CN220352123U - Nucleic acid adsorption column fixing mechanism for nucleic acid extraction instrument - Google Patents
Nucleic acid adsorption column fixing mechanism for nucleic acid extraction instrument Download PDFInfo
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- CN220352123U CN220352123U CN202320617579.0U CN202320617579U CN220352123U CN 220352123 U CN220352123 U CN 220352123U CN 202320617579 U CN202320617579 U CN 202320617579U CN 220352123 U CN220352123 U CN 220352123U
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- nucleic acid
- acid extraction
- box body
- fixed box
- adsorption column
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- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 105
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 105
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 105
- 238000000605 extraction Methods 0.000 title claims abstract description 59
- 238000001179 sorption measurement Methods 0.000 title claims abstract description 37
- 230000007246 mechanism Effects 0.000 title claims abstract description 13
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 36
- 229910052742 iron Inorganic materials 0.000 claims abstract description 18
- 230000000694 effects Effects 0.000 claims abstract description 10
- 230000005389 magnetism Effects 0.000 claims abstract description 4
- 230000009467 reduction Effects 0.000 claims description 4
- 230000033001 locomotion Effects 0.000 abstract description 9
- 230000005611 electricity Effects 0.000 abstract description 7
- 230000002035 prolonged effect Effects 0.000 abstract description 3
- 238000009434 installation Methods 0.000 description 9
- BGPVFRJUHWVFKM-UHFFFAOYSA-N N1=C2C=CC=CC2=[N+]([O-])C1(CC1)CCC21N=C1C=CC=CC1=[N+]2[O-] Chemical compound N1=C2C=CC=CC2=[N+]([O-])C1(CC1)CCC21N=C1C=CC=CC1=[N+]2[O-] BGPVFRJUHWVFKM-UHFFFAOYSA-N 0.000 description 6
- 238000005299 abrasion Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 108010025899 gelatin film Proteins 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The embodiment of the application discloses nucleic acid adsorption column fixing mechanism for nucleic acid extraction instrument, including nucleic acid adsorption column body, fixed box body, nucleic acid extraction instrument body, the back fixed mounting of fixed box body has the iron plate, the iron plate is connected with magnet through the mode that the magnetism was inhaled, the electricity push rod is installed to the one end that the iron plate was kept away from to magnet, the front of electricity push rod and the back fixed connection of nucleic acid extraction instrument body. The utility model provides a through the cooperation between fixed box body, gyro wheel, slide bar and the nucleic acid extraction appearance body, utilize the gyro wheel at the setting of the inside motion of slide bar, realized the linking effect of fixed box body and nucleic acid extraction appearance body, solved among the above-mentioned disclosure technical content effectively fixed box body when taking and put with the spout produce the fricative problem, adopt gyro wheel and slide bar swing joint's mode, reduced the wearing and tearing that lead to the fact after fixed box body and spout contact for a long time to the life of fixed box body is prolonged.
Description
Technical Field
The present application relates to the field of nucleic acid adsorption columns, and more particularly, to a nucleic acid adsorption column fixing mechanism for a nucleic acid extractor.
Background
The nucleic acid extraction instrument is an instrument for automatically completing sample nucleic acid extraction by using matched nucleic acid extraction reagents, and is widely applied to various fields such as disease control centers, clinical disease diagnosis, blood transfusion safety, forensic identification, environmental microorganism detection, food safety detection, animal husbandry, molecular biology research and the like.
