CN219915648U - Immunoassay analyzer - Google Patents

Abstract

The utility model discloses an immunity analyzer, which comprises a frame and a conveying channel connected to one side of the frame, wherein the conveying channel comprises a channel main body with at least one sampling channel, a buffer storage position and a sampling position are sequentially arranged on the sampling channel along the conveying direction of the sampling channel, a buffer storage grip and a sampling grip are respectively arranged on the channel main body corresponding to the buffer storage position and the sampling position, the buffer storage grip and the sampling grip can slide back and forth along the sampling channel, the buffer storage grip can push or/and pull a sample rack positioned at the inlet end of the sampling channel to the buffer storage position, the sampling grip can position and hold the sample rack positioned at the buffer storage position in a pushing or/and pulling mode, and a sample filling system is arranged on the frame corresponding to the sampling position. The sampling accuracy can be improved, the error rate is reduced, the new incubation system, the new dilution system, the structure layout structure of the corresponding handles and the like are combined, the turnover steps and the period are shortened, the working efficiency of the parts is used up and the like, and the detection efficiency of the analyzer is improved.

Description

Immunoassay analyzer

Technical Field

The utility model belongs to the field of medical equipment, and particularly relates to an immunoassay instrument.

Background

In the centralized in-vitro diagnosis process, the collected samples are usually required to be sequentially or separately sent to detection and analysis equipment for detection and analysis, the transportation process is completed by a conveying channel, the existing conveying channel has more structural types, the conveying channel can be directly placed beside the analysis equipment or directly hung on the analysis equipment, for example, the document number is CN217332496U, the patent name is a sample scheduling system, and the system can assemble a conveying module, a supply and recovery module and a buffer scheduling module according to different sample scheduling requirements, so that the universality is higher; and patent with the reference number "CN 207036878U", entitled "sample rack transfer apparatus in sample transfer system".

However, the current conveying channel basically adopts a mode that synchronous belts are directly conveyed and are matched with an in-place sensor to position, the applicant finds that in the research process, because the conveyed sample rack and the synchronous belts are completely driven by friction and are influenced by the tension of the synchronous belts, the sample rack is difficult to accurately position at each position, the inner diameter of a sample tube on the sample rack is smaller, when the position of the sample rack is inaccurate, the sampling accuracy of a sample needle in analysis equipment is directly influenced, the sample needle is likely to deviate from an actual sample bottle opening, sampling failure or error taking and other conditions occur, the detection efficiency and the detection quality are easily influenced, in addition, the reagent is needed to be diluted in most times in the detection process, the layout between a dilution system structure and other modules on the analyzer is unreasonable, the dilution efficiency is directly reduced, and the integral detection efficiency of the analyzer is also influenced.

Disclosure of Invention

In view of the above, the utility model provides an immunoassay analyzer to solve the problems of inaccurate positioning of a sample rack in a conveying channel matched with the analyzer, poor accuracy of sampling position, easy sampling failure, unreasonable distribution of modules such as a dilution system on the analyzer, and further reduced detection efficiency in the prior art.

The technical scheme is as follows:

an immunoassay instrument, includes the frame to and the conveying passageway of articulating in this frame one side, conveying passageway includes the passageway main part that has at least one sampling channel, its key lies in: the sampling channel is provided with a buffer storage position and a sampling position along the conveying direction of the sampling channel in sequence, a buffer storage grip and a sampling grip are arranged on the channel main body corresponding to the buffer storage position and the sampling position, the buffer storage grip and the sampling grip can slide back and forth along the sampling channel, the buffer storage grip can push or/and pull a sample frame positioned at the inlet end of the sampling channel to the buffer storage position, the sampling grip can push or/and pull the sample frame positioned at the buffer storage position to be positioned and kept at the sampling position, and a sample filling system is arranged on the frame corresponding to the sampling position.

Compared with the traditional mode of directly utilizing friction and driving of the sample rack and the conveyor belt, the utility model directly utilizes the grip to convey the sample rack in place in a push-pull mode, and the driving is stopped when the power is stopped, so that the accurate positioning of the sample rack at the sampling position is realized, the sample filling system is ensured to be capable of sampling successfully, and the operation efficiency of the analyzer is indirectly improved.

As preferable: the sampling tongs comprise a claw frame, a sampling driving mechanism for driving the claw frame to move along the conveying direction of the sampling channel, and a track switching mechanism for driving the claw frame to move along the direction perpendicular to the conveying direction of the sampling channel, wherein the claw frame comprises a frame body arranged along the conveying direction of the sampling channel, a fixed claw and a movable claw which are respectively arranged at two ends of the frame body, the extending directions of the fixed claw and the movable claw are mutually perpendicular to the conveying direction of the sampling channel, the fixed claw is close to the outlet end of the sampling channel, and the movable claw can rotate towards one end of the fixed claw. The adoption is above sampling tongs structure, and the activity is grabbed and is not hindered the sample frame to get into the sample position, and utilizes fixed pawl and movable claw to mutually support, and the back-and-forth movement can realize the accurate location of sample frame fast, and utilizes track switching mechanism to realize the track switching of sampling tongs, prevents that it from causing the interference to the outflow of sample frame.

