CN219846941U - Fixing device for proton horizontal beam animal experiment - Google Patents
Fixing device for proton horizontal beam animal experiment Download PDFInfo
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- CN219846941U CN219846941U CN202223394791.XU CN202223394791U CN219846941U CN 219846941 U CN219846941 U CN 219846941U CN 202223394791 U CN202223394791 U CN 202223394791U CN 219846941 U CN219846941 U CN 219846941U
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- tumor
- fixing device
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- 238000010171 animal model Methods 0.000 claims abstract description 25
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- 210000003194 forelimb Anatomy 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
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- 231100000827 tissue damage Toxicity 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
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Abstract
The utility model relates to a fixing device for proton horizontal beam animal experiments, which comprises a transparent leakage-proof shell, wherein a horizontal bracket is arranged on the side wall of the leakage-proof shell, a bottom plate is placed on the horizontal bracket, water is injected into the leakage-proof shell to the lower part of the bottom plate, a plurality of open slots are formed in the bottom plate, an animal bin is detachably arranged in the open slots, the animal bin comprises an animal placing chamber positioned above the bottom plate and a tumor limb fixing plate positioned below the bottom plate, an experimental animal is placed in the animal placing chamber, and the tumor limb of the experimental animal extends out of an opening at the bottom of the animal placing chamber and is fixed on a fixing column below the water surface and on the surface of the tumor limb fixing plate. The utility model provides a fixing device which can be used for proton horizontal beam medical experiments, and the trunk of an experimental animal is kept above the water surface through an animal cabin, and the limb with tumor is fixed below the water surface, so that the management is convenient, and the experimental animal can be prevented from drowning and choking.
Description
Technical Field
The utility model belongs to the technical field of auxiliary devices for medical experiments, and particularly relates to a fixing device for proton horizontal beam animal experiments.
Background
Radiation therapy is one of the key means of comprehensive treatment of tumors, and ideal radiation therapy is to kill all cancer cells in the tumor without damaging normal cells of the patient, so one has defined the final criteria of radiation therapy as "achieving maximum tumor control rate and minimum normal tissue damage rate". The radiation used in traditional radiotherapy is photon rays (X rays and gamma rays) and electron rays, and due to the characteristic of the percentage depth dose, the irradiation dose of normal tissues is increased while the tumor treatment dose is increased, and accordingly the side effects of early stage and late stage are increased. Proton therapy is one of the most advanced and accurate radiotherapy technologies in the world at present, protons are hydrogen nuclei of electrons outside nuclei, high energy reaching 70% of light speed is accelerated by an accelerator, the high energy is injected into a human body under accurate control, and the energy is accurately released to a lesion part, so that the therapeutic effect of protecting normal tissues and killing tumors is achieved. Compared with the traditional photon treatment, the proton treatment has the main advantages that the radiation physical advantage of Bragg peak of proton rays is utilized, the irradiation dose is accurately concentrated on tumor focus, surrounding normal tissues can be safely avoided, compared with photons, the irradiation dose of local tumors is improved, the damage to the surrounding normal tissues can be reduced, and the life quality of patients is improved.
However, the relative biological effects of different positions of Bragg peaks aiming at the physical advantages of protons at present have a lot of complexity and uncertainty, and the different points of the molecular, cellular and tissue level of the proton contrast photon in the killing tumor and normal tissue mechanism are not clear, so that animal experiments are needed for exploration. In animal experiments, mice are used as common animal types, and proton horizontal beam irradiation experiments can be carried out after the mice are anesthetized, but because the proton horizontal beam needs to be irradiated in water, in order to prevent the mice from drowning in water, a fixing device capable of placing the tumor limb of the mice in water and placing the body on the water surface needs to be designed.
Disclosure of Invention
The utility model aims to solve the technical problem of providing a fixing device for proton horizontal beam animal experiments, which is used for placing tumor-bearing limbs of experimental animals such as mice in water and placing other parts on the water surface, and can irradiate a plurality of experimental animals simultaneously.
The technical scheme adopted for solving the technical problems is as follows: a fixing device for proton horizontal beam animal experiments is provided. Including transparent leak protection casing, be equipped with horizontal support on the lateral wall of leak protection casing, place the bottom plate on the horizontal support, water injection extremely in the leak protection casing the bottom plate below, be equipped with a plurality of open slots on the bottom plate, detachably installs the animal storehouse in the open slot, the animal storehouse is including being located animal placing chamber and being located of bottom plate top the tumour limb fixed plate of area below the bottom plate, experimental animal places in the animal placing chamber, experimental animal's tumour limb follow the trompil of animal placing chamber bottom stretches out and is fixed below the surface of water on the fixed column of tumour limb fixed plate surface.
