CN220413408U - Magnetic suction extraction device - Google Patents
Magnetic suction extraction device Download PDFInfo
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- CN220413408U CN220413408U CN202321892033.2U CN202321892033U CN220413408U CN 220413408 U CN220413408 U CN 220413408U CN 202321892033 U CN202321892033 U CN 202321892033U CN 220413408 U CN220413408 U CN 220413408U
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- magnetic
- magnetic attraction
- hole plate
- deep hole
- base
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- 238000000605 extraction Methods 0.000 title claims abstract description 28
- 230000001360 synchronised effect Effects 0.000 claims description 20
- 238000002474 experimental method Methods 0.000 abstract description 8
- 102000039446 nucleic acids Human genes 0.000 abstract description 4
- 108020004707 nucleic acids Proteins 0.000 abstract description 4
- 150000007523 nucleic acids Chemical class 0.000 abstract description 4
- 239000011324 bead Substances 0.000 description 5
- 230000005389 magnetism Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000007885 magnetic separation Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The utility model discloses a magnetic extraction device, which comprises: the upper magnetic attraction structure is arranged at the top of the deep hole plate, and the lower magnetic attraction structure is arranged at the bottom of the deep hole plate. The device can enable a user to perform a nucleic acid magnetic attraction extraction experiment by combining upper magnetic attraction and lower magnetic attraction so as to cope with more complex and high-requirement nucleic acid extraction work, and the device is not limited to a specific magnetic attraction mode, has strong suitability and flexibility and greatly reduces experimental operation steps.
Description
Technical Field
The utility model relates to the field of biochemical experiment auxiliary equipment, in particular to a magnetic extraction device.
Background
Along with the rapid development of life science, the application of biology is wider and wider, the number of samples processed by clinical molecular diagnosis and biological laboratories is more and the sample forms are more diversified, the magnetic separation technology takes biological magnetic beads as carriers to rapidly separate nucleic acid, protein and the like from other substances in cells so as to achieve the purposes of extracting and purifying nucleic acid, and the magnetic attraction device is widely applied in the process. The prior art adopts the selection of using different magnetic attraction devices according to different application scenes, such as the magnetic attraction devices are generally selected for samples with high requirements on extraction time, complex samples and more impurities, the sources of the samples are single, the components are simple, the sensitivity requirements are high, the magnetic attraction devices are selected for the samples, but when the samples are complex and different systems are required to be converted in the extraction process, both modes are limited, and the operation steps are greatly improved.
Disclosure of Invention
In view of the problems mentioned in the background art, an object of the present utility model is to provide a magnetic extraction device, so as to solve the problems mentioned in the background art.
The technical aim of the utility model is realized by the following technical scheme:
a magnetic extraction device comprising: the upper magnetic attraction structure is arranged at the top of the deep hole plate, and the lower magnetic attraction structure is arranged at the bottom of the deep hole plate.
In one embodiment, sliding components are arranged on two sides of the bottom of the lower magnetic attraction structure and are connected with the deep hole plate.
In one embodiment, the sliding assembly comprises a sliding block, a first sliding rail and a deep hole plate base, wherein the deep hole plate base is connected to the bottom of the deep hole plate, the top of the sliding block is connected to the deep hole plate base, and the sliding block is arranged on the first sliding rail.
In one embodiment, the upper magnetic attraction structure comprises a magnetic rod carrier, a magnetic sleeve carrier, magnetic rods and an upper magnetic attraction drive, wherein two sides of the bottom end of the upper magnetic attraction drive are fixedly connected with one end of the first sliding rail, one end of the magnetic rod carrier is connected with the upper magnetic attraction drive, the magnetic rods are arranged in the magnetic rod carrier, and the magnetic sleeve carrier is arranged between the magnetic rod carrier and the deep hole plate.
In one embodiment, the upper magnetic attraction driving device comprises an upper and lower driving motor, a left and right driving motor, a first synchronous belt pulley belt and an upper magnetic attraction driving frame body, wherein the first synchronous belt pulley belt is sleeved at two ends of the upper magnetic attraction driving frame body, the surface of the upper magnetic attraction driving frame body is fixedly connected with the magnetic rod carrier and the magnetic sleeve carrier respectively, and the upper and lower driving motor and the left and right driving motor are arranged on the first synchronous belt pulley belt.