As preferable: the sampling gripper further comprises a sampling gripper seat, the track switching mechanism comprises a track changing guide rail and a track changing guide assembly, the track changing guide rail is mutually perpendicular to the conveying direction of the sampling channel, the frame body is in sliding fit with the track changing guide rail, a reset spring is arranged between the frame body and the sampling gripper seat, the reset spring is arranged in parallel with the track changing guide rail, and under the action of the reset spring in an initial state, the fixed claw and the movable claw at least partially extend into the sampling channel. By adopting the scheme, the fixed claw and the movable claw can be better attached to the front end surface and the rear end surface of the sample rack to realize push-pull, so that slipping is prevented or the sample rack is deflected, the reliability of the sampling gripper is improved, the structure is simplified so as to be convenient to implement, the sampling gripper can be always kept in the sampling channel when in a waiting position by utilizing the reset spring, and the sample rack cannot be prevented from entering between the movable claw and the fixed claw.

As preferable: the track change guiding assembly comprises a follow-up piece arranged on the claw frame and a guiding piece arranged on the sampling channel, when the sampling handle moves towards the outlet end of the sampling channel and exceeds a sampling position, the follow-up piece and the guiding piece can be matched to guide the claw frame to move towards the direction far away from the sampling channel, and the fixed claw and the movable claw withdraw from the sampling channel. By adopting the scheme, the passive structure is utilized to cooperate with the guiding mode, so that the implementation cost is reduced, and the later maintenance and replacement are convenient.

As preferable: the sampling gripper seat is positioned below the sampling channel, a sliding window for the fixed claw and the movable claw to extend in and slide is formed in the bottom wall of the sampling channel, the follower is a roller, and the axis of the roller is perpendicular to the length direction of the sampling channel;

the guide piece comprises two baffles which are arranged on one side of the sampling channel in a deflectable way and an avoidance rail positioned below the sampling channel, the two baffles are distributed along the length direction of the sampling channel and positioned at the front end and the rear end of the avoidance rail, and the roller and the baffles are provided with space overlapping parts in the width direction of the sampling channel. By adopting the scheme, compared with the mode that the sampling gripper seat is arranged on one side of the sampling channel, the occupation of the width space of the whole conveying unit can be reduced, the occupation of a certain height space is only increased, and only the supporting structure is arranged below the original sampling channel, so that the space layout is relatively more reasonable.

As preferable: the frame includes the frame upper strata, be close to the middle part position on the frame upper strata and be equipped with the system of incubating, the sample filling system is located between incubation system and the conveying channel, just the system of incubating is including incubating the module to and set up in the filling ring of incubating the module circumference outside with rotatable mode, the filling is encircled and is the filling reaction cup that the circumference array distributes and places the hole. The integrated filling ring in the incubation system is adopted, the filling ring is used as a transfer component, and the transfer distance between two connected modules can be effectively shortened by rotating and connecting a plurality of modules on the analyzer, so that the turnover time is shortened, and the detection efficiency is further improved.

As preferable: the incubation system comprises an incubation base, the incubation module is rotatably supported on the incubation base, and the incubation base is provided with an incubation disc rotating motor and a filling ring rotating motor which are used for respectively driving the incubation module and the filling ring to rotate.

As preferable: a dilution system is arranged between the sample filling system and the incubation system, the dilution system comprises a dilution channel module and a dilution mixing module which are distributed at an included angle, wherein the dilution channel module comprises a dilution trolley translation assembly and a dilution needle group lifting assembly, and the dilution trolley translation assembly comprises a dilution translation channel and a dilution trolley which is in sliding fit with the dilution translation channel;

the dilution mixing module comprises a mixing frame and a stirring assembly arranged on the mixing frame, wherein the stirring assembly comprises a stirring rod, a dilution mixing lifting assembly and a dilution mixing translation assembly, the dilution mixing lifting assembly and the dilution mixing translation assembly are respectively used for driving the stirring rod to lift and translate, and a stirring motor is used for driving the stirring rod to rotate, and a translation path of the dilution trolley and a translation path of the stirring rod are provided with intersection parts. By adopting the scheme, the dilution channel module and the dilution mixing module can be better arranged on the analysis instrument, the modular installation is realized, and meanwhile, the dilution uniformity effect is improved by utilizing the stirring mode after the diluent is filled, so that the accuracy of subsequent detection is improved.

As preferable: the mixing rack is arranged in parallel with the conveying channel, at least one washing system is arranged on the upper layer of the rack, the dilution translation channel is positioned between the incubation system and one of the washing systems, a second transferring gripper is arranged between the washing system and the incubation system, and the moving track of the second transferring gripper is opposite to the rotating center of the incubation module. The dilution system adopts the layout, so that the space utilization rate of the analyzer can be further improved, the transfer period between the washing system and the incubation module is shortened, the transfer of the reaction cup in the washing system is realized by utilizing the second transfer gripper, the cup dropping operation of the reaction cup in the dilution system can be realized, and the utilization efficiency of the second transfer gripper is improved.

As preferable: the upper layer of the rack is provided with a reaction cup loading system, the reaction cup loading system comprises a cup discharging module, a cup discharging channel module and a cup separating module, and the number of the washing systems is two;

the cup discharging module is close to one corner of the upper layer of the rack, the cup separating module is positioned between the two washing systems, a first transfer gripper is arranged between the cup separating module and the incubation system, an intersection part is arranged between the first transfer gripper and the dilution translation channel, the intersection part is a reaction cup loading and unloading position of the dilution channel, and the moving tracks of the first transfer gripper and the second transfer gripper are opposite to the rotation center of the incubation module. By adopting the scheme, the space utilization efficiency is improved, meanwhile, the space intersection arrangement mode is utilized, the loading efficiency of the reaction cup on the filling ring can be improved by the first transfer gripper, meanwhile, the loading and unloading efficiency of the reaction cup in the dilution system is considered, the transfer gripper can be used for grabbing the reaction cup in the dilution channel and losing the cup, the gripper function is fully utilized, and the integral structure is facilitated to be simplified.

