CN219765221U - Preparation device for protecting injection in low-oxygen environment by filling inert gas - Google Patents
Preparation device for protecting injection in low-oxygen environment by filling inert gas Download PDFInfo
- Publication number
- CN219765221U CN219765221U CN202320767520.XU CN202320767520U CN219765221U CN 219765221 U CN219765221 U CN 219765221U CN 202320767520 U CN202320767520 U CN 202320767520U CN 219765221 U CN219765221 U CN 219765221U
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- China
- Prior art keywords
- inert gas
- injection
- valve
- jacket
- feeding
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- 239000011261 inert gas Substances 0.000 title claims abstract description 53
- 239000001301 oxygen Substances 0.000 title claims abstract description 42
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 40
- 238000002347 injection Methods 0.000 title claims abstract description 31
- 239000007924 injection Substances 0.000 title claims abstract description 31
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000007788 liquid Substances 0.000 claims abstract description 33
- 238000010438 heat treatment Methods 0.000 claims abstract description 32
- 238000001816 cooling Methods 0.000 claims description 19
- 239000007789 gas Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 10
- 238000001514 detection method Methods 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims 5
- 239000004744 fabric Substances 0.000 claims 1
- 210000003437 trachea Anatomy 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 4
- 239000008215 water for injection Substances 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 206010021143 Hypoxia Diseases 0.000 abstract description 2
- 230000007954 hypoxia Effects 0.000 abstract description 2
- 238000007599 discharging Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 description 1
- 235000019136 lipoic acid Nutrition 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
Abstract
The utility model relates to a preparation device for protecting inert gas filling in an injection hypoxia environment, which comprises a preparation liquid tank, wherein an oxygen discharging pipe and a feeding hopper with a cover plate are arranged at the upper end of the preparation liquid tank, an inert gas valve and an emptying valve are arranged on the cover plate, a feeding valve is arranged at the lower end of the feeding hopper, heating jackets are arranged at the outer side and the bottom side of the preparation liquid tank, an inert gas distribution pipe is arranged in the preparation liquid tank, and a stirrer is arranged in the lower end of the preparation liquid tank. The utility model has short time consumption and good deoxidizing effect, and can not increase oxygen content caused by the entering of external air during feeding, and the low oxygen content of the water for injection can effectively ensure the quality of medicines.
Description
Technical Field
The utility model relates to the field of pharmaceutical equipment, in particular to a preparation device for protecting injection in a low-oxygen environment by filling inert gas.
Background
Most injections require lower oxygen content of water for injection in the preparation process, so that the product quality is ensured, for example, lipoic acid injection, VC injection and the like are required to have lower oxygen content, and oxygen removal and inert gas filling are required to protect. The Chinese patent publication No. CN215505620U discloses a novel deoxidizing device for injection preparation process, which is characterized in that injection water in a preparation tank enters an deoxidizing box from a liquid circulating pipe and is filtered by a titanium rod in the deoxidizing box during the use, and inert gas is fully contacted with the injection water and brings oxygen in the injection water out during the filtering process of the titanium rod, so that the injection water is quickly deoxidized to meet the process requirements. However, the existing device generally adopts a cover opening and feeding mode, namely, a feeding hopper cover plate arranged at the upper end of the configuration tank is opened and then is fed into the tank, and because no sealing protection exists during feeding, external air easily enters the configuration tank to cause the increase of the oxygen content in the tank.
Disclosure of Invention
The utility model aims to provide a preparation device for protecting injection in a low-oxygen environment by filling inert gas, which has the advantages of short time consumption, good deoxidization effect, no increase of oxygen content caused by the entering of external air during feeding, and low oxygen content of injection water can effectively ensure the quality of medicines.
The aim of the utility model is realized by the following technical scheme:
the utility model provides a preparation facilities that injection hypoxia environment fills inert gas protection, includes the liquid preparation jar, liquid preparation jar upper end is equipped with the oxygen pipe and takes the charging hopper of apron to be equipped with inert gas valve and evacuation valve on the apron, the charging hopper lower extreme is equipped with the charging valve, liquid preparation jar outside and bottom side are equipped with the heating jacket, liquid preparation jar inside is equipped with inert gas distribution pipe, liquid preparation jar lower extreme inside is equipped with the agitator.
The heating jacket is provided with a jacket inlet and a jacket outlet, wherein the jacket inlet is connected with a first heating pipeline and a first cooling pipeline, and the jacket outlet is connected with a second heating pipeline and a second cooling pipeline.
The lower end of the inert gas distribution pipe is provided with a gas distribution head with a plurality of gas distribution support rods, and each gas distribution support rod is provided with a plurality of gas distribution holes.
The upper end of the liquid preparation tank is provided with a feeding pipe, and the feeding hopper is arranged on the feeding pipe.
The upper end of the liquid preparation tank is provided with a pressure gauge, and oxygen content detection sensors are arranged in the liquid preparation tank and the feeding hopper.
