CN220171059U - Full-automatic sample processing system - Google Patents

Abstract

The utility model discloses a full-automatic sample processing system, which belongs to the field of in-vitro diagnosis medical equipment, and comprises a workbench, wherein a bracket is arranged on the workbench, a translation component is transversely arranged on the bracket, a sample tube storage area, a sample adding reaction area and a gun head storage area are sequentially arranged on the front side of the bracket from left to right, a sample tube rack and a sample tube clamping mechanism are arranged in the sample tube storage area, a first oscillation mechanism is arranged below the sample tube rack, a material taking mechanism is arranged above the sample tube rack, and the material taking mechanism can linearly move under the drive of the translation component; the sample adding reaction zone is provided with a centrifuge tube rack and a reagent storage box, centrifuge tubes are uniformly distributed on the centrifuge tube rack, and a second oscillating mechanism is arranged below the centrifuge tube rack; the gun head storage area is provided with a gun head frame, liquid-moving gun heads are uniformly distributed on the gun head frame, and a liquid-moving mechanism is arranged above the gun head frame. The full-automatic sample processing system provided by the utility model has high automation degree and improves the detection efficiency.

Description

Full-automatic sample processing system

Technical Field

The utility model belongs to the field of in-vitro diagnosis medical instruments, and particularly relates to a full-automatic sample processing system.

Background

In the field of in vitro diagnostics, pretreatment and testing of collected samples is often required. Sample pretreatment typically includes impurity separation, target component extraction (e.g., nucleic acid extraction, protein separation, etc.).

The existing sample processing device can only realize simple automatic sampling and automatic sample loading, can not transfer samples, and for samples needing solid-liquid separation processing, the samples need to be transferred from a sample tube to a centrifuge tube, separated after being centrifuged in the centrifuge, and then put into a sample processing system for sample loading and reaction procedures. The solid-liquid separation of the sample is carried out manually, the operation process is complex, errors are easy to occur, and the inspection efficiency is low.

Disclosure of Invention

Aiming at the defects of the prior art, the utility model aims to provide a full-automatic sample processing system, which aims to solve the problems of complex manual sample processing operation, easy error and low inspection efficiency.

In order to achieve the above purpose, the utility model provides a full-automatic sample processing system, which comprises a workbench, wherein a bracket is arranged on the workbench, a translation component is transversely arranged on the bracket, a sample tube storage area, a sample adding reaction area and a gun head storage area are sequentially arranged on the front side of the bracket from left to right, a sample tube rack and a sample tube clamping mechanism are arranged in the sample tube storage area, a first oscillating mechanism is arranged below the sample tube rack, a material taking mechanism is arranged above the sample tube rack, and the material taking mechanism can move left and right under the drive of the translation component; the sample adding reaction zone is provided with a centrifuge tube rack and a reagent storage box, and a second oscillating mechanism is arranged below the centrifuge tube rack; the gun head storage area is provided with a gun head frame, a liquid moving mechanism is arranged above the gun head frame, and the liquid moving mechanism and the material taking mechanism are arranged in parallel and synchronously move left and right under the drive of the translation assembly.

Still further, the extracting mechanism is including first drive assembly and first lifting assembly, first drive assembly can drive first lifting assembly back-and-forth movement, the output of first lifting assembly is equipped with the rotatory clamping jaw subassembly that is used for pressing from both sides the sample pipe and opens the sample pipe lid of rotation, fixed being equipped with on the first lifting assembly is used for sweeping the sign indicating number subassembly of sweeping the sign indicating number record to the sample pipe that presss from both sides and gets.

Still further, pipetting mechanism is including second drive assembly and second lifting assembly, second drive assembly can drive second lifting assembly back-and-forth movement, second lifting assembly's output is equipped with the pipette and uncaps the subassembly with the centrifuging tube.

Furthermore, a heating temperature control module and a magnetic separation module are also arranged on the centrifuge tube rack; and/or the workbench is also provided with a waste recycling area.

Still further, translation subassembly including install perpendicularly in motor and the pivot of support lateral wall, be fixed with the driving pulley on the output shaft of motor, be equipped with the driven pulley in the pivot, the driving pulley with tensioning is connected with the hold-in range between the driven pulley, be equipped with on the hold-in range be used for with extracting mechanism the clamp splice subassembly of pipetting mechanism fixed connection, still be equipped with on the support be used for extracting mechanism pipetting mechanism removes the guide rail of direction.