Compared with the prior art, the utility model has the beneficial effects that:

the immunity analyzer provided by the utility model is matched with an optimized conveying channel, so that the sampling accuracy is improved, the error rate is reduced, and meanwhile, the new incubation system, the new dilution system, the structure layout structure of the corresponding handles and the like are combined, so that the turnover steps and the period are shortened, the working efficiency of parts is used up, the detection efficiency of the analyzer is improved, and the single detection time is shortened.

Drawings

FIG. 1 is a schematic diagram of the structure of the present utility model;

FIG. 2 is an isometric view of FIG. 1;

FIG. 3 is a schematic view of the structure and principle of the present utility model;

FIG. 4 is a schematic diagram of a conveying path structure;

FIG. 5 is a perspective view of FIG. 4;

FIG. 6 is a schematic diagram of a sample driving mechanism and a track switching mechanism;

FIG. 7 is a side view of FIG. 6;

FIG. 8 is a top view of FIG. 7;

FIG. 9 is a schematic view of a sampling gripper;

FIG. 10 is a schematic diagram of the operation of the track switching mechanism;

FIG. 11 is a perspective view corresponding to FIG. 10;

FIG. 12 is a schematic diagram of an incubation system;

FIG. 13 is a schematic illustration of a fill ring mounting structure;

FIG. 14 is a cross-sectional view of FIG. 13;

FIG. 15 is a perspective view of the dilution system (dilution trolley in dilution/dilution waste suction position);

FIG. 16 is an isometric view of FIG. 15 (dilution trolley in dilution blending position);

FIG. 17 is a schematic diagram of a sample filling system;

FIG. 18 is a schematic view of a sample filling module;

FIG. 19 is a schematic diagram of a cuvette loading system.

Detailed Description

The present utility model will be described in further detail with reference to the accompanying drawings.

Referring to fig. 1 to 19, the immunoassay analyzer includes a frame 100, and a conveying channel R hung on one side of the frame 100, where the conveying channel R is usually hung on the frame 100 by a fastening hanging manner, or can be directly supported on the same supporting surface as the frame 100 by a supporting structure, where a sample filling system is disposed on the frame 100, and the conveying channel R is mainly used for receiving and conveying a sent sample frame to an upper sample filling system near the frame 100 for sampling and detection.

As shown in the figure, the conveying channel R mainly comprises a channel main body R200, at least one sampling channel R210 is arranged on the channel main body R200, the bottom of the sampling channel R210 is in a plate shape or a slideway structure, two sides are provided with side plates, the side plates and the bottom are surrounded to form the sampling channel R200, and two ends and the top of the sampling channel R are open.

According to the utility model, a buffer position and a sampling position are sequentially arranged in the sampling channel R210 along the conveying direction of the sampling channel, a buffer grip R300 and a sampling grip R400 are respectively arranged on the channel main body R200 corresponding to the buffer position and the sampling position, the buffer grip R300 and the sampling grip R400 can slide reciprocally along the sampling channel R210, wherein the buffer grip R300 can push or/and pull a sample frame positioned at the inlet end of the sampling channel R210 to the buffer position, and the sampling grip R400 can position and hold the sample frame positioned at the buffer position at the sampling position in a push or/and pull manner.

As shown in the drawings, the sampling gripper R400 mainly includes a gripper frame R410, a sampling driving mechanism R420 for driving the gripper frame R410 to move along the conveying direction of the sampling channel R210, and a track switching mechanism for driving the gripper frame R410 to move along a direction perpendicular to the conveying direction (the direction from the inlet end to the outlet end) of the sampling channel R210.

The claw rack R410 includes a rack R411 disposed along a conveying direction of the sampling channel R210, and a fixed claw R412 and a movable claw R413 disposed at two ends of the rack R411, where extension directions of the fixed claw R412 and the movable claw R413 are perpendicular to the conveying direction of the sampling channel R210, the fixed claw R412 is close to an outlet end of the sampling channel R210, and the movable claw R413 can rotate toward an end where the fixed claw R412 is located.

Referring to fig. 9, in the specific implementation, the movable claw R413 is mounted at the end of the frame body R411 through a torsion spring, and a limiting protrusion R414 is correspondingly disposed, in an initial state, the movable claw R413 is abutted against the limiting protrusion R414 under the action of the torsion spring, and is opposite to the fixed claw R412, one side of the movable claw R413, facing away from the fixed claw R412, is provided with an inclined guiding surface, and when the inclined guiding surface is pressed, the upper end of the inclined guiding surface rotates towards the end where the fixed claw R412 is located, so that interference to a rear component is avoided.

In order to realize the further accurate location of sample frame in the sample position, so the straight line distance of stationary dog R412 and movable dog R413 is greater than the length of supporting sample frame that uses, like this at sample tongs R400 removal in-process, stationary dog R412 and movable dog R413 all can promote the sample frame respectively and carry out position adjustment.

The track switching mechanism is mainly used for driving the fixed claw R412 and the movable claw R413 to be separated from the inner space range of the sampling channel R210, so that interference to movement of a sample frame is avoided.

As shown in the drawing, the sampling gripper R400 further includes a sampling gripper seat R430, the gripper seat R430 is mainly used for bearing the hook rack R410, the track switching mechanism includes a track changing guide rail R431 and a track changing guide assembly, the track changing guide rail R431 is perpendicular to the conveying direction of the sampling channel R210, and is mainly used for guiding the hook rack R410 to stably move in the direction close to or far away from the sampling channel R210, so that the rack body R411 is in sliding fit with the track changing guide rail R431, a return spring R432 is disposed between the rack body R411 and the sampling gripper seat R430, the return spring R432 is parallel to the track changing guide rail R431, in an initial state, under the action of the return spring R432, the rack body R411 is located at the position closest to the sampling channel R210, and both the fixed gripper R412 and the movable gripper R413 extend into the sampling channel R210.

