CN220110456U - Simple device for improving efficiency of macroporous resin chromatographic column - Google Patents
Simple device for improving efficiency of macroporous resin chromatographic column Download PDFInfo
- Publication number
- CN220110456U CN220110456U CN202321480372.XU CN202321480372U CN220110456U CN 220110456 U CN220110456 U CN 220110456U CN 202321480372 U CN202321480372 U CN 202321480372U CN 220110456 U CN220110456 U CN 220110456U
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- Prior art keywords
- semicircular
- chromatographic column
- storage tank
- resin storage
- mounting plate
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- 239000011347 resin Substances 0.000 title claims abstract description 65
- 229920005989 resin Polymers 0.000 title claims abstract description 65
- 238000007789 sealing Methods 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims description 14
- 238000004587 chromatography analysis Methods 0.000 abstract description 3
- 238000007599 discharging Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model discloses a simple device for improving the efficiency of a macroporous resin chromatographic column, which belongs to the technical field of chromatography and comprises a support, wherein a mounting plate is arranged on the support in a sliding manner, a chromatographic column clamp is fixedly arranged on the support, the chromatographic column clamp is clamped with a chromatographic column, a semicircular resin storage tank is fixedly connected to the mounting plate through a fixing ring, a sealing cover is rotatably arranged at the top end of the semicircular resin storage tank, an arc-shaped plate is arranged in a sliding manner in the semicircular resin storage tank, the arc-shaped plate is in sliding connection with the mounting plate, a sealing plug is fixedly connected to the bottom end of the semicircular resin storage tank, and an ultrasonic device is detachably arranged on the chromatographic column.
Description
Technical Field
The utility model relates to the technical field of chromatography, in particular to a simple device for improving the efficiency of a macroporous resin chromatographic column.
Background
In the pharmaceutical chemistry production, the chromatographic technique operation is often required, the use of chromatographic columns in chemical equipment is quite common, but when the macroporous resin is filled into the traditional macroporous resin column, the problems of more bubbles and difficult compaction exist, and the problems lead to poor purification effect and low chromatographic efficiency.
Disclosure of Invention
The utility model aims to provide a simple device for improving the efficiency of a macroporous resin chromatographic column, which is used for solving the problems in the prior art.
The aim of the utility model can be achieved by the following technical scheme:
the simple device for improving the efficiency of the macroporous resin chromatographic column comprises a bracket, wherein a mounting plate is arranged on the bracket in a sliding manner, a chromatographic column clamp is also fixedly arranged on the bracket, and a chromatographic column is clamped on the chromatographic column clamp;
the semicircular resin storage tank is fixedly connected to the mounting plate through a fixing ring, the sealing cover is rotatably arranged at the top end of the semicircular resin storage tank, the arc-shaped plate is slidably arranged in the semicircular resin storage tank, and the arc-shaped plate is slidably connected with the mounting plate;
the bottom end of the semicircular resin storage tank is fixedly connected with a sealing plug, a semicircular through hole is formed in the sealing plug, a semicircular top cover is arranged on the other side of the semicircular through hole, and a liquid inlet is formed in the semicircular top cover;
an ultrasonic device is detachably arranged on the chromatographic column.
Further, the support is fixedly provided with a first telescopic cylinder and a telescopic rod, and the output end of the first telescopic cylinder and the extension end of the telescopic rod are fixedly connected with the mounting plate.
Further, fixedly connected with connecting rod on the arc, the upper and lower ends of mounting panel are fixed respectively and are equipped with the flexible jar of second, the output and the connecting rod fixed connection of flexible jar of second, connecting rod and mounting panel sliding connection.
Furthermore, a slot is further formed in the semicircular resin storage tank, and the arc plate can slide to the outer side of the semicircular resin storage tank through the slot.
Further, the semicircular through hole is used for communicating the semicircular resin storage tank with the sealing plug, and the semicircular through hole is symmetrical with the semicircular dome cover.
The utility model has the beneficial effects that:
according to the utility model, the semicircular resin storage tank is arranged, the arc-shaped plate is arranged in the semicircular resin storage tank in a sliding manner, the storage tank is divided into a plurality of spaces for storing the swelled macroporous resin in a layering manner, the ultrasonic device is detachably arranged on the chromatographic column, so that bubbles in the chromatographic column can be removed conveniently, meanwhile, the ultrasonic device can move on the chromatographic column, when the macroporous resin falls into the chromatographic column, liquid is filled into the chromatographic column through the liquid inlet, the ultrasonic device is moved to the macroporous resin added in the first section, the first section of macroporous resin is compacted, the macroporous resin in the first section is sequentially added to the macroporous resin in the second section of the chromatographic column after being compacted, the ultrasonic device is moved to the macroporous resin in the second section of the chromatographic column after being compacted, and the macroporous resin is compacted to reach the designated column volume.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described, and it will be obvious to those skilled in the art that other drawings can be obtained according to these drawings without inventive effort;
FIG. 1 is a schematic diagram I of the structure of the present utility model;
FIG. 2 is an enlarged schematic view of the structure of part A of the present utility model;
FIG. 3 is a schematic diagram II of the structure of the present utility model;
fig. 4 is a schematic view of a part of the structure of the present utility model.