Still further, the sample tube clamping mechanism comprises a base, and a clamping jaw motor is vertically arranged on the base.

Further, a filter tube storage area is also arranged on the workbench.

Still further, first lifting assembly is including the fixed plate of vertical setting, the symmetry is equipped with linear guide on the fixed plate, be fixed with on linear guide's the slider and be used for installing rotatory clamping jaw subassembly's connecting plate, still be equipped with elevator motor on the fixed plate, elevator motor's output is connected with the lead screw, the lead screw with connecting plate threaded connection, elevator motor during operation, through the lead screw drive the connecting plate goes up and down.

Still further, the full-automatic sample processing system still include with sample pipe of sample pipe support looks adaptation, the sample pipe includes the sampling tube, the sampling tube is inside to be equipped with to hold chamber and upper end and is equipped with the opening, it is hollow filter tube to hold intracavity detachable to be equipped with inside, the filter tube will hold the chamber and separate into impurity chamber and filtrate chamber, the filter tube upper end be equipped with be used for with the opening cooperation is used for sealedly the first sealed lid in impurity chamber, be equipped with in the middle of the first sealed lid with the liquid mouth of getting of filtrate chamber intercommunication, first sealed lid top detachable is equipped with and is used for sealedly the second sealed lid in filtrate chamber.

Still further, the fully automated sample processing system further comprises a sample tube adapted to the sample tube rack, the sample tube comprising a sampling tube for containing a sample and a push-type filter tube; the pressing type filter tube comprises a filter part at the lower end and a tube body at the upper end, wherein the filter part comprises a plurality of layers of cylindrical filter screens which are coaxially arranged, the pore diameters of the cylindrical filter screens are sequentially reduced from outside to inside, and the pressing type filter tube is used for carrying out multilayer solid-liquid separation on a sample to obtain filtrate; the top end of the filtering part is provided with a sealing ring along the circumferential direction, the sealing ring is connected with the outermost cylindrical filter screen and is abutted with the inner wall of the sampling tube when in use, and the sealing ring is used for sealing a gap between the inner wall of the sampling tube and the outer wall of the pressing type filtering tube; the pipe body is concentrically connected with the cylindrical filter screen at the innermost layer and is used for accommodating the filtrate obtained after filtration; the pressing type filter tube is configured to extend into the sampling tube in the length direction and can slide along the inner wall of the sampling tube, so that solid-liquid separation of a sample is realized in a pressing mode.

Compared with the prior art, the technical scheme of the utility model has the advantages that as the first oscillating mechanism is arranged, samples in the sample tube can be uniformly mixed and subjected to solid-liquid separation before taking materials, the taking mechanism is arranged, the sample tube can be automatically taken and placed, the tube cover of the sampling tube is rotated and opened by matching with the sample tube clamping mechanism, the centrifuge tube cover can be opened and closed by the centrifuge tube cover opening component on the pipetting mechanism, the sample in the sample tube is transferred into the centrifuge tube by adopting the pipetting gun, the detection reagent is automatically added by the pipetting gun, the centrifuge tube cover is closed, the centrifuge tube is oscillated by the second oscillating mechanism, and after the oscillation is completed, the samples in the centrifuge tube can be subjected to solid-liquid separation by the pipetting mechanism; the automation degree is high, manual operation is not needed in the whole process, manual operation errors are avoided, and the detection efficiency is improved; meanwhile, the heating temperature control module is arranged on the centrifuge tube rack, heating can be performed in the oscillating process, the reaction between the sample and the reagent in the centrifuge tube is quickened, the sample processing time is further shortened, and the magnetic separation module is arranged on the centrifuge tube rack, so that the magnetic purification and separation treatment can be performed.

Drawings

FIG. 1 is a schematic diagram of the structure of a workbench of a fully automated sample processing system provided by the present utility model;

FIG. 2 is a schematic diagram of the translation assembly of the fully automated sample processing system provided by the present utility model;

FIG. 3 is a schematic view of the configuration of the take-out mechanism of the fully automated sample processing system provided by the present utility model;

FIG. 4 is a schematic diagram of a fully automated sample processing system according to the present utility model;

FIG. 5 is a schematic view of the sample tube gripping device of the fully automated sample processing system provided by the present utility model;

FIG. 6 is a schematic view showing the structure of a sample tube of the fully automatic sample processing system according to embodiment 3 of the present utility model;

FIG. 7 is a cross-sectional view of a sample tube of the fully automated sample processing system provided in embodiment 3 of the present utility model;

FIG. 8 is a schematic view showing the overall structure of a sample tube of the fully automatic sample processing system according to embodiment 4 of the present utility model;

fig. 9 is a schematic view of the structure of the full-automatic sample processing system according to embodiment 4 of the present utility model, in which the press-type filter tube is not mounted with the cylindrical filter screen;

FIG. 10 is an exploded view of a push-on filter tube in a sample tube of a fully automated sample processing system according to example 4 of the present utility model.