The track change guiding component comprises a follower R433 arranged on the claw frame R410 and a guiding piece arranged on the sampling channel R210, when the sampling gripper R400 moves towards the outlet end direction of the sampling channel R210 and exceeds the sampling position, the follower R433 and the guiding piece can cooperate to guide the claw frame R410 to move towards the direction far away from the sampling channel R210, and the fixed claw R412 and the movable claw R413 withdraw from the area of the sampling channel R210.

As shown in the drawing, in this embodiment, the sampling gripper seat R430 is located below the sampling channel R210, the track-changing rail R431 and the return spring R432 are vertically disposed on the gripper seat R430, and are located on one side of the gripper seat R430, and the upper and lower ends of the gripper seat R430 have protruding portions for limiting the lifting stroke of the hook frame R410, and the hook frame R410 is in an upper stop position under the action of the return spring R432.

The bottom wall of the sampling channel R210 is provided with a sliding window R211 for the fixed claw R412 and the movable claw R413 to extend into and slide, the follower R433 is a roller, the roller is rotatably arranged on the frame body R411, and the axis of the roller is vertical to the length direction of the sampling channel R210.

The guide member includes two baffles R434 disposed on one side of the sampling channel R210 in a deflectable manner and a avoidance rail R435 disposed below the sampling channel R210, where the two baffles R434 are distributed along the length direction of the sampling channel R210 and are disposed at front and rear ends of the avoidance rail R435, and the rollers and the baffles R434 have space overlapping portions in the width direction of the sampling channel R210, and in specific implementation, the baffles R434 are also mounted at a side lower position of the sampling channel R210 by torsion springs.

Referring to fig. 10 and 11 with emphasis, the baffle R434 is in an obtuse V shape, and includes a front baffle portion R4340 and a rear baffle portion R4341 (in this embodiment, the front and rear sides are both referenced to the inlet end of the sampling channel R210, the front side is close to the front side, the rear side is far away from the front side), hereinafter referred to as a first baffle near the front end of the sampling channel R210, and the other is a second baffle, where the front baffle portion R4340 of the first baffle is sunk under the avoidance rail R435 and the roller under the action of the torsion spring in the initial state, the rear baffle portion R4341 is tilted upward, on the translation path of the roller, the front baffle portion R4340 of the second baffle is substantially flush with or slightly lower than the avoidance rail R435, and the rear baffle portion R4341 is tilted upward on the translation path of the roller, and the highest point is flush with or slightly higher than the roller.

When the sampling gripper R400 moves towards the end of the sampling channel R210, the roller can easily cross the first baffle and the second baffle, after crossing, the first baffle and the second baffle are reset, and when the sampling gripper R400 returns to move towards the front end of the sampling channel R210, the roller contacts with the back side of the back baffle portion R4341 of the second baffle, guided by the back side, a downward guiding force is indirectly applied to the frame R411, and the frame R411 compresses the return spring R432 to move downwards until the roller contacts with the surface of the avoidance rail R435.

When the sampling gripper R400 moves towards the front end of the sampling channel R210 and the roller contacts with the back side of the first baffle, the first baffle can be rotated and lifted clockwise without obstructing the forward movement of the sampling gripper R400, at the moment, after the roller passes forward over the first baffle, the first baffle is reset again, the frame body R411 is reset to be at an upper stop position under the action of the reset spring R432 and returns to an initial state, and the fixed claw R412 and the movable claw R413 extend into the sampling channel, so that the push-pull positioning operation of the sample frame can be performed.

In this embodiment, the follower R433 adopts a roller structure, so that the sliding smoothness can be improved, and of course, the follower R433 can also directly adopt a fixing protrusion structure, which is within the protection scope of the present utility model.

The sampling driving mechanism R420 mainly comprises a sampling motor R421, a sampling positioning belt R422 and a sampling guide rail R423, wherein the sampling positioning belt R422 and the sampling guide rail R423 are arranged along the length direction of the sampling channel R210, a sampling slide block R436 which is in sliding fit with the sampling guide rail R423 is arranged on one side, deviating from the frame body R411, of the gripper seat R430, and the gripper seat R430 is fixedly connected with the sampling positioning belt R422.

It should be noted that, the sampling gripper R400 may be disposed on one side of the sampling channel R210, that is, the frame R411 is disposed on one side of the sampling channel R210, the fixed claw R412 and the movable claw R413 are disposed horizontally and protrude right above the sampling channel R210 along the width direction of the sampling channel R210, the corresponding track-changing rail R431 and the return spring R432 are disposed along the width direction of the sampling channel R210, and the avoiding rail R435 and the similar guide structure are disposed on the side of the sampling channel R210.

On the basis of the above embodiment, in order to further ensure the accuracy of the sampling position and the reliability of the push-pull force point of the sampling handle, the sliding window R211 is formed near a side wall of the sampling channel R210, meanwhile, a side extrusion member R212 corresponding to the setting of the sampling position is provided on one side of the sampling channel R210, and the side extrusion member R212 protrudes into the sampling channel R210 at least partially under the action of the torsion spring, so that the sample rack located at the sampling position is attached to the side wall on the opposite side, thereby preventing the uncertainty of the relative position of the sample rack and the sampling channel side wall when the sample rack is at the sampling position, and further facilitating the accurate positioning of the sample rack.