In one embodiment, the lower magnetic structure comprises a magnetic frame, a magnetic frame magnetic rod, a magnetic frame base and a lower magnetic drive, wherein the top end of the magnetic frame base is provided with the magnetic frame, the magnetic frame base is coaxially provided with the deep hole plate, the magnetic frame magnetic rod is arranged inside the magnetic frame base, the magnetic frame magnetic rod can penetrate through the deep hole plate base, and the lower magnetic drive is arranged on one side of the magnetic frame base.
In one embodiment, the lower magnetic attraction driving device comprises a lower magnetic attraction motor, a second synchronous pulley belt, a second sliding rail and a connecting block, wherein the connecting block is connected with the second sliding rail and the magnetic frame base, the second synchronous pulley belt can drive the connecting block to move, the connecting block slides on the second sliding rail, and the lower magnetic attraction motor is arranged on the second synchronous pulley belt.
In summary, the utility model has the following advantages: the upper magnetic attraction structure and the lower magnetic attraction structure are arranged at the top and the bottom of the deep pore plate, so that scientists can conduct the magnetic attraction extraction experiment on lighter and heavier samples at the same time when conducting the magnetic attraction extraction experiment, the specific magnetic attraction mode is not limited, the suitability and the flexibility are strong, and the experimental operation steps are greatly reduced.
Drawings
FIG. 1 is a schematic diagram of the structure of the present utility model;
FIG. 2 is a schematic view of a deep hole plate base structure removed in accordance with the present utility model;
FIG. 3 is a schematic view of a part of the structure of the lower magnetic attraction structure of the utility model;
fig. 4 is a front view of the lower magnetic structure of the present utility model.
In the figure: 1. a magnetic attraction structure is arranged; 11. a magnetic bar carrier; 12. a magnetic sleeve carrier; 13. a magnetic rod; 14. driving by magnetic attraction; 141. an up-down driving motor; 142. a left-right driving motor; 143. a first synchronous pulley belt; 144. the upper magnet drives the frame body; 2. a lower magnetic attraction structure; 2. a lower magnetic attraction structure; 21. a sliding assembly; 211. a slide block; 212. a first slide rail; 213. a deep hole plate base; 22. a magnetic frame; 23. a magnetic bar of a magnetic frame; 24. a magnetic frame base; 25. driving by lower magnetic attraction; 251. a lower magnetic attraction motor; 252. a second synchronous pulley belt; 253. a second slide rail; 254. a connecting block; 3. deep well plate.
Detailed Description
In order to better understand the technical solutions in the present application, the following description will clearly and completely describe the technical solutions in the embodiments of the present application in conjunction with the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only some embodiments of the present application, not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.
It will be understood that when an element is referred to as being "fixed" or "disposed" on another element, it can be directly on the other element or be indirectly on the other element; when an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.
It is to be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate or are based on the orientation or positional relationship shown in the drawings, merely to facilitate description of the present application and simplify description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be configured and operated in a particular orientation, and therefore should not be construed as limiting the present application.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present application, the meaning of "a plurality" or "a number" is two or more, unless explicitly defined otherwise.
The present utility model provides an embodiment, a magnetic attraction extraction device for oscillating and magnetically attracting samples in a deep well plate, as shown in fig. 1-4, comprising: the upper magnetic attraction structure 1 and the lower magnetic attraction structure 2 are arranged at the top of the deep hole plate 3, and the lower magnetic attraction structure 2 is arranged at the bottom of the deep hole plate 3.
Above-mentioned extraction element is inhaled to magnetism adopts and inhales structure 1 and lower magnetism and inhale structure 2 and set up in dark orifice plate 3 top and bottom for the scientist is when carrying out the magnetism and inhale the extraction experiment, can carry out lighter and heavier sample simultaneously and inhale the extraction experiment, is not limited specific magnetism and inhale the mode, and suitability and flexibility are strong, and experimental operation step significantly reduces.
In one embodiment, sliding components 21 are arranged on two sides of the bottom of the lower magnetic attraction structure 2, and the sliding components 21 are connected with the deep hole plate 3.
In one embodiment, the sliding assembly 21 includes a sliding block 211, a first sliding rail 212, and a deep-hole plate base 213, the deep-hole plate base 213 is connected to the bottom of the deep-hole plate 3, the top of the sliding block 211 is connected to the deep-hole plate base 213, and the sliding block 211 is disposed on the first sliding rail 212.
The cross section of the sliding block 211 is in a C shape, the sliding block 211 is fixed on the deep hole plate base 213 through a bolt and sleeved on the surface of the first sliding rail 212, and the deep hole plate base 213 drives the deep hole plate 3 through the sliding block 211, so that the deep hole plate 3 can replace a sample.
