CN220074777U - Liver specimen gridding sequential manufacturing device - Google Patents
Liver specimen gridding sequential manufacturing device Download PDFInfo
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- CN220074777U CN220074777U CN202321400536.3U CN202321400536U CN220074777U CN 220074777 U CN220074777 U CN 220074777U CN 202321400536 U CN202321400536 U CN 202321400536U CN 220074777 U CN220074777 U CN 220074777U
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- cutting
- box body
- grid
- lifting
- gridding
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- 210000004185 liver Anatomy 0.000 title claims abstract description 26
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 25
- 238000001179 sorption measurement Methods 0.000 claims description 17
- 238000011160 research Methods 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 3
- 238000004321 preservation Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 10
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 210000005228 liver tissue Anatomy 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- Sampling And Sample Adjustment (AREA)
Abstract
The liver specimen gridding sequential manufacturing device comprises a manufacturing table, wherein a cutting opening is formed in the manufacturing table, a lifting table and a lifting driving mechanism are arranged at the cutting opening, and the lifting driving mechanism is used for driving the lifting table to do lifting movement at the cutting opening; in summary, the utility model realizes the gridding cutting of the liver specimen through the cooperation of the lifting table, the grid cutting frame, the cutting frame and the electric cylinder, completes the gridding sequential of the liver specimen, has high cutting efficiency and is neat, can cut a large number of tissue specimens, has good tissue preservation effect and has important significance to scientific research.
Description
Technical Field
The utility model relates to a liver specimen gridding sequential manufacturing device.
Background
In the liver disease research process, the differences of the molecular level of the liver at the lesion site, the adjacent lesion site and the normal site need to be researched by applying the basic experimental technique. In the research of liver cancer, cancer tissues, tissues beside cancer and normal tissues are usually cut, differences of protein expression, RNA, protein modification and the like among tissues are researched by using technologies such as immunohistochemistry, mass spectrometry, protein electrophoresis, PCR and the like, differential factors are screened, and then the roles of the differential factors in the occurrence and development of diseases are further researched, so that the method is a basic thought of liver pathophysiology research.
At present, when liver samples are obtained, a surgical knife, scissors and other instruments are usually adopted to cut tissue samples, and then the samples are marked and then placed into formalin solution or liquid nitrogen for freezing. However, the method is troublesome to operate, the tissue specimens are required to be split in layers and then split sequentially, the specimen acquisition and splitting process takes a long time, usually tens of minutes or a few hours, a lot of enzyme substances are contained in liver cells, and when the specimen is split for too long, the enzymes are easy to digest proteins and RNA in the cells, so that the difference of the results of subsequent experiments is verified, and the whole scientific research process is influenced. Therefore, the device for rapidly cutting and holding the liver specimen has important significance.
Disclosure of Invention
The utility model aims to provide a sequential liver specimen gridding making device, which solves the technical problems that a large amount of tissue specimens are inconvenient to cut and the tissue preservation effect is poor when the liver specimens are acquired in the prior art.
In order to solve the technical problems, the utility model adopts the following technical scheme:
the liver specimen gridding sequential manufacturing device comprises a manufacturing table, wherein a cutting opening is formed in the manufacturing table, a lifting table and a lifting driving mechanism are arranged at the cutting opening, and the lifting driving mechanism is used for driving the lifting table to do lifting movement at the cutting opening;
the manufacturing table is also provided with a first box body and a second box body, the first box body is positioned right above the cutting opening, the top and the bottom of the first box body and the bottom of the second box body are of an open structure, two supporting bars are fixed on the inner wall of the lower end of the first box body, the two supporting bars are oppositely arranged, a configuration block and a plurality of layers of grid cutting frames are arranged in the first box body, the grid cutting frame of the lowest layer is placed on the two supporting bars, the balancing weight is placed on the grid cutting frame of the uppermost layer, the grid cutting frame is provided with a grid cutting plate, two opposite box walls at the lower end of the first box body are provided with first through openings, and the width of the first through openings is larger than that of the grid cutting frames;
a plurality of layers of cutting frames are arranged in the second box body, each cutting frame consists of three side plates and one cutting plate, a second port is formed in two opposite box walls at the lower end of the second box body, an electric cylinder is further arranged on the manufacturing table, and the end part of a push rod of the electric cylinder is connected to the side plate of the cutting port.
