CN220584063U - Novel cytotoxicity experiment detects device - Google Patents
Novel cytotoxicity experiment detects device Download PDFInfo
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- CN220584063U CN220584063U CN202321858089.6U CN202321858089U CN220584063U CN 220584063 U CN220584063 U CN 220584063U CN 202321858089 U CN202321858089 U CN 202321858089U CN 220584063 U CN220584063 U CN 220584063U
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- 231100000135 cytotoxicity Toxicity 0.000 title claims abstract description 19
- 230000003013 cytotoxicity Effects 0.000 title claims abstract description 19
- 238000002474 experimental method Methods 0.000 title claims abstract description 18
- 238000001514 detection method Methods 0.000 claims abstract description 92
- 239000000523 sample Substances 0.000 claims description 23
- 230000001681 protective effect Effects 0.000 claims description 12
- 231100000263 cytotoxicity test Toxicity 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 description 10
- 238000000034 method Methods 0.000 description 6
- 238000013461 design Methods 0.000 description 5
- 239000000654 additive Substances 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
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- 239000000463 material Substances 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 1
- 102000013563 Acid Phosphatase Human genes 0.000 description 1
- 108010051457 Acid Phosphatase Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000022534 cell killing Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000002784 cytotoxicity assay Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007877 drug screening Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
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- 210000003470 mitochondria Anatomy 0.000 description 1
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- 239000006228 supernatant Substances 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model belongs to the field of cell detection, in particular to a novel cytotoxicity experiment detection device, which aims at the problems that the prior device can only be held by hands when being carried, the device can not be carried by hands, and is inconvenient.
Description
Technical Field
The utility model relates to the technical field of cell detection, in particular to a novel cytotoxicity experiment detection device.
Background
Cytotoxicity is a simple cell killing event caused by a cell or chemical substance, independent of the cell death mechanism of apoptosis or necrosis. Sometimes it is desirable to conduct assays for cytotoxicity of specific substances, such as drug screening. Cytotoxicity assays are based on changes in cell membrane permeability, and are commonly used in several ways: MTT, XTT method: specific tetrazolium salts can be converted by utilizing the activity of enzymes in mitochondria, and then detected by an enzyme-labeled instrument; the LDH method comprises the following steps: detecting cytotoxicity by detecting enzymatic activity of LDH in the cell culture supernatant; other enzymatic methods: such as detecting alkaline phosphatase and acid phosphatase activity in the supernatant.
Through retrieving, the patent with the bulletin number of CN217846087U discloses a novel cytotoxicity experiment detection device, including supporting assembly subassembly, cell bearing assembly, cultivate the feed subassembly, direction locating component, image monitoring component, power drive the subassembly and shade shows the subassembly, this cytotoxicity experiment detection device will be equipped with image probe's monitoring seat frame and install on the guide rail, and drive its removal through the drive lead screw, can adjust image probe's position as required, and carry the household utensils in-process of taking the additive with image probe and remove suitable position, avoid causing the influence to the operation process, display panel passes through the hinge and installs on the shade roof, can show monitoring image when carrying out shade protection to the household utensils and image probe the place ahead, make the experiment process more directly perceived, and make the experiment process more convenient and fast.
The following problems exist in the technical scheme:
when the equipment is required to be carried, the equipment can be held by hands and cannot be carried by hands, so that the equipment is inconvenient;
in order to solve the problems, the utility model provides a novel cytotoxicity experiment detection device.
Disclosure of Invention
The utility model provides a novel cytotoxicity experiment detection device, which solves the defects that in the prior art, when the equipment needs to be carried, the equipment can be held by hands only and cannot be carried by hands, so that the equipment is inconvenient to carry.
The utility model provides the following technical scheme:
the utility model provides a novel cytotoxicity experiment detection device, includes detection case, display panel and image probe, display panel sets up in one side of detection case, the top fixedly connected with mounting panel of detection case, the top of image probe and the bottom fixedly connected with of mounting panel, the bottom inner wall of detection case has the bearing vessel through the screw fixation, the bearing vessel is located image probe's under, the bottom inner wall of detection case has the feed to carry the dish through the screw fixation, the bottom inner wall fixedly connected with baffle of feed carries the dish, the bottom inner wall fixedly connected with elasticity cutting ferrule of feed carries the dish, the joint has the pipettes that moves on the elasticity cutting ferrule, one side of detection case is equipped with the revolving door, one side fixedly connected with second handle of revolving door, image probe and display panel electric connection;
the carrying mechanism is arranged on the detection box and is convenient for the detection box to carry;
the fixing mechanism is arranged on the detection box and used for fixing the revolving door.