The corresponding structure of each numerical mark in the attached drawings is as follows: the filter comprises a first workbench, a second support, a 3-translation assembly, a 31-motor, a 32-rotating shaft, a 33-synchronous belt, a 34-clamp block assembly, a 35-guide rail, a 4-sample tube storage area, a 41-sample tube rack, a 42-sample tube clamping mechanism, a 421-base, a 422-clamp jaw motor, a 5-sample adding reaction area, a 51-centrifuge tube rack, a 52-reagent storage box, a 6-gun head storage area, a 61-gun head, a 62-liquid-taking gun head, a 7-material taking mechanism, a 71-first driving assembly, a 72-first lifting assembly, a 721-fixed plate, a 722-linear guide rail, a 723-connecting plate, a 724-lifting motor, a 725-screw, a 73-rotating clamp jaw assembly, a 74-code sweeping assembly, an 8-pipetting mechanism, an 81-second driving assembly, an 82-second lifting assembly, an 83-liquid-pipetting gun, an 84-centrifuge tube assembly, a 9-waste recycling area, a 10-housing, a 110-taking, a 111-opening, a 112-filter tube, a 113-first sealing tube, a 114-second sealing tube, a 115-liquid-taking tube, a 116-filter tube, a 125-filter tube, a reinforcing tube, a 125-filter rib, a 125-filter tube, a reinforcing tube, a 125-filter tube, a 125-filter tube, a reinforcing tube, a filter tube, a 125, a filter tube-shaped filter body, and a filter body and a reinforcing tube, and a filter body which are connected to the filter.

Detailed Description

The present utility model will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present utility model more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the utility model.

The utility model will be further described with reference to specific drawings and examples.

Example 1

The present utility model provides a fully automated sample processing system that can be used to process fecal samples, blood samples, urine samples, saliva samples, alveolar lavage fluid, cervical exfoliated cell samples, or other biological samples.

Referring to fig. 1 to 5, the full-automatic sample processing system of the present utility model includes a workbench 1, a support 2 is provided on the workbench 1, a translation assembly 3 is horizontally provided on the support, a sample tube storage area 4, a sample adding reaction area 5 and a gun head storage area 6 are sequentially provided on the front side of the support 2 from left to right, wherein the sample tube storage area 4 is provided with a sample tube rack 41 and a sample tube clamping mechanism 42, and a first oscillation mechanism is provided below the sample tube rack 41 to drive the sample tube rack 41 to oscillate, so that the sample oscillation is uniform. In one embodiment, sample tube storage area 4 or sample addition reaction area 5 is further provided with a filter tube storage area for storing filter tube 112 or push filter tube 121.

In order to facilitate taking and placing of the sample tube, and simultaneously, the sample tube cover is matched with the sample tube clamping mechanism 42 to be opened and closed in a rotating way, a material taking mechanism 7 is arranged above the sample tube rack 41, and the material taking mechanism 7 can move left and right under the drive of the translation assembly 3; the sample adding reaction zone 5 is provided with a centrifuge tube rack 51 and a reagent storage box 52, and one or more storage areas are arranged on the reagent storage box 52 and used for storing different detection reagents.

In this embodiment, in order to improve the sample processing efficiency, the number of centrifuge tube racks 51 is 2, and the number of sample tube clamping mechanisms 42 is two, so that two groups of samples can be processed synchronously, and the corresponding number can be adjusted according to the actual detection requirement; centrifuge tubes (for example, an EP tube) are uniformly distributed on the centrifuge tube rack 51, and serve as reaction vessels for adding samples and detection reagents and reacting, and a second oscillating mechanism is arranged below the centrifuge tube rack 51 for promoting the reaction of the samples and the detection reagents; the gun head storage area 6 is provided with a gun head frame 61, a liquid-transferring gun head 62 is uniformly distributed on the gun head frame 61, a liquid-transferring mechanism 8 is arranged above the gun head frame 61, and the liquid-transferring mechanism 8 and the material-taking mechanism 7 are arranged in parallel and synchronously move left and right under the drive of the translation assembly 3; as shown in fig. 1, the pipetting mechanism 8 is used to automatically aspirate the sample in the sample tube, the reagent in the reagent storage cartridge 52, and the sample in the centrifuge tube reacted with the detection reagent. In particular, the first oscillating mechanism and the second oscillating mechanism may be implemented using solutions known in the art, such as oscillating mechanisms of a shaker. In one embodiment, the oscillation mechanism includes an oscillation driving motor, which is connected to the sample tube rack 41 and can drive the sample tube rack 41 to oscillate, and drive the sample tube or the centrifuge tube to mix and oscillate.