Further, the lifting table is provided with an adsorption fixing area, the adsorption fixing area is provided with a plurality of adsorption holes, a negative pressure cavity is formed in the adsorption fixing area and communicated with the adsorption holes, and the negative pressure cavity is connected with a negative pressure pipeline.
Further, four foot pads are arranged at the bottom of the grid cutting frame, and the grid cutting frame above is supported at four corners of the top of the grid cutting frame below through the four foot pads at the bottom.
Compared with the prior art, the utility model has the beneficial effects that: according to the utility model, the meshing cutting of the liver specimen is realized through the cooperation of the lifting table, the grid cutting frame, the cutting frame and the electric cylinder, the meshing sequence of the liver specimen is completed, the cutting efficiency is high, the cutting is neat, a large number of tissue specimens can be cut, the tissue preservation effect is good, and the method has important significance for scientific research.
Drawings
The accompanying drawings are included to provide a further understanding of the utility model and are incorporated in and constitute a part of this specification, illustrate the utility model and together with the embodiments of the utility model, serve to explain the utility model. In the drawings:
FIG. 1 is a schematic diagram of a sequential fabrication apparatus for gridding liver specimens according to the present utility model;
FIG. 2 is a schematic view of a structure of a lifting platform;
FIG. 3 is a top view of a grid cut frame;
FIG. 4 is a schematic view of the location of a stay;
FIG. 5 is a schematic diagram of stacking two adjacent grid cut frames;
fig. 6 is a state diagram of the cutting frame and the grid cutting frame when being matched for cutting.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
The present utility model is described in further detail below with reference to examples.
As shown in fig. 1 to 6, a specific embodiment 1 of a sequential manufacturing apparatus for gridding liver specimens according to the present utility model:
the liver specimen gridding sequential manufacturing device comprises a manufacturing table 1, wherein a cutting opening 2 is formed in the manufacturing table 1, a lifting table 3 and a lifting driving mechanism 4 are arranged at the cutting opening 2, and the lifting driving mechanism 4 is used for driving the lifting table 3 to do lifting movement at the cutting opening 2;
as shown in fig. 2, the lifting platform 3 is provided with an adsorption fixing area 5, the adsorption fixing area 5 is provided with a plurality of adsorption holes 6, a negative pressure cavity is arranged in the adsorption fixing area 5 and is communicated with the adsorption holes 6, and the negative pressure cavity is connected with a negative pressure pipeline 7.
The manufacturing table 1 is further provided with a first box body 8 and a second box body 9, the first box body 8 is located right above the cutting opening 2, the top and the bottom of the first box body 8 and the bottom of the second box body 9 are of open structures, as shown in fig. 4, two supporting rods 10 are fixed on the inner wall of the lower end of the first box body 8, the two supporting rods 10 are oppositely arranged, a configuration block 11 and a plurality of layers of grid cutting frames 12 are arranged in the first box body 8, the grid cutting frames 12 of the lowest layer are placed on the two supporting rods 10, a balancing weight is placed on the grid cutting frames 12 of the uppermost layer, as shown in fig. 3, the grid cutting frames 12 are provided with grid cutting plates 13, two opposite box walls at the lower end of the first box body 8 are provided with first through openings 14, and the width of the first through openings 14 is larger than that of the grid cutting frames 12; four foot pads 15 are arranged at the bottom of the grid cutting frame 12, the upper grid cutting frame 12 is supported at four corners at the top of the lower grid cutting frame 12 through the four foot pads 15 at the bottom, as shown in fig. 5, the foot pads 15 are arranged, so that a gap 18 is formed between two adjacent grid cutting frames 12, and a cutting plate 17 of the cutting frame 16 cuts liver tissues through the gap 18;
a plurality of layers of cutting frames 16 are arranged in the second box body 9, each cutting frame 16 consists of three side plates 19 and one cutting plate 17, a second through hole 20 is formed in two opposite box walls at the lower end of the second box body 9, an electric cylinder 21 is further arranged on the manufacturing table 1, and the end part of a push rod of the electric cylinder 21 is connected to the side plate 19 of the cutting opening 2.