As shown in the figure, the side extrusion member R212 is also in a roller structure, the axis of the side extrusion member R212 is arranged along the height direction of the sampling channel R210, the side wall of the sampling channel R210 is provided with a through hole for the side extrusion member 212 to protrude into the sampling channel R210, and the side extrusion member R212 and the sliding window R211 are arranged at two opposite sides, so that the sample rack is close to one side provided with the sliding window R211, the push-pull operation of the sampling gripper R400 is facilitated, the position stability of the sample rack in the sampling channel R210 can be better ensured, the roller structure is adopted to contact with the side part of the sample rack, the friction force can be reduced, and the smoothness of sliding is ensured.

The buffer gripper R300 mainly serves to convey the sample bin SU to or convey the prepared sample rack to the middle position of the sampling channel R210, the buffer gripper R300 can reduce the stroke of the sampling gripper R400, so as to reduce the movement of the sampling gripper R400 to actually improve the efficiency, and the buffer gripper R300 comprises a buffer gripper frame R310 and a buffer driving mechanism R320 for driving the buffer gripper frame R310 to slide reciprocally along the length direction of the sampling channel R210, the buffer gripper R311 is movably mounted at the front end and the rear end of the buffer gripper frame R310 through torsion springs, the buffer gripper R311 is arranged along the width direction of the sampling channel R210 and extends at least partially to the position right above the sampling channel R210, and with reference to fig. 4, the buffer gripper R311 is mounted in a manner similar to the movable gripper R413, one end of the sampling channel R210 can rotate clockwise towards the outlet end of the sampling channel R210 under the thrust action towards the outlet end of the sampling channel R210, but cannot rotate reversely, and when the thrust is eliminated, the buffer gripper R311 is reset.

The rotatable directions of the two buffer claw R311 are kept consistent, and one side of the two buffer claw R311 facing the front end of the sampling channel R210 is provided with a guiding inclined plane, which is more beneficial to pushing the sample rack between the two buffer claw R311 and pulling the sample rack out from the buffer claw R311 at the tail end to the sampling position.

To further increase the supply system functionality, and to meet more diagnostic needs, the channel body R200 further includes an emergency channel R230 and a return channel R220, and an emergency positioning grip and an emergency transfer grip R240 disposed corresponding to the emergency channel 230, and a return grip R221 disposed corresponding to the return channel R220, as shown, the emergency channel R230, the sampling channel R210, and the return channel R220 are disposed side by side, with the emergency positioning grip being similar in structure to the sampling grip R400.

On the other hand, in the normal case, the conveying channel R is used together with the sample bin unit SU and the recovery unit R500, where the sample bin unit SU has a dispatching unit SU100, and the structure of the emergency transfer gripper R240 is similar to that of the buffer gripper R300, and the difference is that the moving stroke of the emergency transfer gripper R240 is relatively larger, and the moving stroke is mainly used to pull the sample rack into the emergency channel R230 to the emergency sampling position, and after finishing the inspection, the sample rack is sent to the recovery unit R500, and similarly, a finishing gripper R250 is disposed at a position near the end of the sampling channel R210, where the finishing gripper R250 has a single-claw structure, similar to the second half of the buffer gripper R300, and is used to push the sample rack after finishing the inspection in the sampling channel R210 into the recovery unit R500.

In order to prevent the sample rack in the emergency channel R230 and the sampling channel R210 from being pushed out and not being received by the recovery unit R500 in the case of accident, the conveying ends of the emergency channel R230 and the sampling channel R210 are provided with the stop structures R260, and in the initial state, the stop structures R260 at least partially protrude to the right front of the corresponding channel outlet ends, and form a blocking state for the channel outlet ends, which can release the blocking state in a deflecting or sliding manner.

Specifically, as shown in the figure, the stop structure R260 includes a stop piece R261 and a return tension spring R262 rotatably disposed at the outlet ends of the emergency channel R230 and the sampling channel R210, where the stop piece R261 is kept in a vertical state under the pull of the return tension spring R262, the outlet ends of the two channels are stopped, the rotation pivot of the stop piece R261 is lower than the bottom wall of the channel, the return tension spring R262 is located below the rotation pivot, one end of the return tension spring R262 is fixed at the end of the stop piece R261, when the stop piece R261 is subjected to a thrust force along the channel width direction (in the practical implementation process, the recovery trolley R510 slides along the channel width direction to push the upper end of the stop piece 261 to rotate), the stop piece R261 can rotate to a position lower than the bottom wall of the channel, at this time, the sample rack in the corresponding channel can slide out, and when the thrust force is eliminated, the stop piece R261 returns to the initial vertical state under the action of the return tension spring R262.

As shown in the drawing, the rack 100 in the present utility model mainly includes a rack upper layer 110 and a rack upper layer 120, the rack upper layer 110 is used for installing each main module, an incubation system 700 is disposed on the rack upper layer near the middle, a sample filling system is located between the incubation system 700 and a conveying channel R, the incubation system 700 includes an incubation module 720, and a filling ring 730 rotatably disposed on the outer side of the incubation module 720, and filling ring 730 has filling reaction cup placement holes distributed in a circumferential array.

Referring specifically to fig. 12 to 14, specifically, the incubation system 700 includes an incubation base 710, the incubation base 710 is fixedly disposed on the upper frame layer 110, the incubation module 720 is rotatably supported on the incubation base 710, and the incubation base 710 is provided with an incubation disc rotation motor 721 and a filling ring rotation motor 731 for respectively driving the incubation module 720 and the filling ring 730 to rotate.