At present, large-sized automatic instruments are high in price and powerful in function, but functional configuration is excessive for most biological enterprises, and small-sized automatic instruments can simultaneously extract too little sample, have relatively few functions and are difficult to meet the needs of enterprises, and a nucleic acid adsorption column fixing mechanism of the extractor is generally fixed by adopting a fixing hole, so that the nucleic acid adsorption column is inserted into the fixing hole no matter large-sized equipment or small-sized equipment. However, in consideration of use, the aperture of the fixing hole is generally larger than the pipe diameter of the nucleic acid adsorption column, so that the nucleic acid adsorption column can shake in the hole to affect the accuracy of dosing, therefore, in order to avoid the influence of the shake of the nucleic acid adsorption column on the accuracy of dosing, the technical structure of the nucleic acid adsorption column is proposed to strengthen the accuracy of dosing of the nucleic acid adsorption column, for example, the patent of the utility model with publication number CN201922500754.4 proposes a nucleic acid adsorption column fixing mechanism of an automatic nucleic acid extractor with silica gel film adsorption, which comprises a lower fixing plate fixedly mounted on a frame of the nucleic acid extractor and a fixing box body below a sample adding plate of the nucleic acid extractor, the fixing box body is in sliding connection with the lower fixing plate, a fixing groove penetrating the fixing box body is formed on the fixing box body, and a clamping groove matched with the position of each row of sample adding holes of the sample adding plate is fixedly arranged above the fixing box body, and the clamping groove is in an inverted-convex structure for clamping the pipe mouth of the nucleic acid adsorption column. Through adopting above-mentioned technical matter, on the basis of original fixed slot, set up the draw-in groove and fixed the mouth of pipe of nucleic acid adsorption column, through dual fixed mode, firmly fix the nucleic acid adsorption column in instrument and equipment, how vibrations are no matter the equipment during the application of sample, can both guarantee the mouth of pipe of nucleic acid adsorption column just to the application of sample mouth, greatly guaranteed the precision of application of sample.
From the technical content disclosed above, based on theory, the implementation of the related technical structure is beneficial to strengthening the nucleic acid adsorption column, but according to the description in the technical content disclosed above, in order to facilitate the placement of the fixed box body into the sliding grooves on the left side and the right side, a gap exists between the fixed box body and the sliding grooves, friction is generated between the fixed box body and the sliding grooves in the process of taking and placing, long-term friction not only causes abrasion of the outer wall of the fixed box body, but also causes abrasion of the inner wall of the sliding grooves, so that the service life of the fixed box body is shortened; and, fixed box body needs staff to hold the handle and take it out from the inside of spout, then can reduce staff's work efficiency this moment.
Disclosure of Invention
In view of the above problems, the present application proposes a nucleic acid adsorption column immobilization mechanism for a nucleic acid extractor to improve the above problems.
In order to achieve the above purpose, the utility model is realized by the following technical scheme: the utility model provides a nucleic acid extraction is nucleic acid adsorption column fixed establishment for appearance, includes nucleic acid adsorption column body, fixed box body, nucleic acid extraction instrument body, the back fixed mounting of fixed box body has the iron plate, the iron plate is connected with the magnet through the mode that the magnetism was inhaled, the magnet is kept away from the one end of iron plate and is installed the electricity push rod, the front of electricity push rod and the back fixed connection of nucleic acid extraction instrument body, and the outer wall of the inside output shaft of electricity push rod cup joints with the inner wall activity at the nucleic acid extraction instrument body back, the equal fixed mounting in left and right sides of fixed box body has the slide bar, the inner wall activity that fixed box body one side was kept away from to the slide bar has cup jointed the gyro wheel, the left and right sides of fixed box body is provided with the splint that are located the slide bar below, the lower extreme fixed mounting of splint has movable assembly.
Optionally, the front fixed mounting of nucleic acid extraction appearance body has the controller, the front of nucleic acid extraction appearance body articulates through the hinge has the door that opens and shuts that is located the base below, the lower extreme fixed mounting of nucleic acid extraction appearance body has the base, the back fixed mounting of nucleic acid extraction appearance body has the bracing piece, and the one end that the bracing piece kept away from the nucleic acid extraction appearance body and the lower terminal surface fixed connection of electric putter.
Optionally, the inner wall activity of gyro wheel has cup jointed the round bar, the one end fixed mounting that the gyro wheel was kept away from to the round bar has the baffle, and the bottom surface fixed connection of the lower extreme and the nucleic acid extraction appearance body inner wall of baffle.
Optionally, the lower extreme fixed mounting of splint has the diaphragm, the one end fixed mounting that the diaphragm kept away from the splint has the montant.
Optionally, the movable component comprises a ball nut fixedly connected with the lower end of the driving motor, the ball screw is sleeved on the inner wall threads of the ball nut, and the threads arranged on the outer walls of the ball screws on the left side and the right side are in opposite directions.
Optionally, the inner wall of ball screw is fixed to be cup jointed the pivot, the right-hand member fixed mounting of pivot has the driving motor who is located nucleic acid extraction appearance body right side, and is provided with the reduction gear on driving motor's the output shaft, driving motor's outside fixed mounting has the quick-witted case, and the right side fixed connection of left end and the base of machine case.