In one possible design, the carrying mechanism comprises a frame body and a first handle, wherein the bottom of the frame body is fixedly connected with the top of the detection box, two sides of the first handle are fixedly connected with rotating shafts, and one ends, far away from each other, of the two rotating shafts are respectively connected with the inner walls of the two sides of the frame body in a rotating manner.
In a possible design, fixed establishment is including T piece, concave type piece and threaded rod, the bottom of T piece and the top fixed connection of revolving door, the bottom of concave type piece and the top fixed connection of detecting box, the T piece is pegged graft in concave type piece, threaded rod and concave type piece threaded connection, the round hole has been seted up to one side of T piece, peg graft in the round hole in the bottom of threaded rod, the top fixedly connected with of threaded rod is convenient for the threaded rod to carry out pivoted carousel.
In one possible design, a protective cover for protecting the display panel is arranged on one side of the detection box, the protective cover is fixed on the detection box through screws, and the display panel is positioned in the protective cover.
In one possible design, one side of the detection box is fixedly connected with two hinges which are convenient for the revolving door to rotate, and one side of each hinge is fixedly connected with one side of the revolving door.
In one possible design, the bottom of the detection box is fixedly connected with a rubber block for preventing the detection box from slipping
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the utility model as claimed.
According to the utility model, the T-shaped block is inserted into the concave-shaped block, the turntable is rotated, the rotation of the turntable drives the threaded rod to rotate, and one end of the threaded rod is inserted into the round hole of the T-shaped block, so that the revolving door can be fixed;
according to the utility model, as the first handle is arranged, the detection box can be conveniently carried by the first handle, so that the detection box does not need to be held by hands, and is more convenient and faster;
according to the utility model, the protective cover is arranged, so that the display panel can be protected during carrying, and the service life is prolonged;
the portable detection box is reasonable in structure, the detection box can be conveniently carried through the carrying mechanism, the detection box does not need to be held by hands, the portable detection box is more convenient and fast, the revolving door can be fixed through the fixing mechanism, and the revolving door is prevented from being opened during carrying.
Drawings
FIG. 1 is a schematic diagram of a front view of a novel cytotoxicity test assay device according to an embodiment of the present utility model;
FIG. 2 is a schematic side view of a novel cytotoxicity test assay device according to an embodiment of the present utility model;
FIG. 3 is a schematic diagram of the internal structure of a detection box of the novel cytotoxicity test detection apparatus according to the embodiment of the present utility model;
fig. 4 is a schematic structural diagram of a carrying mechanism and a fixing mechanism of the novel cytotoxicity test detection apparatus according to the embodiment of the present utility model.
Reference numerals:
1. a detection box; 2. a protective cover; 3. a revolving door; 4. a frame; 5. a rubber block; 6. a T block; 7. a concave block; 8. a turntable; 9. a threaded rod; 10. a rotating shaft; 11. a first handle; 12. a carrying vessel; 13. an image probe; 14. a feed carrier tray; 15. a hinge; 16. a display panel.
Detailed Description
Embodiments of the present utility model will be described below with reference to the accompanying drawings in the embodiments of the present utility model.
In describing embodiments of the present utility model, it should be noted that, unless explicitly stated and limited otherwise, the terms "coupled" and "mounted" should be interpreted broadly, and for example, "coupled" may or may not be detachably coupled; may be directly connected or indirectly connected through an intermediate medium. In addition, "communication" may be direct communication or may be indirect communication through an intermediary. Wherein, "fixed" means that the relative positional relationship is not changed after being connected to each other. References to orientation terms, such as "inner", "outer", "top", "bottom", etc., in the embodiments of the present utility model are merely to refer to the orientation of the drawings and, therefore, the use of orientation terms is intended to better and more clearly illustrate and understand the embodiments of the present utility model, rather than to indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be construed as limiting the embodiments of the present utility model.
