CN220294167U - Continuous preparation chromatographic device - Google Patents
Continuous preparation chromatographic device Download PDFInfo
- Publication number
- CN220294167U CN220294167U CN202321828204.5U CN202321828204U CN220294167U CN 220294167 U CN220294167 U CN 220294167U CN 202321828204 U CN202321828204 U CN 202321828204U CN 220294167 U CN220294167 U CN 220294167U
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- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 82
- 238000003860 storage Methods 0.000 claims abstract description 19
- 230000001502 supplementing effect Effects 0.000 claims abstract description 18
- 238000004587 chromatography analysis Methods 0.000 claims abstract description 15
- 230000005540 biological transmission Effects 0.000 claims abstract description 10
- 230000000712 assembly Effects 0.000 abstract description 8
- 238000000429 assembly Methods 0.000 abstract description 8
- 238000002347 injection Methods 0.000 abstract description 7
- 239000007924 injection Substances 0.000 abstract description 7
- 239000000463 material Substances 0.000 description 8
- 239000003480 eluent Substances 0.000 description 7
- 239000008367 deionised water Substances 0.000 description 6
- 229910021641 deionized water Inorganic materials 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 230000009471 action Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 238000004262 preparative liquid chromatography Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000013543 active substance Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model relates to the technical field of chromatography, in particular to a continuous preparation chromatographic device, which comprises a chromatographic column, wherein the top of the chromatographic column is communicated with a liquid outlet end of a three-way pipe, two liquid inlet ends of the three-way pipe are respectively communicated with a liquid outlet end of a four-way pressure supplementing assembly, and three liquid inlet ends of the four-way pressure supplementing assembly are respectively communicated with a liquid storage tank; the four-way pressure supplementing assembly comprises a four-way part, a liquid inlet end of the four-way part is communicated with the liquid storage tank, a liquid outlet end of the four-way part is communicated with a liquid inlet end of the three-way pipe, a pressurizing plate is vertically and slidably connected in the four-way part, the pressurizing plate is in transmission connection with a driving assembly, liquid leakage holes are formed in the pressurizing plate at equal intervals in the circumferential direction, and a non-return part is arranged on the liquid leakage holes. The utility model can realize hydraulic compensation, and the four-way pressure compensating assemblies at the two ends alternately compensate pressure, thereby realizing continuous injection of liquid in the chromatographic column.
Description
Technical Field
The utility model relates to the technical field of chromatography, in particular to a continuous preparation chromatography device.
Background
Along with the development of preparative liquid chromatography technology and the research and development of a large amount of active substances and the requirements of purification and separation of novel medicines, the efficient, large-batch, green and energy-saving separation and purification technology is attracting more attention. The laboratory adopts preparative liquid chromatography to separate and prepare pure substances on a small scale, and can only meet the requirements of biological activity test, toxicity research and clinical test research.
At present, conventional preparation chromatography needs advanced raw materials, the raw materials enter into the eluent after finishing, then other materials need manual control every time, the operation is labor-consuming, continuous production cannot be realized, the existing automatic continuous preparation chromatography device can realize continuous feeding through a PLC control four-way electromagnetic valve, but the condition that hydraulic pressure loss exists after liquid phase passes through the electromagnetic valve, so that the hydraulic pressure is low when entering into a chromatographic column, the chromatographic column separation effect is poor, and therefore, the problem of the continuous preparation chromatography device is needed to be solved.
Disclosure of Invention
The object of the present utility model is to provide a continuous preparation chromatography device to solve the above problems.