The application provides a nucleic acid extraction is nucleic acid adsorption column fixed establishment for appearance possesses following beneficial effect:
1. the utility model provides a through the cooperation between fixed box body, gyro wheel, slide bar and the nucleic acid extraction appearance body, utilize the gyro wheel at the setting of the inside motion of slide bar, realized the linking effect of fixed box body and nucleic acid extraction appearance body, solved among the above-mentioned disclosure technical content effectively fixed box body when taking and put with the spout produce the fricative problem, adopt gyro wheel and slide bar swing joint's mode, reduced the wearing and tearing that lead to the fact after fixed box body and spout contact for a long time to the life of fixed box body is prolonged.
2. This application is through the cooperation between fixed box body, nucleic acid extraction appearance body, electric putter, iron plate and the magnet, utilize the setting of electric putter, realized the effect of fixed box body automatic business turn over nucleic acid extraction appearance body, solved among the above-mentioned public technical content staff with the inside problem of fixed box body push in and take out the nucleic acid extraction appearance body effectively, adopt the flexible mode that drives fixed box body motion of the inside output shaft of electric putter, saved the step that the staff's manual work took fixed box body, alleviateed staff's work load to staff's work efficiency has been improved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the description of the embodiments will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 shows a schematic structural diagram of the present application;
FIG. 2 shows a rear view of the electrical putter of the present application;
FIG. 3 shows a front view of the splint of the present application;
FIG. 4 shows a side view of the slide bar of the present application;
fig. 5 shows a top view of the spindle of the present application.
In the figure: 1. a nucleic acid adsorption cartridge; 2. fixing the box body; 3. a nucleic acid extraction instrument body; 4. iron blocks; 5. a magnet; 6. an electric push rod; 7. a slide bar; 8. a roller; 9. a clamping plate; 10. a movable assembly; 101. a ball nut; 102. a ball screw; 11. a controller; 12. a base; 13. an opening/closing door; 14. a support rod; 15. a round bar; 16. a baffle; 17. a cross plate; 18. a vertical rod; 19. a rotating shaft; 20. a driving motor; 21. and a case.
Detailed Description
The following description of the embodiments of the present application will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all, of the embodiments of the present application. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments herein without making any inventive effort, are intended to be within the scope of the present application.
Referring to fig. 1 and 2, the present utility model provides the following technical solutions: the fixing mechanism of the nucleic acid adsorption column for the nucleic acid extraction instrument comprises a nucleic acid adsorption column 1, a fixing box body 2 and a nucleic acid extraction instrument body 3, wherein the fixing box body 2 is arranged to provide support for the placement of the nucleic acid adsorption column 1, the nucleic acid extraction instrument body 3 is arranged to detect the nucleic acid adsorption column 1, an iron block 4 is fixedly arranged on the back surface of the fixing box body 2, the iron block 4 and a magnet 5 can be connected in a magnetic attraction manner, the iron block 4 and the magnet 5 can be separated conveniently, the iron block 4 is connected with the magnet 5 in a magnetic attraction manner, an electric push rod 6 is arranged at one end of the magnet 5 away from the iron block 4, the electric push rod 6 is arranged, the automatic feeding and discharging of the fixing box body 2 in the nucleic acid extraction instrument body 3 is realized by utilizing the extension of an internal output shaft of the electric push rod 6, thus the workload of a worker when the fixing box body 2 is taken and placed is reduced, the front of the electric push rod 6 is fixedly connected with the back of the nucleic acid extraction instrument body 3, the outer wall of the output shaft inside the electric push rod 6 is movably sleeved with the inner wall of the back of the nucleic acid extraction instrument body 3, the installation of the electric push rod 6 is provided with a support and a platform for the installation of the nucleic acid extraction instrument body 3, the left side and the right side of the fixed box body 2 are fixedly provided with slide bars 7, the installation of the slide bars 7 plays a role in connecting the fixed box body 2 with the roller 8, simultaneously the installation of the slide bars 7 also provides space for the rotation of the roller 8, the inner wall of one side of the slide bars 7, far away from the fixed box body 2, is movably sleeved with the roller 8, the rolling of the roller 8 reduces friction generated when the fixed box body 2 is contacted with the nucleic acid extraction instrument body 3, the abrasion caused after the friction is reduced, thereby the service life of the fixed box body 2 is prolonged, the left side and the right side of the fixed box body 2 are provided with clamping plates 9 positioned below the slide bars 7, the stability of the fixed box body 2 in the nucleic acid extraction instrument body 3 is reinforced by the arrangement of the clamping plate 9, the movable assembly 10 is fixedly arranged at the lower end of the clamping plate 9, and the movable assembly 10 is arranged to provide power for the movement of the clamping plate 9.