Specifically, referring to fig. 2, the translation assembly 3 includes a motor 31 and a rotating shaft 32 vertically installed on a side wall of the bracket 2, wherein the motor 31 is used as a power output element, a driving pulley is fixed on an output shaft of the motor, meanwhile, a driven pulley is arranged on the rotating shaft 32, and a synchronous belt 33 is connected between the driving pulley and the driven pulley in a tensioning manner; for conveniently driving the material taking mechanism 7 and the liquid transferring mechanism 8 to move, a clamping block assembly 34 which is fixedly connected with the material taking mechanism 7 and the liquid transferring mechanism 8 is arranged on a synchronous belt 33, as shown in fig. 2, the clamping block assembly 34 and the synchronous belt are clamped and fixed, for conveniently guiding the movement of the material taking mechanism 7 and the liquid transferring mechanism 8, a guide rail 35 is further arranged on the support 2, and a sliding block on the guide rail 35 is fixedly connected with the material taking mechanism 7 and the liquid transferring mechanism 8 respectively.

In this embodiment, as shown in fig. 5, the sample tube clamping mechanism 42 includes a base 421, and a jaw motor 422 is vertically disposed on the base 421.

Further, the material taking mechanism 7 includes a first driving component 71 and a first lifting component 72, where the first driving component 71 and the translating component 3 have the same structure, and all adopt motor synchronous belts to implement linear motion, and the moving direction of the translating component 3 is set as an X axis, the moving direction of the first driving component 71 is set as a Y axis, then the moving direction of the first lifting component 72 is set as a Z axis, the first driving component 71 can drive the first lifting component 72 to move back and forth along the Y axis, an output end of the first lifting component 72 is provided with a rotary clamping jaw component 73 for clamping a sample tube and opening a sample tube cover in a rotating manner, in this embodiment, the rotary clamping jaw component 73 includes a rotary clamping jaw motor 731, and an output end of the rotary clamping jaw motor is provided with a clamping block 732. Meanwhile, in order to record the information of the sample tube conveniently, a two-dimensional code is attached to the sample tube, a code scanning component 74 for scanning the clamped sample tube is fixedly arranged on the first lifting component 72, and in the embodiment, the code scanning component 74 adopts a common two-dimensional code image scanner.

Specifically, as shown in fig. 3, the first lifting assembly 72 includes a fixing plate 721 vertically disposed, linear guide rails 722 are symmetrically disposed on the fixing plate 721, a connecting plate 723 for mounting the rotating clamping jaw assembly 73 is fixed on a sliding block of the linear guide rails 722, a lifting motor 724 is further disposed on the fixing plate 721, an output end of the lifting motor 724 is connected with a screw 725, the screw 725 is in threaded connection with the connecting plate 723, and the lifting motor 724 drives the connecting plate 723 to lift through the screw 725 when in operation.

Example 2

As shown in fig. 1 and 2, this embodiment is a further improvement on the basis of embodiment 1, and is specifically as follows:

the pipetting mechanism 8 comprises a second driving component 81 and a second lifting component 82, wherein the second driving component 81 and the first driving component 71 have the same structure, the second lifting component 82 and the first lifting component 72 have the same structure or the second lifting component 82 adopts an electric cylinder as a power element, a motor and a screw rod are not needed for matching transmission, and the structure is simpler; the second driving component 81 can drive the second lifting component 82 to move back and forth along the Y-axis direction, and the output end of the second lifting component 82 is provided with a pipette 83 and a centrifuge tube cover opening component 84.

