CN220141799U - Implantable electrode device - Google Patents

Abstract

The present utility model provides an implantable electrode device for generating an electric field and suppressing growth of target cells in a target region by using the electric field, comprising: the electrode part comprises a plurality of electric field generating contacts for generating a variable electric field, and the electrode part is deformed to enable the plurality of electric field generating contacts to be in contact with the inner wall of the target area after being implanted into the target area. In this case, the electrode device implanted forms an electric field inside the target region, so that the killing ability of the electrode device against the target cells can be improved, and the electric field generating contact point in contact with the inner wall of the target region after the electrode portion is implanted into the target region can further improve the killing ability of the electrode device against the target cells located on the inner wall.

Description

Implantable electrode device

Technical Field

The present utility model relates to an implantable electrode device.

Background

The operation treatment is an important means for treating malignant tumor, and the operation not only can provide final pathological diagnosis, but also can rapidly remove most of tumor cells, relieve the symptoms of patients and provide convenience for other treatments in the next step. For some low grade gliomas, such as hairy cell astrocytomas, complete resection of the surgery allows patients to be cured and survive for long periods of time. However, partial tumors (e.g., gliomas) cannot be completely cured by surgical excision, and a large probability of recurrence occurs after surgical treatment, and it is counted that patients with gliomas have a survival rate of less than 5% after surgical treatment for 5 years.

In order to improve the treatment effect on tumors after surgical treatment, patients are treated by using radiotherapy or chemotherapy, however, the current radiotherapy or chemotherapy has limited treatment effect on tumors, and normal cells near the tumors are easily damaged. Currently, a tumor electric field therapy (Tumor Treating Fields, TTF) is proposed, in which the growth of tumor cells is suppressed by an alternating electric field, thereby achieving the treatment of tumor cells. The patent of application number CN200780034204.5 discloses a device for destroying cancer cells, however, the device does not adaptively change the shape of the electrode portion to conform to the inner wall of the cavity, and the efficiency of the electric field is low.

Disclosure of Invention

The present utility model has been made in view of the above-described conventional circumstances, and an object thereof is to provide an implantable electrode device capable of being deformed after implantation into a target region to bring an electric field generating contact into contact with an inner wall of the target region, thereby improving electric field efficiency of electric field generating contact formation.

To this end, the present disclosure provides an implantable electrode device, which is an electrode device generating an electric field and inhibiting growth of target cells of a target region using the electric field, comprising: the electrode part comprises a plurality of electric field generating contacts for generating a variable electric field, and the electrode part is deformed to enable the electric field generating contacts to be in contact with the inner wall of the target area after being implanted into the target area. In this case, the electrode device implanted forms an electric field inside the target region, so that the killing ability of the electrode device against the target cells can be improved, and the electric field generating contact point in contact with the inner wall of the target region after the electrode portion is implanted into the target region can further improve the killing ability of the electrode device against the target cells located on the inner wall.

In the implantable electrode device according to the present utility model, the electrode portion may include a center electrode and an outer peripheral electrode, and the center electrode and the outer peripheral electrode may be provided with a plurality of electric field generating contacts, respectively. In this case, different electric fields can be formed by using a plurality of electric field generating contacts of the center electrode and the outer peripheral electrode.

In addition, in the implantable electrode device according to the present utility model, the variable electric field may be generated by at least two electric field generating contacts among the plurality of electric field generating contacts. In this case, the electric field can be formed in various ways, so that the electric field can have different directions, and the diversity of the formed electric field can be improved, and the increase of the direction of the electric field helps to better inhibit the mitosis of the tumor cells, so that the therapeutic effect on the tumor cells can be effectively improved by generating the variable electric field by using at least two electric field generating contacts.

In the implantable electrode device according to the present utility model, the center electrode may include a fixing portion for fixing the center electrode and an implantation portion extending from the fixing portion to the target region, and a plurality of electric field generating contacts may be provided in the implantation portion. In this case, the position of the center electrode can be fixed by the fixing portion and implanted to the target region by the implantation portion to achieve formation of the electric field within the target region.

In the implantable electrode device according to the present utility model, the electrode portion may include at least one peripheral electrode, and the at least one peripheral electrode may be rotatably provided in the fixed portion. In this case, the plurality of outer peripheral electrodes can form an appropriate electric field at each position in the target region, so that an electric field can be formed for a specific position of a different target region. Meanwhile, the plurality of peripheral electrodes can form electric fields in different directions, so that the diversity of the electric fields formed by the electrode devices is improved. In addition, the plurality of peripheral electrodes can also improve the accuracy of the electric field.