In embodiments of the present utility model, the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature.
In the embodiment of the present utility model, "and/or" is merely an association relationship describing an association object, and indicates that three relationships may exist, for example, a and/or B may indicate: a exists alone, A and B exist together, and B exists alone. In addition, the character "/" herein generally indicates that the front and rear associated objects are an "or" relationship.
Reference in the specification to "one embodiment" or "some embodiments" or the like means that a particular feature, structure, or characteristic described in connection with the embodiment is included in one or more embodiments of the utility model. Thus, appearances of the phrases "in one embodiment," "in some embodiments," "in other embodiments," and the like in the specification are not necessarily all referring to the same embodiment, but mean "one or more but not all embodiments" unless expressly specified otherwise. The terms "comprising," "including," "having," and variations thereof mean "including but not limited to," unless expressly specified otherwise.
Example 1
Referring to fig. 1-4, a novel cytotoxicity experiment detection device comprises a detection box 1, a display panel 16 and an image probe 13, wherein the display panel 16 is arranged on one side of the detection box 1, the top of the detection box 1 is fixedly connected with a mounting plate, the top of the image probe 13 is fixedly connected with the bottom of the mounting plate, the bottom inner wall of the detection box 1 is fixedly provided with a bearing vessel 12 through a screw, the bearing vessel 12 is positioned right below the image probe 13, the bottom inner wall of the detection box 1 is fixedly provided with a feeding carrier plate 14 through a screw, the bottom inner wall of the feeding carrier plate 14 is fixedly connected with a partition plate, the bottom inner wall of the feeding carrier plate 14 is fixedly connected with an elastic clamping sleeve, a liquid-transferring dropper is clamped on the elastic clamping sleeve, one side of the detection box 1 is provided with a revolving door 3, one side of the revolving door 3 is fixedly connected with a second handle, and the image probe 13 is electrically connected with the display panel 16;
the carrying mechanism is arranged on the detection box 1 and is convenient for carrying the detection box 1;
and the fixing mechanism is arranged on the detection box 1 and is used for fixing the revolving door 3.
Above-mentioned technical scheme can be convenient for detect case 1 and carry through carrying the mechanism, just need not hold by the hand, and is more convenient, can fix revolving door 3 through fixed establishment, revolving door 3 opens when avoiding carrying.
Referring to fig. 4, the carrying mechanism includes a frame body 4 and a first handle 11, wherein the bottom of the frame body 4 is fixedly connected with the top of the detection box 1, two sides of the first handle 11 are fixedly connected with rotating shafts 10, and one ends, far away from each other, of the two rotating shafts 10 are respectively connected with two side inner walls of the frame body 4 in a rotating manner.
According to the technical scheme, the detection box 1 can be conveniently carried through the first handle 11, so that the detection box is not held by hands, and the detection box is more convenient and rapid.
Referring to fig. 4, the fixing mechanism comprises a T block 6, a concave block 7 and a threaded rod 9, wherein the bottom of the T block 6 is fixedly connected with the top of the revolving door 3, the bottom of the concave block 7 is fixedly connected with the top of the detection box 1, the T block 6 is inserted into the concave block 7, the threaded rod 9 is in threaded connection with the concave block 7, a round hole is formed in one side of the T block 6, the bottom end of the threaded rod 9 is inserted into the round hole, and a turntable 8 which is convenient for the threaded rod 9 to rotate is fixedly connected with the top of the threaded rod 9.
Above-mentioned technical scheme T piece 6 inserts in concave type piece 7, rotates carousel 8, and the rotation of carousel 8 has driven the rotation of threaded rod 9, makes the one end of threaded rod 9 insert in the round hole of T piece 6 to can fix revolving door 3.