The incubation module 720 mainly comprises an incubation tray 722 and an incubation tray heat-insulating shell 727 covered on the outer side of the incubation tray 722, incubation tray 722 is provided with incubation reaction cup placement holes distributed in a circumferential array, and the distribution density of filling reaction cup placement holes is consistent with that of the incubation reaction cup placement holes, namely, the radian between every two adjacent filling reaction cup placement holes is equal to that between every two adjacent incubation reaction cup placement holes, so that the filling reaction cup placement holes are more convenient to control in the rotation process and the incubation reaction cup placement holes are in the same radial direction, and in order to further reduce the control difficulty of a gripper when in implementation, the incubation tray 722 is flush with the upper surface of the filling ring 730, and the top of the incubation tray heat-insulating shell 727 is provided with incubation loading and unloading holes 728 for placing and exposing incubation reaction cups.

The incubation base 710 is provided with a fixed base shaft 711 which is vertically and fixedly arranged, the fixed base shaft 711 is of a hollow structure, an incubation disc rotating shaft 712 is rotatably arranged in the fixed base shaft, the incubation module 720 is fixedly supported on the incubation disc rotating shaft 712, and a filling ring synchronous wheel is rotatably arranged outside the incubation module, so that the coaxial arrangement of the incubation disc and the filling ring is realized. The fixed base shaft 711 is fixedly sleeved with an incubation plate support plate 713, the incubation plate support plate 713 is of an annular hollow plate-shaped structure, the bottom of the incubation plate heat preservation shell 727 is fixedly connected with the incubation plate support plate 713 through a screw, and meanwhile, the middle of the incubation plate 722 is fixedly connected with the incubation plate rotating shaft 712 through the screw.

Referring to fig. 15 and 16, in the present utility model, a dilution system 400 is disposed between a sample filling system and an incubation system 700, as shown in the drawing, the dilution system 400 includes a dilution channel module 410 and a dilution mixing module 420 which are distributed at an included angle, wherein the dilution channel module 410 includes a dilution trolley translation assembly 430 and a dilution needle set lifting assembly 460, the dilution trolley translation assembly 430 includes a dilution translation channel 431 and a dilution trolley 432 slidingly matched with the dilution translation channel 431, the dilution needle set lifting assembly 460 is used for driving a dilution liquid filling needle 464 and a waste liquid sucking needle 461 to lift, and a dilution translation driving mechanism for driving the dilution trolley 432 to slide along the length direction and stay at a preset position is disposed on the dilution trolley translation assembly 430 for corresponding operation of a reaction cup disposed on the corresponding dilution trolley 432.

The dilution and mixing module 420 comprises a mixing frame 421 and a stirring assembly 440 arranged on the mixing frame 421, wherein the stirring assembly 440 comprises a stirring rod 441, a dilution and mixing lifting assembly 442 and a dilution and mixing translation assembly 443 which are respectively used for driving the stirring rod 441 to lift and translate, and a stirring motor 444 for driving the stirring rod 441 to rotate, and a translation path of the dilution trolley 432 and a translation path of the stirring rod 441 are provided with an intersection part.

The mixing rack 421 and the conveying channel R are arranged in parallel, that is, the translation path of the stirring rod 441 and the conveying channel R are arranged in parallel, at least one washing system 800 is arranged on the upper layer 110 of the rack, the dilution translation channel 431 is located between the incubation system 700 and one of the washing systems 800, a second transferring gripper 300b is arranged between the washing system 800 and the incubation system 700, the second transferring gripper 300b can transfer the reaction cups on the washing system 800 and the incubation system 700 in an interactive manner, and meanwhile, after the dilution and sampling are carried out on the dilution translation channel 431, the reaction cups which are subjected to solid-liquid separation can be gripped and lost.

In the utility model, the stirring rod 441 is further provided with a cleaning cup 450, as shown in the figure, the cleaning cup 450 is positioned below the stirring rod 441, and when the dilution mixing translation assembly 443 drives the stirring rod 441 to translate, the stirring rod 441 can be positioned right above the cleaning cup 450, and is driven to extend into the cleaning cup 450 for cleaning by the dilution mixing lifting assembly 442. The stirring rod 441 is mainly used for cleaning and maintaining the stirring rod, the stirring rod 441 stretches into the cleaning cup 450 to be soaked and cleaned, the risk of carrying pollution by the stirring rod 441 is reduced, and the stirring rod 441 is in a rotating state in the cleaning descending and ascending processes, so that the cleaning effect can be further improved, and the carrying pollution is reduced.

Referring to fig. 17 and 18, in order to improve the overall working efficiency when being used in combination with the dilution system 400, the sample filling system mainly comprises a sample filling system base 510, two sample filling modules 520 arranged on the sample filling system base 510, and a needle washing module 530 configured on each sample filling module 520, wherein the sample filling module 520 comprises a sample needle base 521, a sample needle cantilever 522 arranged above the sample needle base 521, and a cantilever driving motor 523 and a cantilever lifting motor 524 for driving the sample needle cantilever 522 to reciprocally rotate and lift, respectively, the cantilever driving motor 523 and the cantilever lifting motor 524 are fixedly arranged on the sample needle base 521 through a tensioning mechanism 525, and a vertically downward sample filling needle 5221 is arranged on the sample needle cantilever 522.

