CN220049352U - Chromatographic column cleaning instrument - Google Patents
Chromatographic column cleaning instrument Download PDFInfo
- Publication number
- CN220049352U CN220049352U CN202320911316.0U CN202320911316U CN220049352U CN 220049352 U CN220049352 U CN 220049352U CN 202320911316 U CN202320911316 U CN 202320911316U CN 220049352 U CN220049352 U CN 220049352U
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- China
- Prior art keywords
- connector
- column
- chromatographic column
- liquid outlet
- pipeline
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- 238000004140 cleaning Methods 0.000 title claims abstract description 32
- 239000007788 liquid Substances 0.000 claims abstract description 88
- 239000012535 impurity Substances 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 239000004696 Poly ether ether ketone Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920002530 polyetherether ketone Polymers 0.000 description 2
- 238000011001 backwashing Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model relates to the technical field of medical analysis equipment, in particular to a chromatographic column cleaning instrument. The chromatographic column cleaning instrument comprises a shell and a connector, wherein the shell is provided with a pump and a metering proportion valve which are connected through a pipeline, and a master controller which is respectively and electrically connected with the pump and the metering proportion valve; the top of the shell is provided with a bracket for placing a chromatographic column, the bracket is provided with a shunt controller, and the liquid inlet end of the shunt controller is connected with the liquid outlet end of the pump through a pipeline; the connector comprises a connecting pipe and a first connector and a second connector which are respectively arranged at two ends of the connecting pipe, wherein the first connector is in threaded connection with the liquid outlet end of the split flow controller, and the second connector is in threaded connection with the liquid inlet end of the chromatographic column. The chromatographic column cleaning instrument provided by the utility model can realize quick taking and placing of chromatographic columns and is convenient for disassembling the clamping structure.
Description
Technical Field
The utility model relates to the technical field of medical analysis equipment, in particular to a chromatographic column cleaning instrument.
Background
The prior art generally uses cleaning liquid to directly lavage the chromatographic column or uses ultrasonic wave combined cleaning liquid to clean the chromatographic column. Although the existing chromatographic column cleaning instrument with various models can support single-tube cleaning and simultaneously support multi-tube cleaning, so that the cleaning efficiency is effectively saved. However, in order to avoid liquid leakage, the chromatographic column to be cleaned generally adopts a double-head clamping mode, however, the clamping mode is inconvenient for disassembling the clamping head and taking and placing the chromatographic column, and seriously affects the cleaning efficiency.
Disclosure of Invention
In order to overcome the defects in the prior art, the technical problems to be solved by the utility model are as follows: the chromatographic column cleaning instrument is convenient for taking and placing chromatographic columns and convenient for disassembling the clamping structure.
In order to solve the technical problems, the utility model adopts the following technical scheme: the chromatographic column cleaning instrument comprises a shell and a connector, wherein the shell is provided with a pump and a metering proportioning valve which are connected through a pipeline, and a master controller which is respectively and electrically connected with the pump and the metering proportioning valve; the top of the shell is provided with a bracket for placing a chromatographic column, the bracket is provided with a shunt controller, and the liquid inlet end of the shunt controller is connected with the liquid outlet end of the pump through a pipeline;
the connector comprises a connecting pipe and a first connector and a second connector which are respectively arranged at two ends of the connecting pipe, wherein the first connector is in threaded connection with the liquid outlet end of the split flow controller, and the second connector is in threaded connection with the liquid inlet end of the chromatographic column.
Wherein, be formed with the inclined plane on the support, be provided with the holder on the inclined plane, the holder is used for the centre gripping chromatographic column.
Wherein, the holder includes the support that takes the form of strip to and set up at least one recess in the support length direction, the chromatographic column is embedded in the recess.
The support is provided with a containing cavity, the top of the containing cavity is provided with an opening, a storage bottle is arranged in the containing cavity, and the storage bottle is connected with the pump through a pipeline.
The split-flow controller comprises a main body and a switch, wherein the main body comprises a first liquid inlet and at least one first liquid outlet, the first liquid inlet is connected with the metering proportioning valve through a pipeline, and the switch is arranged on the pipeline where the first liquid outlet is connected with the chromatographic column.