In the implantable electrode device according to the present utility model, the outer peripheral electrode may have a tubular structure, and a cable connecting the electric field generating contact and a land provided in the center electrode may be provided in an inner cavity of the tubular structure. Under this kind of circumstances, can utilize the inner chamber to hold the cable, reduce the harm that the cable exposes to the target object, reduce the hindrance of cable to peripheral electrode activity, guide the cable to the patch panel in unison through the inner chamber simultaneously, can be convenient for the management and the maintenance of cable.

In the implantable electrode device according to the present utility model, the outer peripheral electrode may be provided on the fixing portion so as to be capable of adjusting an angle between the outer peripheral electrode and the center electrode, and the outer peripheral electrode may be spaced apart from the center electrode and may be in contact with an inner wall of the target region by adjusting an angle between the outer peripheral electrode and the center electrode. In this case, the electrode portion can be deformed to adapt to target regions of different shapes by adjusting the angle between the outer peripheral electrode and the center electrode.

In the implantable electrode device according to the present utility model, the electrode portion may further include a plurality of temperature monitoring contacts for detecting temperature, and the temperature monitoring contacts may be spaced apart from the electric field generating contacts. In this case, the temperature information in the vicinity of the electric field generating contact can be detected, and further, the parameters of the electric field can be adjusted based on the temperature information in the vicinity of the electric field generating contact, so that the influence of the excessive temperature on other cells in the target region can be reduced.

In addition, in the implantable electrode device according to the present utility model, optionally, the center electrode is provided with a first electric field generating contact surrounding the center electrode in an array, and the outer peripheral electrode is provided with a second electric field generating contact surrounding the outer peripheral electrode in an array. In this case, the first electric field generating contact and the second electric field generating contact can be used to form electric fields in a plurality of directions, the second electric field generating contact in different outer peripheral electrodes can be used to form electric fields in a plurality of directions, and the different first electric field generating contacts of the center electrode can be used to form electric fields in a plurality of directions.

In addition, in the implantable electrode device according to the present utility model, optionally, the implantable electrode device further includes a control module configured to control the electric signal generated by the signal generating module to form electric fields with different frequencies, field strengths, directions, electric field direction switching periods, or duty ratios through the electric field generating contacts. In this case, parameters such as frequency, direction, field strength, electric field direction switching period, or duty ratio of the formed electric field can be controlled.

According to the present utility model, it is possible to provide an implantable electrode device capable of being deformed after implantation into a target region to bring an electric field generating contact into contact with an inner wall of the target region, thereby improving electric field efficiency of electric field generating contact formation.

Drawings

Embodiments of the present disclosure will now be explained in further detail by way of example only with reference to the accompanying drawings, in which:

fig. 1 is a schematic view illustrating an application scenario of an implantable electrode device according to an embodiment of the present disclosure.

Fig. 2a is a schematic diagram illustrating a patient's head in accordance with embodiments of the present disclosure.

Fig. 2b is a schematic diagram illustrating a patient's head after removal of tumor tissue in accordance with embodiments of the present disclosure.

Fig. 3 is a schematic diagram illustrating an implantable electrode device according to an embodiment of the present disclosure.

Fig. 4 is a schematic view showing the structure of an implantable electrode device according to an embodiment of the present disclosure.

Fig. 5 is a front view showing an implantable electrode part according to an embodiment of the present disclosure.

Fig. 6 is a plan view showing an implantable electrode part according to an embodiment of the present disclosure.

Fig. 7a is a front view illustrating an open state of an implantable electrode part according to an embodiment of the present disclosure.

Fig. 7b is a front view showing an implantable electrode part according to an embodiment of the present disclosure in a gathered state.

Fig. 8 is a schematic diagram illustrating an implantable electric field generating contact and a temperature monitoring contact according to an embodiment of the present disclosure.

Reference numerals illustrate:

1 … target object 1, 11 … target area 11, 14 … skull 14, 12 … tumor tissue 12, 13 … brain tissue 13,

2 … electrode assembly 2, 21 … signal generating module 21, 22 … electrode portion 22, 23 … control module 23,

221 … center electrode 221, 2211 … fixation portion 2211, 2212 … implant portion 2212, 222 … outer peripheral electrode 222, 223 … electric field generating contact 223, 224 … temperature monitoring contact 224

Detailed Description

Hereinafter, preferred embodiments of the present disclosure will be described in detail with reference to the accompanying drawings. In the following description, the same members are denoted by the same reference numerals, and overlapping description thereof is omitted. In addition, the drawings are schematic, and the ratio of the sizes of the components to each other, the shapes of the components, and the like may be different from actual ones.