Example 2
Referring to fig. 1-4, a novel cytotoxicity experiment detection device comprises a detection box 1, a display panel 16 and an image probe 13, wherein the display panel 16 is arranged on one side of the detection box 1, the top of the detection box 1 is fixedly connected with a mounting plate, the top of the image probe 13 is fixedly connected with the bottom of the mounting plate, the bottom inner wall of the detection box 1 is fixedly provided with a bearing vessel 12 through a screw, the bearing vessel 12 is positioned right below the image probe 13, the bottom inner wall of the detection box 1 is fixedly provided with a feeding carrier plate 14 through a screw, the bottom inner wall of the feeding carrier plate 14 is fixedly connected with a partition plate, the bottom inner wall of the feeding carrier plate 14 is fixedly connected with an elastic clamping sleeve, a liquid-transferring dropper is clamped on the elastic clamping sleeve, one side of the detection box 1 is provided with a revolving door 3, one side of the revolving door 3 is fixedly connected with a second handle, and the image probe 13 is electrically connected with the display panel 16;
the carrying mechanism is arranged on the detection box 1 and is convenient for carrying the detection box 1;
and the fixing mechanism is arranged on the detection box 1 and is used for fixing the revolving door 3.
Above-mentioned technical scheme can be convenient for detect case 1 and carry through carrying the mechanism, just need not hold by the hand, and is more convenient, can fix revolving door 3 through fixed establishment, revolving door 3 opens when avoiding carrying.
Referring to fig. 4, the carrying mechanism includes a frame body 4 and a first handle 11, wherein the bottom of the frame body 4 is fixedly connected with the top of the detection box 1, two sides of the first handle 11 are fixedly connected with rotating shafts 10, and one ends, far away from each other, of the two rotating shafts 10 are respectively connected with two side inner walls of the frame body 4 in a rotating manner.
According to the technical scheme, the detection box 1 can be conveniently carried through the first handle 11, so that the detection box is not held by hands, and the detection box is more convenient and rapid.
Referring to fig. 4, the fixing mechanism comprises a T block 6, a concave block 7 and a threaded rod 9, wherein the bottom of the T block 6 is fixedly connected with the top of the revolving door 3, the bottom of the concave block 7 is fixedly connected with the top of the detection box 1, the T block 6 is inserted into the concave block 7, the threaded rod 9 is in threaded connection with the concave block 7, a round hole is formed in one side of the T block 6, the bottom end of the threaded rod 9 is inserted into the round hole, and a turntable 8 which is convenient for the threaded rod 9 to rotate is fixedly connected with the top of the threaded rod 9.
Above-mentioned technical scheme T piece 6 inserts in concave type piece 7, rotates carousel 8, and the rotation of carousel 8 has driven the rotation of threaded rod 9, makes the one end of threaded rod 9 insert in the round hole of T piece 6 to can fix revolving door 3.
Referring to fig. 2, a protective cover 2 for protecting a display panel 16 is provided on one side of the detection case 1, the protective cover 2 is fixed to the detection case 1 by screws, and the display panel 16 is positioned in the protective cover 2.
The technical scheme can protect the display panel 16 when carrying through the protective cover 2, and the service life is prolonged.
Referring to fig. 2, two hinges 15 facilitating rotation of the revolving door 3 are fixedly connected to one side of the detection box 1, and one side of each hinge 15 is fixedly connected to one side of the revolving door 3.
According to the technical scheme, the revolving door 3 can be rotated through the hinge 15, so that the revolving door 3 can be conveniently opened or closed.
Referring to fig. 1, a rubber block 5 for preventing the detection case 1 from slipping is fixedly connected to the bottom of the detection case 1.
The above technical scheme can be used for skid resistance when the detection box 1 is placed through the rubber block 5.
The working principle and the using flow of the technical scheme are as follows: when the cells need to be detected, the cells to be detected are placed in the bearing vessel 12, the cells are detected through the image probe 13, the cells are displayed through the display panel 16, the culture additives for culturing the cells can be placed in the feed carrying tray 14 through the feed carrying tray 14, the additives in the feed carrying tray 14 can be taken into the bearing vessel 12 through the liquid drop transferring pipe to keep the cells alive, when the cells need to be carried, the revolving door 3 can be rotated through the hinge 15 through closing the revolving door 3, the revolving door 3 is convenient to open or close, the T block 6 is inserted into the concave block 7 when the revolving door 3 is closed, the turntable 8 is rotated, the rotation of the turntable 8 drives the rotation of the threaded rod 9, make the one end of threaded rod 9 insert in the round hole of T piece 6 to can fix revolving door 3, owing to set up first handle 11, can be convenient for detect case 1 through first handle 11 and carry, just need not hold by the hand, can hide first handle 11 in framework 4 when first handle 11 does not use, owing to set up safety cover 2, can protect display panel 16 when carrying through safety cover 2, increase of service life, second display panel 16's material is transparent PP material, or other transparent materials, display panel 16 and image probe 13's theory of operation is the same with the theory of operation of authorized number CN217846087U, therefore not excessively described in this text.
