

b. When an operator or a mechanical arm clamps one micro-porous plate 500 to reach the window 720, the control part 900 controls the door control part 800 to operate, the third driving part 810 drives the baffle door plate 820 to descend, the baffle door plate 820 moves downwards on the sliding rail 830 through the sliding block 840, the baffle door plate 820 is opened, and the window 720 and the picking and placing opening 620 are completely exposed by the baffle door plate 820.

c. An operator or robotic arm extends into the window 720 and the access port 620 to place the microplate 500 onto the basket 320 in the A-plate position.

d. After power-on, the control part 900 controls the first driving part 200 to brake, the control part 900 sends out a braking signal, the braking part receives the braking signal, drives the electromagnetic wire 250 to generate magnetic force, and is closely combined with the adsorption of the brake disc 240, and the brake disc 240 locks the rotating shaft 230, so that the rotating shaft 230 cannot rotate, and the braking of the rotating shaft 230 is realized.

e. The control part 900 controls the second driving part 400 to work, the second driving part 400 receives the control signal, the driving part 410 drives the first driving wheel 420 to rotate, the driving part 440 drives the second driving wheel 430 to rotate, and then drives the first driving part 200 and the centrifugal part 300 to rotate, and further drives the rotating frame 310 connected with the rotating shaft 230 to rotate 180 degrees, so that the A plate position of the micro-pore plate 500 is rotated to be far away from the baffle plate 820 and one end of the opposite direction of the picking and placing port 620 and the window 720, and at the moment, the B plate position is rotated to be opposite to the baffle plate 820, the picking and placing port 620 and the window 720. When the rotating frame 310 rotates to the zero position (i.e., the light blocking sheet 330 blocks the groove of the photoelectric switch 630), the second driving part 400 stops rotating.

The sample to be centrifuged is placed in advance in the microplate 500. In step d, since the basket 320 is provided in two, that is, only two of the a plate and the B plate, it is only necessary to control the first driving part 200 to rotate 180 °, and when the basket 320 is three, each plate is required to rotate 120 °; when the basket 320 is four, each plate needs to be rotated 90 °, and so on.

f. Repeating the steps B-e, transferring another microplate 500 to be centrifuged to the window 720 by an operator or a mechanical arm, extending the operator or the mechanical arm into the window 720 and the taking and placing opening 620, and placing the microplate 500 on the basket 320 at the B plate position.

g. The control part 900 controls the door control part 800 to operate, the third driving part 810 drives the baffle door plate 820 to ascend, the baffle door plate 820 moves upwards on the sliding rail 830 through the sliding block 840, the baffle door plate 820 is closed, and the baffle door plate 820 completely cuts off the window 720 from the taking and placing opening 620. At this time, the microplates 500 are placed on both baskets 320, awaiting the centrifugation operation.

h. The control part 900 controls the first driving part 200 to operate, the brake part receives the release signal, the electromagnetic coil 250 is powered off to lose magnetic force, at the moment, the return spring separates the brake disc 240 from the electromagnetic coil 250, the brake disc 240 releases the rotating shaft 230, the rotor 210 drives the rotating shaft 230 to start rotating according to the set centrifugal parameters, and then drives the rotating frame 310 connected with the rotating shaft 230 to rotate, and the hanging basket 320 is gradually thrown from a horizontal state until the hanging basket is rotated to a 90-degree state.

i. After the centrifugation, the control unit 900 controls the first driving unit 200 to brake, and the braking unit brakes the rotation shaft 230, so that the basket 320 returns to the horizontal state. After the centrifugation is finished, the photoelectric switch 630 and the light blocking sheet 330 judge positions, and the fixed position where the hanging basket 320 finally and accurately stops is determined, namely, the position A (or the position B) stops at the positions of the window 720 and the taking and placing port 620.

j. The control part 900 controls the door control part 800 to operate, the third driving part 810 drives the baffle door plate 820 to descend, the baffle door plate 820 moves downwards on the sliding rail 830 through the sliding block 840, the baffle door plate 820 is opened, the baffle door plate 820 exposes the window 720 and the taking and placing opening 620 completely, and at this time, an operator or a mechanical arm stretches into the window 720 and the taking and placing opening 620 to take away the micro-porous plate 500 on the A plate position.

k. The control part 900 controls the second driving part 400 to work, the driving part 410 drives the first driving wheel 420 to rotate, the driving part 440 drives the second driving wheel 430 to rotate, and then drives the first driving part 200 and the centrifugal part 300 to rotate so as to drive the rotating frame 310 connected with the rotating shaft 230 to rotate 180 degrees, so that the B plate position on which the micro-pore plate 500 is installed is rotated to the position opposite to the baffle door plate 820, the taking and placing opening 620 and the window 720, and at the moment, an operator or a mechanical arm stretches into the window 720 and the taking and placing opening 620 to take away the micro-pore plate 500 on the B plate position for subsequent experimental operation.