The cantilever driving motor 523 drives the sample needle cantilever 522 to rotate, so that the sample needle cantilever 522 can stay at a common sampling position, an emergency sampling position, a needle washing position, a direct sample adding position (which means that a sample is directly added into a reaction cup on the filling ring 730) and a dilution sample adding (taking) position (which is intersected with the dilution translation channel 431), and initially, the sample needle cantilever 522 is at a high position, and when the sample needle cantilever stays at the common sampling position and the emergency sampling position, the sample needle cantilever 522 can descend to sample the common sample or the emergency sample in the sample supply system, then the sample needle cantilever is lifted and rotated to the direct sample adding position or rotated to the dilution sample adding (taking) position to perform sample adding operation through descending again, and after each sample adding is completed, the sample needle washing can be performed by rotating to the needle washing position, so that cross contamination of the sample can be avoided, and the detection reliability is ensured.

Referring to fig. 1 to 3 and 19, the upper frame layer 110 is further provided with a cuvette loading system 200, the cuvette loading system 200 includes a cuvette discharging module 210, a cuvette discharging channel module 220 and a cuvette dividing module 230, the cuvette discharging module 210 is close to one corner of the upper frame layer 110, the cuvette discharging channel module 220 is arranged along the edge of the upper frame layer 110, the cuvette dividing module 230 is located between the two washing systems 800, a first transferring gripper 300a is arranged between the cuvette dividing module 230 and the incubation system 700, and an intersection part is formed between the first transferring gripper 300a and the dilution translation channel 431, the intersection part is a loading and unloading position of a cuvette in the cuvette dividing module 230, and the first transferring gripper 300a can be used for loading the cuvette in the cuvette dividing module 230 onto the dilution trolley 432 and the filling ring 730 on the dilution channel, or can be used for grabbing and dropping the cuvette in the intersection part.

Thus, dilution trolley 432 has at least six rest positions on dilution translation channel 431: the cuvette loading site, i.e., the site where it intersects the first transfer gripper 300a, at which time the first transfer gripper 300a may place the cuvette on the dilution trolley 432; diluting the sample filling position, namely rotating the intersection position with the sample filling needle 5221 to finish sample filling; the mixing position is diluted, and the reaction cup is positioned under the stirring rod 441 at this time, so that the mixing operation can be performed; the diluted sample sampling position is the same as the diluted sample filling position, and the diluted sample is returned to the diluted sample filling position after being uniformly mixed; the dilution waste liquid sucking position, the dilution trolley 432 is positioned right below the waste liquid sucking needle, and solid-liquid separation is completed; the cup-dropping position of the diluted reaction cup, the diluted trolley 432 is located at the intersection position with the second transferring gripper 300b, the reaction cup on the diluted trolley 432 is grabbed and discarded by the second transferring gripper 300b, that is, the cup-loading position, and the grabbing and moving of the reaction cup are completed by the first transferring gripper 300 a.

In particular, in order to improve the space utilization efficiency, in this embodiment, the moving tracks of the first transferring gripper 300a and the second transferring gripper 300b are opposite to the rotation center of the incubation module 720, and the moving track of the second transferring gripper 300b is perpendicular to the dilution translation channel 431.

Referring to the immunoassay analyzer shown in fig. 1 to 19, a sample rack with a sample bottle is initially stored in a sample bin unit SU, and after starting detection, a transportation unit SU100 feeds the sample rack into a sampling channel R210 or an emergency channel R230 by a diagnosis type. Then, the sampling gripper R400 or the emergency positioning gripper is used for positioning the sample rack in the corresponding channel so as to accurately sample and detect in a matching way, and the sampling error rate is reduced.

After the sample filling system samples, the corresponding sample rack is sent into the recovery trolley R510 through the completing hand R250 or the emergency treatment transferring hand R240, then pulled into the return channel R220 through the return hand R221 in the return channel R220, and finally sent into the idle sample warehouse unit SU through the dispatching unit SU 100.

After the sample filling system draws the sample, the sample is directly filled into the dilution trolley 432 or a reaction cup on the filling ring 730, for example, after the sample is filled into the reaction cup on the dilution trolley 432, the sample is uniformly diluted and mixed, then is sucked by the sample filling needle 5221 and finally is filled into the reaction cup on the filling ring 730, after reagent filling and independent uniform mixing operation, the sample is sent into the washing system 800 for washing and substrate operation, and then is sent back to the incubation plate 722, after incubation is completed, the sample is sent into the detection system for detection, the whole process takes the filling ring 730 as an intermediate medium, the operation requirement of a corresponding module is met through rotation, the operation period can be greatly shortened, and the detection efficiency is improved.

Finally, it should be noted that the above description is only a preferred embodiment of the present utility model, and that many similar changes can be made by those skilled in the art without departing from the spirit and scope of the utility model as defined in the appended claims.

Claims (10)

1. An immunoassay analyzer comprising a frame (100) and a transfer channel (R) attached to one side of the frame (100), the transfer channel (R) comprising a channel body (R200) having at least one sampling channel (R210), characterized in that: the sampling channel (R210) is sequentially provided with a buffer position and a sampling position along the conveying direction of the sampling channel, a buffer grip (R300) and a sampling grip (R400) are arranged on the channel main body (R200) corresponding to the buffer position and the sampling position respectively, the buffer grip (R300) and the sampling grip (R400) can slide reciprocally along the sampling channel (R210), the buffer grip (R300) can convey a sample frame positioned at the inlet end of the sampling channel (R210) to the buffer position in a pushing or/and pulling mode, the sampling grip (R400) can position and hold the sample frame positioned at the buffer position in the sampling position in a pushing or/and pulling mode, and a sample filling system is arranged on the frame (100) corresponding to the sampling position.