It should be noted that the terms "comprises" and "comprising," and any variations thereof, in this disclosure, such as a process, method, system, article, or apparatus that comprises or has a list of steps or elements is not necessarily limited to those steps or elements expressly listed or inherent to such process, method, article, or apparatus, but may include or have other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

Embodiments of the present disclosure relate to an implantable electrode device that can be implanted into a target region of a target object and form an electric field at the target region to inhibit growth of target cells of an inner wall of the target region.

Embodiments of the present disclosure relate to implantable electrode devices, which may also be referred to as, for example, electric field application devices, implantable electrodes, or therapeutic devices. The names are used to indicate the implantable electrode device according to the present embodiment, and should not be construed as limiting.

Fig. 1 is a schematic view showing an application scenario of an implantable electrode device 2 according to an embodiment of the present disclosure. Fig. 2a is a schematic diagram illustrating a patient's head in accordance with embodiments of the present disclosure. Fig. 2b is a schematic diagram illustrating the head of a patient after removal of tumor tissue 12 in accordance with an embodiment of the present disclosure. Fig. 3 is a schematic diagram illustrating an implantable electrode device according to an embodiment of the present disclosure. Fig. 4 is a schematic view showing the structure of an implantable electrode device according to an embodiment of the present disclosure.

In some examples, referring to fig. 1, embodiments of the present disclosure relate to an implantable electrode device 2 that may be implanted to a target region 11 of a target object 1.

In some examples, the target object 1 may be an animal. In some examples, the target object 1 may be a person. In some examples, the target object 1 may be a patient with tumor tissue 12. In some examples, referring to fig. 1, the target object 1 may be a patient with an intracranial tumor. It should be noted that the electrode device 2 according to the present disclosure may be transplanted into the vicinity of the tumor tissue 12, and the tumor may include, but is not limited to, gastric tumor, brain tumor, lung tumor, and liver tumor. The electrode device 2 will be described below with reference to brain glioma as an example.

In some examples, the target region 11 may be located intracranially. In some examples, referring to fig. 2a, a brain glioma patient's head may include: skin, skull 14, cerebrospinal fluid, brain tissue 13 and tumor tissue 12. In some examples, tumor tissue 12 may be resected using surgery.

In some examples, referring to fig. 2b, after removal of tumor tissue 12, a cavity may be formed within brain tissue 13. In this case, the head of the glioma patient after removal of the tumor tissue 12 may include: skin, skull 14, cerebrospinal fluid, brain tissue 13 and cavities. In some examples, the target region 11 is a cavity that may refer to after removal of tumor tissue 12.

Due to the limitations of current procedures, there is no guarantee that there are no tumor cells left behind on the inner wall of the target area 11 after the tumor tissue 12 has been surgically removed. In this case, after the implantation of the electrode device 2 according to the present disclosure into the target region 11 of the target object 1, the growth of tumor cells in the vicinity of the inner wall can be suppressed by the electric field formed by the electrode device 2. In other words, the target cell may refer to a tumor cell located near the inner wall.

However, the present disclosure is not limited thereto, and the implantable electrode device 2 according to the present disclosure can also be implanted near the tumor tissue 12 before the tumor tissue 12 is resected, and form an electric field near the tumor tissue 12 to treat tumor cells (or tumor tissue 12).

Treatment of tumor cells (or tumor tissue 12) may be referred to as inhibiting the growth of tumor cells near the inner wall. For example, treatment of a tumor cell (or tumor tissue 12) may refer to the application of an alternating electric field of a specific frequency to the tumor cell to inhibit mitosis of the tumor cell, treatment of a tumor cell (or tumor tissue 12) may refer to the application of an alternating electric field of a specific frequency to the tumor cell to cause death and apoptosis of the tumor cell and thereby kill the tumor cell, and treatment of a tumor cell (or tumor tissue 12) may refer to the application of an alternating electric field in combination with other tumor treatment methods such as chemotherapy, radiation therapy, or drugs to enhance the efficacy of the corresponding treatment methods.

In some examples, referring to fig. 3, the implantable electrode device 2 may be an electrode device 2 that generates an electric field and inhibits target cell growth of the target region 11 with the electric field. In this case, after the implanted electrode device 2 is implanted in the target area 11, an electric field can be formed near the target area 11, and thus treatment of the target cells can be achieved, and at the same time, since the effect of treatment on the target cells and the electric field intensity in the environment where the target cells are located are positively correlated, if the electrode device 2 is placed outside the cranium, the skin, the cranium 14, cerebrospinal fluid, and the brain tissue 13 all cause redistribution of the electric field and consume electric field energy, the energy consumption of the electrode device 2 can be greatly increased, and therefore, the implantation of the electrode device 2 near the target area 11 can effectively improve the energy utilization efficiency of the electrode device 2, prolong the service cycle of the electrode device 2, and reduce the influence on the daily life of the target object 1.