The utility model has the advantages and positive effects that:
1. the oxygen-removing agent has good oxygen-removing effect, can not increase oxygen content caused by the entering of external air during feeding, and can effectively ensure the quality of medicines due to the low oxygen content of water for injection.
2. The utility model utilizes the heating jacket to realize the heating and cooling operation in the liquid preparation tank, has simple and convenient control and reduces the time consumption.
Drawings
Fig. 1 is a schematic structural view of the present utility model.
Wherein, 1 is a liquid preparation tank, 2 is a heating jacket, 3 is a jacket inlet, 4 is an inert gas distribution pipe, 5 is a gas distribution hole, 6 is a stirrer, 7 is a stirrer motor, 8 is a discharge hole, 9 is a jacket outlet, 10 is an oxygen discharge pipe, 11 is a pressure gauge, 12 is an inert gas connection pipe, 13 is an inert gas valve, 14 is an emptying valve, 15 is a charging hopper, 16 is a charging valve, and 17 is a charging pipe.
Detailed Description
The utility model is described in further detail below with reference to the accompanying drawings.
As shown in fig. 1, the utility model comprises a liquid preparation tank 1, wherein an oxygen discharge pipe 10 and a feeding hopper 15 with a cover plate are arranged at the upper end of the liquid preparation tank 1, an inert gas valve 13 connected with an inert gas pipeline and an emptying valve 14 connected with an emptying pipeline are arranged on the cover plate, a feeding valve 16 is arranged at the lower end of the feeding hopper 15, a heating jacket 2 is arranged at the outer side and the bottom side of the liquid preparation tank 1, an inert gas distribution pipe 4 is arranged in the liquid preparation tank 1, and a stirrer 6 is arranged in the lower end of the liquid preparation tank 1. When the utility model works, injection water is added into the liquid preparation tank 1, then the heating jacket 2 is started to heat and boil injection water in the tank, the inert gas distribution pipe 4 is started to charge inert gas into the tank to fully contact with the water, the inert gas rapidly brings oxygen in the water out when the injection water is boiled, meanwhile, the oxygen discharge pipe 10 is started to continuously suck out overflowed oxygen, when the oxygen content in the water is lower than a set value, the heating and cooling are stopped, meanwhile, the oxygen discharge pipe 10 is closed, the inert gas distribution pipe 4 is continuously charged with the inert gas to protect the injection water until the temperature is reduced to the process requirement, and then materials are put into the tank through the feed hopper 15. When the material is fed, the feeding valve 16 is closed firstly, then the cover plate is opened to put the material into the feeding hopper 15, the cover plate is closed, the inert gas valve 13 and the emptying valve 14 on the cover plate are opened, inert gas flows in from the inert gas valve 13 and flows out through the emptying valve 14, the inert gas flows to replace air in the feeding hopper 15 and form an inert gas protection layer, and when no oxygen is detected in the feeding hopper 15, the feeding valve 16 is opened to feed the material into the tank.
As shown in fig. 1, the heating jacket 2 is provided with a jacket inlet 3 and a jacket outlet 9, wherein the jacket inlet 3 is connected with a first heating pipeline 301 and a first cooling pipeline 302, and the jacket outlet 9 is correspondingly connected with a second heating pipeline and a second cooling pipeline. When the injection water needs to be heated and boiled, the control valves on the first heating pipeline 301 and the second heating pipeline are opened, meanwhile, the control valves on the first cooling pipeline 302 and the second cooling pipeline are closed, at this time, heating substances are input into the heating jacket 2 to realize heating, and the heating substances can be selected from steam, heat conducting oil and the like according to the requirements. When the tank needs to be cooled, the control valves on the first cooling pipeline 302 and the second cooling pipeline are opened, meanwhile, the control valves on the first heating pipeline 301 and the second heating pipeline are closed, at this time, cooling substances are input into the heating jacket 2 to achieve the cooling effect, and the cooling substances can adopt cooling water.
As shown in fig. 1, an inert gas connecting pipe 12 connected with an inert gas pipeline is arranged at the upper end of the liquid distribution tank 1, the upper end of the inert gas distributing pipe 4 is connected with the inert gas connecting pipe 12, a gas distributing head with a plurality of gas distributing struts is arranged at the lower end of the inert gas distributing pipe 4, a plurality of gas distributing holes 5 are formed in each gas distributing strut, and the gas distributing head ensures that inert gas and water for injection are fully contacted and oxygen is quickly brought out.
As shown in fig. 1, a feeding pipe 17 is arranged at the upper end of the liquid preparation tank 1, and the feeding hopper 15 is mounted on the feeding pipe 17.
As shown in figure 1, the lower end of the liquid preparation tank 1 is provided with a stirrer motor 7 for driving a stirrer 6 in the tank to stir in a rotating way, and the utility model can uniformly distribute a proper number of stirrers 6 in the lower end of the liquid preparation tank 1 along the circumferential direction according to actual needs.