The pipette gun 83 is a standard component known in the industry, the pipette gun 83 is provided with a suction head at the lower end, automatic disassembly and assembly of the pipette gun head 62 can be achieved under pressure, when the pipette gun head 62 needs to be installed, the pipette gun 83 is driven by the second driving component 81 to align with the pipette gun head 62, the second lifting component 82 drives the pipette gun 83 to move downwards to sleeve the pipette gun head 62 on the pipette gun 83, in this embodiment, in order to sample samples and reagents respectively, the number of the pipette gun 83 is 2, the number of the pipette gun 83 can be correspondingly set according to different types of samples and different required added reagents, and the same pipette gun and the pollution of different reagents are avoided.

In order to facilitate the recovery of the used pipette tips 62 and the recovery of the waste solution generated in the centrifuge tube, a waste recovery area 9 is further arranged on the workbench 1, a garbage can is arranged in the waste recovery area, and a solid-liquid separation area is arranged in the garbage can and is respectively used for storing the pipette tips and the waste solution; further, as shown in fig. 4, since a plurality of mechanisms are provided on the table 1, a cover is provided outside the table 1 in order to ensure safety when a worker uses the table.

The centrifuge tube is an EP tube, the EP tube is in a flip structure, the tube body of the centrifuge tube is clamped on the centrifuge tube rack 51, as shown in fig. 1, a clamping groove is formed in the centrifuge tube uncapping assembly 84, and when the centrifuge tube is uncapped, the clamping groove is clamped between the tube body and the cover body of the centrifuge tube, and the cover body can be opened by upward driving; when the cover is closed, the upper end of the cover body is matched with the clamping groove, the centrifuge tube cover opening assembly 84 is driven by the translation assembly 3 to enable the cover body to turn over, and the cover is pressed down under the driving of the second lifting assembly 82.

In order to accelerate the reaction speed in the centrifuge tube, meanwhile, the temperature required by the reaction of different samples is different, a heating temperature control module is further arranged on the centrifuge tube rack 51, and different temperatures can be set. Some samples need to be subjected to magnetic attraction purification separation treatment, magnetic bead suspension needs to be added, when solid-liquid separation is avoided, magnetic beads are mistakenly sucked into a pipetting gun, a magnetic attraction separation module is further arranged on an offline pipe support 51, and specifically, the magnetic attraction separation module is arranged below the centrifuge pipe support 51 or on one side of a concave position of a centrifuge tube for adsorbing the magnetic beads in reaction liquid, so that the magnetic beads are separated from the reaction liquid. When the magnetic separation module is electrified, the magnetic separation module has magnetism, and magnetic beads are adsorbed to the bottom or one side of the centrifugal tube, so that the supernatant is conveniently sucked.

Example 3

Based on the embodiment 1 or the embodiment 2, the full-automatic sample processing system is matched with the sample tube with the filtering device, the separation of solid impurities in the sample can be realized through the oscillation action, the supernatant fluid can permeate the filter screen in the sample tube, and the oscillation filtration can be realized (the sample tube with the filtering device can refer to the content described in Chinese patent application 202223134628X, and the whole content of the patent is incorporated herein).

As a specific embodiment, as shown in fig. 6 and 7, the sample tube structure with the filtering device comprises a sampling tube 110, wherein a containing cavity is arranged in the sampling tube 110, an opening 111 is arranged at the upper end of the sampling tube, a filtering tube 112 with a hollow inside is detachably arranged in the containing cavity, the filtering tube 112 separates the containing cavity into an impurity cavity 116 and a filtrate cavity 117, a first sealing cover 113 which is used for being matched with the opening 111 to seal the impurity cavity 12 is arranged at the upper end of the filtering tube 112, a liquid taking opening 115 which is communicated with the filtrate cavity 117 is arranged in the middle of the first sealing cover 113, and a second sealing cover 114 which is used for sealing the filtrate cavity 117 is detachably arranged above the first sealing cover 113; the pipe diameter of the filter pipe 112 is smaller than that of the sampling pipe 111, and specifically, the pipe diameter of the filter pipe 112 is 1/3-1/2 of that of the sampling pipe 111. The filter tube may include one, two or more layers of filter mesh arranged in a stacked manner to achieve a solid-liquid separation effect. The pore size of the outer layer filter screen is 70-250 μm, the pore size of the inner layer filter screen is 1-50 μm, if the middle layer filter screen is present, the pore size of the middle layer filter screen is 50-70 μm. The structure of the screen and the filter pore size can be determined according to the type of sample.