The control unit 900 controls the door control unit 800 to operate, the third driving unit 810 drives the shutter plate 820 to move upward, the shutter plate 820 moves upward on the slide rails 830 through the sliders 840, the shutter plate 820 closes, and the shutter plate 820 completely blocks the window 720 from the access opening 620.

To this end, a complete workflow of the centrifuge device 1 is completely completed.

Compared with the existing centrifugal equipment, in the centrifugal device 1 of the present application, the second driving portion 400 is in transmission connection with the first driving portion 200 through the belt pulley and the synchronous belt, so that the first driving portion 200 does not influence the first driving portion 200 and does not increase noise and vibration when the centrifugal component 300 is driven to rotate and centrifuge. When the rotating frame 310 performs positioning rotation, the braking part in the first driving part 200 locks the rotating shaft 230, and the second driving part 400 can drive the first driving part 200 and the centrifugal component to rotate, so that the hanging basket 320 can be conveniently taken and placed by an operator or a mechanical arm on the micro-porous plate 500 after rotating to a preset position.

The centrifugal device 1 of the present utility model can be applied to the field of gene detection for performing centrifugal processing on nucleic acid samples in peripheral venous blood, tissues, and other body fluids of a subject. The centrifugal device 1 can also be used for eliminating bubbles in liquid, layering the liquids with different densities, collecting the liquid on the side wall of the micro-pore plate, and the like, and can greatly improve the centrifugal treatment efficiency.

The present application also provides a sample processing device comprising a centrifugation apparatus 1 as described above. The centrifugal device 1 can be integrated in sample processing equipment for use, and after centrifugal operation treatment is completed, other experimental operations can be directly carried out in the sample processing equipment, so that the pollution risk in the sample transfer process is reduced, and the treatment efficiency is improved.

It should be noted that, without conflict, features in the embodiments of the present application may be combined with each other.

The foregoing is merely a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and variations may be made to the present application by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims (12)

1. A centrifugal apparatus, comprising:

a base;

the first driving part is arranged on the base and comprises a rotor, a stator and a rotating shaft connected with the rotor;

the centrifugal component is connected with the rotating shaft, and the rotor drives the rotating shaft to drive the centrifugal component to rotate and centrifuge;

the second driving part is arranged on the base and is connected with the stator;

when the first driving part is braked, the second driving part drives the first driving part and the centrifugal part to rotate, so that the centrifugal part rotates to a preset position, and centrifugal sample taking and placing are performed.

2. The centrifugal device according to claim 1, wherein the centrifugal component comprises: a rotating frame and at least one basket; the rotating frame is connected with the rotating shaft, and the hanging basket is arranged on the rotating frame.

3. The centrifugal device according to claim 1, wherein the first driving portion further comprises: brake disc, solenoid and frame;

the brake disc is fixed at the bottom of the rotating shaft, and the electromagnetic coil is fixedly connected with the base; the stator is fixedly connected with the machine base; in the energized state, the brake disc and the electromagnetic coil adsorb and brake the rotating shaft.

4. The centrifugal device according to claim 1, wherein the second driving portion includes: the driving piece, the first driving wheel, the second driving wheel and the driving piece;

the driving piece is connected with the first driving wheel, the second driving wheel is arranged on the stator, and the first driving wheel is in transmission connection with the second driving wheel through the driving piece.

5. The centrifuge device of claim 1, further comprising: the first shell is arranged outside the centrifugal component and is fixed on the base through the supporting part.

6. The centrifugal device according to claim 5, wherein the first housing is provided with a photoelectric switch, and the centrifugal component is provided with a light blocking piece matched with the photoelectric switch.

7. The centrifugal device of claim 5, wherein the first housing is provided with a pick-and-place opening.

8. The centrifuge of claim 7, further comprising: the second shell is arranged outside the first driving part, the centrifugal part and the second driving part, is connected with the base and is connected with a cover body.

9. The centrifuge device of claim 8, further comprising: a door control part arranged on the base;

the door control section includes: a third driving part and a baffle plate; the third driving part is arranged on the base and connected with the baffle door plate, a window is formed in the wall surface of one side of the picking and placing opening of the second shell, the window is opposite to the picking and placing opening, and the third driving part drives the baffle door plate to lift so as to separate the window from the picking and placing opening.

10. The centrifugal apparatus according to claim 9, wherein the gate control portion further comprises: the sliding rail is arranged on the wall surface of one side of the picking and placing opening of the second shell, the sliding block is arranged on the baffle door plate, and the baffle door plate moves along the sliding rail through the sliding block.

11. The centrifugal device according to claim 1 or 9, wherein the centrifugal device further comprises: and the control part is arranged on the base and is connected with the first driving part and the second driving part.

12. A sample processing device comprising a centrifugation apparatus as claimed in any one of claims 1 to 11.