The front fixed mounting of nucleic acid extraction appearance body 3 has controller 11, the control to the workflow of nucleic acid extraction appearance body 3 is played in the setting of controller 11, the front of nucleic acid extraction appearance body 3 articulates through the hinge has the door 13 that opens and shuts that is located the base 12 below, hinge articulated mode, be convenient for open and close to the door 13 that opens and shuts, the lower extreme fixed mounting of nucleic acid extraction appearance body 3 has base 12, the setting of base 12 provides the platform for the installation of nucleic acid extraction appearance body 3, the back fixed mounting of nucleic acid extraction appearance body 3 has bracing piece 14, the reinforcement of electric putter 6 installation stability has been consolidated in the installation of bracing piece 14, and the one end that the nucleic acid extraction appearance body 3 was kept away from to bracing piece 14 and the lower terminal surface fixed connection of electric putter 6.
Referring to fig. 3 and 4, the inner wall of the roller 8 is movably sleeved with a round rod 15, the round rod 15 is installed to provide support and a platform for the installation of the roller 8, a baffle 16 is fixedly installed at one end of the round rod 15 far away from the roller 8, the baffle 16 is installed to provide a platform for the installation of the round rod 15, and the lower end of the baffle 16 is fixedly connected with the bottom surface of the inner wall of the nucleic acid extraction instrument body 3.
The lower extreme fixed mounting of splint 9 has diaphragm 17, and the setting of diaphragm 17 plays to the connection of splint 9 with montant 18, and the one end fixed mounting that diaphragm 17 kept away from splint 9 has montant 18, and the setting of montant 18 plays to the connection of diaphragm 17 with ball nut 101.
Referring to fig. 5, the movable assembly 10 includes a ball nut 101 fixedly connected to the lower end of the driving motor 20, the ball nut 101 moves to provide power for the movement of the clamping plate 9, a ball screw 102 is sleeved on the inner wall of the ball nut 101, the circumferential rotation of the ball screw 102 provides power for the horizontal movement of the ball nut 101, the threads formed on the outer walls of the ball screws 102 on the left and right sides are in opposite directions, and the threads of the ball screws 102 on the left and right sides are in directions, so that the ball screws 102 on the left and right sides rotate and simultaneously drive the ball nuts 101 on the left and right sides to move towards the direction of the fixed box 2.
The inner wall of ball screw 102 is fixed to be cup jointed pivot 19, the setting of pivot 19 provides power for ball screw 102's rotation, the right-hand member fixed mounting of pivot 19 has the driving motor 20 that is located the right side of nucleic acid extraction appearance body 3, and be provided with the reduction gear on driving motor 20's the output shaft, the setting of reduction gear plays the regulation effect to driving motor 20 output shaft rotational speed, driving motor 20's outside fixed mounting organic case 21, and the right side fixed connection of left end and the base 12 of case 21, case 21 plays the guard action to driving motor 20.
To sum up, when using, at first, put into the inside of fixed box body 2 with nucleic acid adsorption cylinder 1, the mode of recycling magnetism is inhaled, be connected iron plate 4 and magnet 5, simultaneously, slide bar 7 is put in the outside of gyro wheel 8, open the power of electricity push rod 6, the back is opened to electricity push rod 6 and is driven the withdrawal of output shaft, the connection of reuse iron plate 4 and magnet 5, advance the inside of fixed box body 2 to nucleic acid extraction appearance body 3 with fixed box body 2, then, open driving motor 20's power, driving motor 20 opens the rotation of back drive pivot 19, the rotation of pivot 19 drives the simultaneous rotation of ball screw 102 of left and right sides simultaneously, because the setting of ball screw 102 screw thread of left and right sides drives the ball nut 101 of left and right sides simultaneously to the motion of fixed box body 2 direction, and the motion of ball nut 101 passes through montant 18, the connection of diaphragm 17 drives the motion of splint 9, until the outer wall contact of splint 9 and fixed box body 2 of left and right sides, can close the rotation of drive motor 20, the work appearance that the output shaft 3 is stretched out through the fixed box body 3 after the time of the rotation of pivot 19 drives the rotation of ball screw 102, can realize the work appearance that the nucleic acid extraction appearance is 3, the work is stretched out from the fixed body 3.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present application, and are not limiting thereof; although the present application has been described in detail with reference to the foregoing embodiments, one of ordinary skill in the art will appreciate that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not drive the essence of the corresponding technical solutions to depart from the spirit and scope of the technical solutions of the embodiments of the present application.