In operation, a fecal sample obtained by mixing fecal matter with a preserving fluid is introduced into sampling tube 110, filter tube 112 is fitted with fluid sampling port 115 facing up into opening 111 of sampling tube 110, the gap between filter tube 112 and sampling tube 110 is sealed with first seal cap 113, and fluid sampling port 115 is sealed with second seal cap 114. The assembled sample tube is placed on the sample tube rack 41 and the first oscillating mechanism is activated. The sample tube is driven to oscillate, filtrate in the fecal sample sequentially passes through the filter screen from the filter tube 112 under the action of oscillation force and enters the filtrate cavity 117 of the sampling tube 110 to realize solid-liquid separation of the fecal sample.

Example 4

Based on embodiment 1 or embodiment 2, the full-automatic sample processing system is matched with a sample tube with a filtering device, and can realize separation of solid impurities in a sample through oscillation action, so that supernatant liquid can permeate a filter screen in the sample tube, and oscillation filtering is realized. As one embodiment, the sample tube structure with the filtering device is shown in fig. 8-10, which comprises a sampling tube 110 and a pressing type filtering tube 121, wherein the sampling tube 110 is used for containing a sample; the push type filter tube 121 comprises a lower filtering part 122 and an upper tube body 123, the filtering part 122 comprises a plurality of layers of coaxially arranged cylindrical filter screens 124, and the apertures of the cylindrical filter screens 124 are sequentially reduced from outside to inside and are used for carrying out multi-layer solid-liquid separation on a sample to obtain filtrate; the top end of the filtering part 122 is provided with a sealing ring 125 along the circumferential direction, the sealing ring 125 is connected with the outermost cylindrical filter screen 124, and is abutted with the inner wall of the sampling tube 110 when in use, so as to seal the gap between the inner wall of the sampling tube 110 and the outer wall of the pressing type filtering tube 121; the pipe body 123 is concentrically connected with the cylindrical filter screen 124 at the innermost layer and is used for accommodating the filtrate obtained after filtration; the push type filter tube is configured to be extendable into the sampling tube 110 in a longitudinal direction and slidable along an inner wall of the sampling tube 110 to achieve solid-liquid separation of a sample by push. Specifically, the filtering portion 122 includes less than or equal to three layers of cylindrical filter screens 124, preferably two layers of cylindrical filter screens 124 are adopted, wherein the aperture of the outer layer of cylindrical filter screen 124 is 45 μm to 425 μm, the aperture of the inner layer of cylindrical filter screen 124 is 3 μm to 30 μm, and reinforcing connection ribs 126 are arranged on the outer side of each layer of cylindrical filter screen 124 for supporting.

In operation, a fecal sample formed by mixing fecal and preservation solution is added to sampling tube 110, then push-type filter tube 121 is inserted vertically along the inner wall of sampling tube 110, the liquid in the fecal sample permeates cylindrical filter screen 124 under pressure, and the filtrate enters the interior of cylindrical filter screen 124 and tube 123.

When the fully automatic sample processing system is used, the main working flow of the device is introduced by taking the nucleic acid extraction and purification treatment of the fecal sample as an example as follows:

1. a fecal sample preservation solution is added to the sampling tube 110, sampled and added to the fecal preservation solution, and the tube cover is closed.

2. The sampling tube 110 is placed on the sample tube rack 41, the sampling mechanism 7 clamps one sampling tube 110 from the sample tube rack 41, moves to the position of the code scanning component 74 to scan codes, acquires information on the sampling tube 110 and records data.

3. The sampling mechanism 7 conveys the sampling tube 110 to the upper part of the sample tube clamping mechanism 42 to clamp the lower part of the sampling tube 110, the rotary clamping jaw assembly 73 is used for uncovering the sampling tube 110, the rotary clamping jaw assembly 73 is used for grabbing the filter tube 112 and placing the filter tube 110 into the sampling tube 110 for assembly, the first sealing cover 113 and the second sealing cover 114 are tightly covered to obtain a complete sample tube, the sample tube is placed back on the sample tube rack 41, the first oscillating mechanism is started to drive the sample tube to move, the sample in the sample tube oscillates, the liquid in the sample tube penetrates through the filter screen on the filter tube 112 and enters the filter cavity 117, and impurities which cannot penetrate through the filter screen are reserved in the sampling tube 110 on the outer side, so that the filtration of the sample liquid is realized;

or, the sampling mechanism 7 transports the sampling tube 110 to the upper part of the sample tube clamping mechanism 42 to clamp the lower part of the sample tube, the rotary clamping jaw assembly 73 is used for uncapping the sampling tube 110, the rotary clamping jaw assembly 73 is used for grabbing the push-type filter tube 121 to be inserted into the sampling tube 110, and the filtration of the sample liquid is realized in a push-type manner to obtain a complete sample tube;