In some examples, referring to fig. 4, the electrode device 2 may include: a signal generating module 21 for generating an electrical signal and an electrode portion 22 for implanting into the target area 11 and receiving the electrical signal to form an electric field. In this case, it is possible to form an electric signal by the signal generating module 21 and to receive the electric signal by the electrode portion 22 to form a corresponding electric field.

In some examples, the electric field formed by the electrode portion 22 may have a specific frequency or have a preset frequency range. For example, in some examples, the center frequency of the electric field may be between 50 and 500kHz when the electrode arrangement 2 is utilized to inhibit mitosis of tumor cells. The present disclosure is not limited thereto and the range of the center frequency of the electric field may be adjusted based on the therapeutic principle.

In some examples, the electric field formed by the electrode portion 22 may have different frequencies. For example, different frequencies may be selected for different treatment principles. In this case, the target cells can be treated simultaneously using a plurality of therapeutic principles.

In some examples, referring to fig. 4, the electrode portion 22 may include a plurality of electric field generating contacts 223 for generating a varying electric field. In this case, the electric field can be formed by at least two electric field generating contacts 223 among the plurality of electric field generating contacts 223, and the electric field generating contacts 223 can be provided at different positions by the adjustment electrode portion 22. Note that fig. 4, 5, 6 and 7 denote only a part of the electric field generating contact 223, and in fig. 4, 5, 6 and 7, other unlabeled areas filled with the mesh should be understood as the electric field generating contact 223 of the present disclosure.

In some examples, after the electrode portion 22 is implanted into the target region 11, the electrode portion 22 is deformed to bring the electric field generating contact 223 into contact with or close to the inner wall of the target region 11. In this case, the electric field generating contact 223 in contact with or close to the inner wall of the target region 11 can further enhance the killing ability of the electrode device 2 against the target cells located on the inner wall.

In some examples, the signal generation module 21 may be disposed intracranially. In this case, the influence on the daily life of the target object 1 can be reduced.

In other examples, the signal generation module 21 may be disposed extracranial and connected to the electrode portion 22 with a cable. In this case, the maintenance of the signal generation module 21 can be facilitated on a daily basis.

In some examples, the electrical signal may be adjusted by the signal generation module 21 to change the electric field formed by the electrode portion 22.

Fig. 5 is a front view showing the implantable electrode portion 22 according to the embodiment of the present disclosure. Fig. 6 is a plan view showing the implantable electrode portion 22 according to the embodiment of the present disclosure. Fig. 7a is a front view showing the implanted electrode section 22 according to the embodiment of the present disclosure in an open state. Fig. 7b is a front view showing the implantable electrode part 22 according to the embodiment of the present disclosure in a gathered state.

In some examples, referring to fig. 5 and 6, the electrode device 2 may include a center electrode 221 and a peripheral electrode 222, the center electrode 221 and the peripheral electrode 222 being provided with a plurality of electric field generating contacts 223, respectively. In this case, different electric fields can be formed by the plurality of electric field generating contacts 223 of the center electrode 221 and the outer peripheral electrode 222. Since a target cell partially located at the inner wall of the target region 11 may grow toward the inner cavity of the target region 11 or a target cell partially located at the inner wall of the target region 11 may be pushed toward the inner cavity of the target region 11, an electric field can be formed in the inner cavity of the target region 11 using the center electrode 221 in cooperation with the outer peripheral electrode 222 to act on a target cell located at the inner cavity of the target region 11. However, the electrode device 2 may not include the center electrode 221.

In some examples, the central electrode 221 and the peripheral electrode 222 may be constructed of a flexible material with good biocompatibility. In this case, the center electrode 221 and the outer peripheral electrode 222 can be made to have a certain flexibility while maintaining rigidity so as to conform to the shape of the skull 14.

In some examples, referring to fig. 5, the center electrode 221 may include a fixing portion 2211 for fixing the center electrode 221 and an implant portion 2212 extending from the fixing portion 2211 to the target region 11, in which case the position of the center electrode 221 can be fixed with the fixing portion 2211 and implanted to the target region 11 with the implant portion 2212 to achieve formation of an electric field within the target region 11.