The present utility model is not limited to the above embodiments, and any person skilled in the art can easily think about the changes or substitutions within the technical scope of the present utility model, and the changes or substitutions are intended to be covered by the scope of the present utility model; embodiments of the utility model and features of the embodiments may be combined with each other without conflict. Therefore, the protection scope of the utility model is subject to the protection scope of the claims.
Claims (6)
1. The utility model provides a novel cytotoxicity experiment detection device, includes detection case (1), display panel (16) and image probe (13), its characterized in that, display panel (16) set up in one side of detection case (1), the top fixedly connected with mounting panel of detection case (1), the top of image probe (13) is fixedly connected with the bottom of mounting panel, the bottom inner wall of detection case (1) has through the screw fixation to bear household utensils (12), bear household utensils (12) and be located under image probe (13), the bottom inner wall of detection case (1) has feed carrier disc (14) through the screw fixation, the bottom inner wall fixedly connected with baffle of feed carrier disc (14), the bottom inner wall fixedly connected with elasticity of feed carrier disc (14), the joint has the liquid transfer burette on the elasticity cutting ferrule, one side of detection case (1) is equipped with revolving door (3), one side fixedly connected with second handle of revolving door (3), image probe (13) and display panel (16) electric connection;
the carrying mechanism is arranged on the detection box (1) and is convenient for carrying the detection box (1);
the fixing mechanism is arranged on the detection box (1) and used for fixing the revolving door (3).
2. The novel cytotoxicity test detection device according to claim 1, wherein the carrying mechanism comprises a frame body (4) and a first handle (11), the bottom of the frame body (4) is fixedly connected with the top of the detection box (1), two sides of the first handle (11) are fixedly connected with rotating shafts (10), and one ends, away from each other, of the two rotating shafts (10) are respectively connected with the inner walls of two sides of the frame body (4) in a rotating manner.
3. The novel cytotoxicity experiment detection device according to claim 1, wherein the fixing mechanism comprises a T block (6), a concave block (7) and a threaded rod (9), the bottom of the T block (6) is fixedly connected with the top of the revolving door (3), the bottom of the concave block (7) is fixedly connected with the top of the detection box (1), the T block (6) is inserted into the concave block (7), the threaded rod (9) is in threaded connection with the concave block (7), a round hole is formed in one side of the T block (6), the bottom of the threaded rod (9) is inserted into the round hole, and a turntable (8) which is convenient for the threaded rod (9) to rotate is fixedly connected with the top of the threaded rod (9).
4. The novel cytotoxicity experiment detection apparatus as set forth in claim 1, wherein a protective cover (2) for protecting the display panel (16) is provided on one side of the detection box (1), the protective cover (2) is fixed on the detection box (1) by screws, and the display panel (16) is located in the protective cover (2).
5. The novel cytotoxicity experiment detection device according to claim 1, wherein one side of the detection box (1) is fixedly connected with two hinges (15) which are convenient for the revolving door (3) to rotate, and one side of each hinge (15) is fixedly connected with one side of the revolving door (3).
6. The novel cytotoxicity experiment detection device according to claim 1, wherein the bottom of the detection box (1) is fixedly connected with a rubber block (5) for preventing the detection box (1) from slipping.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321858089.6U CN220584063U (en) | 2023-07-14 | 2023-07-14 | Novel cytotoxicity experiment detects device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321858089.6U CN220584063U (en) | 2023-07-14 | 2023-07-14 | Novel cytotoxicity experiment detects device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220584063U true CN220584063U (en) | 2024-03-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321858089.6U Active CN220584063U (en) | 2023-07-14 | 2023-07-14 | Novel cytotoxicity experiment detects device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220584063U (en) |
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2023
- 2023-07-14 CN CN202321858089.6U patent/CN220584063U/en active Active
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