Further, the animal placing chamber is in a cube shape, one side of the animal placing chamber is provided with a placing opening, and the bottom surface of the animal placing chamber is provided with at least two openings.
Further, the leakage-proof shell is made of PMMA.
Further, handles are arranged at two ends of the bottom plate.
Further, an overflow baffle with the height lower than that of the side wall of the leakage-proof shell is arranged in the leakage-proof shell, one side of the overflow baffle is filled with water, and the bottom plate is arranged on the side filled with water.
Further, an overflow pipe is arranged on the surface of the leakage-proof shell and is communicated with one side of the overflow partition plate, which is not filled with water, and an overflow groove is arranged at the bottom of the leakage-proof shell.
Advantageous effects
The utility model provides a fixing device which can be used for proton horizontal beam medical experiments, and the trunk of an experimental animal is kept above the water surface through an animal cabin, and the limb with tumor is fixed below the water surface, so that the management is convenient, and the experimental animal can be prevented from drowning and choking.
The bottom plate is provided with a plurality of open slots, and a plurality of animal bins can be correspondingly placed, so that tumor-bearing limbs of a plurality of experimental animals can be irradiated simultaneously, a control group is provided, the experimental time is saved, and the working efficiency is improved.
Drawings
Fig. 1 is a schematic structural diagram of a fixing device for proton horizontal beam animal experiments.
Fig. 2 is a schematic view of the structure of the animal chamber in fig. 1.
Fig. 3 is a schematic bottom view of the animal enclosure of fig. 2.
Wherein, 1-the leak-proof shell; 2-a horizontal bracket; 3-a bottom plate; 4-an animal bin; 401-animal holding chamber; 402-tumor-bearing limb fixation plates; 403-fixing columns; 404-opening holes; 405-placing the mouth; 406-C template; 407-graduation line; 5-overflow pipe; 6-overflow partition plates; 7-overflow tank.
Like reference symbols in the various drawings indicate like elements.
Detailed Description
The utility model will be further illustrated with reference to specific examples. It is to be understood that these examples are illustrative of the present utility model and are not intended to limit the scope of the present utility model. Furthermore, it should be understood that various changes and modifications can be made by one skilled in the art after reading the teachings of the present utility model, and such equivalents are intended to fall within the scope of the utility model as defined in the appended claims.
As shown in fig. 1, the utility model provides a fixing device for proton horizontal beam animal experiments, which comprises a transparent anti-leakage shell 1, wherein a horizontal bracket 2 is arranged on the side wall of the anti-leakage shell 1, a bottom plate 3 is arranged on the horizontal bracket 2, water is injected into the anti-leakage shell 1 to the lower part of the bottom plate 3, a plurality of open slots are arranged on the bottom plate 3, and an animal bin 4 is detachably arranged in each open slot. In this embodiment, the animal bin 4 is fixed on the bottom plate 3 through bolt positioning holes on two sides of the animal bin, and in other embodiments, a buckle or other detachable structure can be adopted.
As shown in fig. 2 and 3, the animal house 4 comprises an animal placing chamber 401 above the base plate 3 and a limb fixation plate 402 with tumor below the base plate 3. In this embodiment, the experimental animal is a common mouse, and in other embodiments, the experimental animal may be a monkey or other experimental animal with limbs, and the size of the animal placing chamber 401 should be matched with the body shape of the experimental animal. In use, an experimental animal is placed in the animal cabin 4, the trunk is limited in the animal placing chamber 401, so that the tumor limb of the experimental animal extends out of the opening 404 at the bottom of the animal placing chamber 401 and is fixed on the fixing column 403 below the water surface and on the surface of the tumor limb fixing plate 402. In this embodiment, the limb fixing plate 402 with tumor is a vertical plate, and is integrally formed with the side wall of the animal placing chamber 401. At least two fixing columns 403 are arranged on the surface of the limb fixing plate 402 with tumor. In this embodiment, the fixing column 403 is a fixing column, and has a through hole, and the tie rope passing through the through hole pulls the tumor limb of the experimental animal into the water and fixes the tumor limb. The surface of the limb fixing plate 402 is also provided with graduation marks 407 extending downwards from the bottom surface of the animal placing chamber 401, so as to conveniently indicate the underwater depth position of the limb.