In one embodiment, the upper magnetic attraction structure 1 comprises a magnetic rod carrier 11, a magnetic sleeve carrier 12, magnetic rods 13 and an upper magnetic attraction driving 14, two sides of the bottom end of the upper magnetic attraction driving 14 are fixedly connected with one end of the first sliding rail 212, one end of the magnetic rod carrier 11 is connected with the upper magnetic attraction driving 14, the magnetic rods 13 are arranged inside the magnetic rod carrier 11, and the magnetic sleeve carrier 12 is arranged between the magnetic rod carrier 11 and the deep hole plate 3.
In one embodiment, the upper magnetic attraction drive 14 includes an upper and lower drive motor 141, a left and right drive motor 142, a first synchronous pulley belt 143, and an upper magnetic attraction drive frame 144, the first synchronous pulley belt 143 is sleeved at two ends of the upper magnetic attraction drive frame 144, and the surfaces of the upper magnetic attraction drive frame 144 are respectively fixedly connected with the magnetic rod carrier 11 and the magnetic sleeve carrier 12, and the upper and lower drive motor 141 and the left and right drive motor 142 are mounted on the first synchronous pulley belt 143.
Wherein, the upper magnetic attraction driving 14 drives the magnetic rod carrier 11 and the magnetic sleeve carrier 12, so that the magnetic rod carrier 11 and the magnetic sleeve carrier 12 can move up and down/left and right; the upper magnetic attraction driving 14 drives the deep hole plate base 213 to move back and forth; thereby forming a moving form in three-dimensional space. The magnetic rod carrier 11 and the magnetic sleeve carrier 12 are designed to move synchronously left and right, the magnetic rod carrier 11 and the magnetic sleeve carrier 12 are designed to move synchronously up and down and can move independently, the magnetic sleeve carrier 12 moves firstly when the control system sets to move independently downwards, and the moving distance of the magnetic rod carrier 11 is smaller than or equal to the moving distance of the magnetic sleeve carrier 12; the control system sets that the magnetic rod carrier 11 moves first when moving upwards independently, and the moving distance of the magnetic sleeve carrier 12 is smaller than or equal to the moving distance of the magnetic rod carrier 11. The control system is provided with a deep hole plate for moving the bottoms of the single magnetic rod carrier 11 and the magnetic sleeve carrier 12, and the magnetic rod carrier 11 and the magnetic sleeve carrier 12 can be moved at the rear.
In one embodiment, as shown in fig. 3 and 4, the lower magnetic structure includes a magnetic frame 22, a magnetic frame magnetic rod 23, a magnetic frame base 24, and a lower magnetic drive 25, where the magnetic frame 22 is disposed at the top end of the magnetic frame base 24, the magnetic frame base 24 is coaxially disposed on the deep hole plate, the magnetic frame magnetic rod 23 is disposed inside the magnetic frame base 24, the magnetic frame magnetic rod 23 can pass through the deep hole plate base 213, and the lower magnetic drive 25 is disposed on one side of the magnetic frame base 24.
Wherein the magnetic rack magnetic bars 23 are arranged for columns and for magnetic bars.
In one embodiment, the lower magnetic driving unit 25 includes a lower magnetic motor 251, a second synchronous pulley belt 252, a second sliding rail 253, and a connection block 254, where the connection block 254 connects the second sliding rail 253 with the magnetic frame base 24, the second synchronous pulley belt 252 can drive the connection block 254 to move, the connection block 254 slides on the second sliding rail 253, and the lower magnetic motor 251 is mounted on the second synchronous pulley belt 252.
Wherein, the lower magnetic motor 251 drives the connecting block 254, the connecting block 254 drives the magnetic frame base 24 to move left and right; after the magnetic frame base 24 is connected with the deep hole plate 3, the deep hole plate base 213 can drive the magnetic frame base 24 to move back and forth on the first slide rail.
A magnetic extraction device performs the magnetic extraction experimental steps as follows:
adding a sample and a reaction solution with magnetic beads into a deep pore plate;
the deep hole plate base moves to the position right below the magnetic frame base;
the magnetic frame base moves upwards to enable the magnetic rod of the magnetic frame to be inserted into the bottom of the deep hole plate for magnetic attraction, so that an operation environment (such as removing supernatant, repeatedly washing, removing viscous fluid and the like) is provided;
after other actions (such as removing supernatant, repeatedly washing and the like) are completed, the magnetic frame base moves downwards to the bottommost part, and the magnetic beads are released;
the magnetic sleeve carrier moves downwards independently, and the magnetic sleeve is inserted into the deep hole plate to be stirred, oscillated and mixed uniformly;
the magnetic sleeve carrier and the magnetic rod carrier synchronously move downwards and are inserted into the deep hole plate to carry out magnetic attraction;
after the magnetic attraction is finished, the magnetic sleeve carrier and the magnetic rod carrier synchronously move upwards, then synchronously move right/left and move downwards to insert into the other hole of the deep hole plate to transfer the magnetic beads;
the magnetic rod carrier moves upwards to release the magnetic beads, and the magnetic sleeve carrier is stirred and mixed uniformly in the deep hole plate holes.