In order to achieve the above object, the present utility model provides the following solutions:
the continuous preparation chromatographic device comprises a chromatographic column, wherein the top of the chromatographic column is communicated with a liquid outlet end of a three-way pipe, two liquid inlet ends of the three-way pipe are respectively communicated with a liquid outlet end of a four-way pressure supplementing assembly, and three liquid inlet ends of the four-way pressure supplementing assembly are respectively communicated with a liquid storage tank;
the four-way pressure supplementing assembly comprises a four-way part, a liquid inlet end of the four-way part is communicated with the liquid storage tank, a liquid outlet end of the four-way part is communicated with a liquid inlet end of the three-way pipe, a pressurizing plate is vertically and slidably connected in the four-way part, the pressurizing plate is in transmission connection with a driving assembly, liquid leakage holes are formed in the pressurizing plate at equal intervals in the circumferential direction, and a non-return part is arranged on the liquid leakage holes.
Preferably, the non-return portion includes a check valve disposed in the weeping hole.
Preferably, the driving assembly comprises a threaded rod, the threaded rod is in threaded connection with the axis of the pressurizing plate, and a second driving part is in transmission connection with the top of the threaded rod.
Preferably, the second driving part comprises a second motor, the fixed end of the second motor is fixedly connected to the top of the four-way part, and an output shaft of the second motor is in shaft connection with the threaded rod.
Preferably, the four-way part comprises an inner pressurizing pipe, three channels are formed in the side wall of the top of the inner pressurizing pipe at equal intervals in the circumferential direction, the bottom of the inner pressurizing pipe is communicated with the liquid inlet end of the three-way pipe, the pressurizing plate is vertically and slidably connected in the inner pressurizing pipe, a communicating part is coaxially sleeved outside the inner pressurizing pipe, and the communicating part is communicated with the inner pressurizing pipe through the channels.
Preferably, the communicating part comprises a communicating shaft sleeve, the communicating shaft sleeve is coaxially sleeved outside the inner pressurizing pipe, the communicating shaft sleeve is rotationally connected with the inner pressurizing pipe, a first channel is formed in the side wall of the top of the communicating shaft sleeve, one end of the first channel is communicated with any channel, the other end of the first channel is communicated with any liquid storage tank, and the communicating shaft sleeve is in transmission connection with a first driving part.
Preferably, the first driving part comprises a first motor, a driving gear is connected with an output shaft of the first motor in a shaft way, and the driving gear is connected with the bottom of the communicating shaft sleeve in a meshed mode.
Preferably, two vertically arranged sliding grooves are symmetrically arranged in the inner pressurizing pipe, clamping blocks are connected in a sliding manner in the sliding grooves, and the two clamping blocks are fixedly connected to the two ends of the pressurizing plate.
The utility model has the following technical effects: when the four-way pressure supplementing assembly is used, the tops of the three liquid storage tanks communicated with the four-way pressure supplementing assemblies at the two ends of the three-way pipe are respectively communicated with materials, deionized water and eluent, under the action of the four-way pressure supplementing assemblies, the two ends of the three-way pipe simultaneously enter the materials or the deionized water or the eluent, because a certain injection pressure is needed for injecting the chromatographic column, after the materials, the deionized water and the eluent enter the four-way pressure supplementing assemblies, hydraulic losses exist, the driving assembly drives the pressurizing plate to move up and down in the four-way part at the moment, liquid in the four-way part is pressed into the chromatographic column through the three-way pipe when the pressurizing plate is pressed down, at the moment, the liquid leakage hole is under the action of the non-return part, the liquid is prevented from entering the upper part of the four-way part, and when the pressurizing plate is lifted, the liquid leakage hole is opened, the liquid is convenient to enter the lower part of the four-way part, and further hydraulic compensation is realized, the four-way pressure supplementing assemblies at the two ends alternately supplement pressure, and further continuous injection of the liquid in the chromatographic column is realized.