The reference numerals in the figures illustrate:
1. a bracket; 2. a first telescopic cylinder; 3. a telescopic rod; 4. a mounting plate; 5. a chromatographic column clamp; 6. a chromatographic column; 7. slotting; 8. a second telescopic cylinder; 9. a semicircular resin storage tank; 10. sealing cover; 11. an arc-shaped plate; 12. a connecting rod; 13. a sealing plug; 14. a liquid inlet; 15. an ultrasonic device; 16. a fixing ring; 1301. a semicircular through hole; 1302. a semicircular top cap.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
In the description of the present utility model, it should be understood that the terms "open," "upper," "lower," "thickness," "top," "middle," "length," "inner," "peripheral," and the like indicate orientation or positional relationships, merely for convenience in describing the present utility model and to simplify the description, and do not indicate or imply that the components or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present utility model.
As shown in fig. 1-3, a simple device for improving efficiency of macroporous resin chromatographic columns is provided, a support 1, a first telescopic cylinder 2 and a telescopic rod 3 are fixedly arranged on the support 1, an output end of the first telescopic cylinder 2 and an extension end of the telescopic rod 3 are fixedly provided with a mounting plate 4, two chromatographic column clamps 5 are fixedly arranged on the support 1, a chromatographic column 6 is clamped between the two chromatographic column clamps 5, a second telescopic cylinder 8 is fixedly arranged at the upper end and the lower end of the mounting plate 4 respectively, a semicircular resin storage tank 9 is fixedly connected to the mounting plate 4 through a fixing ring 16, a sealing cover 10 is rotatably arranged at the top end of the semicircular resin storage tank 9, a plurality of arc plates 11 are arranged in the semicircular resin storage tank 9, the semicircular resin storage tank 9 is divided into a plurality of spaces, the diameter of the arc plates 11 is equal to the inner diameter of the semicircular resin storage tank 9, the arc plates 11 are in sliding connection with the semicircular resin storage tank 9, a plurality of grooves 7 are further formed in the semicircular resin storage tank 9, the arc plates 11 can slide to the outer sides of the semicircular resin storage tank 9 through the grooves 7, a person skilled in the art should know that the technical scheme is not limited in the embodiment, the number of the embodiment is as described in the embodiment, but the number of the embodiment is large as the number of the arc plates 11 can be conveniently added into the embodiment.
The arc plate 11 is fixedly connected with a connecting rod 12, the connecting rod 12 is slidably connected with the mounting plate 4, and the output ends of the two second telescopic cylinders 8 are respectively fixedly connected with the connecting rod 12, so that a person skilled in the art should know that the technical scheme is not limited to the specific number described in the above embodiment, for example, the number of the connecting rod 12, the number of the second telescopic cylinders 8 and the number of the arc plates 11 in the embodiment need to be kept consistent, and each arc plate 11 is ensured to be driven to move by the independent second telescopic cylinder 8.
The sealing plug 13 is fixedly connected to the bottom end of the semicircular resin storage tank 9, a discharging area is further arranged at the joint of the semicircular resin storage tank 9 and the sealing plug 13, a semicircular through hole 1301 is formed in the sealing plug 13, the semicircular resin storage tank 9 is communicated with the sealing plug 13 through the semicircular through hole 1301, the discharging area of the semicircular resin storage tank 9 is opposite to the semicircular through hole 1301, discharging is facilitated, a semicircular dome cover 1302 is arranged on the other side of the semicircular through hole 1301, the semicircular through hole 1301 is symmetrical to the semicircular dome cover 1302, a liquid inlet 14 is formed in the semicircular dome cover 1302, and a person skilled in the art should know that the liquid inlet 14 is formed in the semicircular dome cover 1302.