Claims (6)
1. Nucleic acid extraction is nucleic acid adsorption column fixed establishment for appearance, including nucleic acid adsorption column body (1), fixed box body (2), nucleic acid extraction appearance body (3), its characterized in that: the back fixed mounting of fixed box body (2) has iron plate (4), iron plate (4) are connected with magnet (5) through the mode that the magnetism was inhaled, electric putter (6) are installed to the one end that magnet (5) kept away from iron plate (4), the front of electric putter (6) and the back fixed connection of nucleic acid extraction appearance body (3), and the outer wall of the inside output shaft of electric putter (6) cup joints with the inner wall activity at nucleic acid extraction appearance body (3) back, the equal fixed mounting in left and right sides of fixed box body (2) has slide bar (7), slide bar (7) are kept away from the inner wall activity of fixed box body (2) one side and have been cup jointed gyro wheel (8), the left and right sides of fixed box body (2) is provided with splint (9) that are located slide bar (7) below, the lower extreme fixed mounting of splint (9) has movable assembly (10).
2. The nucleic acid adsorption column immobilization mechanism for a nucleic acid extractor according to claim 1, wherein: the front fixed mounting of nucleic acid extraction appearance body (3) has controller (11), the front of nucleic acid extraction appearance body (3) is articulated through the hinge has opening and shutting door (13) that are located base (12) below, the lower extreme fixed mounting of nucleic acid extraction appearance body (3) has base (12), the back fixed mounting of nucleic acid extraction appearance body (3) has bracing piece (14), and the one end that nucleic acid extraction appearance body (3) was kept away from to bracing piece (14) is with the lower terminal surface fixed connection of electric putter (6).
3. The nucleic acid adsorption column immobilization mechanism for a nucleic acid extractor according to claim 1, wherein: the inner wall activity of gyro wheel (8) has cup jointed round bar (15), the one end fixed mounting that gyro wheel (8) were kept away from to round bar (15) has baffle (16), and the bottom surface fixed connection of the lower extreme of baffle (16) and nucleic acid extraction appearance body (3) inner wall.
4. The nucleic acid adsorption column immobilization mechanism for a nucleic acid extractor according to claim 1, wherein: the lower extreme fixed mounting of splint (9) has diaphragm (17), the one end that diaphragm (17) kept away from splint (9) is fixed mounting has montant (18).
5. The nucleic acid adsorption column immobilization mechanism for a nucleic acid extractor according to claim 1, wherein: the movable assembly (10) comprises a ball nut (101) fixedly connected with the lower end of the driving motor (20), a ball screw (102) is sleeved on the inner wall threads of the ball nut (101), and threads arranged on the outer walls of the ball screws (102) on the left side and the right side are in opposite directions.
6. The nucleic acid adsorption column immobilization mechanism for a nucleic acid extractor according to claim 5, wherein: the inner wall of ball screw (102) is fixed to be cup jointed pivot (19), the right-hand member fixed mounting of pivot (19) has driving motor (20) that are located nucleic acid extraction appearance body (3) right side, and is provided with the reduction gear on the output shaft of driving motor (20), the outside fixed mounting of driving motor (20) has quick-witted case (21), and the right side fixed connection of the left end of machine case (21) and base (12).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320617579.0U CN220352123U (en) | 2023-03-27 | 2023-03-27 | Nucleic acid adsorption column fixing mechanism for nucleic acid extraction instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320617579.0U CN220352123U (en) | 2023-03-27 | 2023-03-27 | Nucleic acid adsorption column fixing mechanism for nucleic acid extraction instrument |
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| Publication Number | Publication Date |
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| CN220352123U true CN220352123U (en) | 2024-01-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202320617579.0U Active CN220352123U (en) | 2023-03-27 | 2023-03-27 | Nucleic acid adsorption column fixing mechanism for nucleic acid extraction instrument |
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- 2023-03-27 CN CN202320617579.0U patent/CN220352123U/en active Active
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