The animal placing chamber 401 is cubic, and one side of the animal placing chamber is provided with a placing opening, and the placing opening is used for placing the laboratory animal after anesthesia into the animal placing chamber 401 and plays a role in ventilation. The placing opening is positioned on one side of the side wall of the animal placing chamber 401, and in this embodiment, the placing opening is closed by a C-shaped plate and locked by a bolt, so as to prevent the experimental animal from escaping from the animal placing chamber 401 due to unexpected wakening. In other embodiments, the animal holding chamber may be an integral animal holding chamber with a holding opening formed in only one side of the side wall without closing. The bottom surface of the animal placing chamber 401 is provided with at least two openings 404, the size of the openings 404 is larger than that of the experimental animal tumor limb, and the two openings 404 generally correspond to the forelimb and the hindlimb of the experimental animal respectively.
In this embodiment, the material of the leakage-proof casing 1 is PMMA, and the material is colorless and transparent, and has good transparency and is easy to process.
In this embodiment, handles are arranged at two ends of the bottom plate 3, so that an experimenter can conveniently take and put the bottom plate 3.
In this embodiment, still be equipped with in the leak protection casing 1 the height is less than overflow baffle 6 of leak protection casing 1 lateral wall, one side of overflow baffle 6 is filled with water, bottom plate 3 is placed in the one side that annotates water, overflow baffle 6 is convenient for control the water level in the leak protection casing 1, prevents to overflow bottom plate 3 when the water injection is too much and leads to experimental animals drowning. The surface of the leakage-proof shell 1 is provided with an overflow pipe 5 at a position communicated with one side of the overflow baffle 6, which is not filled with water, and the bottom of the leakage-proof shell 1 is provided with an overflow groove 7. For timely discharging the overflowed water in the overflow partition 6.
Claims (6)
1. A fixing device for proton horizontal beam animal experiments is characterized by comprising a transparent leakage-proof shell (1), wherein a horizontal support (2) is arranged on the side wall of the leakage-proof shell (1), a bottom plate (3) is placed on the horizontal support (2), water is injected into the leakage-proof shell (1) to the lower part of the bottom plate (3), a plurality of open slots are formed in the bottom plate (3), an animal bin (4) is detachably arranged in the open slots, the animal bin (4) comprises an animal placing chamber (401) positioned above the bottom plate (3) and a tumor limb fixing plate (402) positioned below the bottom plate (3), an experimental animal is placed in the animal placing chamber (401), and a tumor limb of the experimental animal stretches out from an opening (404) in the bottom of the animal placing chamber (401) and is fixed on a fixing column (403) on the surface of the tumor limb fixing plate (402).
2. A fixing device for proton horizontal beam animal experiments according to claim 1, characterized in that the animal placing chamber (401) is in the shape of a cube, one side is provided with a placing opening (405), and the bottom surface is provided with at least two openings (404).
3. The fixing device for proton horizontal beam animal experiments according to claim 1, wherein the material of the leak-proof housing (1) is PMMA.
4. The fixing device for proton horizontal beam animal experiments according to claim 1, wherein handles are provided at both ends of the bottom plate (3).
5. The fixing device for proton horizontal beam animal experiments according to claim 1, wherein an overflow baffle (6) with a height lower than that of the side wall of the leak-proof shell (1) is arranged in the leak-proof shell (1), one side of the overflow baffle (6) is filled with water, and the bottom plate (3) is arranged on the side filled with water.
6. The fixing device for proton horizontal beam animal experiments according to claim 4, wherein an overflow pipe (5) is arranged on the surface of the leakage-proof shell (1) and is communicated with one side of the overflow baffle plate (6) which is not filled with water, and an overflow groove (7) is arranged at the bottom of the leakage-proof shell (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223394791.XU CN219846941U (en) | 2022-12-19 | 2022-12-19 | Fixing device for proton horizontal beam animal experiment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223394791.XU CN219846941U (en) | 2022-12-19 | 2022-12-19 | Fixing device for proton horizontal beam animal experiment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219846941U true CN219846941U (en) | 2023-10-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202223394791.XU Active CN219846941U (en) | 2022-12-19 | 2022-12-19 | Fixing device for proton horizontal beam animal experiment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219846941U (en) |
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2022
- 2022-12-19 CN CN202223394791.XU patent/CN219846941U/en active Active
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