4. the sample tube is transported to the sample tube clamping mechanism 42 by the material taking mechanism 7, the lower part of the sample tube is clamped, the second sealing cover 114 of the sample tube is opened by the rotary clamping jaw assembly 73, the pipetting mechanism 8 moves to the position where the pipette tip 62 is installed on the gun tip box and then moves to the position where the sample tube clamping mechanism 42 is arranged, filtered sample liquid is sucked from a liquid suction port of the sample tube filtrate cavity 117, filled into the EP tube with the cover opened, moves to the position of the garbage can and the used pipette tip 62 is discarded into the garbage can; subsequently, the rotating jaw assembly 73 closes the second sealing cap 114 of the sample tube and the take out mechanism 7 returns the sample tube to the sample tube rack 41 and takes the next sample tube and opens the next processing cycle;

or the pipetting mechanism 8 moves to the pipette head 62 mounted on the pipette head box, then moves to the sample tube clamping mechanism 42, sucks the filtered sample liquid from the opening of the tube body 123 of the push type filter tube 121, fills the filtered sample liquid into the EP tube with the cover opened, moves to the garbage can, and discards the used pipette head 62 into the garbage can; subsequently, the take-off mechanism 7 returns the sample tube to the sample tube rack 41 and takes off the next sample tube 110, opening the next processing cycle;

5. the pipetting mechanism moves to the tip box to mount a new pipetting tip, then moves to the reagent storage area, aspirates the lysing agent, adds into the EP tube, then discards the pipetting tip 62, and closes the EP tube; setting the reaction temperature of the heating temperature control module, and starting or closing the second oscillating mechanism according to the reaction requirement to perform reaction;

6. the centrifuge tube uncapping mechanism opens the EP tube, the pipetting mechanism moves to the gun head box to mount a new pipetting gun head 62, then moves to the reagent storage area, absorbs the magnetic bead suspension, adds the magnetic bead suspension into the EP tube, closes the EP tube, opens the second oscillating mechanism to capture the magnetic beads, and opens the magnetic attraction separation module after the reaction is finished to enable the magnetic beads to be adsorbed at one position of the EP tube;

7. the centrifuge tube uncapping mechanism opens the EP pipe, and the pipetting mechanism moves to the gun head box and installs new pipetting gun heads to move to the EP pipe support, absorb the supernatant from the EP pipe, discharge the supernatant into the garbage bin, accomplish solid-liquid separation, and abandon pipetting gun heads.

It will be readily appreciated by those skilled in the art that the foregoing description is merely a preferred embodiment of the utility model and is not intended to limit the utility model, but any modifications, equivalents, improvements or alternatives falling within the spirit and principles of the utility model are intended to be included within the scope of the utility model.

Claims (10)

1. A fully automated sample processing system, characterized by: the automatic feeding device comprises a workbench (1), wherein a support (2) is arranged on the workbench (1), a translation component (3) is transversely arranged on the support, a sample tube storage area (4), a sample adding reaction area (5) and a gun head storage area (6) are sequentially arranged on the front side of the support (2) from left to right, a sample tube storage area (4) is provided with a sample tube rack (41) and a sample tube clamping mechanism (42), a first oscillating mechanism is arranged below the sample tube rack (41), a material taking mechanism (7) is arranged above the sample tube rack (41), and the material taking mechanism (7) can move left and right under the driving of the translation component (3); the sample adding reaction zone (5) is provided with a centrifuge tube rack (51) and a reagent storage box (52), and a second oscillating mechanism is arranged below the centrifuge tube rack (51); the gun head storage area (6) is provided with a gun head frame (61), a liquid transferring mechanism (8) is arranged above the gun head frame (61), the liquid transferring mechanism (8) and the material taking mechanism (7) are arranged in parallel, and the liquid transferring mechanism and the material taking mechanism are driven by the translation assembly (3) to synchronously move left and right.

2. The fully automated sample processing system of claim 1, wherein: the material taking mechanism (7) comprises a first driving assembly (71) and a first lifting assembly (72), the first driving assembly (71) can drive the first lifting assembly (72) to move back and forth, the output end of the first lifting assembly (72) is provided with a rotary clamping jaw assembly (73) for clamping a sample tube and opening a sample tube cover in a rotary mode, and a code scanning assembly (74) for scanning a clamped sample tube is fixedly arranged on the first lifting assembly (72).