The ultrasonic device 15 is arranged on the chromatographic column 6 in a sliding and detachable manner, and the ultrasonic device 15 removes bubbles in the chromatographic column 6 through ultrasonic waves generated in the ultrasonic device 15, wherein the detachable manner can be that after the ultrasonic device 15 such as threaded connection, clamping connection and the like slides to a proper position on the chromatographic column 6, the ultrasonic device 15 is fixed again in a threaded connection or clamping connection manner, so that the ultrasonic device 15 can be conveniently moved to different positions
When the device is used, fully swelled macroporous resin is stored in the semicircular resin storage tank 9, the macroporous resin is stored in layers through the arc plates 11, when the macroporous resin is filled, the second telescopic cylinder 8 below the mounting plate 4 is controlled to shrink to draw out the arc plate 11 at the lowest layer, the punched resin on the arc plate 11 at the lowest layer falls into the chromatographic column 6 through the semicircular through holes 1301, a liquid pipeline can be connected to the liquid inlet 14, liquid is slowly injected into the chromatographic column 6, after the liquid rises to a proper height, the ultrasonic device 15 is moved to a proper position, the ultrasonic device 15 is started to remove bubbles between the macroporous resin and the injected liquid, the macroporous resin is compacted, the second telescopic cylinder 8 above the mounting plate 4 is controlled to shrink, the upper arc plate 11 is slowly drawn out, the macroporous resin in the second telescopic cylinder falls into the chromatographic column 6, the liquid is injected until the injected liquid reaches a certain height, the ultrasonic device 15 is moved to a second section position again, the ultrasonic device 15 is started, the bubbles in the second layer of the macroporous resin are removed, the resin is compacted to a designated volume, and the number of the macropores is easily added in layers, so that the number of the bubbles is reduced, and the occurrence of the excessive bubbles due to the excessive chromatographic column 6 is avoided.
In the description of the present specification, the descriptions of the terms "one embodiment," "example," "specific example," and the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present utility model. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing has shown and described the basic principles, principal features and advantages of the utility model. It will be understood by those skilled in the art that the present utility model is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present utility model, and various changes and modifications may be made without departing from the spirit and scope of the utility model, which is defined in the appended claims.
Claims (5)
1. The simple device for improving the efficiency of the macroporous resin chromatographic column is characterized by comprising a bracket (1), wherein a mounting plate (4) is arranged on the bracket (1) in a sliding manner, a chromatographic column clamp (5) is also fixedly arranged on the bracket (1), and a chromatographic column (6) is clamped on the chromatographic column clamp (5);
the mounting plate (4) is fixedly connected with a semicircular resin storage tank (9) through a fixing ring (16), a sealing cover (10) is rotatably arranged at the top end of the semicircular resin storage tank (9), an arc-shaped plate (11) is slidably arranged in the semicircular resin storage tank (9), and the arc-shaped plate (11) is slidably connected with the mounting plate (4);
a sealing plug (13) is fixedly connected to the bottom end of the semicircular resin storage tank (9), a semicircular through hole (1301) is formed in the sealing plug (13), a semicircular top cover (1302) is arranged on the other side of the semicircular through hole (1301) of the sealing plug (13), and a liquid inlet (14) is formed in the semicircular top cover (1302);
an ultrasonic device (15) is arranged on the chromatographic column (6) in a sliding way.
2. The device for simply improving the efficiency of the macroporous resin chromatographic column according to claim 1, wherein the first telescopic cylinder (2) and the telescopic rod (3) are fixedly arranged on the bracket (1), and the output end of the first telescopic cylinder (2) and the extension end of the telescopic rod (3) are fixedly connected with the mounting plate (4).
3. The device for simply improving the efficiency of the macroporous resin chromatographic column according to claim 1, wherein the connecting rod (12) is fixedly connected to the arc-shaped plate (11), the upper end and the lower end of the mounting plate (4) are respectively fixedly provided with a second telescopic cylinder (8), the output end of the second telescopic cylinder (8) is fixedly connected with the connecting rod (12), and the connecting rod (12) is in sliding connection with the mounting plate (4).
4. The simple device for improving the efficiency of the macroporous resin chromatographic column according to claim 1, wherein the semicircular resin storage tank (9) is further provided with a slot (7), and the arc-shaped plate (11) can slide to the outer side of the semicircular resin storage tank (9) through the slot (7).
5. The simple device for improving the efficiency of the macroporous resin chromatographic column according to claim 1, wherein the semicircular through hole (1301) is used for communicating the semicircular resin storage tank (9) with the sealing plug (13), and the semicircular through hole (1301) is symmetrical with the semicircular dome cover (1302).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321480372.XU CN220110456U (en) | 2023-06-09 | 2023-06-09 | Simple device for improving efficiency of macroporous resin chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321480372.XU CN220110456U (en) | 2023-06-09 | 2023-06-09 | Simple device for improving efficiency of macroporous resin chromatographic column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220110456U true CN220110456U (en) | 2023-12-01 |
Family
ID=88915109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321480372.XU Active CN220110456U (en) | 2023-06-09 | 2023-06-09 | Simple device for improving efficiency of macroporous resin chromatographic column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220110456U (en) |
-
2023
- 2023-06-09 CN CN202321480372.XU patent/CN220110456U/en active Active
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