In some examples, the fixation portion 2211 may be fixed to the skull bone 14 after implantation of the electrode device 2. In this case, the center electrode 221 can be fixed to the skull bone 14 with the fixing portion 2211. In some examples, the fixation portion 2211 may include a splint and a fixation unit that secures the splint to the skull bone 14. In some examples, the fixation unit may be a screw, a jackscrew, a suture, or the like.

In some examples, the fixture 2211 may be provided with a patch panel, in which case the cable can be converged to the fixture 2211 with the patch panel and connected to the signal generation module 21.

In some examples, implant 2212 may be provided with electric field generating contacts 223. For example, the implant 2212 may be provided with one or more electric field generating contacts 223 (described later), in which case an electric field can be formed by the one or more electric field generating contacts 223 of the implant 2212 in cooperation with the electric field generating contacts 223 provided to the outer peripheral electrode 222.

In some examples, referring to fig. 5, 6, 7a, and 7b, the electrode portion 22 may include at least one peripheral electrode 222. In some examples, the electrode portion 22 may include at least 2-10 peripheral electrodes 222, e.g., the electrode portion 22 may include at least 2, 3, 4, 5, 6, 7, 8, 9, or 10 peripheral electrodes 222. The present disclosure is not limited thereto and the electrode portion 22 may also include 10, 12, 20 or more peripheral electrodes 222. In this case, the plurality of outer peripheral electrodes 222 can form an appropriate electric field at each position in the target region 11, so that an electric field can be formed for a specific position of a different target region 11. Meanwhile, the plurality of outer peripheral electrodes 222 can form electric fields in different directions, thereby improving the diversity of the electric fields formed by the electrode device 2. Also, the plurality of peripheral electrodes 222 can also improve the accuracy of the electric field.

In some examples, the peripheral electrode 222 may be disposed in a manner surrounding the central electrode 221. In some examples, referring to fig. 6, in a top view of the electrode portion 22, the outer peripheral electrodes 222 may be distributed in central symmetry with the geometric center of the fixed portion 2211 as a center of symmetry. In this case, the outer peripheral electrodes 222 can be uniformly distributed in the target region 11.

In some examples, the peripheral electrode 222 may have an arc-shaped structure, and in particular, one end of the peripheral electrode 222 may be a fixed end fixed to the fixing portion 2211, and the other end of the peripheral electrode 222 may be a free end. In some examples, the curvature may be from fixed end to free end. In this case, since the target region 11 is substantially spherical or ellipsoidal, the outer peripheral electrode 222 of the arc-shaped structure can more effectively conform to the inner wall of the target region 11.

In some examples, the peripheral electrode 222 may be generally cylindrical, elongated, pyramidal, mesh, or the like in shape. In this case, a specific shape can be selected based on the electric field to be formed and/or the inner wall of the target region 11, so that the electrode portion 22 can form a different electric field or the outer peripheral electrode 222 can be made to better fit the inner wall of the target region 11.

In some examples, the shape of the peripheral electrode 222 may be substantially the same as the shape of the corresponding inner wall of the target region 11, e.g., the shape from the fixed end to the free end may be substantially the same as the shape of the peripheral electrode 222 at the corresponding inner wall of the target region 11. In other words, the shape of the outer peripheral electrode 222 can be designed according to the inner wall of the target region 11 so that the outer peripheral electrode 222 can better fit the inner wall of the target region 11.

In some examples, the outer peripheral electrode 222 may be rotatably disposed at the fixation portion 2211. For example, a revolute pair may be provided between the outer peripheral electrode 222 and the fixed portion 2211. In this case, the outer peripheral electrodes 222 can be bonded to the inner wall of the target region 11 by adjusting the posture of each outer peripheral electrode 222.

In some examples, the peripheral electrode 222 is disposed at the fixed portion 2211 in such a manner that an angle between the peripheral electrode 222 and the central electrode 221 can be adjusted so that the peripheral electrode 222 can be away from the central electrode 221 and in contact with or close to the inner wall of the target region 11 by adjusting the angle between the peripheral electrode 222 and the central electrode 221. In this case, the electrode portion 22 can be deformed to adapt to the target region 11 of different shapes by adjusting the angle of the outer peripheral electrode 222 and the center electrode 221.