When the liver specimen gridding sequential manufacturing device of the embodiment is used, firstly, a liver specimen 100 to be cut is placed in an adsorption fixing area 5, a negative pressure pipeline 7 is externally connected with negative pressure equipment, the negative pressure equipment is started, negative pressure is generated in a negative pressure cavity, and the negative pressure adsorbs and fixes the liver specimen 100 on a lifting table 3 through an adsorption hole 6;
then starting a lifting driving mechanism 4, wherein the lifting driving mechanism 4 pushes the lifting table 3 upwards, the moving distance is equal to the width of the grid cutting frame 12, in the moving process of the lifting table 3, the uppermost part of liver tissue enters the grid cutting frame 12, the grid cutting plate 13 in the grid cutting frame 12 cuts the entered liver tissue, then starting an electric cylinder 21, the electric cylinder 21 pushes the cutting frame 16 to move, the size of the cutting frame 16 is slightly larger than that of the grid cutting frame 12, as shown in fig. 6, the cutting plate 17 enters from the bottom of the grid cutting frame 12, the liver tissue is transversely cut, and then the side plate 19 of the cutting frame 16 ejects the grid cutting frame 12 through the first through hole 14; after ejection, the electric cylinder 21 is retracted, the upper grid cutting frame 12 and the cutting frame 16 fall down one, then the lifting driving mechanism 4 continues to push the lifting table 3 to move upwards for a certain distance, the steps are installed, the grid cutting frame 12 and the cutting frame 16 are utilized to cut the liver specimen 100 again, the grid sequential cutting can be carried out on the liver specimen 100 through the cyclic reciprocating cutting, and marks can be stuck on the grid cutting frame 12 for direct freezing or soaking with formalin.
It should be noted that in this document, terms such as "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (3)
1. Liver sample gridding is making device in succession, its characterized in that: the device comprises a manufacturing table, wherein a cutting opening is formed in the manufacturing table, a lifting table and a lifting driving mechanism are arranged at the cutting opening, and the lifting driving mechanism is used for driving the lifting table to do lifting movement at the cutting opening;
the manufacturing table is also provided with a first box body and a second box body, the first box body is positioned right above the cutting opening, the top and the bottom of the first box body and the bottom of the second box body are of an open structure, two supporting bars are fixed on the inner wall of the lower end of the first box body, the two supporting bars are oppositely arranged, a configuration block and a plurality of layers of grid cutting frames are arranged in the first box body, the grid cutting frame of the lowest layer is placed on the two supporting bars, the balancing weight is placed on the grid cutting frame of the uppermost layer, the grid cutting frame is provided with a grid cutting plate, two opposite box walls at the lower end of the first box body are provided with first through openings, and the width of the first through openings is larger than that of the grid cutting frames;
a plurality of layers of cutting frames are arranged in the second box body, each cutting frame consists of three side plates and one cutting plate, a second port is formed in two opposite box walls at the lower end of the second box body, an electric cylinder is further arranged on the manufacturing table, and the end part of a push rod of the electric cylinder is connected to the side plate of the cutting port.
2. The liver specimen gridding sequential fabrication apparatus of claim 1, wherein: the lifting table is provided with an adsorption fixing area, the adsorption fixing area is provided with a plurality of adsorption holes, a negative pressure cavity is arranged in the adsorption fixing area and communicated with the adsorption holes, and the negative pressure cavity is connected with a negative pressure pipeline.
3. The liver specimen gridding sequential fabrication apparatus of claim 1, wherein: the bottom of the grid cutting frame is provided with four foot pads, and the grid cutting frame above is supported at four corners of the top of the grid cutting frame below through the four foot pads at the bottom.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321400536.3U CN220074777U (en) | 2023-06-05 | 2023-06-05 | Liver specimen gridding sequential manufacturing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321400536.3U CN220074777U (en) | 2023-06-05 | 2023-06-05 | Liver specimen gridding sequential manufacturing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220074777U true CN220074777U (en) | 2023-11-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321400536.3U Active CN220074777U (en) | 2023-06-05 | 2023-06-05 | Liver specimen gridding sequential manufacturing device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220074777U (en) |
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2023
- 2023-06-05 CN CN202321400536.3U patent/CN220074777U/en active Active
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