Drawings
For a clearer description of an embodiment of the utility model or of the solutions of the prior art, the drawings that are needed in the embodiment will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the utility model, and that other drawings can be obtained according to these drawings without inventive effort for a person skilled in the art:
FIG. 1 is a schematic diagram of the structure of the present utility model;
FIG. 2 is an enlarged view of a portion of the utility model at A in FIG. 1;
FIG. 3 is an enlarged view of a portion of the utility model at B in FIG. 2;
FIG. 4 is a top view of a four-way pressure compensating assembly according to the present utility model;
FIG. 5 is a schematic view of a structure of a pressure plate of the present utility model;
wherein, 1, a chromatographic column; 2. a first motor; 3. a drive gear; 4. a communicating shaft sleeve; 5. an inner booster tube; 6. a first channel; 7. a communicating pipe; 8. a liquid storage tank; 9. a three-way pipe; 10. a chute; 11. a threaded rod; 12. a pressurizing plate; 13. a channel; 14. a second motor; 15. a weeping hole; 16. a one-way valve; 17. and (5) clamping blocks.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
In order that the above-recited objects, features and advantages of the present utility model will become more readily apparent, a more particular description of the utility model will be rendered by reference to the appended drawings and appended detailed description.
Referring to fig. 1 to 5, the utility model provides a continuous preparation chromatographic device, which comprises a chromatographic column 1, wherein the top of the chromatographic column 1 is communicated with a liquid outlet end of a three-way pipe 9, two liquid inlet ends of the three-way pipe 9 are respectively communicated with a liquid outlet end of a four-way pressure compensating assembly, and three liquid inlet ends of the four-way pressure compensating assembly are respectively communicated with a liquid storage tank 8;
the four-way pressure supplementing assembly comprises a four-way part, a liquid inlet end of the four-way part is communicated with the liquid storage tank 8, a liquid outlet end of the four-way part is communicated with a liquid inlet end of the three-way pipe 9, a pressurizing plate 12 is vertically and slidably connected in the four-way part, the pressurizing plate 12 is connected with a driving assembly in a transmission manner, liquid leakage holes 15 are formed in the pressurizing plate 12 at equal intervals in the circumferential direction, and a non-return part is arranged on the liquid leakage holes 15.
When the chromatographic column 1 is used, the tops of the three liquid storage tanks 8 communicated with the four-way pressure supplementing assemblies at the two ends of the three-way pipe 9 are respectively communicated with materials, deionized water and eluent, under the action of the four-way pressure supplementing assemblies, the two ends of the three-way pipe 9 simultaneously enter the materials or the deionized water or the eluent, and as a certain injection pressure is required for injecting the chromatographic column 1, the materials, the deionized water and the eluent after entering the four-way pressure supplementing assemblies have hydraulic loss, the pressurizing plate 12 is driven to move up and down in the four-way part by the driving assembly at the moment, when the pressurizing plate 12 is pressed down, liquid in the four-way part is pressed into the chromatographic column 1 by the three-way pipe 9, at the moment, the liquid leakage hole 15 is prevented from entering the upper part of the four-way part under the action of the non-return part, and when the pressurizing plate 12 is lifted, the liquid leakage hole 15 is opened, so that the liquid enters the lower part of the four-way part, thereby realizing hydraulic compensation, and further realizing the continuous injection of the liquid in the chromatographic column 1.
Further optimizing scheme, the check part comprises a check valve 16, and the check valve 16 is arranged in the liquid leakage hole 15.
The check valve 16 is preferably an H41F-10S type check valve. A baffle plate can be hinged at the bottom of the liquid leakage hole 15, when the pressurizing plate 12 moves downwards, the liquid leakage hole 15 is closed under the action of the baffle plate, and when the pressurizing plate 12 moves upwards, the liquid leakage hole 15 is opened.
Further preferably, the driving assembly comprises a threaded rod 11, the threaded rod 11 is in threaded connection with the axis of the pressurizing plate 12, and a second driving part is connected to the top of the threaded rod 11 in a transmission manner.
In a further optimized scheme, the second driving part comprises a second motor 14, the fixed end of the second motor 14 is fixedly connected to the top of the four-way part, and the output shaft of the second motor 14 is in shaft connection with the threaded rod 11.
The threaded rod 11 is driven to rotate by the second motor 14 so that the pressing plate 12 can move up and down.