It should be noted that, since the peripheral electrode 222 and the central electrode 221 are not necessarily in a standard column shape, the angle between the peripheral electrode 222 and the central electrode 221 can be understood in this way: the angle between the peripheral electrode 222 and the central electrode 221 may be the angle between the axis of the geometric center of the central electrode 221 and the line connecting the fixed end and the free end of the peripheral electrode 222. Of course, the present disclosure is not limited thereto, and the description of the angle between the peripheral electrode 222 and the central electrode 221 of the present disclosure is for explaining the relationship of the position or posture between the peripheral electrode 222 and the central electrode 221, and understanding of the angle between the peripheral electrode 222 and the central electrode 221 may be adjusted according to actual conditions, for example, the angle between the peripheral electrode 222 and the central electrode 221 may be the angle of the position where the peripheral electrode 222 and the central electrode 221 are connected.

In some examples, the included angle between the peripheral electrode 222 and the central electrode 221 may be adjusted at will within a preset range, for example, the adjustment range of the included angle between the peripheral electrode 222 and the central electrode 221 may be 0 ° to 80 °, that is, the included angle between the peripheral electrode 222 and the central electrode 221 may be adjusted to 0 °, 1 °, 2 °, 3 °, 10 °, 30 °, 60 ° or the like as required.

In some examples, with implant 2212 having center electrode 221, referring to fig. 7a and 7b, peripheral electrode 222 may be adjusted to draw implant 2212 together or away from implant 2212 to place electrode 22 in a bunched or expanded state, respectively. In some examples, with implant 2212 having center electrode 221, outer peripheral electrodes 222 may be adjusted toward or away from each other to place electrode portions 22 in a bunched or expanded state, respectively. Specifically, in the gathered state, the free ends of the plurality of outer peripheral electrodes 222 may be brought close to each other. In the expanded state, the free ends of the plurality of peripheral electrodes 222 may be spaced apart from each other, and the peripheral electrodes 222 may be in contact with the inner wall of the target region 11 or may be in contact with the inner wall of the target region 11.

In some examples, multiple peripheral electrodes 222 may be adjusted simultaneously to move peripheral electrodes 222 away from each other. In other words, when one peripheral electrode 222 is adjusted, the other peripheral electrodes 222 may also be rotated in synchronization. In this case, the convenience of adjustment can be improved.

In some examples, each of the peripheral electrodes 222 may also be adjusted so that each of the peripheral electrodes 222 is positioned so as to be able to fit against the inner wall of the target region 11. In this case, since a part of the target region 11 is irregularly shaped, the posture of each of the outer peripheral electrodes 222 can be adjusted to accommodate the target regions 11 of different shapes.

In some examples, the peripheral electrode 222 may have an inner cavity, and in particular, the peripheral electrode 222 may be a tubular structure in which a cable connecting the electric field generating contact 223 and a land provided to the center electrode 221 is provided. In this case, the inner cavity can be used to accommodate the cable, so that damage to the target object 1 caused by cable exposure is reduced, obstruction of the cable to the movement of the peripheral electrode 222 is reduced, and meanwhile, the cable is uniformly guided to the wiring disc through the inner cavity, so that management and maintenance of the cable can be facilitated.

In some examples, the electrode portion 22 may not be provided with the implant portion 2212, and in particular, the electrode portion 22 may include a fixing portion 2211 and an outer peripheral electrode 222 provided to the fixing portion 2211. In this case, an electric field can be formed by the electric field generating contact 223 in the outer peripheral electrode 222.

In some examples, the electrode portion 22 may include a click structure, which may be a structure for fixing the relative positional relationship of the center electrode 221 and the outer peripheral electrode 222. In this case, the outer peripheral electrode 222 can be fixed by the click structure, and the stability of the electrode portion 22 can be improved.

In some examples, the varying electric field is generated by at least two electric field generating contacts 223 of the plurality of electric field generating contacts 223. Specifically, the electric field formed by the electrode portion 22 may be formed by any two electric field generating contacts 223, or may be formed by a plurality of electric field generating contacts 223 in cooperation. For example, the electric field formed by the electrode portion 22 may be formed between the plurality of electric field generating contacts 223 located at the center electrode 221, the electric field formed by the electrode portion 22 may be formed between the plurality of electric field generating contacts 223 located at the outer peripheral electrode 222, and the electric field formed by the electrode portion 22 may be formed between the electric field generating contacts 223 located at the center electrode 221 and the electric field generating contacts 223 located at the outer peripheral electrode 222. In this case, the electric field can be formed in various ways, so that the electric field can have different directions, and thus the diversity of the formed electric field can be improved, and the increase in the direction of the electric field helps to better inhibit the mitosis of the tumor cells, so that the therapeutic effect on the tumor cells can be effectively improved by generating the varying electric field by using at least two electric field generating contacts 223.