The switch comprises a cylindrical column body, one axial end of the column body is connected with the support, an opening of an internal cavity of the column body is formed at the other axial end of the column body, a second liquid inlet and a second liquid outlet, the second liquid inlet and the first liquid outlet are arranged on the column body and communicated with the cavity, the second liquid inlet is connected with the first liquid outlet through a pipeline, and the first connector is connected with the second liquid outlet;
the knob comprises an end cover and a space occupying block arranged on one side of the end cover, and the space occupying block stretches into the cavity and blocks the second liquid inlet and the second liquid outlet when the knob is screwed into the opening to an extreme value.
The utility model has the beneficial effects that: according to the chromatographic column cleaning instrument provided by the utility model, the connection of the pipelines of the chromatographic column is realized through the connector, the fixation of the chromatographic column is realized through the clamp holder, and meanwhile, the clamp holder is arranged on the inclined plane of the bracket, so that an operator can conveniently take and put the chromatographic column, and meanwhile, the connector can be conveniently disassembled, so that the cleaning efficiency of the chromatographic column is improved.
Drawings
FIG. 1 is a schematic view of a chromatographic column cleaner according to the present utility model in one embodiment;
fig. 2 is a schematic structural view of a chromatographic column cleaner according to another embodiment of the utility model.
Description of the reference numerals: 1. a bracket; 11. a receiving chamber; 12. an inclined plane; 13. a support; 131. a groove; 2. a chromatographic column; 3. a housing; 4. a master controller; 5. a pump; 6. a shunt controller; 61. a main body; 62. a switch; 621. a knob; 63. a connector; 631. a first joint; 632. a connecting pipe; 633. and a second joint.
Detailed Description
In order to describe the technical contents, the achieved objects and effects of the present utility model in detail, the following description will be made with reference to the embodiments in conjunction with the accompanying drawings.
Referring to fig. 1 and 2, a chromatographic column cleaner comprises a housing 3 and a connector 63, wherein the housing 3 is provided with a pump 5 and a metering proportioning valve which are connected through a pipeline, and a master controller 4 which is electrically connected with the pump 5 and the metering proportioning valve respectively; the top of the shell 3 is provided with a bracket 1 for placing the chromatographic column 2, the bracket 1 is provided with a split flow controller 6, and the liquid inlet end of the split flow controller 6 is connected with the liquid outlet end of the pump 5 through a pipeline; the connector 63 includes a connection pipe 632, and a first joint 631 and a second joint 633 respectively disposed at two ends of the connection pipe 632, the first joint 631 is in threaded connection with the liquid outlet end of the split flow controller 6, and the second joint 633 is in threaded connection with the liquid inlet end of the chromatographic column 2.
Wherein the connector 63 is connected with the chromatographic column 2 through a first joint 631 and a second joint 633 by a pipeline of the shunt controller 6, so as to allow the washing liquid to be controlled to be filled into the chromatographic column 2 through the shunt controller 6, thereby washing the chromatographic column 2. Of course, the cleaning solution poured into the chromatographic column 2 needs to be discharged quickly because of the mixing of a large amount of impurities in the chromatographic column 2, so as to avoid the adsorption and deposition of the impurities in the chromatographic column 2 again, and therefore, it should be understood that the liquid outlet end of the chromatographic column 2 is also provided with the connector 63, so as to connect a waste liquid collecting bottle or connect back to the shunt controller 6 by using the connector 63, so as to collect the waste liquid or realize the backwashing of the chromatographic column 2.
Since the cleaning fluid is injected into the chromatographic column 2 in a high pressure state through the pump 5, the materials of the first and second connectors 631 and 633 are required to avoid leakage or burst during the high pressure injection. Preferably, the first connector 631 and the second connector 633 are made of PEEK (polyetheretherketone).
Specifically, the storage tank loaded with the cleaning solution is connected with the pump 5 through a pipeline, namely the cleaning solution is led out of the storage tank through the pump 5 and sequentially enters the chromatographic column 2 through the shunt controller 6 and the connector 63 to carry out impurity flushing. In order to achieve a proportional mixing of the various washing liquids for the application to the various chromatographic columns 2 or to chromatographic columns 2 containing different impurities, it is preferred to provide a metering proportioning valve on the line connecting the pump 5 and the reservoir.
The master controller 4 is used for controlling the opening and closing of the pump 5, the opening of the metering proportioning valve, and other parameters, such as temperature, etc., and it can be understood that a temperature regulating device for regulating the temperature of the cleaning liquid is also arranged in the shell 3. The control manner of the overall controller 4 is a conventional technical means, and will not be described in detail herein.