Further optimizing scheme, four-way portion includes interior booster pipe 5, and three passageway 13 are offered to interior booster pipe 5 top lateral wall circumference equidistant, and interior booster pipe 5 bottom and three-way pipe 9 feed liquor end intercommunication, in booster pipe 5 was gone up to the vertical sliding connection of pressurization board 12, and interior booster pipe 5 outer coaxial cover is equipped with the intercommunication portion, and the intercommunication portion is through passageway 13 and interior booster pipe 5 intercommunication.
Further optimizing scheme, the intercommunication portion includes intercommunication axle sleeve 4, and outside the 5 with the axle sleeve of intercommunication axle sleeve 4 was established in interior booster pipe 5, the intercommunication axle sleeve 4 rotated with interior booster pipe 5 and is connected, and first passageway 6 has been seted up to intercommunication axle sleeve 4 top lateral wall, and the one end and the arbitrary passageway 13 intercommunication of first passageway 6, the other end and the arbitrary liquid storage pot 8 intercommunication of first passageway 6, and the transmission of intercommunication axle sleeve 4 are connected with first drive division.
Further optimizing scheme, first drive part includes first motor 2, and first motor 2 output shaft has the drive gear 3 in the coupling, and drive gear 3 is connected with the meshing of communicating axle sleeve 4 bottom.
The driving gear 3 is driven to rotate by the first motor 2, under the meshing effect of the driving gear 3 and the communicating shaft sleeve 4, the driving gear 3 drives the communicating shaft sleeve 4 to rotate, one end of the first channel 6 on the communicating shaft sleeve 4 is communicated with the liquid outlet end of the communicating pipe 7 at the bottom of the liquid storage tank 8 when rotating, then liquid in one of the liquid storage tanks 8 enters the first channel 6, the other end of the first channel 6 is communicated with a corresponding channel 13 formed in the side wall of the top of the inner pressurizing pipe 5, and the liquid enters the inner pressurizing pipe 5.
The liquid outlet end of the communicating pipe 7 of the rest liquid storage tank 8 is abutted on the outer wall of the communicating shaft sleeve 4, so that liquid leakage is prevented.
The first channel 6 may be designed to have a reduced diameter so as to increase the flow rate of the liquid and increase the injection pressure.
After the material is injected, the communicating shaft sleeve 4 is driven to rotate by the driving gear 3, so that the first channel 6 is communicated with the liquid outlet end of the communicating pipe 7 of the other liquid storage tank 8, and further the injection of other liquid is realized.
The three-way pipe 9 is a metal pipe, the three-way pipe 9 is fixedly connected and communicated with the top of the chromatographic column 1, and the inner booster pipe 5 is fixedly arranged at the end part of the three-way pipe 9.
In a further optimization scheme, two vertically arranged sliding grooves 10 are symmetrically formed in the inner pressurizing pipe 5, clamping blocks 17 are connected in a sliding mode in the sliding grooves 10, and the two clamping blocks 17 are fixedly connected to two ends of the pressurizing plate 12.
Two vertically arranged sliding grooves 10 are symmetrically formed in the inner pressurizing pipe 5, two clamping blocks 17 are fixedly connected to two ends of the pressurizing plate 12, the pressurizing plate 12 is prevented from rotating through vertical sliding fit of the clamping blocks 17 and the sliding grooves 10, and then the pressurizing plate 12 moves up and down through the threaded rod 11.
In the description of the present utility model, it should be understood that the terms "longitudinal," "transverse," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate or are based on the orientation or positional relationship shown in the drawings, merely to facilitate description of the present utility model, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present utility model.
The above embodiments are only illustrative of the preferred embodiments of the present utility model and are not intended to limit the scope of the present utility model, and various modifications and improvements made by those skilled in the art to the technical solutions of the present utility model should fall within the protection scope defined by the claims of the present utility model without departing from the design spirit of the present utility model.