In some examples, the electric field generating contacts 223 may include a first electric field generating contact 223 disposed at the center electrode 221 and a second electric field generating contact 223 disposed at the outer peripheral electrode 222. In some examples, the electric field generating contact 223 may use a conductive material, such as silver, platinum iridium alloy, or the like. In some examples, the electric field generating contact 223 may use a non-conductive material, such as a high dielectric constant ceramic, and in some examples, when using a non-conductive material, a metal may be plated on an inner surface of the non-conductive material and remain insulated from an outer surface. In some examples, the electric field generating contact 223 may also include both a metal electrode of a metal material and an insulated electrode comprising a high dielectric constant ceramic.

In some examples, the center electrode 221 may be provided with a first electric field generating contact 223 surrounding the center electrode 221 in an array, and the outer peripheral electrode 222 is provided with a second electric field generating contact 223 surrounding the outer peripheral electrode 222 in an array. In this case, the first electric field generating contact 223 and the second electric field generating contact 223 can be used to form electric fields in a plurality of directions, the second electric field generating contact 223 in the different outer peripheral electrodes 222 can be used to form electric fields in a plurality of directions, and the different first electric field generating contact 223 of the center electrode 221 can be used to form electric fields in a plurality of directions.

In some examples, the center electrode 221 may include 1-8 rows of first electric field generating contacts 223, e.g., the center electrode 221 may include 1, 2, 3, 4, 5, 6, 7, 8 rows of first electric field generating contacts 223. The center electrode 221 may include 5 rows of first electric field generating contacts 223, in which case an electric field can be formed using the first electric field generating contacts 223 of the plurality of rows.

In some examples, the number of first electric field generating contacts 223 of each row may be the same. In some examples, the number of first electric field generating contacts 223 of each row may not be exactly the same.

In some examples, the first electric field generating contacts 223 of each row may include a plurality of first electric field generating contacts 223. In some examples, the first electric field generating contacts 223 of each row may comprise 2-16 first electric field generating contacts 223, e.g. a row of first electric field generating contacts 223 may comprise 2, 3, 4, 8, 16 first electric field generating contacts 223, preferably a row of first electric field generating contacts 223 may comprise 4 first electric field generating contacts 223. In this case, the electric field can be formed in a plurality of directions.

In some examples, the first electric field generating contacts 223 of each row may be uniformly distributed at the outer circumference of the center electrode 221. In this case, different electric fields can be formed at the outer circumference of the center electrode 221.

In some examples, the peripheral electrode 222 may include 1-8 rows of second electric field generating contacts 223, for example, the peripheral electrode 222 may include 1, 2, 3, 4, 5, 6, 7, 8 rows of second electric field generating contacts 223. The outer peripheral electrode 222 may include 5 rows of the second electric field generating contacts 223, in which case an electric field can be formed using the plurality of rows of the second electric field generating contacts 223.

In some examples, the number of second electric field generating contacts 223 of each row may be the same. In some examples, the number of second electric field generating contacts 223 of each row may not be exactly the same.

In some examples, the 1 st electric field generating contact 223 of each row may include only one second electric field generating contact 223. In some examples, the second electric field generating contacts 223 of each row may comprise 1-16 first electric field generating contacts 223, e.g., a row of second electric field generating contacts 223 may comprise 1, 2, 3, 4, 8, 16 second electric field generating contacts 223, preferably a row of first electric field generating contacts 223 may comprise 1 second electric field generating contact 223. In this case, the electric field can be formed in a plurality of directions.

In some examples, the first electric field generating contacts 223 of each row may be uniformly distributed at the outer circumference of the center electrode 221. In this case, different electric fields can be formed at the outer circumference of the center electrode 221.

In some examples, the electric field generating contact 223 may be rectangular, circular, or any polygonal shape. In some examples, referring to fig. 7a, the electric field generating contact 223 may be rectangular.

Fig. 8 is a schematic diagram illustrating an implantable electric field generating contact 223 and a temperature monitoring contact according to an embodiment of the present disclosure.

In some examples, referring to fig. 8, the electrode part 22 may further include a control module 23, the control module 23 being configured to control the electric signal generated by the signal generating module 21 to form electric fields of different frequencies, field strengths, directions, electric field direction switching periods, or duty cycles through the electric field generating contacts 223. In this case, parameters such as frequency, field strength, direction, electric field direction switching period, or duty ratio of the formed electric field can be controlled.

In some examples, the electrode portion 22 may also be provided with a signal feedback sensor. In this case, information of the target region 11 can be collected, and further, parameters of the electric field can be adjusted based on the information of the target region 11.