In one embodiment, the support 1 has a bevel 12 formed thereon, and the bevel 12 has a gripper provided thereon for gripping the chromatographic column 2. Preferably, the holder comprises a support 13 in the form of a strip and at least one recess 131 arranged in the length direction of the support 13, the chromatographic column 2 being embedded in the recess 131. In a more preferred embodiment, as shown in fig. 1 or 2, the number of the holders 13 is at least two, the adjacent holders 13 are spaced apart, and the grooves 131 are aligned with each other, that is, the arrangement is such that the inclined surface 12 allows the placed column 2 to be completely exposed while allowing both ends of the column 2 to be connected by the connector 63, and allowing an operator to directly take and place the column 2 and detach or mount the connector 63.
In one embodiment, the support 1 is formed with a containing cavity 11, the top of the containing cavity 11 is provided with an opening, a storage bottle is arranged in the containing cavity 11, and the storage bottle is connected with the pump 5 through a pipeline, namely, the storage bottle is placed through the arrangement, so that the occupied area of the chromatographic column cleaner is reduced. Of course, the shape of the opening is not limited to that shown in fig. 1 or 2, and any shape of the opening is possible, and if a plurality of openings are provided and are circular, the position of the storage bottle is allowed to be restricted by the opening, thereby achieving a certain positioning effect.
In one embodiment, the split-flow controller 6 includes a main body 61 and a switch 62, where the main body 61 includes a first liquid inlet and at least one first liquid outlet, the first liquid inlet is connected to the metering proportioning valve through a pipeline, and the switch 62 is disposed on the pipeline where the first liquid outlet is connected to the chromatographic column 2.
In an alternative embodiment, the switch 62 includes a cylindrical column, one axial end of the column is connected to the bracket 1, an opening of an internal cavity of the column is formed at the other axial end of the column, and a second liquid inlet and a second liquid outlet are disposed on the column and are communicated with the cavity, the second liquid inlet is connected with the first liquid outlet through a pipeline, and the first connector 631 is connected with the second liquid outlet; the knob 621 comprises an end cover and a space occupying block arranged on one side of the end cover, and the space occupying block stretches into the cavity and blocks the second liquid inlet and the second liquid outlet when the knob 621 is screwed into the opening to the extreme value.
Specifically, by rotating the knob 621 on the column, the knob 621 and the occupation block thereof move along the axial direction of the column in the rotating process of the knob 621 due to threaded connection, and the second liquid inlet and the second liquid outlet are both communicated with the cavity, so that the connectivity between the second liquid inlet and the second liquid outlet can be regulated by utilizing the movement of the occupation block in the cavity, namely, the opening and closing control of the pipeline is realized.
Example 1
Referring to fig. 1 and 2, a chromatographic column cleaner comprises a housing 3 and a connector 63, wherein the housing 3 is provided with a pump 5 and a metering proportioning valve which are connected through a pipeline, and a master controller 4 which is electrically connected with the pump 5 and the metering proportioning valve respectively; the top of the shell 3 is provided with a bracket 1 for placing the chromatographic column 2, the bracket 1 is provided with a split flow controller 6, and the liquid inlet end of the split flow controller 6 is connected with the liquid outlet end of the pump 5 through a pipeline;
the connector 63 comprises a connecting pipe 632, a first joint 631 and a second joint 633 respectively arranged at two ends of the connecting pipe 632, wherein the first joint 631 is in threaded connection with the liquid outlet end of the split flow controller 6, and the second joint 633 is in threaded connection with the liquid inlet end of the chromatographic column 2;
an inclined plane 12 is formed on the bracket 1, and a clamp is arranged on the inclined plane 12 and used for clamping the chromatographic column 2; wherein the holder comprises a strip-shaped support 13 and at least one groove 131 arranged in the length direction of the support 13, and the chromatographic column 2 is embedded in the groove 131;
the bracket 1 is provided with a containing cavity 11, the top of the containing cavity 11 is provided with an opening, a storage bottle is arranged in the containing cavity 11, and the storage bottle is connected with the pump 5 through a pipeline;
the split flow controller 6 comprises a main body 61 and a switch 62, the main body 61 comprises a first liquid inlet and at least one first liquid outlet, the first liquid inlet is connected with the metering proportioning valve through a pipeline, and the switch 62 is arranged on the pipeline where the first liquid outlet is connected with the chromatographic column 2;
the switch 62 comprises a cylindrical column body, one axial end of the column body is connected with the bracket 1, an opening of an internal cavity of the column body is formed at the other axial end of the column body, a second liquid inlet and a second liquid outlet which are arranged on the column body and are communicated with the cavity, the second liquid inlet is connected with the first liquid outlet through a pipeline, and the first connector 631 is connected with the second liquid outlet;
the knob 621 comprises an end cover and a space occupying block arranged on one side of the end cover, and the space occupying block stretches into the cavity and blocks the second liquid inlet and the second liquid outlet when the knob 621 is screwed into the opening to the extreme value.