Claims (8)
1. A continuous preparation chromatography apparatus, characterized in that: the chromatographic column comprises a chromatographic column (1), wherein the top of the chromatographic column (1) is communicated with a liquid outlet end of a three-way pipe (9), two liquid inlet ends of the three-way pipe (9) are respectively communicated with a liquid outlet end of a four-way pressure supplementing assembly, and three liquid inlet ends of the four-way pressure supplementing assembly are respectively communicated with a liquid storage tank (8);
the four-way pressure supplementing assembly comprises a four-way part, wherein a liquid inlet end of the four-way part is communicated with the liquid storage tank (8), a liquid outlet end of the four-way part is communicated with a liquid inlet end of the three-way pipe (9), a pressurizing plate (12) is vertically and slidably connected in the four-way part, the pressurizing plate (12) is in transmission connection with a driving assembly, liquid leakage holes (15) are formed in the pressurizing plate (12) at equal intervals in the circumferential direction, and a non-return part is arranged on the liquid leakage holes (15).
2. The continuous preparation chromatography device of claim 1, wherein: the non-return part comprises a one-way valve (16), and the one-way valve (16) is arranged in the liquid leakage hole (15).
3. A continuous preparation chromatography apparatus according to claim 2, wherein: the driving assembly comprises a threaded rod (11), the threaded rod (11) is in threaded connection with the axis of the pressurizing plate (12), and a second driving part is connected to the top of the threaded rod (11) in a transmission mode.
4. A continuous preparation chromatography apparatus according to claim 3, wherein: the second driving part comprises a second motor (14), the fixed end of the second motor (14) is fixedly connected to the top of the four-way part, and the output shaft of the second motor (14) is in shaft connection with the threaded rod (11).
5. The continuous preparation chromatography device of claim 1, wherein: the four-way part comprises an inner pressurizing pipe (5), three channels (13) are formed in the circumferential direction of the side wall of the top of the inner pressurizing pipe (5) at equal intervals, the bottom of the inner pressurizing pipe (5) is communicated with the liquid inlet end of the three-way pipe (9), the pressurizing plate (12) is vertically and slidably connected in the inner pressurizing pipe (5), a communicating part is coaxially sleeved outside the inner pressurizing pipe (5), and the communicating part is communicated with the inner pressurizing pipe (5) through the channels (13).
6. The continuous preparation chromatography device of claim 5, wherein: the utility model discloses a liquid storage tank, including connecting portion, including connecting sleeve (4), connecting sleeve (4) coaxial sleeve is in outside interior booster pipe (5), connecting sleeve (4) with interior booster pipe (5) rotate and connect, first passageway (6) have been seted up to connecting sleeve (4) top lateral wall, the one end and arbitrary of first passageway (6) passageway (13) intercommunication, the other end and arbitrary of first passageway (6) liquid storage tank (8) intercommunication, connecting sleeve (4) transmission is connected with first drive portion.
7. The continuous preparation chromatography device of claim 6, wherein: the first driving part comprises a first motor (2), a driving gear (3) is connected with an output shaft of the first motor (2) in a shaft way, and the driving gear (3) is connected with the bottom of the communicating shaft sleeve (4) in a meshed mode.
8. The continuous preparation chromatography device of claim 5, wherein: two vertically arranged sliding grooves (10) are symmetrically arranged in the inner pressurizing pipe (5), clamping blocks (17) are connected in a sliding mode in the sliding grooves (10), and the two clamping blocks (17) are fixedly connected to two ends of the pressurizing plate (12).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321828204.5U CN220294167U (en) | 2023-07-12 | 2023-07-12 | Continuous preparation chromatographic device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321828204.5U CN220294167U (en) | 2023-07-12 | 2023-07-12 | Continuous preparation chromatographic device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220294167U true CN220294167U (en) | 2024-01-05 |
Family
ID=89374147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321828204.5U Active CN220294167U (en) | 2023-07-12 | 2023-07-12 | Continuous preparation chromatographic device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220294167U (en) |
-
2023
- 2023-07-12 CN CN202321828204.5U patent/CN220294167U/en active Active
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