In some examples, referring to fig. 8, the electrode portion 22 further includes a plurality of temperature monitoring contacts 224 for detecting temperature, the temperature monitoring contacts 224 being spaced apart from the electric field generating contacts 223. In this case, temperature information in the vicinity of the electric field generating contact 223 can be detected, and further, parameters of the electric field can be adjusted based on the temperature information in the vicinity of the electric field generating contact 223, so that influence on other cells in the target region 11 due to excessive temperature can be reduced.

In some examples, the electrode portion 22 may also be deformed in another manner, in particular, the electrode portion 22 may include a base portion and a peripheral electrode 222 telescopically disposed to the base portion in a radial manner. In this case, the extension and contraction length of the extendable and contractible outer peripheral electrode 222 can be adjusted to deform the electrode portion 22, and the electric field generating contact 223 can be brought into contact with or close to the inner wall of the target region 11.

In some examples, the electrode portion may also change the range of action of the electric field (i.e. the coverage of the effective electric field) by deformation. Specifically, the position of the electric field generating contact may be changed to change the range of action of the electric field.

In some examples, the electrode portion may include an extension electrode. In some examples, the ductile electrode may be columnar. In some examples, the electric field generating contacts of the extension electrode may be arranged in the same manner as the peripheral electrode.

In some examples, after the electrode portion is implanted into the target area, the ductile electrode may be implanted into the inner wall of the target area. In other words, a portion of the ductile electrode may be inserted into the inner wall. In this case, since the center electrode 221 and the outer peripheral electrode 222 are located at the target region, when the target cell has a large distance from the inner wall of the target region (i.e., the target cell), the electric field formed by the center electrode 221 and the outer peripheral electrode 222 is weak at this position according to the distribution rule of the electric field, and thus the coverage of the electric field can be enlarged by forming the electric field using the electric field generating contact inserted into the inner wall, thereby improving the therapeutic effect of the target cell located at the inner wall.

While the utility model has been described in detail in connection with the drawings and embodiments, it should be understood that the foregoing description is not intended to limit the utility model in any way. Modifications and variations of the utility model may be made as desired by those skilled in the art without departing from the true spirit and scope of the utility model, and such modifications and variations fall within the scope of the utility model.

Claims (10)

1. An implantable electrode device for generating an electric field and suppressing growth of target cells in a target region by using the electric field, comprising: the electrode part comprises a plurality of electric field generating contacts for generating a variable electric field, and after the electrode part is implanted into the target area, the electrode part deforms to enable the electric field generating contacts to be in contact with the inner wall of the target area or adjust the action range of the electric field.

2. The electrode device of claim 1, wherein the electrode device comprises a plurality of electrodes,

the electrode portion includes a center electrode and an outer peripheral electrode, which are respectively provided with a plurality of electric field generating contacts.

3. An electrode arrangement according to claim 2, characterized in that,

the varying electric field is generated by at least two electric field generating contacts of the plurality of electric field generating contacts.

4. An electrode arrangement according to claim 2, characterized in that,

the center electrode includes a fixing portion for fixing the center electrode and an implantation portion extending from the fixing portion to the target region, in which a plurality of electric field generating contacts are provided.

5. The electrode device according to claim 4, wherein,

the electrode portion includes at least one peripheral electrode rotatably provided to the fixing portion.

6. The electrode device according to claim 5, wherein,

the outer peripheral electrode is of a tubular structure, and a cable for connecting the electric field generating contact and the wiring disc arranged on the central electrode is arranged in an inner cavity of the tubular structure.

7. The electrode device of claim 6, wherein the electrode device comprises a plurality of electrodes,

the peripheral electrode is disposed at the fixing portion in such a manner that an angle between the peripheral electrode and the center electrode can be adjusted so that the peripheral electrode can be away from the center electrode and be in contact with an inner wall of the target region by adjusting the angle between the peripheral electrode and the center electrode.

8. The electrode device of claim 1, wherein the electrode device comprises a plurality of electrodes,

the electrode part also comprises a plurality of temperature monitoring contacts for detecting temperature, and the temperature monitoring contacts and the electric field generating contacts are distributed at intervals.

9. An electrode arrangement according to claim 2, characterized in that,

the central electrode is provided with first electric field generating contacts surrounding the central electrode in an array,

the peripheral electrode is provided with second electric field generating contacts surrounding the peripheral electrode in an array.

10. The electrode device of claim 1, wherein the electrode device comprises a plurality of electrodes,

the control module is configured to control the electric signals generated by the signal generation module to form electric fields with different frequencies, field strengths, directions, electric field direction switching periods or duty ratios through the electric field generation contacts.