3. The fully automated sample processing system of claim 1, wherein: the pipetting mechanism (8) comprises a second driving assembly (81) and a second lifting assembly (82), the second driving assembly (81) can drive the second lifting assembly (82) to move back and forth, and a pipetting gun (83) and a centrifuge tube cover opening assembly (84) are arranged at the output end of the second lifting assembly (82).

4. The fully automated sample processing system of claim 1, wherein: the centrifuge tube rack (51) is also provided with a heating temperature control module and a magnetic separation module; and/or the workbench (1) is also provided with a waste recovery area (9).

5. The fully automated sample processing system of claim 2, wherein: the translation subassembly (3) including install perpendicularly in motor (31) and pivot (32) of support (2) lateral wall, be fixed with the driving pulley on the output shaft of motor (31), be equipped with the driven pulley on pivot (32), the driving pulley with tensioning is connected with hold-in range (33) between the driven pulley, be equipped with on hold-in range (33) be used for with extracting mechanism (7) clamping piece subassembly (34) of pipetting mechanism (8) fixed connection, still be equipped with on support (2) be used for extracting mechanism (7) pipetting mechanism (8) remove guide rail (35) of direction.

6. The fully automated sample processing system of claim 1, wherein: the sample tube clamping mechanism (42) comprises a base (421), and a clamping jaw motor (422) is vertically arranged on the base (421).

7. The fully automated sample processing system of claim 1, wherein: the workbench (1) is also provided with a filter tube storage area.

8. The fully automated sample processing system of claim 2, wherein: the first lifting assembly (72) comprises a fixing plate (721) which is vertically arranged, linear guide rails (722) are symmetrically arranged on the fixing plate (721), connecting plates (723) used for installing the rotary clamping jaw assemblies (73) are fixed on sliding blocks of the linear guide rails (722), lifting motors (724) are further arranged on the fixing plate (721), the output ends of the lifting motors (724) are connected with screw rods (725), the screw rods (725) are in threaded connection with the connecting plates (723), and when the lifting motors (724) work, the connecting plates (723) are driven to lift through the screw rods (725).

9. The fully automated sample processing system of any of claims 1-8, wherein: the full-automatic sample processing system further comprises a sample tube matched with the sample tube rack, the sample tube comprises a sampling tube (110), an accommodating cavity is formed in the sampling tube (110), an opening (111) is formed in the upper end of the sampling tube, a hollow filter tube (112) is arranged in the accommodating cavity in a detachable mode, the filter tube (112) separates the accommodating cavity into an impurity cavity (116) and a filtrate cavity (117), a first sealing cover (113) used for sealing the impurity cavity (116) in cooperation with the opening (111) is arranged at the upper end of the filter tube (112), a liquid taking port (115) communicated with the filtrate cavity (117) is formed in the middle of the first sealing cover (113), and a second sealing cover (114) used for sealing the filtrate cavity (117) is detachably arranged above the first sealing cover (113).

10. The fully automated sample processing system of any of claims 1-8, wherein: the fully automatic sample processing system further comprises a sample tube matched with the sample tube rack, wherein the sample tube comprises a sampling tube (110) and a pressing type filtering tube (121), and the sampling tube (110) is used for containing samples; the pressing type filter tube (121) comprises a filter part (122) at the lower end and a tube body (123) at the upper end, the filter part (122) comprises a plurality of layers of cylindrical filter screens (124) which are coaxially arranged, the pore diameters of the cylindrical filter screens (124) are sequentially reduced from outside to inside, and the pressing type filter tube is used for carrying out multilayer solid-liquid separation on a sample to obtain filtrate; the top end of the filtering part (122) is provided with a sealing ring (125) along the circumferential direction, the sealing ring (125) is connected with an outermost cylindrical filter screen (124) and is abutted with the inner wall of the sampling tube (110) when in use, so as to seal a gap between the inner wall of the sampling tube (110) and the outer wall of the pressing type filtering tube (121); the pipe body (123) is concentrically connected with the cylindrical filter screen (124) at the innermost layer and is used for accommodating filtrate obtained after filtration; the push type filter tube is configured to be capable of extending into the sampling tube (110) in the length direction and sliding along the inner wall of the sampling tube (110) so as to realize solid-liquid separation of a sample in a push mode.