2. The immunoassay analyzer of claim 1, wherein: the sampling gripper (R400) comprises a gripper frame (R410), a sampling driving mechanism (R420) for driving the gripper frame (R410) to move along the conveying direction of a sampling channel (R210), and a track switching mechanism for driving the gripper frame (R410) to move along the direction perpendicular to the conveying direction of the sampling channel (R210), wherein the gripper frame (R410) comprises a frame body (R411) arranged along the conveying direction of the sampling channel (R210), and a fixed gripper (R412) and a movable gripper (R413) which are respectively arranged at two ends of the frame body (R411), the extending directions of the fixed gripper (R412) and the movable gripper (R413) are mutually perpendicular to the conveying direction of the sampling channel (R210), the fixed gripper (R412) is close to the outlet end of the sampling channel (R210), and the movable gripper (R413) can rotate towards one end where the fixed gripper (R412) is located.

3. The immunoassay analyzer of claim 2, wherein: the sampling gripper (R400) further comprises a sampling gripper seat (R430), the track switching mechanism comprises a track changing guide rail (R431) and a track changing guide assembly, the track changing guide rail (R431) is perpendicular to the conveying direction of the sampling channel (R210), a frame body (R411) is in sliding fit with the track changing guide rail (R431), a reset spring (R432) is arranged between the frame body (R411) and the sampling gripper seat (R430), the reset spring (R432) is arranged in parallel with the track changing guide rail (R431), and under the action of the reset spring (R432), the fixed claw (R412) and the movable claw (R413) at least partially extend into the sampling channel (R210) in an initial state.

4. An immunoassay according to claim 3, wherein: the track change guide assembly comprises a follower (R433) arranged on the claw frame (R410) and a guide piece arranged on the sampling channel (R210), when the sampling gripper (R400) moves towards the outlet end of the sampling channel (R210) and exceeds a sampling position, the follower (R433) and the guide piece can be matched to guide the claw frame (R410) to move towards the direction far away from the sampling channel (R210), and the fixed claw (R412) and the movable claw (R413) withdraw from the sampling channel (R210).

5. The immunoassay analyzer of claim 4, wherein: the sampling gripper seat (R430) is positioned below the sampling channel (R210), a sliding window (R211) for the fixed claw (R412) and the movable claw (R413) to extend into and slide is formed in the bottom wall of the sampling channel (R210), the follower (R433) is a roller, and the axis of the roller is perpendicular to the length direction of the sampling channel (R210);

the guide piece comprises two baffles (R434) which are arranged on one side of the sampling channel (R210) in a deflectable way and an avoidance rail (R435) which is arranged below the sampling channel (R210), the two baffles (R434) are distributed along the length direction of the sampling channel (R210) and are positioned at the front end and the rear end of the avoidance rail (R435), and the roller and the baffles (R434) are provided with space overlapping parts in the width direction of the sampling channel (R210).

6. The immunoassay analyzer of claim 1, wherein: the rack (100) comprises a rack upper layer (110), an incubation system (700) is arranged on the rack upper layer (110) close to the middle, a sample filling system is arranged between the incubation system (700) and a conveying channel (R), the incubation system (700) comprises an incubation module (720) and a filling ring (730) which is rotatably arranged on the circumferential outer side of the incubation module (720), and filling reaction cup placing holes distributed in a circumferential array are formed in the filling ring (730).

7. The immunoassay analyzer of claim 6, wherein: the incubation system (700) comprises an incubation base (710), an incubation module (720) is rotatably supported on the incubation base (710), and the incubation base (710) is provided with an incubation disc rotation motor (721) and a filling ring rotation motor (731) for driving the incubation module (720) and the filling ring (730) to rotate, respectively.

8. The immunoassay analyzer of claim 6 or 7, wherein: a dilution system (400) is arranged between the sample filling system and the incubation system (700), the dilution system (400) comprises a dilution channel module (410) and a dilution mixing module (420) which are distributed at an included angle, the dilution channel module (410) comprises a dilution trolley translation assembly (430) and a dilution needle group lifting assembly (460), and the dilution trolley translation assembly (430) comprises a dilution translation channel (431) and a dilution trolley (432) which is in sliding fit with the dilution translation channel (431);

the dilution mixing module (420) comprises a mixing frame (421) and a stirring assembly (440) arranged on the mixing frame (421), wherein the stirring assembly (440) comprises a stirring rod (441), a dilution mixing lifting assembly (442) and a dilution mixing translation assembly (443) which are respectively used for driving the stirring rod (441) to lift and translate, and a stirring motor (444) for driving the stirring rod (441) to rotate, and a translation path of the dilution trolley (432) and a translation path of the stirring rod (441) are provided with intersection positions.

9. The immunoassay analyzer of claim 8, wherein: the mixing rack (421) is arranged in parallel with the conveying channels (R), at least one washing system (800) is arranged on the upper layer (110) of the rack, the dilution translation channel (431) is located between the incubation system (700) and one of the washing systems (800), and a second transfer gripper (300 b) is arranged between the washing system (800) and the incubation system (700).

10. The immunoassay analyzer of claim 9, wherein: the upper layer (110) of the rack is provided with a reaction cup loading system (200), the reaction cup loading system (200) comprises a cup discharging module (210), a cup discharging channel module (220) and a cup separating module (230), and the number of the washing systems (800) is two;

the cup discharging module (210) is close to one corner of the upper layer (110) of the rack, the cup separating module (230) is located between the two washing systems (800), a first transferring gripper (300 a) is arranged between the cup separating module (230) and the incubation system (700), an intersection part is arranged between the first transferring gripper (300 a) and the dilution translation channel (431), the intersection part is a dilution channel reaction cup loading and unloading position, and the moving tracks of the first transferring gripper (300 a) and the second transferring gripper (300 b) are opposite to the rotation center of the incubation module (720).