As shown in fig. 1, a pressure gauge 11 is arranged at the upper end of the liquid preparation tank 1 for monitoring the pressure in the tank in real time, and in addition, oxygen content detection sensors are arranged in the liquid preparation tank 1 and the feeding hopper 15 for monitoring the oxygen content in the tank or the feeding hopper 15 in real time. The pressure gauge 11 and the oxygen content detection sensor are both well known in the art and commercially available products.
As shown in fig. 1, the oxygen exhaust pipe 10 is provided with a control valve for controlling the on-off of the pipeline, and in this embodiment, the oxygen exhaust pipe 10 is connected with a vacuum pipeline and uses a vacuum pumping mode to suck oxygen.
As shown in fig. 1, the lower end of the liquid preparation tank 1 is provided with a discharge port 8 for outputting materials in the tank.
The individual valves of the present utility model are well known in the art and are commercially available.
The working principle of the utility model is as follows:
when the utility model works, injection water is added into the liquid preparation tank 1, then a first heating pipeline 301 and a second heating pipeline which are connected with a heating jacket 2 are started, the first cooling pipeline 302 and the second cooling pipeline are closed at the same time, at the moment, the heating jacket 3 is heated to boil injection water in the tank, meanwhile, an inert gas distribution pipe 4 is started to charge inert gas into the injection water in the tank, the inert gas is fully contacted with the injection water and quickly brings out oxygen in the water when the injection water boils, an oxygen discharge pipe 10 is also started and continuously sucks out overflowed oxygen, when the oxygen content in the water is lower than a set value (lower than 1.5 percent in the embodiment), the heating is stopped, the first cooling pipeline 302 and the second cooling pipeline are started, meanwhile, an oxygen discharge pipe 10 is closed, at the moment, the inert gas distribution pipe 4 is continuously charged with inert gas to protect the injection water until the temperature is reduced to the technological requirement, and then materials are put into the tank through a feed hopper 15.
When the material is fed, the feeding valve 16 is closed firstly, then the cover plate is opened to put the material into the feeding hopper 15, then the cover plate is closed, the inert gas valve 13 and the emptying valve 14 on the cover plate are opened, inert gas flows in from the inert gas valve 13 and flows out through the emptying valve 14, the inert gas flows to replace air in the feeding hopper 15 and form an inert gas protection layer, and when no oxygen is detected in the feeding hopper 15, the feeding valve 16 is opened to feed the material into the tank.
Claims (5)
1. The utility model provides a preparation facilities that injection low oxygen environment fills inert gas protection which characterized in that: including joining in marriage fluid reservoir (1), join in marriage fluid reservoir (1) upper end and be equipped with oxygen discharge tube (10) and take throwing hopper (15) of apron, and be equipped with inert gas valve (13) and evacuation valve (14) on the apron, throwing hopper (15) lower extreme is equipped with throws material valve (16), join in marriage fluid reservoir (1) outside and downside and be equipped with heating jacket (2), join in marriage fluid reservoir (1) inside and be equipped with inert gas cloth trachea (4), join in marriage fluid reservoir (1) lower extreme inside agitator (6) that are equipped with.
2. The device for preparing the injection under the protection of inert gas according to claim 1, wherein the device is characterized in that: the heating jacket (2) is provided with a jacket inlet (3) and a jacket outlet (9), wherein the jacket inlet (3) is connected with a first heating pipeline (301) and a first cooling pipeline (302), and the jacket outlet (9) is connected with a second heating pipeline and a second cooling pipeline.
3. The device for preparing the injection under the protection of inert gas according to claim 1, wherein the device is characterized in that: the lower end of the inert gas distribution pipe (4) is provided with a gas distribution head with a plurality of gas distribution support rods, and each gas distribution support rod is provided with a plurality of gas distribution holes (5).
4. The device for preparing the injection under the protection of inert gas according to claim 1, wherein the device is characterized in that: the upper end of the liquid distribution tank (1) is provided with a feeding pipe (17), and the feeding hopper (15) is arranged on the feeding pipe (17).
5. The device for preparing the injection under the protection of inert gas according to claim 1, wherein the device is characterized in that: the upper end of the liquid preparation tank (1) is provided with a pressure gauge (11), and oxygen content detection sensors are arranged in the liquid preparation tank (1) and the feeding hopper (15).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320767520.XU CN219765221U (en) | 2023-04-10 | 2023-04-10 | Preparation device for protecting injection in low-oxygen environment by filling inert gas |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320767520.XU CN219765221U (en) | 2023-04-10 | 2023-04-10 | Preparation device for protecting injection in low-oxygen environment by filling inert gas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219765221U true CN219765221U (en) | 2023-09-29 |
Family
ID=88103975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320767520.XU Active CN219765221U (en) | 2023-04-10 | 2023-04-10 | Preparation device for protecting injection in low-oxygen environment by filling inert gas |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219765221U (en) |
-
2023
- 2023-04-10 CN CN202320767520.XU patent/CN219765221U/en active Active
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| GR01 | Patent grant |