Specifically, the pump 5 is controlled by the overall controller 4 to introduce the cleaning liquid loaded in the storage bottle into the main body 61 of the shunt controller 6, and the main body 61 shunts the cleaning liquid to the corresponding switch 62. At this time, the knob 621 in the switch 62 corresponding to the chromatographic column 2 is manually rotated to open the passage between the second liquid inlet and the second liquid outlet, so that the cleaning liquid enters the chromatographic column 2 from the second liquid outlet through the connector 63, the chromatographic column 2 is cleaned, the cleaning liquid mixed with impurities after cleaning flows out from the liquid outlet end of the chromatographic column 2, and finally flows into a waste liquid collecting bottle.
In summary, according to the chromatographic column cleaning instrument provided by the utility model, the connection of the pipeline of the chromatographic column is realized through the connector, the fixation of the chromatographic column is realized through the clamp holder, and meanwhile, the clamp holder is arranged on the inclined plane of the bracket, so that an operator can conveniently take and put the chromatographic column, and meanwhile, the connector can be conveniently detached, so that the cleaning efficiency of the chromatographic column is improved.
The foregoing description is only illustrative of the present utility model and is not intended to limit the scope of the utility model, and all equivalent changes made by the specification and drawings of the present utility model, or direct or indirect application in the relevant art, are included in the scope of the present utility model.
Claims (6)
1. The chromatographic column cleaning instrument is characterized by comprising a shell and a connector, wherein the shell is provided with a pump and a metering proportioning valve which are connected through a pipeline, and a master controller which is respectively and electrically connected with the pump and the metering proportioning valve; the top of the shell is provided with a bracket for placing a chromatographic column, the bracket is provided with a shunt controller, and the liquid inlet end of the shunt controller is connected with the liquid outlet end of the pump through a pipeline;
the connector comprises a connecting pipe and a first connector and a second connector which are respectively arranged at two ends of the connecting pipe, wherein the first connector is in threaded connection with the liquid outlet end of the split flow controller, and the second connector is in threaded connection with the liquid inlet end of the chromatographic column.
2. The column cleaner of claim 1, wherein the support has a bevel formed thereon, and wherein the bevel has a gripper disposed thereon for gripping the column.
3. The column cleaner of claim 2, wherein the holder includes a support in the form of a bar, and at least one recess provided in a length direction of the support, the column being inserted into the recess.
4. The chromatographic column cleaning device according to claim 1, wherein the support is provided with a containing cavity, the top of the containing cavity is provided with an opening, and a storage bottle is arranged in the containing cavity and connected with the pump through a pipeline.
5. The column cleaner of claim 1, wherein the split flow controller includes a main body and a switch, the main body includes a first liquid inlet and at least one first liquid outlet, the first liquid inlet is connected to the metering proportioning valve via a pipeline, and the switch is disposed on the pipeline where the first liquid outlet is connected to the column.
6. The chromatographic column cleaning device according to claim 5, wherein the switch comprises a cylindrical column body, one axial end of the column body is connected with the bracket, an opening of an internal cavity of the column body is formed at the other axial end of the column body, and a second liquid inlet and a second liquid outlet which are arranged on the column body and are communicated with the cavity, the second liquid inlet is connected with the first liquid outlet through a pipeline, and the first connector is connected with the second liquid outlet;
the knob comprises an end cover and a space occupying block arranged on one side of the end cover, and the space occupying block stretches into the cavity and blocks the second liquid inlet and the second liquid outlet when the knob is screwed into the opening to an extreme value.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320911316.0U CN220049352U (en) | 2023-04-21 | 2023-04-21 | Chromatographic column cleaning instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320911316.0U CN220049352U (en) | 2023-04-21 | 2023-04-21 | Chromatographic column cleaning instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220049352U true CN220049352U (en) | 2023-11-21 |
Family
ID=88764211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320911316.0U Active CN220049352U (en) | 2023-04-21 | 2023-04-21 | Chromatographic column cleaning instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220049352U (en) |
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2023
- 2023-04-21 CN CN202320911316.0U patent/CN220049352U/en active Active
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