The method enables scientists to simultaneously perform the magnetic extraction experiment on lighter and heavier samples when performing the magnetic extraction experiment, is not limited to a specific magnetic extraction mode, has strong suitability and flexibility, and greatly reduces experimental operation steps.
The technical features of the above embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples illustrate only a few embodiments of the utility model, which are described in detail and are not to be construed as limiting the scope of the utility model. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the utility model, which are all within the scope of the utility model. Accordingly, the scope of protection of the present utility model is to be determined by the appended claims.
Claims (7)
1. A magnetic extraction device for vibrating and magnetically attracting samples in a deep well plate, comprising: the upper magnetic attraction structure is arranged at the top of the deep hole plate, and the lower magnetic attraction structure is arranged at the bottom of the deep hole plate.
2. The magnetic extraction device of claim 1, wherein: and sliding components are arranged on two sides of the bottom of the lower magnetic attraction structure and are connected with the deep hole plate.
3. The magnetic extraction device of claim 2, wherein: the sliding assembly comprises a sliding block, a first sliding rail and a deep hole plate base, wherein the deep hole plate base is connected to the bottom of the deep hole plate, the top of the sliding block is connected to the deep hole plate base, and the sliding block is arranged on the first sliding rail.
4. A magnetic extraction device according to claim 3, wherein: the upper magnetic attraction structure comprises a magnetic rod carrier, a magnetic sleeve carrier, magnetic rods and an upper magnetic attraction drive, wherein two sides of the bottom end of the upper magnetic attraction drive are fixedly connected with one end of the first sliding rail, one end of the magnetic rod carrier is connected with the upper magnetic attraction drive, the magnetic rods are arranged in the magnetic rod carrier, and the magnetic sleeve carrier is arranged between the magnetic rod carrier and the deep hole plate.
5. The magnetic extraction device of claim 4, wherein: the upper magnetic attraction driving device comprises an upper and lower driving motor, a left and right driving motor, a first synchronous belt pulley belt and an upper magnetic attraction driving frame body, wherein the first synchronous belt pulley belt is sleeved at two ends of the upper magnetic attraction driving frame body, the surface of the upper magnetic attraction driving frame body is fixedly connected with a magnetic rod carrier and a magnetic sleeve carrier respectively, and the upper and lower driving motor and the left and right driving motor are arranged on the first synchronous belt pulley belt.
6. A magnetic extraction device according to claim 3, wherein: the lower magnetic attraction structure comprises a magnetic rack, a magnetic rack magnetic rod, a magnetic rack base and a lower magnetic attraction drive, wherein the top end of the magnetic rack base is provided with the magnetic rack, the magnetic rack base is coaxially provided with the deep hole plate, the magnetic rack magnetic rod is arranged inside the magnetic rack base, the magnetic rack magnetic rod can penetrate through the deep hole plate base, and the lower magnetic attraction drive is arranged on one side of the magnetic rack base.
7. The magnetic extraction device of claim 6, wherein: the lower magnetic attraction drive comprises a lower magnetic attraction motor, a second synchronous pulley belt, a second sliding rail and a connecting block, wherein the connecting block is connected with the second sliding rail and the magnetic frame base, the second synchronous pulley belt can drive the connecting block to move, the connecting block slides on the second sliding rail, and the lower magnetic attraction motor is arranged on the second synchronous pulley belt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321892033.2U CN220413408U (en) | 2023-07-18 | 2023-07-18 | Magnetic suction extraction device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321892033.2U CN220413408U (en) | 2023-07-18 | 2023-07-18 | Magnetic suction extraction device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220413408U true CN220413408U (en) | 2024-01-30 |
Family
ID=89652953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321892033.2U Active CN220413408U (en) | 2023-07-18 | 2023-07-18 | Magnetic suction extraction device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220413408U (en) |
-
2023
- 2023-07-18 CN CN202321892033.2U patent/CN220413408U/en active Active
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